Factors associated with suicidal attempts in female patients with mood disorder

AimThis study aims to establish a nomogram model to predict the relevance of SA in Chinese female patients with mood disorder (MD).MethodThe study included 396 female participants who were diagnosed with MD Diagnostic Group (F30–F39) according to the 10th Edition of Disease and Related Health Problems (ICD-10). Assessing the differences of demographic information and clinical characteristics between the two groups. LASSO Logistic Regression Analyses was used to identify the risk factors of SA. A nomogram was further used to construct a prediction model. Bootstrap re-sampling was used to internally validate the final model. The Receiver Operating Characteristic (ROC) curve and C-index was also used to evaluate the accuracy of the prediction model.ResultLASSO regression analysis showed that five factors led to the occurrence of suicidality, including BMI (β = −0.02, SE = 0.02), social dysfunction (β = 1.72, SE = 0.24), time interval between first onset and first dose (β = 0.03, SE = 0.01), polarity at onset (β = −1.13, SE = 0.25), and times of hospitalization (β = −0.11, SE = 0.06). We assessed the ability of the nomogram model to recognize suicidality, with good results (AUC = 0.76, 95% CI: 0.71–0.80). Indicating that the nomogram had a good consistency (C-index: 0.756, 95% CI: 0.750–0.758). The C-index of bootstrap resampling with 100 replicates for internal validation was 0.740, which further demonstrated the excellent calibration of predicted and observed risks.ConclusionFive factors, namely BMI, social dysfunction, time interval between first onset and first dose, polarity at onset, and times of hospitalization, were found to be significantly associated with the development of suicidality in patients with MD. By incorporating these factors into a nomogram model, we can accurately predict the risk of suicide in MD patients. It is crucial to closely monitor clinical factors from the beginning and throughout the course of MD in order to prevent suicide attempts

Breastmilk microbiome changes associated with lactational mastitis and treatment with dandelion extract

IntroductionDandelion (Pugongying) is one of the most frequently used Chinese herbs for treating lactational mastitis (LM). Pugongying granules, a patented medication primarily comprised of dandelion extract, have been approved by CFDA for LM treatment in China. The aims of this study were to investigate the etiology of LM and the mechanism by which Pugongying granules decrease LM symptoms, with a particular focus on the microbial communities found in breastmilk.MethodsParticipants were recruited from a previously performed randomized controlled trial (Identifier: NCT03756324, ClinicalTrials.gov). Between 2019 and 2020, women diagnosed with unilateral LM at the Beijing University of Chinese Medicine Third Affiliated Hospital were enrolled. In total, 42 paired breastmilk samples from the healthy and affected breasts of the participants were collected. Additionally, 37 paired pre- and post-treatment breastmilk samples from the affected breast were collected from women who received a 3-day course of either Pugongying granules (20 women) or cefdinir (17 women). Clinical outcomes [e.g., body temperature, visual analogue scale (VAS) score for breast pain, the percentage of neutrophils (NE%)] were analyzed pre- and post-treatment, and the breastmilk samples were subjected to 16S rRNA gene sequencing to analyze the alpha and beta diversities and identify significant bacteria. Finally, the relationship between microorganisms and clinical outcomes was analyzed.ResultsThere was no significant difference in fever and pain between the Pugongying group and cefdinir group. The most prevalent bacterial genera in breastmilk were Streptococcus and Staphylococcus. Compared to healthy breastmilk, microbial diversity was reduced in affected breastmilk, and there was a higher relative abundance of Streptococcus. After Pugongying treatment, there was an increase in microbial diversity with significantly higher abundance of Corynebacterium. A negative correlation was found between Corynebacterium, VAS score, and NE%. Treatment with cefdinir did not affect microbial diversity. Taken together, our results show a correlation between LM and reduced microbial diversity, as well as an increased abundance of Streptococcus in affected breastmilk.ConclusionPugongying granules enhanced microbial diversity in breastmilk samples. Given the substantial variation in individual microbiomes, identifying specific species of Streptococcus and Corynebacterium associated with LM may provide additional insight into LM pathogenesis and treatment

Numerical Simulation of the Gas-Solid Flow by DEM-CFD Approach with Application to a Spouted Bed

Abstract: The paper presents a computational study of the gas-solid flow in a three-dimensional spouted bed by a combined approach of discrete element method and computational fluid dynamics (DEM-CFD).The coupling between the discrete particle and continuum gas was achieved by applying the principle of Newton’s third law of motion. As a result, it is found that the motion of particles was forming a distinct circulation between center zone and boundary zone of the 3D spouted bed in macro, and there was a stagnant zone near the bottom of the bed in which the particle velocity is almost zero near the wall, they do not move anywhere. Pressure drop will be affected by wind speed and particle density. With enhancing of wind velocity, pressure drop appears an increasing trend until it is up to a certain value, and then the curve will have a certain degree of back and keep in an extension; Adding particle density, pressure drop and its swing is increased markedly. The results of this study provide important information in the spouted bed and may be helpful for better application and modification of this type of spouted bed to the industrial process. Copyright © 2014 IFSA Publishing, S. L

Study on the Influence of Tourists’ Value on Sustainable Development of Huizhou Traditional Villages-- A Case of Hongcun and Xidi

The tourists’ value of traditional village representing personal values, influences the tourists’ behavior deeply. This paper, with the soft ladder method of MEC theory from the perspective of the tourist, studies the value of tourists born in the 60s, 70s, 80s, and 90s of the traditional villages in Hongcun and Xidi, which indicates 39 MEC value chains, and reveals 11 important attributes of Huizhou traditional villages, 16 tourism results, and 9 types of tourists’ values. With constructing a sustainable development model of Huizhou traditional villages based on tourists’ value, it shows an inherent interaction between tourists’ value and traditional village attributes subdividing the tourism products and marketing channels of Huizhou traditional villages, which is of great significance to the sustainable development of traditional villages in Huizhou

The Discrepancy between Coal Ash from Muffle, Circulating Fluidized Bed (CFB), and Pulverized Coal (PC) Furnaces, with a Focus on the Recovery of Iron and Rare Earth Elements

Coal ash (CA) is not only one of the most solid wastes from combustion, easily resulting in a series of concerns, but it is also an artificial deposit with considerable metals, such as iron and rare earth. The variation in the coal ash characteristics due to the origins, combustion process, and even storage environment has been hindering the metal utilization from coal ash. In this study, three ash sample from lab muffle, circulating fluidized bed (CFB), and pulverized coal (PC) furnace was derived for the discrepancy study from the combustion furnace, including properties, iron, and rare earth recovery. The origins of the coal feed samples have more of an effect on their properties than combustion furnaces. Magnetic separation is suitable for coal ash from PC because of the magnetite product, and the iron content is 58% in the Mag-1 fraction, with a yield of 3%. The particles in CA from CFB appear irregular and fragmental, while those from PC appear spherical with a smooth surface. The results of sequential chemical extraction and observation both indicated that the aluminosilicate phase plays an essential role in rare earth occurrences. Rare earth in CA from muffling and CFB is facilely leached, with a recovery of approximately 50%, which is higher than that from PC ash. This paper aims to offer a reference to easily understand the difference in metal recovery from coal ash

<i>Polygonatum odoratum</i> Polysaccharides Modulate Gut Microbiota and Mitigate Experimentally Induced Obesity in Rats

Increasing evidence suggests that the gut microbiota plays vital roles in metabolic diseases. Polygonatum odoratum extract alleviates hyperglycemia and hyperlipidemia, but the underlying mechanism remains unclear. This study investigated the effects of P. odoratum polysaccharides (POPs) on high-fat diet (HFD)-induced obesity in rats and whether these effects were related to modulation of gut microbiota. POP treatment attenuated weight gain, fat accumulation, epididymal adipocyte size, liver triglycerides, and total liver cholesterol content in HFD-fed rats. POP administration also increased short-chain fatty acids (SCFAs), including isobutyric acid, butyric acid, and valeric acid. POP upregulated the expression of genes involved in adipocyte differentiation (Pparg, Cebpa, Cebpb) and lipolysis (Ppara, Atgl), and downregulated those related to lipid synthesis (Srebpf1, Fabp4, Fas), with corresponding changes in PPAR&#947; and FABP4 protein expression. Finally, POP enhanced species richness and improved the gut microbiota community structure, reducing the relative abundances of Clostridium, Enterococcus, Coprobacillus, Lactococcus, and Sutterella. Principal coordinates analysis (PCoA) revealed a clear separation between HFD-fed rats and all other treatment groups. Correlation analysis identified negative and positive associations between obesity phenotypes and 28 POP-influenced operational taxonomic units (OTUs), including putative SCFA-producing bacteria. Our data suggest that POP supplementation may attenuate features of obesity in HFD-fed rats in association with the modulation of gut microbiota

Transitional Effects of Double-lateral Drip Irrigation and Straw Mulch on Irrigation Water Consumption, Mineral Nutrition, Yield, and Storability of Sweet Cherry

A field trial was conducted on a Cherryhill silt loam soil at The Dalles, OR, from 2006 to 2008. The impacts of switching from the traditional micro sprinkler irrigation (MS) to double-lateral drip irrigation (DD) and from no groundcover with herbicide control of weeds (NC) to in-row wheat (Triticum aestivum) straw mulching (ST) were evaluated in a split-plot design with four replicates. Irrigation water use, mineral nutrition, and productivity of ‘Lapins’ sweet cherry (Prunus avium) on ‘Mazzard’ rootstock (P. avium) and soil quality were measured on a plot basis. DD reduced irrigation water consumption by 47.6% to 58.2% compared with MS. Straw mulch lowered irrigation water use by 9.7% relative to NC. Total fruit yield and fruit quality of firmness, size, and sugar at harvest were similar for the irrigation treatments. Straw mulch increased fruit size by 0.6 mm on average relative to NC, which could result in increased grower profitability. The DD system enhanced percentage of marketable fruit by 8.6% relative to MS. Leaf phosphorus (P), boron (B), zinc (Zn), and iron (Fe) concentrations were reduced with DD over MS; consequently, more P, B, Zn, and Fe fertilizers might be needed under DD. Straw mulch markedly decreased the populations of flagellates and amoebae but slightly increased the population of ciliates. Straw mulch resulted in a soil microbial community with remarkably less protozoa. Overall, DD is a viable alternate irrigation system for producing sweet cherry orchards with limited water resources for irrigation. Switching from NC to ST could lower irrigation water use, reduce herbicide runoff, and protect soil from erosion.Keywords: soil microbial communities, leaf nutrient concentrations, Prunus avium, fruit qualit

Biopotentials of marine sponges from China oceans; past and future

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