FAST TCP: Motivation, Architecture, Algorithms, Performance

We describe FAST TCP, a new TCP congestion control algorithm for high-speed long-latency networks, from design to implementation. We highlight the approach taken by FAST TCP to address the four difficulties which the current TCP implementation has at large windows. We describe the architecture and summarize some of the algorithms implemented in our prototype. We characterize its equilibrium and stability properties. We evaluate it experimentally in terms of throughput, fairness, stability, and responsiveness

Global Exponential Stability of FAST TCP

We consider a single-link multi-source network with the FAST TCP sources. We propose a continuous-time dynamic model for the FAST TCP sources and a static model to describe the queuing delay behavior at the link. The proposed model turns out to be in a form revealing the network feedback delay, which allows us to analyze FAST TCP in due consideration of the network feedback delay. Based on the proposed model, we show the boundedness of both each source's congestion window and the queuing delay at the link; and the global exponential stability under a trivial condition that each source's congestion control parameter a is positive. The simulation results illustrate the validity of the proposed model and the global exponential stability of FAST TCP

Deposition of La2Zr2O7 Film by Chemical Solution Deposition

La2Zr2O7 (LZO) formation of bulk powders and of films by Chemical Solution Deposition (CSD) process have been studied using propionates. The treatment involved a one step cycle in the reducing forming gas (Ar-5%H2) to be compatible with Ni-5at%W RABITS. Large amount of residual carbon was found in LZO powders formed in these conditions (10 wt %). The volume fraction of the cube texture in LZO films on Ni-5at%w RABITS was found to be a function of the speed of the gas flown above sample. This phenomenon is discussed in considering the C deposited from the carbon-containing gases emitted during the pyrolysis of the precursor. Using proper conditions (950 ^\circC and the speed of gas of 6.8\times10^{-2} m/s), LZO films with good surface crystallinity could be obtained on Ni-5at%W RABITS as demonstrated by X-ray diffraction, electron backscattered diffraction and RHEED. The existence of residual carbon in oxide films is a common question to films deposited by CSD processes under reducing condition

Broadband Dispersion-Free Optical Cavities Based on Zero Group Delay Dispersion Mirror Sets

A broadband dispersion-free optical cavity using a zero group delay dispersion (zero-GDD) mirror set is demonstrated. In general zero-GDD mirror sets consist of two or more mirrors with opposite group delay dispersion (GDD), that when used together, form an optical cavity with vanishing dispersion over an enhanced bandwidth in comparison with traditional low GDD mirrors. More specifically, in this paper, we show a realization of such a two-mirror cavity, where the mirrors show opposite GDD and simultaneously a mirror reflectivity of 99.2% over 100 nm bandwidth (480 nm - 580 nm).Physic

Defining the Essential Function of Yeast Hsf1 Reveals a Compact Transcriptional Program for Maintaining Eukaryotic Proteostasis

Despite its eponymous association with the heat shock response, yeast heat shock factor 1 (Hsf1) is essential even at low temperatures. Here we show that engineered nuclear export of Hsf1 results in cytotoxicity associated with massive protein aggregation. Genome-wide analysis revealed that Hsf1 nuclear export immediately decreased basal transcription and mRNA expression of 18 genes, which predominately encode chaperones. Strikingly, rescuing basal expression of Hsp70 and Hsp90 chaperones enabled robust cell growth in the complete absence of Hsf1. With the exception of chaperone gene induction, the vast majority of the heat shock response was Hsf1 independent. By comparative analysis of mammalian cell lines, we found that only heat shock-induced but not basal expression of chaperones is dependent on the mammalian Hsf1 homolog (HSF1). Our work reveals that yeast chaperone gene expression is an essential housekeeping mechanism and provides a roadmap for defining the function of HSF1 as a driver of oncogenesis

Common variants in FOXP1 are associated with generalized vitiligo

In a recent genome-wide association study of generalized vitiligo, we identified ten confirmed susceptibility loci. By testing additional loci that showed suggestive association in the genome-wide study, using two replication cohorts of European descent, we observed replicated association of generalized vitiligo with variants at 3p13 encompassing FOXP1 (rs17008723, combined P = 1.04 × 10−8) and with variants at 6q27 encompassing CCR6 (rs6902119, combined P = 3.94 × 10−7)