491 research outputs found
SECMACE: Scalable and Robust Identity and Credential Management Infrastructure in Vehicular Communication Systems
Several years of academic and industrial research efforts have converged to a
common understanding on fundamental security building blocks for the upcoming
Vehicular Communication (VC) systems. There is a growing consensus towards
deploying a special-purpose identity and credential management infrastructure,
i.e., a Vehicular Public-Key Infrastructure (VPKI), enabling pseudonymous
authentication, with standardization efforts towards that direction. In spite
of the progress made by standardization bodies (IEEE 1609.2 and ETSI) and
harmonization efforts (Car2Car Communication Consortium (C2C-CC)), significant
questions remain unanswered towards deploying a VPKI. Deep understanding of the
VPKI, a central building block of secure and privacy-preserving VC systems, is
still lacking. This paper contributes to the closing of this gap. We present
SECMACE, a VPKI system, which is compatible with the IEEE 1609.2 and ETSI
standards specifications. We provide a detailed description of our
state-of-the-art VPKI that improves upon existing proposals in terms of
security and privacy protection, and efficiency. SECMACE facilitates
multi-domain operations in the VC systems and enhances user privacy, notably
preventing linking pseudonyms based on timing information and offering
increased protection even against honest-but-curious VPKI entities. We propose
multiple policies for the vehicle-VPKI interactions, based on which and two
large-scale mobility trace datasets, we evaluate the full-blown implementation
of SECMACE. With very little attention on the VPKI performance thus far, our
results reveal that modest computing resources can support a large area of
vehicles with very low delays and the most promising policy in terms of privacy
protection can be supported with moderate overhead.Comment: 14 pages, 9 figures, 10 tables, IEEE Transactions on Intelligent
Transportation System
Application of machine learning to automated analysis of cerebral edema in large cohorts of ischemic stroke patients
Cerebral edema contributes to neurological deterioration and death after hemispheric stroke but there remains no effective means of preventing or accurately predicting its occurrence. Big data approaches may provide insights into the biologic variability and genetic contributions to severity and time course of cerebral edema. These methods require quantitative analyses of edema severity across large cohorts of stroke patients. We have proposed that changes in cerebrospinal fluid (CSF) volume over time may represent a sensitive and dynamic marker of edema progression that can be measured from routinely available CT scans. To facilitate and scale up such approaches we have created a machine learning algorithm capable of segmenting and measuring CSF volume from serial CT scans of stroke patients. We now present results of our preliminary processing pipeline that was able to efficiently extract CSF volumetrics from an initial cohort of 155 subjects enrolled in a prospective longitudinal stroke study. We demonstrate a high degree of reproducibility in total cranial volume registration between scans (R = 0.982) as well as a strong correlation of baseline CSF volume and patient age (as a surrogate of brain atrophy, R = 0.725). Reduction in CSF volume from baseline to final CT was correlated with infarct volume (R = 0.715) and degree of midline shift (quadratic model, p < 2.2 × 10−16). We utilized generalized estimating equations (GEE) to model CSF volumes over time (using linear and quadratic terms), adjusting for age. This model demonstrated that CSF volume decreases over time (p < 2.2 × 10−13) and is lower in those with cerebral edema (p = 0.0004). We are now fully automating this pipeline to allow rapid analysis of even larger cohorts of stroke patients from multiple sites using an XNAT (eXtensible Neuroimaging Archive Toolkit) platform. Data on kinetics of edema across thousands of patients will facilitate precision approaches to prediction of malignant edema as well as modeling of variability and further understanding of genetic variants that influence edema severity
The effect of conditional EFNB1 deletion in the T cell compartment on T cell development and function
<p>Abstract</p> <p>Background</p> <p>Eph kinases are the largest family of cell surface receptor tyrosine kinases. The ligands of Ephs, ephrins (EFNs), are also cell surface molecules. Ephs interact with EFNs transmitting signals in both directions, i.e., from Ephs to EFNs and from EFNs to Ephs. EFNB1 is known to be able to co-stimulate T cells <it>in vitro </it>and to modulate thymocyte development in a model of foetal thymus organ culture. To further understand the role of EFNB1 in T cell immunity, we generated T-cell-specific EFNB1 gene knockout mice to assess T cell development and function in these mice.</p> <p>Results</p> <p>The mice were of normal size and cellularity in the thymus and spleen and had normal T cell subpopulations in these organs. The bone marrow progenitors from KO mice and WT control mice repopulated host spleen T cell pool to similar extents. The activation and proliferation of KO T cells was comparable to that of control mice. Naïve KO CD4 cells showed an ability to differentiate into Th1, Th2, Th17 and Treg cells similar to control CD4 cells.</p> <p>Conclusions</p> <p>Our results suggest that the function of EFNB1 in the T cell compartment could be compensated by other members of the EFN family, and that such redundancy safeguards the pivotal roles of EFNB1 in T cell development and function.</p
A Penalized Multi-trait Mixed Model for Association Mapping in Pedigree-based GWAS
In genome-wide association studies (GWAS), penalization is an important
approach for identifying genetic markers associated with trait while mixed
model is successful in accounting for a complicated dependence structure among
samples. Therefore, penalized linear mixed model is a tool that combines the
advantages of penalization approach and linear mixed model. In this study, a
GWAS with multiple highly correlated traits is analyzed. For GWAS with multiple
quantitative traits that are highly correlated, the analysis using traits
marginally inevitably lose some essential information among multiple traits. We
propose a penalized-MTMM, a penalized multivariate linear mixed model that
allows both the within-trait and between-trait variance components
simultaneously for multiple traits. The proposed penalized-MTMM estimates
variance components using an AI-REML method and conducts variable selection and
point estimation simultaneously using group MCP and sparse group MCP. Best
linear unbiased predictor (BLUP) is used to find predictive values and the
Pearson's correlations between predictive values and their corresponding
observations are used to evaluate prediction performance. Both prediction and
selection performance of the proposed approach and its comparison with the
uni-trait penalized-LMM are evaluated through simulation studies. We apply the
proposed approach to a GWAS data from Genetic Analysis Workshop (GAW) 18
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