Nano-La\u3csub\u3e2\u3c/sub\u3eO\u3csub\u3e3\u3c/sub\u3e Induces Honeybee (\u3cem\u3eApis mellifera\u3c/em\u3e) Death and Enriches for Pathogens in Honeybee Gut Bacterial Communities

Honeybees (Apis mellifera) can be exposed via numerous potential pathways to ambient nanoparticles (NPs), including rare earth oxide (REO) NPs that are increasingly used and released into the environment. Gut microorganisms are pivotal in mediating honeybee health, but how REO NPs may affect honeybee health and gut microbiota remains poorly understood. To address this knowledge gap, honeybees were fed pollen and sucrose syrup containing 0, 1, 10, 100, and 1000mgkg−1 of nano-La2O3 for 12days. Nano-La2O3 exerted detrimental effects on honeybee physiology, as reflected by dose-dependent adverse effects of nano-La2O3 on survival, pollen consumption, and body weight (p\u3c0.05). Nano-La2O3 caused the dysbiosis of honeybee gut bacterial communities, as evidenced by the change of gut bacterial community composition, the enrichment of pathogenic Serratia and Frischella, and the alteration of digestion-related taxa Bombella (p\u3c0.05). There were significant correlations between honeybee physiological parameters and the relative abundances of pathogenic Serratia and Frischella (p\u3c0.05), underscoring linkages between honeybee health and gut bacterial communities. Taken together, this study demonstrates that nano-La2O3 can cause detrimental effects on honeybee health, potentially by disordering gut bacterial communities. This study thus reveals a previously overlooked effect of nano-La2O3 on the ecologically and economically important honeybee species Apis mellifera

The Coarse-Position-Free Coarse-Time Positioning Method for BDS Receiver

The Coarse-Time Positioning method is important for the quick positioning of the BeiDou Navigation Satellite System (BDS) navigation receiver in the weak signal environment. The coarse position estimation is the key technology of the Coarse-Time Positioning (CTP) for the BDS navigation receiver without coarse position assistance. In this paper, a Coarse-Position-Free Coarse-Time Positioning method based on mixed-type code phase ambiguity resolution is proposed. In this CTP method, in order to estimate the approximate position, the coarse position estimation method based on the mixed-type code phase ambiguity search is used. This method does not require any additional external auxiliary position information to complete the coarse position estimation. Based on the real observation data and dynamic simulation observation data, the test experiment is designed. According to the error of coarse position estimation, the positioning accuracy, and the success rate of the coarse-time solution, the Coarse-Position-Free Coarse-Time Positioning (CPFCTP) method of the BDS receiver based on the mixed-type code phase ambiguity resolution is evaluated. The experimental results show that, when the coarse-time deviation is within 30 s, the CPFCTP method has a success rate of over 97%. When the coarse-time deviation is within 5 s, the success rate of positioning is 100%. At the same time, the experimental results also show that, for the situation that the navigation signals of some BeiDou satellites are completely occluded, the CPFCTP method proposed in this paper can obtain the correct code phase ambiguity and still maintain a high success rate of CTP at the same time

Plant diversity enhances soil fungal network stability indirectly through the increase of soil carbon and fungal keystone taxa richness

Plant diversity is critical to the stability of ecosystems. However, our knowledge about the plant diversity effect on the stability of belowground communities is limited. Here, we characterized soil fungal diversity and co-occurrence network across a plant diversity gradient in a diversity manipulation experiment. We found that higher plant diversity resulted in higher fungal diversity, network complexity and stability. The positive plant diversity effect on fungal network stability was indirect via the increase of soil carbon and fungal keystone taxa richness based on structural equation modeling analysis. The model explained 44% variations of network stability when combining soil carbon and fungal keystone taxa richness, but explained approximate 30% variations of network stability when considering either one of the two factors, indicating that environmental filtering and biotic interaction processes play comparable roles in mediating the plant diversity effect on soil fungal network stability. The plant diversity-induced fungal network stability was significantly correlated with community-level functions including community resistance and enzyme activities. This study, from the view of networks, provides new insights into the plant diversity effect on the stability of soil microbial communities, which have implications for biodiversity conservation and policy development

Self-Assisted First-Fix Method for A-BDS Receivers with Medium- and Long-Term Ephemeris Extension

As a sensor for standalone position and velocity determination, the BeiDou Navigation Satellite System (BDS) receiver is becoming an important part of the intelligent logistics systems under rapid development in China. The applications in the mass market urgently require the BDS receivers to improve the performance of such functions, that is, shorter Time to First Fix (TTFF) and faster navigation signal acquisition speed with Ephemeris Extension (EE) in standalone mode. As a practical way to improve such functions of the Assisted BDS (A-BDS) receivers without the need for specialized hardware support, a Self-Assisted First-Fix (SAFF) method with medium- and long-term EE is proposed in this paper. In this SAFF method, the dynamic Medium- and Long-Term Orbit Prediction (MLTOP) method, which uses the historical broadcast ephemeris data with the optimal configuration of the dynamic models and orbit fitting time interval, is utilized to generate the extended ephemeris. To demonstrate the performance of the MLTOP method used in the SAFF method, a suit of tests, which were based on the real data of broadcast ephemeris and precise ephemeris, were carried out. In terms of the positioning accuracy, the overall performance of the SAFF method is illustrated. Based on the characteristics of the medium- and long-term EE, the simulation tests for the SAFF method were conducted. Results show that, for the SAFF method with medium- and long-term EE of the BeiDou MEO/IGSO satellites, the horizontal positioning accuracy is about 12 meters, and the overall positioning accuracy is about 25 meters. The results also indicate that, for the BeiDou satellites with different orbit types, the optimal configurations of the MLTOP method are different

DataSheet_1_Safety and efficacy of dual PI3K-δ, γ inhibitor, duvelisib in patients with relapsed or refractory lymphoid neoplasms: A systematic review and meta-analysis of prospective clinical trials.docx

BackgroundDuvelisib is the first FDA-approved oral dual inhibitor of phosphatidylinositol-3-kinase PI3K-delta (PI3K-δ) and PI3K-gamma (PI3K-γ). Although many clinical studies support the efficacy of duvelisib, the safety of duvelisib remains with great attention. This systematic review and meta-analysis aimed to evaluate the safety and efficacy of duvelisib in treating different relapsed or refractory (RR) lymphoid neoplasm types.MethodsWe searched prospective clinical trials from PUBMED, EMBASE, Cochrane Library, and ClinicalTrials.gov. For efficacy analysis, Overall response rate (ORR), complete response rate (CR), partial response rate (PR), rate of stable disease (SDR), rate of progressive disease (PDR), median progression-free survival (mPFS), 12-/24-month PFS, and 12-month overall survival (OS) were assessed. For safety analysis, the incidences of any grade and grade ≥3 adverse events (AEs), serious AEs, and treatment-related discontinuation and death were evaluated. Subgroup analysis based on the disease type was performed.ResultsWe included 11 studies and 683 patients, including 305 chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL), 187 B-cell indolent non-Hodgkin lymphoma (iNHL), 39 B-cell aggressive non-Hodgkin lymphoma (aNHL), and 152 T-cell non-Hodgkin lymphoma (T-NHL) patients. The pooled ORR in CLL/SLL, iNHL, aNHL and T-NHL was 70%, 70%, 28% and 47%, respectively. Additionally, the pooled ORR in CLL/SLL patients with or without TP53 mutation/17p-deletion (62% vs. 74%, p=0.45) and in follicular lymphoma (FL) or other iNHL (69% vs. 57%, p=0.38) had no significant differences. Mantle cell lymphoma (MCL) patients had higher pooled ORR than other aNHL (68% vs. 17%, p=0.04). Angioimmunoblastic TCL (AITL) patients had higher pooled ORR than other PTCL patients (67% vs. 42%, p=0.01). The pooled incidence of any grade, grade ≥3, serious AEs, treatment-related discontinuation and death was 99%, 79%, 63%, 33% and 3%, respectively. The most frequent any-grade AEs were diarrhea (47%), ALT/AST increase (39%), and neutropenia (38%). The most frequent grade ≥3 AEs were neutropenia (25%), ALT/AST increased (16%), diarrhea (12%), and anemia (12%).ConclusionGenerally, duvelisib could offer favorable efficacy in patients with RR CLL/SLL, iNHL, MCL, and AITL. Risk and severity in duvelisib treatment may be mitigated through proper identification and management.</p

Van der Waals ferroelectric transistors: the all-round artificial synapses for high-precision neuromorphic computing

ABSTRACT: State number, operation power, dynamic range and conductance weight update linearity are key synaptic device performance metrics for high-accuracy and low-power-consumption neuromorphic computing in hardware. However, high linearity and low power consumption couldn't be simultaneously achieved by most of the reported synaptic devices, which limits the performance of the hardware. This work demonstrates van der Waals (vdW) stacked ferroelectric field-effect transistors (FeFET) with single-crystalline ferroelectric nanoflakes. Ferroelectrics are of fine vdW interface and partial polarization switching of multi-domains under electric field pulses, which makes the FeFETs exhibit multi-state memory characteristics and excellent synaptic plasticity. They also exhibit a desired linear conductance weight update with 128 conductance states, a sufficiently high dynamic range of Gmax/Gmin > 120, and a low power consumption of 10 fJ/spike using identical pulses. Based on such an all-round device, a two-layer artificial neural network was built to conduct Modified National Institute of Standards and Technology (MNIST) digital numbers and electrocardiogram (ECG) pattern-recognition simulations, with the high accuracies reaching 97.6% and 92.4%, respectively. The remarkable performance demonstrates that vdW-FeFET is of obvious advantages in high-precision neuromorphic computing applications

Semi-Transparent ZnO-CuI/CuSCN Photodiode Detector with Narrow-Band UV Photoresponse

The ZnO homogeneous pn junction photodiode is quite difficult to fabricate due to the absence of stable p-type ZnO. So exploring reliable p-type materials is necessary to build a heterogeneous pn junction with n-type ZnO. Herein, we develop a simple and low-cost solution-processed method to obtain inorganic p-type CuI/CuSCN composite film with compact morphology, high conductivity, and low surface state. The improved performance of CuI/CuSCN composite film can be confirmed based on high-rectification ratio, responsivity, and open voltage of ZnO-CuI/CuSCN photodiode UV detectors. Moreover, photodiodes with novel top electrodes are investigated. Compared with commonly used Au and graphene/Ag nanowire (NWs) electrode, poly­(3,4-ethylenedioxythiophene):poly­(4-styrenesulfonate) (PEDOT:PSS) electrode prepared by Meyer rod-coating technique opens one route to obtain a semitransparent photodiode. The photodiode with PEDOT:PSS as the top electrode under reverse illumination has the highest photocurrent density due to higher UV transmittance of PEDOT:PSS transparent electrode compared with ITO glass. The low-energy consumption, and high responsivity, UV to visible rejection ratio and air stability make this ZnO-CuI/CuSCN photodiode quite promising in the UV-A detection field

Nano-La₂O₃ Induces Honeybee (<em>Apis mellifera</em>) Death and Enriches for Pathogens in Honeybee Gut Bacterial Communities

Honeybees (Apis mellifera) can be exposed via numerous potential pathways to ambient nanoparticles (NPs), including rare earth oxide (REO) NPs that are increasingly used and released into the environment. Gut microorganisms are pivotal in mediating honeybee health, but how REO NPs may affect honeybee health and gut microbiota remains poorly understood. To address this knowledge gap, honeybees were fed pollen and sucrose syrup containing 0, 1, 10, 100, and 1000mgkg−1 of nano-La2O3 for 12days. Nano-La2O3 exerted detrimental effects on honeybee physiology, as reflected by dose-dependent adverse effects of nano-La2O3 on survival, pollen consumption, and body weight (p<0.05). Nano-La2O3 caused the dysbiosis of honeybee gut bacterial communities, as evidenced by the change of gut bacterial community composition, the enrichment of pathogenic Serratia and Frischella, and the alteration of digestion-related taxa Bombella (p<0.05). There were significant correlations between honeybee physiological parameters and the relative abundances of pathogenic Serratia and Frischella (p<0.05), underscoring linkages between honeybee health and gut bacterial communities. Taken together, this study demonstrates that nano-La2O3 can cause detrimental effects on honeybee health, potentially by disordering gut bacterial communities. This study thus reveals a previously overlooked effect of nano-La2O3 on the ecologically and economically important honeybee species Apis mellifera