Chlorido{μ-2,6-bis­[(2-amino­eth­yl)imino­meth­yl]-4-chloro­phenolato}-μ-oxido-dicopper(II) trihydrate

In the title dinuclear complex, [Cu2(C14H20ClN4O)ClO]·3H2O, one CuII cation assumes a distorted square-planar coordination geometry and the other a distorted square-pyramidal coordination geometry. Both CuII cations are N,N′,O-chelated by one arm of the 2,6-bis­[(2-amino­eth­yl)imino­meth­yl]-4-chloro­phenolate anion, and one oxide anion bridges the two CuII cations, forming a dinuclear complex. One of the CuII cations is further coordinated by an Cl− anion in the apical direction. In the crystal, lattice water mol­ecules are linked with the complex mol­ecule via O—H⋯Cl hydrogen bonds while O—H⋯O hydrogen bonding occurs between lattice water mol­ecules , forming three-dimensional network structure

Ecological model to predict potential habitats of Oncomelania hupensis, the intermediate host of Schistosoma japonicum in the mountainous regions, China

Schistosomiasis japonica is a parasitic disease that remains endemic in seven provinces in the People's Republic of China (P.R. China). One of the most important measures in the process of schistosomiasis elimination in P.R. China is control of Oncomelania hupensis, the unique intermediate host snail of Schistosoma japonicum. Compared with plains/swamp and lake regions, the hilly/mountainous regions of schistosomiasis endemic areas are more complicated, which makes the snail survey difficult to conduct precisely and efficiently. There is a pressing call to identify the snail habitats of mountainous regions in an efficient and cost-effective manner.; Twelve out of 56 administrative villages distributed with O. hupensis in Eryuan, Yunnan Province, were randomly selected to set up the ecological model. Thirty out of the rest of 78 villages (villages selected for building model were excluded from the villages for validation) in Eryuan and 30 out of 89 villages in Midu, Yunnan Province were selected via a chessboard method for model validation, respectively. Nine-year-average Normalized Difference Vegetation Index (NDVI) and Land Surface Temperature (LST) as well as Digital Elevation Model (DEM) covering Eryuan and Midu were extracted from MODIS and ASTER satellite images, respectively. Slope, elevation and the distance from every village to its nearest stream were derived from DEM. Suitable survival environment conditions for snails were defined by comparing historical snail presence data and remote sensing derived images. According to the suitable conditions for snails, environment factors, i.e. NDVI, LST, elevation, slope and the distance from every village to its nearest stream, were integrated into an ecological niche model to predict O. hupensis potential habitats in Eryuan and Midu. The evaluation of the model was assessed by comparing the model prediction and field investigation. Then, the consistency rate of model validation was calculated in Eryuan and Midu Counties, respectively. The final ecological niche model for potential O. hupensis habitats prediction comprised the following environmental factors, namely: NDVI (≥ 0.446), LST (≥ 22.70°C), elevation (≤ 2,300 m), slope (≤ 11°) and the distance to nearest stream (≤ 1,000 m). The potential O. hupensis habitats in Eryuan distributed in the Lancang River basin and O. hupensis in Midu shows a trend of clustering in the north and spotty distribution in the south. The consistency rates of the ecological niche model in Eryuan and Midu were 76.67% and 83.33%, respectively.; The ecological niche model integrated with NDVI, LST, elevation, slope and distance from every village to its nearest stream adequately predicted the snail habitats in the mountainous regions

LHC Search of New Higgs Boson via Resonant Di-Higgs Production with Decays into 4W

Searching for new Higgs particle beyond the observed light Higgs boson h(125GeV) will unambiguously point to new physics beyond the standard model. We study the resonant production of a CP-even heavy Higgs state $H^0$ in the di-Higgs channel via, $gg\to H^0\to h^0h^0\to WW^*WW^*$, at the LHC Run-2 and the high luminosity LHC (HL-LHC). We analyze two types of the $4W$ decay modes, one with the same-sign di-leptons ($4W\to\ell^\pm\nu\ell^\pm\nu 4q$) and the other with tri-leptons ($4W\to\ell^\pm\nu\ell^\mp\nu\ell^\pm\nu 2q$). We perform a full simulation for the signals and backgrounds, and estimate the discovery potential of the heavy Higgs state at the LHC Run-2 and the HL-LHC, in the context of generical two-Higgs-doublet models (2HDM). We determine the viable parameter space of the 2HDM as allowed by the theoretical constraints and the current experimental limits. We systematically analyze the allowed parameter space of the 2HDM which can be effectively probed by the heavy Higgs searches of the LHC, and further compare this with the viable parameter region under the current theoretical and experimental bounds.Comment: v3: JHEP published version, 34pp, 10 Figs(36 plots) and 9 Tables. Only minor typos fixed, references added. v2: JHEP version. All results and conclusions un-changed, discussions and references added. (This update is much delayed due to author's traveling and flu.

Role of tissue factor pathway inhibitor-2 in the expressions of matrix metallopro- teinases in keratocytes in vitro

AIM:To elucidate the relation between tissue factor pathway inhibitor-2(TFPI-2)expression and the expression of matrix metalloproteinases(MMPs)in keratocytes. METHODS: Primary culture and subculture of rabbit keratocytes were established in vitro. Plasmid vector pBos-Cite-neo/TFPI-2 was transfected into keratocytes with Lipofectamine 2000. After being selected by G418, three groups of cells including TFPI-2 gene transfected cells K-TFPI-2, empty vector transfected cells K-V and non-transfected cells K-P were screened for TFPI-2 mRNA and protein by reverse transcription-polymerase chain reaction and Western blot analysis, respectively. The activity of MMPs in the three groups of cells was detected by substrate zymography and compared by ANOVA. RESULTS: Expression of mRNA and protein of TFPI-2 was more in the cells of K-TFPI-2 than in the other cells of K-P and K-V with a significant difference(mRNA:0.79±0.02 vs 0.51±0.03 and 0.48±0.02, P=0.000 and P=0.000; Protein:24.5±0.8 vs 15.5±0.5 and 14.9±0.9,P=0.000 and P=0.000). Compared with the two groups of K-P and K-V, the cells of K-TFPI-2 had a significant decreased activity of MMP1(12.3±0.7 vs 16.7±1.2 and 15.9±0.7, P=0.001 and P=0.003)and MMP2(15.4±1.3 vs 18.2±1.1 and 17.8±1.1, P=0.027 and P=0.046). CONCLUSION: It is suggested that the expression of TFPI-2 may strongly inhibit the activity of MMPs in keratocytes in vitro, which provides an experimental basis for curing CNV with gene therapy

Efficient double-quenching of electrochemiluminescence from CdS:Eu QDs by hemin-graphene-Au nanorods ternary composite for ultrasensitive immunoassay

A novel ternary composite of hemin-graphene-Au nanorods (H-RGO-Au NRs) with high electrocatalytic activity was synthesized by a simple method. And this ternary composite was firstly used in construction of electrochemiluminescence (ECL) immunosensor due to its double-quenching effect of quantum dots (QDs). Based on the high electrocatalytic activity of ternary complexes for the reduction of H(2)O(2) which acted as the coreactant of QDs-based ECL, as a result, the ECL intensity of QDs decreased. Besides, due to the ECL resonance energy transfer (ECL-RET) strategy between the large amount of Au nanorods (Au NRs) on the ternary composite surface and the CdS:Eu QDs, the ECL intensity of QDs was further quenched. Based on the double-quenching effect, a novel ultrasensitive ECL immunoassay method for detection of carcinoembryonic antigen (CEA) which is used as a model biomarker analyte was proposed. The designed immunoassay method showed a linear range from 0.01 pg mL(−1) to 1.0 ng mL(−1) with a detection limit of 0.01 pg mL(−1). The method showing low detection limit, good stability and acceptable fabrication reproducibility, provided a new approach for ECL immunoassay sensing and significant prospect for practical application

A green and efficient synthesis of quinoxaline derivatives catalyzed by 1-n-butyl-3-methylimmidazolium tetrafluoroborate

The room temperature ionic liquid 1-n-butyl-3-methylimmidazolium tetrafluoroborate ([bmim]BF4) was used to promote the synthesis of quinoxaline derivatives under grinding condition. The yields were ranged in 86.0-95.1%. It was shown that the proposed method is fast, efficient and environmentally benign.KEY WORDS: Ionic liquid, Quinoxaline derivatives, Synthesis Bull. Chem. Soc. Ethiop. 2011, 25(3), 455-460

2-(1-Ethyl-5-meth­oxy-1H-indol-3-yl)-N-(4-meth­oxy­phen­yl)-2-oxoacetamide

The title compound, C20H20N2O4, crystallizes with four independent mol­ecules in the asymmetric unit. In the mol­ecules, the dihedral angles between the benzene rings and indole mean planes are 24.5 (1), 22.5 (1), 8.8 (1) and 13.9 (1)°. In the crystal, inter­molecular N—H⋯O hydrogen bonds are present between the imino groups and the adjacent carbonyl groups. π–π stacking is also observed with a centroid–centroid distance between nearly parallel pyrrole rings of 3.745 (3) Å

Solution-processed small-molecule solar cells: breaking the 10% power conversion efficiency.

A two-dimensional conjugated small molecule (SMPV1) was designed and synthesized for high performance solution-processed organic solar cells. This study explores the photovoltaic properties of this molecule as a donor, with a fullerene derivative as an acceptor, using solution processing in single junction and double junction tandem solar cells. The single junction solar cells based on SMPV1 exhibited a certified power conversion efficiency of 8.02% under AM 1.5 G irradiation (100 mW cm(-2)). A homo-tandem solar cell based on SMPV1 was constructed with a novel interlayer (or tunnel junction) consisting of bilayer conjugated polyelectrolyte, demonstrating an unprecedented PCE of 10.1%. These results strongly suggest solution-processed small molecular materials are excellent candidates for organic solar cells