Cylindrical Cloak with Axial Permittivity/Permeability Spatially Invariant

In order to reduce the difficulties in the experimental realizations of the cloak but still keep good performance of invisibility, we proposed a perfect cylindrical invisibility cloak with spatially invariant axial material parameters. The advantage of this kind of TE (or TM) cloak is that only rho and phi components of mu (or epsilon) are spatially variant, which makes it possible to realize perfect invisibility with two-dimensional (2D) magnetic (or electric) metamaterials. The effects of perturbations of the parameters on the performance of this cloak are quantitatively analyzed by scattering theory. Our work provides a simple and feasible solution to the experimental realization of cloaks with ideal parameters

Computer-based tracking, analysis, and visualization of linguistically significant nonmanual events in American Sign Language (ASL)

Our linguistically annotated American Sign Language (ASL) corpora have formed a basis for research to automate detection by computer of essential linguistic information conveyed through facial expressions and head movements. We have tracked head position and facial deformations, and used computational learning to discern specific grammatical markings. Our ability to detect, identify, and temporally localize the occurrence of such markings in ASL videos has recently been improved by incorporation of (1) new techniques for deformable model-based 3D tracking of head position and facial expressions, which provide significantly better tracking accuracy and recover quickly from temporary loss of track due to occlusion; and (2) a computational learning approach incorporating 2-level Conditional Random Fields (CRFs), suited to the multi-scale spatio-temporal characteristics of the data, which analyses not only low-level appearance characteristics, but also the patterns that enable identification of significant gestural components, such as periodic head movements and raised or lowered eyebrows. Here we summarize our linguistically motivated computational approach and the results for detection and recognition of nonmanual grammatical markings; demonstrate our data visualizations, and discuss the relevance for linguistic research; and describe work underway to enable such visualizations to be produced over large corpora and shared publicly on the Web

Estimation of liquid water path below the melting layer in stratiform precipitation systems using radar measurements during MC3E

In this study, the liquid water path (LWP) below the melting layer in stratiform precipitation systems is retrieved, which is a combination of rain liquid water path (RLWP) and cloud liquid water path (CLWP). The retrieval algorithm uses measurements from the vertically pointing radars (VPRs) at 35 and 3 GHz operated by the US Department of Energy Atmospheric Radiation Measurement (ARM) and National Oceanic and Atmospheric Administration (NOAA) during the field campaign Midlatitude Continental Convective Clouds Experiment (MC3E). The measured radar reflectivity and mean Doppler velocity from both VPRs and spectrum width from the 35 GHz radar are utilized. With the aid of the cloud base detected by a ceilometer, the LWP in the liquid layer is retrieved under two different situations: (I) no cloud exists below the melting base, and (II) cloud exists below the melting base. In (I), LWP is primarily contributed from raindrops only, i.e., RLWP, which is estimated by analyzing the Doppler velocity differences between two VPRs. In (II), cloud particles and raindrops coexist below the melting base. The CLWP is estimated using a modified attenuation-based algorithm. Two stratiform precipitation cases (20 and 11 May 2011) during MC3E are illustrated for two situations, respectively. With a total of 13 h of samples during MC3E, statistical results show that the occurrence of cloud particles below the melting base is low (9 %); however, the mean CLWP value can be up to 0.56 kgm(2), which is much larger than the RLWP (0.10 kgm(2)). When only raindrops exist below the melting base, the average RLWP value is larger (0.32 kgm(2)) than the with-cloud situation. The overall mean LWP below the melting base is 0.34 kgm(2) for stratiform systems during MC3E.DOE CMDV project [DE-SC0017015]; NASA CERES project [NNX17AC52G]; DOE ASR project [DE-SC0014294]Open access journalThis item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at [email protected]

ELUCID - Exploring the Local Universe with reConstructed Initial Density field III: Constrained Simulation in the SDSS Volume

A method we developed recently for the reconstruction of the initial density field in the nearby Universe is applied to the Sloan Digital Sky Survey Data Release 7. A high-resolution N-body constrained simulation (CS) of the reconstructed initial condition, with $3072^3$ particles evolved in a 500 Mpc/h box, is carried out and analyzed in terms of the statistical properties of the final density field and its relation with the distribution of SDSS galaxies. We find that the statistical properties of the cosmic web and the halo populations are accurately reproduced in the CS. The galaxy density field is strongly correlated with the CS density field, with a bias that depend on both galaxy luminosity and color. Our further investigations show that the CS provides robust quantities describing the environments within which the observed galaxies and galaxy systems reside. Cosmic variance is greatly reduced in the CS so that the statistical uncertainties can be controlled effectively even for samples of small volumes.Comment: submitted to ApJ, 19 pages, 22 figures. Please download the high-resolution version at http://staff.ustc.edu.cn/~whywang/paper

Advances in research on autophagy mechanisms in resistance to endometrial cancer treatment

Administering medication is a crucial strategy in improving the prognosis for advanced endometrial cancer. However, the rise of drug resistance often leads to the resurgence of cancer or less-than-ideal treatment outcomes. Prior studies have shown that autophagy plays a dual role in the development and progression of endometrial cancer, closely associated with drug resistance. As a result, concentrating on autophagy and its combination with medical treatments might be a novel approach to improve the prognosis for endometrial cancer. This study explores the impact of autophagy on drug resistance in endometrial cancer, investigates its core mechanisms, and scrutinizes relevant treatments aimed at autophagy, aiming to illuminate the issue of treatment resistance in advanced endometrial cancer

Polypropylene Blend with Polyphenols through Dynamic Vulcanization: Mechanical, Rheological, Crystalline, Thermal, and UV Protective Property

International audienceTannin and lignin were blended with polypropylene (PP) through dynamic vulcanization technique. Their influence of mechanical property, crystallinity, thermal stability, as well as ultraviolet (UV) protection property on the PP matrix was investigated and compared with native tannin and lignin. According to our experimental results, tannin and lignin undergo dynamic vulcanization and were more compatible with the PP matrix. Besides, tannin and vulcanized tannin can perform as nucleating agents of PP because of their relatively small particle size. Moreover, vulcanized tannin/lignin have a better performance on the thermal stability of PP compared with native tannin/lignin, especially PP/vulcanized lignin blend. Furthermore, vulcanized tannin/lignin present better UV protective performance, concluded from fewer changes on surface morphology, carbonyl index, crystallinity, viscosity, and tensile property

Specific Targeting MRI of Chitosan Oligosaccharide Modified Fe3O4 Nanoprobe on Macrophage and the Inhibition of Macrophage Foaming Induced by ox-LDL

Atherosclerosis (AS) is a primary cause of morbidity and mortality all over the world. Molecular imaging techniques can enable early localization and diagnosis of atherosclerosis plaques. Recent newly developed chitooligosaccharides (CSO) is considered to be capable of target mannose receptors on the surface of macrophages and to inhibit foam cell formation. Here we present a targeting magnetic resonance imaging (MRI) nanoprobe, which was successfully constructed with polyacrylic acid (PAA) modified nanometer iron oxide (Fe3O4) as the core, and coating with CSO molecules, possessing the abilities of targeted MRI and specifically inhibition of the formation of foamy macrophages in the atherosclerotic process. The experimental results showed that the distributions of PAA-Fe3O4 and CSO-PAA-Fe3O4 were uniform and the corresponding sizes were about 5.93 nm and 8.15 nm, respectively. The Fourier transform infrared spectra (FTIR) testified the CSO was coupled with PAA-Fe3O4 successfully. After coupled with CSO, the r1 of PAA-Fe3O4 was increased from 5.317 mM s-1 to 6.147 mM s-1, indicating their potential as MRI contrast agent. Oil Red O staining and total cholesterols (TC) determination showed that CSO-PAA-Fe3O4 could significantly inhibit the foaming process of RAW264.7 cells induced by oxidatively modified low density lipoprotein (ox-LDL). In vitro cellular MRI displayed that, compared with PAA-Fe3O4,CSO-PAA-Fe3O4 could lower the T1 relaxation time of RAW264.7 cells better. In summary, construction of CSO-PAA-Fe3O4 nanoprobe in this study could realize the targeted MRI of macrophages and inhibition of ox-LDL induced macrophage foaming process. This will provide a new avenue in the diagnosis and treatment of AS

Political connections, environmental violations and punishment: Evidence from heavily polluting firms

Using hand-collected data on violations of environmental regulations by heavily polluting firms in China, we examine the relationship between political connections and the probability of punishment for breach of such regulations. To this end, we exploit a regulatory reform, the enactment of Rule 18, a key component of China's anti-corruption campaign, which required politically connected independent directors to resign from their positions. Using difference-in-differences specifications, we find that firms from which politically connected directors resigned due to Rule 18 experience a significant increase in both the likelihood of ever being punished for environment-related violations and the frequency of punishment. The effect of Rule 18 is more pronounced among firms located in regions with less efficient judicial systems and higher levels of corruption, as well as firms that are not state-owned. Our evidence indicates that in the absence of effective regulation, political connections can be costly to the environment as they strongly affect the enforcement of environmental regulations

Elevated serum magnesium associated with SGLT2 inhibitor use in type 2 diabetes patients: a meta-analysis of randomised controlled trials

Aims/hypothesis By analysing available evidence from randomised controlled trials (RCTs), we aimed to examine whether and to what extent sodium–glucose cotransporter 2 (SGLT2) inhibitors affect serum electrolyte levels in type 2 diabetes patients. Methods We searched PubMed, EMBASE, Cochrane Central Register of Controlled Trials (CENTRAL) and ClinicalTrials.gov up to 24 May 2016 for published RCTs of SGLT2 inhibitors that reported changes in serum electrolyte levels. Weighted mean differences (WMD) between each SGLT2 inhibitor and placebo were calculated using a random-effects model. Dose-dependent relationships for each SGLT2 inhibitor were evaluated using meta-regression analysis. Results Eighteen eligible RCTs, including 15,309 patients and four SGLT2 inhibitors (canagliflozin, dapagliflozin, empagliflozin and ipragliflozin) were evaluated. In patients without chronic kidney disease, each SGLT2 inhibitor significantly increased serum magnesium levels compared with placebo (canagliflozin: WMD 0.06 mmol/l for 100 mg and 0.09 mmol/l for 300 mg; dapagliflozin: WMD 0.1 mmol/l for 10 mg; empagliflozin: WMD 0.04 mmol/l for 10 mg and 0.07 mmol/l for 25 mg; and ipragliflozin: WMD 0.05 mmol/l for 50 mg). Canagliflozin increased serum magnesium in a linear dose-dependent manner (p = 0.10). Serum phosphate was significantly increased by dapagliflozin. Serum sodium appeared to significantly differ by SGLT2 inhibitor type. No significant changes in serum calcium and potassium were observed. Findings were robust after including trials involving patients with chronic kidney disease. Conclusions/interpretation SGLT2 inhibitors marginally increased serum magnesium levels in type 2 diabetes patients indicating a drug class effect. Further investigations are required to examine the clinical significance of elevated magnesium levels in individuals with type 2 diabetes

Evaluation of Tung Oil (Vernicia fordii (Hemsl.)) for Controlling Termites

In worldwide, the use of chemical pesticides to protect wood has been greatly restricted. In recent years, a large number of researchers devoted to the search for natural, safe and non-polluting bioactive chemical compounds from plants as an alternative to synthetic organic chemical preservative. In Chinese folk, tung oil can be used as paint for wooden furniture to protect them from pests. This study aimed to evaluate the chemical compositions of raw and heated tung oil and their activity against termite. In choice bioassays, weight loss of wood treated with 5% raw or heated tung oil after 4 weeks was significantly less than that of the control group. In no-choice bioassays, there was a significant difference in termite survival and wood weight loss on raw and heated tung oil-treated wood. When tung oil-treatment concentrations increased to 5%, wood weight loss was less than 10%. There was no significant difference in termite survival and wood weight loss between raw and heated tung oil-treated wood. Survival of termites in both tung oil wood treatments was significantly lower than that in the starvation control after 4 weeks. Raw and heated tung oil significantly improved the resistance of pine wood to termites, and have the potential for the development of natural wood preservatives