Could the 21-cm absorption be explained by the dark matter suggested by 8^8Be transitions?

The stronger than expected 21-cm absorption was observed by EDGES recently, and another anomaly of $^8$Be transitions would be signatures of new interactions. These two issues may be related to each other, e.g., pseudoscalar $A$ mediated fermionic millicharged dark matter (DM), and the 21-cm absorption could be induced by photon mediated scattering between MeV millicharged DM and hydrogen. This will be explored in this paper. For fermionic millicharged DM $\bar{\chi} \chi$ with masses in a range of $2 m_A < 2 m_{\chi} < 3 m_A$, the p-wave annihilation $\bar{\chi} \chi \to A A$ would be dominant during DM freeze-out. The s-wave annihilation $\bar{\chi} \chi$ $\to A, \gamma$ $\to e^+ e^-$ is tolerant by constraints from CMB and the 21-cm absorption. The millicharged DM can evade constraints from direct detection experiments. The process of $K^+ \to \pi^+ \pi^0$ with the invisible decay $\pi^0 \to \bar{\chi} \chi$ could be employed to search for the millicharged DM, and future high intensity $K^+$ sources, such as NA62, will do the job.Comment: 6 pages, 2 figures, the accepted version, EPJ

Multiple mating and its relationship to brood size in pregnant fishes versus pregnant mammals and other viviparous vertebrates.

We summarize the literature on rates of multiple paternity and sire numbers per clutch in viviparous fishes vs. mammals, two vertebrate groups in which pregnancy is common but entails very different numbers of embryos (for species surveyed, piscine broods averaged &gt;10-fold larger than mammalian litters). As deduced from genetic parentage analyses, multiple mating by the pregnant sex proved to be common in assayed species but averaged significantly higher in fish than mammals. However, within either of these groups we found no significant correlations between brood size and genetically deduced incidence of multiple mating by females. Overall, these findings offer little support for the hypothesis that clutch size in pregnant species predicts the outcome of selection for multiple mating by brooders. Instead, whatever factors promote multiple mating by members of the gestating sex seem to do so in surprisingly similar ways in live-bearing vertebrates otherwise as different as fish and mammals. Similar conclusions emerged when we extended the survey to viviparous amphibians and reptiles. One notion consistent with these empirical observations is that although several fitness benefits probably accrue from multiple mating, logistical constraints on mate-encounter rates routinely truncate multiple mating far below levels that otherwise could be accommodated, especially in species with larger broods. We develop this concept into a "logistical constraint hypothesis" that may help to explain these mating outcomes in viviparous vertebrates. Under the logistical constraint hypothesis, propensities for multiple mating in each species register a balance between near-universal fitness benefits from multiple mating and species-idiosyncratic logistical limits on polygamy

Optimization of polysaccharides extracted from Verbena officinalis L and their inhibitory effects on invasion and metastasis of colorectal cancer cells

Purpose: To investigate polysaccharides (PEV) extracted from the aerial part of Verbena officinalis L. and their inhibitory effects on the invasion and metastasis of colorectal cancer (CRC) cells.Methods: PEV was extracted by water and the optimization of extraction conditions was performed using a Box-Benhnken design (BBD). The cell viability was evaluated by 4,5-dimethylthiazol-2-yl)2,5-diphenyltetrazolium bromide (MTT) assay. The effects of PEV on cell adhesion and invasion were evaluated by Transwell invasion, wound healing migration and adhesion assays in vitro. The effects of PEV on the expressions of matrix metalloproteinase-9 (MMP-9), mesenchymal-epithelial transition factor (C-met), E-cadherin (E-CAD), cyclooxygenase-2 (COX-2) and E-prostanoid 2 receptor (EP2) were investigated by western blot.Results: The BBD model was established successfully for the optimization of PEV extraction (p &lt;0.0001). The results indicate that PEV (50, 100 and 200 μg/mL) had significant inhibitory effects on cell invasion and migration of SW480 cells (p &lt; 0.05). PEV also significantly decreased cell adhesion of SW480 cells. By treating with PEV, the expressions of C-met, MMP-9, COX-2 and EP2 were decreased, whereas the expression of E-CAD increased in SW480 cells.Conclusion: RSM is effective for optimizing the extraction conditions of PEV. More importantly, PEV significantly inhibits the invasion and metastasis of SW480 cells by regulating the expression of MMP-9, C-met, E-CAD, COX-2 and EP2. Thus, PEV has the potential to be developed into therapeutic drugs for CRC in the future.Keywords: Polysaccharides, Colorectal cancer, Verbena officinalis, SW480 cell lines, Cell invasion, Metastasi

Towards verification of computation orchestration

Recently, a promising programming model called Orc has been proposed to support a structured way of orchestrating distributed Web Services. Orc is intuitive because it offers concise constructors to manage concurrent communication, time-outs, priorities, failure of Web Services or communication and so forth. The semantics of Orc is precisely defined. However, there is no automatic verification tool available to verify critical properties against Orc programs. Our goal is to verify the orchestration programs (written in Orc language) which invoke web services to achieve certain goals. To investigate this problem and build useful tools, we explore in two directions. Firstly, we define a Timed Automata semantics for the Orc language, which we prove is semantically equivalent to the operational semantics of Orc. Consequently, Timed Automata models are systematically constructed from Orc programs. The practical implication is that existing tool supports for Timed Automata, e.g., Uppaal, can be used to simulate and model check Orc programs. An experimental tool has been implemented to automate this approach. Secondly, we start with encoding the operational semantics of Orc language in Constraint Logic Programming (CLP), which allows a systematic translation from Orc to CLP. Powerful constraint solvers like CLP(R) are then used to prove traditional safety properties and beyond, e.g., reachability, deadlock-freeness, lower or upper bound of a time interval, etc. Counterexamples are generated when properties are not satisfied. Furthermore, the stepwise execution traces can be automatically generated as the simulation steps. The two different approaches give an insight into the verification problem of Web Service orchestration. The Timed Automata approach has its merits in visualized simulation and efficient verification supported by the well developed tools. On the other hand, the CPL approach gives better expressiveness in both modeling and verification. The two approaches complement each other, which gives a complete solution for the simulation and verification of Computation Orchestration

Diagnostic value of two dimensional shear wave elastography combined with texture analysis in early liver fibrosis.

BACKGROUND: Staging diagnosis of liver fibrosis is a prerequisite for timely diagnosis and therapy in patients with chronic hepatitis B. In recent years, ultrasound elastography has become an important method for clinical noninvasive assessment of liver fibrosis stage, but its diagnostic value for early liver fibrosis still needs to be further improved. In this study, the texture analysis was carried out on the basis of two dimensional shear wave elastography (2D-SWE), and the feasibility of 2D-SWE plus texture analysis in the diagnosis of early liver fibrosis was discussed. AIM: To assess the diagnostic value of 2D-SWE combined with textural analysis in liver fibrosis staging. METHODS: This study recruited 46 patients with chronic hepatitis B. Patients underwent 2D-SWE and texture analysis; Young\u27s modulus values and textural patterns were obtained, respectively. Textural pattern was analyzed with regard to contrast, correlation, angular second moment (ASM), and homogeneity. Pathological results of biopsy specimens were the gold standard; comparison and assessment of the diagnosis efficiency were conducted for 2D-SWE, texture analysis and their combination. RESULTS: 2D-SWE displayed diagnosis efficiency in early fibrosis, significant fibrosis, severe fibrosis, and early cirrhosis (AUC \u3e 0.7, P \u3c 0.05) with respective AUC values of 0.823 (0.678-0.921), 0.808 (0.662-0.911), 0.920 (0.798-0.980), and 0.855 (0.716-0.943). Contrast and homogeneity displayed independent diagnosis efficiency in liver fibrosis stage (AUC \u3e 0.7, P \u3c 0.05), whereas correlation and ASM showed limited values. AUC of contrast and homogeneity were respectively 0.906 (0.779-0.973), 0.835 (0.693-0.930), 0.807 (0.660-0.910) and 0.925 (0.805-0.983), 0.789 (0.639-0.897), 0.736 (0.582-0.858), 0.705 (0.549-0.883) and 0.798 (0.650-0.904) in four liver fibrosis stages, which exhibited equivalence to 2D-SWE in diagnostic efficiency (P \u3e 0.05). Combined diagnosis (PRE) displayed diagnostic efficiency (AUC \u3e 0.7, P \u3c 0.01) for all fibrosis stages with respective AUC of 0.952 (0.841-0.994), 0.896 (0.766-0.967), 0.978 (0.881-0.999), 0.947 (0.835-0.992). The combined diagnosis showed higher diagnosis efficiency over 2D-SWE in early liver fibrosis (P \u3c 0.05), whereas no significant differences were observed in other comparisons (P \u3e 0.05). CONCLUSION: Texture analysis was capable of diagnosing liver fibrosis stage, combined diagnosis had obvious advantages in early liver fibrosis, liver fibrosis stage might be related to the hepatic tissue hardness distribution

Rigid vortices in MgB2

Magnetic relaxation of high-pressure synthesized MgB$_2$ bulks with different thickness is investigated. It is found that the superconducting dia-magnetic moment depends on time in a logarithmic way; the flux-creep activation energy decreases linearly with the current density (as expected by Kim-Anderson model); and the activation energy increases linearly with the thickness of sample when it is thinner than about 1 mm. These features suggest that the vortices in the MgB$_2$ are rather rigid, and the pinning and creep can be well described by Kim-Anderson model.Comment: Typo corrected & reference adde

Terahertz spectra revealing the collective excitation mode in charge-density-wave single crystal LuFe2 O4

We report a low-energy collective excitation mode in charge-ordered multiferroic LuFe2O4 via terahertz time domain spectroscopy. Upon cooling from 300 K to 40 K, the central resonance frequency showed a pronounced hardening from 0.85 THz to 1.15 THz. In analogy to the well-known low-energy optical properties of LuFe2O4, we attributed this emerging resonance to the charge-density-wave (CDW) collective excitations. By using the Drude-Lorentz model fitting, we observe the CDW col-lective mode becomes increasingly damped with increasing the temperature. Furthermore, we analyze the kinks of the CDW collective mode at the magnetic transition temperature, which indicates the coupling of spin order with electric polarization