202 research outputs found
Launch Editorial
The digital economy is first and foremost a data economy, and data is the first element of the digital economy. Management System Engineering (MSE) is dedicated to the methodology of System Engineering (SE) and the practice of Management Decision Making. The digital economy is a network economy, and the Internet is the basic carrier of the digital economy. [Extracted from the article
Towards Urban General Intelligence: A Review and Outlook of Urban Foundation Models
Machine learning techniques are now integral to the advancement of
intelligent urban services, playing a crucial role in elevating the efficiency,
sustainability, and livability of urban environments. The recent emergence of
foundation models such as ChatGPT marks a revolutionary shift in the fields of
machine learning and artificial intelligence. Their unparalleled capabilities
in contextual understanding, problem solving, and adaptability across a wide
range of tasks suggest that integrating these models into urban domains could
have a transformative impact on the development of smart cities. Despite
growing interest in Urban Foundation Models~(UFMs), this burgeoning field faces
challenges such as a lack of clear definitions, systematic reviews, and
universalizable solutions. To this end, this paper first introduces the concept
of UFM and discusses the unique challenges involved in building them. We then
propose a data-centric taxonomy that categorizes current UFM-related works,
based on urban data modalities and types. Furthermore, to foster advancement in
this field, we present a promising framework aimed at the prospective
realization of UFMs, designed to overcome the identified challenges.
Additionally, we explore the application landscape of UFMs, detailing their
potential impact in various urban contexts. Relevant papers and open-source
resources have been collated and are continuously updated at
https://github.com/usail-hkust/Awesome-Urban-Foundation-Models
Effect of a booster dose of influenza vaccine in patients with hemodialysis, peritoneal dialysis and renal transplant recipients: A systematic literature review and meta-analysis
Booster influenza vaccination has been recommended for patients with chronic renal disease in order to enhance the immune response to the influenza vaccine; however, the efficacy of a booster influenza vaccination is a matter of controversy. Therefore, we made a meta-analysis to determine the efficacy in patients with hemodialysis (HD), peritoneal dialysis (PD) and renal transplant recipient (RT). The sero-protection rate was used as a serologic parameter to describe the immune response to the vaccine. Statistical analysis was performed to calculate the pooled rate difference (RD) and 95% confidence interval (CI). The pooled RD for the H1N1, H3N2 and B influenza vaccines was 0.02 (95% CI: −0.02–0.06), 0.05 (95% CI: −0.01–0.11), 0.04 (95% CI: −0.02–0.10), respectively. We concluded that a booster dose of the influenza vaccine did not effectively enhance immunogenicity. Therefore, a booster dose of vaccine is not recommended for patients with hemodialysis, peritoneal dialysis and renal transplant recipients.Natural Science Foundation of Guangdong Province, Chin
A photo-responsive F-box protein FOF2 regulates floral initiation by promoting FLC expression in Arabidopsis.
Floral initiation is regulated by various genetic pathways in response to light, temperature, hormones and developmental status; however, the molecular mechanisms underlying the interactions between different genetic pathways are not fully understood. Here, we show that the photoresponsive gene FOF2 (F-box of flowering 2) negatively regulates flowering. FOF2 encodes a putative F-box protein that interacts specifically with ASK14, and its overexpression results in later flowering under both long-day and short-day photoperiods. Conversely, transgenic plants expressing the F-box domain deletion mutant of FOF2 (FOF2ΔF), or double loss of function mutant of FOF2 and FOL1 (FOF2-LIKE 1) present early flowering phenotypes. The late flowering phenotype of the FOF2 overexpression lines is suppressed by the flc-3 loss-of-function mutation. Furthermore, FOF2 mRNA expression is regulated by autonomous pathway gene FCA, and the repressive effect of FOF2 in flowering can be overcome by vernalization. Interestingly, FOF2 expression is regulated by light. The protein level of FOF2 accumulates in response to light, whereas it is degraded under dark conditions via the 26S proteasome pathway. Our findings suggest a possible mechanistic link between light conditions and the autonomous floral promotion pathway in Arabidopsis
Construction and Application of “Active Prediction-Passive Warning” Joint Impact Ground Pressure Resilience Prevention System: Take the Kuan Gou Coal Mine as an Example
AbstractWith the increasing depth and intensity of coal mining, the impact on ground pressure has become one of the main disasters facing mining, seriously threatening mine safety. Introducing the concept of toughness urban design, building a joint toughness prevention and control system based on active prediction and analysis of the impact pressure risk at the back mining face according to the geological deposit conditions and mining technology conditions and passive warning using monitoring data to explore the impact precursor characteristics is an important basis for impact pressure management and has important engineering significance to ensure the safe back mining. In this paper, firstly, the whole working face is divided into small unit areas, and the BP neural network prediction model is constructed to predict and analyze each small unit separately, and the distribution of impact ground pressure hazard level in different areas of the working face is derived. Next, a FLAC numerical model was established to analyze the stress distribution and migration characteristics at different retrieval distances of the working face and to explore the main distribution areas of impact hazard. Finally, the trend method, critical value method, and dynamic rate of change method were applied to determine the early warning indicators of impact ground pressure in the Kuan Gou coal mine, establish a comprehensive early warning method of impact ground pressure applicable to the Kuan Gou coal mine, and carry out field application with good effect. The findings of this paper have good scientific significance and reference value for promoting impact hazard analysis and early warning in mines with similar geological conditions and mining technology conditions in China
Regulated internalization of NMDA receptors drives PKD1-mediated suppression of the activity of residual cell-surface NMDA receptors
Background
Constitutive and regulated internalization of cell surface proteins has been extensively investigated. The regulated internalization has been characterized as a principal mechanism for removing cell-surface receptors from the plasma membrane, and signaling to downstream targets of receptors. However, so far it is still not known whether the functional properties of remaining (non-internalized) receptor/channels may be regulated by internalization of the same class of receptor/channels. The N-methyl-D-aspartate receptor (NMDAR) is a principal subtype of glutamate-gated ion channel and plays key roles in neuronal plasticity and memory functions. NMDARs are well-known to undergo two types of regulated internalization – homologous and heterologous, which can be induced by high NMDA/glycine and DHPG, respectively. In the present work, we investigated effects of regulated NMDAR internalization on the activity of residual cell-surface NMDARs and neuronal functions. Results
In electrophysiological experiments we discovered that the regulated internalization of NMDARs not only reduced the number of cell surface NMDARs but also caused an inhibition of the activity of remaining (non-internalized) surface NMDARs. In biochemical experiments we identified that this functional inhibition of remaining surface NMDARs was mediated by increased serine phosphorylation of surface NMDARs, resulting from the activation of protein kinase D1 (PKD1). Knockdown of PKD1 did not affect NMDAR internalization but prevented the phosphorylation and inhibition of remaining surface NMDARs and NMDAR-mediated synaptic functions. Conclusion
These data demonstrate a novel concept that regulated internalization of cell surface NMDARs not only reduces the number of NMDARs on the cell surface but also causes an inhibition of the activity of remaining surface NMDARs through intracellular signaling pathway(s). Furthermore, modulating the activity of remaining surface receptors may be an effective approach for treating receptor internalization-induced changes in neuronal functions of the CNS
A Survey on Evaluation of Large Language Models
Large language models (LLMs) are gaining increasing popularity in both
academia and industry, owing to their unprecedented performance in various
applications. As LLMs continue to play a vital role in both research and daily
use, their evaluation becomes increasingly critical, not only at the task
level, but also at the society level for better understanding of their
potential risks. Over the past years, significant efforts have been made to
examine LLMs from various perspectives. This paper presents a comprehensive
review of these evaluation methods for LLMs, focusing on three key dimensions:
what to evaluate, where to evaluate, and how to evaluate. Firstly, we provide
an overview from the perspective of evaluation tasks, encompassing general
natural language processing tasks, reasoning, medical usage, ethics,
educations, natural and social sciences, agent applications, and other areas.
Secondly, we answer the `where' and `how' questions by diving into the
evaluation methods and benchmarks, which serve as crucial components in
assessing performance of LLMs. Then, we summarize the success and failure cases
of LLMs in different tasks. Finally, we shed light on several future challenges
that lie ahead in LLMs evaluation. Our aim is to offer invaluable insights to
researchers in the realm of LLMs evaluation, thereby aiding the development of
more proficient LLMs. Our key point is that evaluation should be treated as an
essential discipline to better assist the development of LLMs. We consistently
maintain the related open-source materials at:
https://github.com/MLGroupJLU/LLM-eval-survey.Comment: 23 page
Multiple telecouplings and their complex interrelationships
Increasingly, the world is becoming socioeconomically and environmentally connected, but many studies have focused on human-environment interactions within a particular area. Although some studies have considered the impacts of external factors, there is little research on multiple reciprocal socioeconomic and environmental interactions between a focal area and other areas. Here we address this important kowledge gap by applying the new integrated framework of telecouplings (socioeconomic and environmental interactions between two or more areas over distances). Results show that even a protected area - i.e., the Wolong Nature Reserve for giant pandas in southwest China - has multiple telecoupling processes with the rest of the world; these include panda loans, tourism, information dissemination, conservation subsidies, and trade of aricultural and industrial products. The telecoupling processes exhibit nonlinear patterns, they change over time, and they have varying socioeconomic and environmental effects across the world. We also find complex relationships among different telecouplings - e.g., amplification, offsetting, spatial overlaps - which cannot be detected by traditional separate studies. Such an integrated study leads to a more comprehensive understanding of distant human-enviroment interactions and has significant implications for global sustainability and human well-being
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