A Middle School Campus Case Analysis with Dynamic Post-evaluation Strategy of Space Syntax

Due to the lack of technology, the post-evaluation system of spatial syntax has the limitations of inexperience, 3D vision and spatial problems prediction. The paper focuses on: (1) combined with the layout evaluation case of Nanning No.2 Middle School, the application of dynamic post-evaluation system in the evaluation process is refined, and the rationality of the system is verified; (2) combined with sDNA and GIS, a isovist model is built to expand the spatial syntax in 3D; (3) the simulation model is integrated into the post-evaluation system to solve the problem of dynamic feedback space, which enriches the dynamic post-evaluation system and improves the efficiency of campus layout

Dynamic Community Detection Based on Evolutionary DeepWalk

To fully characterize the evolution process of the topological structure of dynamic communities, we propose a dynamic community detection based on Evolutionary DeepWalk (DEDW) for the high-dimensional data and dynamic characteristics. First, DEDW solves the problem of data sparseness in the process of dynamic network data representation through graph embedding. Then, DEDW uses the DeepWalk algorithm to generate node embedding feature vectors based on the characteristics of the stable change of the community structure; finally, DEDW integrates historical network structure information to generate evolutionary graph features and implements dynamic community detection with the K-means algorithm. Experiments show that DEDW can mine the time-smooth change characteristics of dynamic communities, solve the problem of data sparseness in the process of node embedding, fully consider historical structure information, and improve the accuracy and stability of dynamic community detection

Prenatal Lipopolysaccharides Exposure Induces Transgenerational Inheritance of Hypertension

BACKGROUND: Adverse environmental exposure during the prenatal period can lead to diseases in the offspring, including hypertension. Whether or not the hypertensive phenotype can be transgenerationally transmitted is not known. METHODS: Pregnant Sprague Dawley rats were intraperitoneally injected with lipopolysaccharide (LPS) on gestation days 6, 8, 10, and 12 to generate the prenatal LPS exposure model. Blood pressure was monitored by both telemetry and tail-cuff method. RNA sequencing was performed to analyze transcriptome alteration in the kidney of the third generation. Tempol and spironolactone were used to test the potential prevention and therapeutic effect of targeting reactive oxygen species and mineralocorticoid receptor signaling, respectively. Molecular biological experiments were performed to illustrate the mechanism of epigenetic and transcription regulation. RESULTS: Prenatal LPS exposure can impair the ability to excrete a salt load and induce hypertension from the first to the third generations, with the fourth and fifth generations, inducing salt-sensitive hypertension. Compared with control pups, the transcriptome in the kidney of the hypertensive third-generation prenatal LPS-exposed offspring have upregulation of the Ras-related C3 botulinum toxin substrate 1 () gene and activation of mineralocorticoid receptor signaling. Furthermore, we found that LPS exposure during pregnancy triggered oxidative stress that upregulated KDM3B (histone lysine demethylase 3B) in the oocytes of first-generation female rats, leading to an inheritable low level of H3K9me2 (histone H3 lysine 9 dimethylation), resulting in the transgenerational upregulation of . Based on these findings, we treated the LPS-exposed pregnant rats with the reactive oxygen species scavenger, tempol, which successfully prevented hypertension in the first-generation offspring and the transgenerational inheritance of hypertension. CONCLUSIONS: These findings show that adverse prenatal exposure induces transgenerational hypertension through an epigenetic-regulated mechanism and identify potentially preventive and therapeutic strategies for hypertension