41 research outputs found
Diversidad morfológica de higuerilla (RICINUS COMMUNIS L.) del estado de Chiapas México.
- Publication venue
- Publication date
- 01/01/2012
- Field of study
A Gap Analysis Methodology for Collecting Crop Genepools: A Case Study with Phaseolus Beans
- Author
- A Delgado-Salinas
- A Delgado-Salinas
- A Delgado-Salinas
- A Jarvis
- A Jarvis
- A Jarvis
- A Jimenez-Valverde
- AJ Challinor
- Andy Jarvis
- B Hawkins
- BA Loiselle
- BA Meilleur
- C Graham
- C Graham
- C Khoury
- C Liu
- C Prescott-Allen
- C Schinkel
- CF Dormann
- CJ Salcedo
- CJ Salcedo
- Colin Khoury
- Daniel Gabriel Debouck
- DG Debouck
- DG Debouck
- DG Debouck
- DG Debouck
- Dorian Q. Fuller
- FD Garvin
- GC Costa
- GF Freytag
- GP Nabhan
- J Elith
- J Kornegay
- J Smartt
- J VanDerWal
- JA Acosta-Gallegos
- JA Kipe-Nolt
- JM Lobo
- JM Lobo
- JR Busby
- JR Harlan
- Julián Ramírez-Villegas
- KC Shelley-Dessert
- LC Munoz
- Luigi Guarino
- M Lobo Burle
- M Termansen
- MB Burke
- MC Fitzpatrick
- MG Smolik
- MS Wisz
- N Maxted
- N Maxted
- N Maxted
- N Maxted
- P Gepts
- P McClean
- PA Hernandez
- PB Jones
- R Hajjar
- RJ Hijmans
- RJ Hijmans
- RJ Hijmans
- RJ Hijmans
- RJ Hijmans
- RJ Hijmans
- RJ Singh
- RP Guralnick
- SD Tanksley
- SD Veloz
- SJ Phillips
- SJ Phillips
- SJ Phillips
- SP Singh
- TM Brooks
- U Parthasarathy
- W Thuiller
- Publication venue
- Public Library of Science
- Publication date
- 01/01/2010
- Field of study
Background The wild relatives of crops represent a major source of valuable traits for crop improvement. These resources are threatened by habitat destruction, land use changes, and other factors, requiring their urgent collection and long-term availability for research and breeding from ex situ collections. We propose a method to identify gaps in ex situ collections (i.e. gap analysis) of crop wild relatives as a means to guide efficient and effective collecting activities. Methodology/Principal Findings The methodology prioritizes among taxa based on a combination of sampling, geographic, and environmental gaps. We apply the gap analysis methodology to wild taxa of the Phaseolus genepool. Of 85 taxa, 48 (56.5%) are assigned high priority for collecting due to lack of, or under-representation, in genebanks, 17 taxa are given medium priority for collecting, 15 low priority, and 5 species are assessed as adequately represented in ex situ collections. Gap “hotspots”, representing priority target areas for collecting, are concentrated in central Mexico, although the narrow endemic nature of a suite of priority species adds a number of specific additional regions to spatial collecting priorities. Conclusions/Significance Results of the gap analysis method mostly align very well with expert opinion of gaps in ex situ collections, with only a few exceptions. A more detailed prioritization of taxa and geographic areas for collection can be achieved by including in the analysis predictive threat factors, such as climate change or habitat destruction, or by adding additional prioritization filters, such as the degree of relatedness to cultivated species (i.e. ease of use in crop breeding). Furthermore, results for multiple crop genepools may be overlaid, which would allow a global analysis of gaps in ex situ collections of the world's plant genetic resource
Joint Practice Guidelines for Radionuclide Lymphoscintigraphy for Sentinel Node Localization in Oral/Oropharyngeal Squamous Cell Carcinoma
- Author
- A Bilde
- A Bilde
- A Bilde
- A Brobeil
- A Cheng
- A Khafif
- A Terada
- A Wagner
- A. Bilde
- A. Chiti
- A. F. Kovacs
- A. J. Britten
- AC Perkins
- AF Kovacs
- AF Kovács
- AF Kovács
- AF Kovács
- AJ Britten
- AJ Cochran
- AJ Wilhelm
- AM Millar
- B Keller
- Brazilian Head and Neck Cancer Study Group
- C Buchwald von
- C Cicco De
- C. Chiesa
- C. R. Leemans
- CG Gourin
- CG Shores
- CR Leemans
- CT Chone
- DA Burton
- DL Morton
- DM Don
- DM Parkin
- DN Krag
- DW Chicken
- E Even-Sapir
- E Yamamoto
- EC Glass
- EC Glass
- EJ Nieuwenhuis
- EJ Rutgers
- F Chiesa
- F Civantos
- FJ Civantos
- FJ Civantos
- G Tartaglione
- G. L. Ross
- G. Mamelle
- G. Trifiro
- GL Ross
- GL Ross
- GL Ross
- GW Carlson
- H Keski-Santti
- H. W. Gray
- IR Jimenez
- J Alvarez
- J Buscombe
- J Warner
- J. A. Alvarez
- J. A. Sorensen
- J. B. Thomsen
- J. Ballinger
- J. Mortensen
- J. Werner
- JA Werner
- JA Werner
- JA Werner
- JA Werner
- JA Woolgar
- JA Woolgar
- JB Thomsen
- JB Thomsen
- JB Thomsen
- JB Thomsen
- JC Alex
- JC Alex
- JC Alex
- JC Papadimitriou
- JD Spiro
- JF Gallegos-Hernandez
- JJ Albertini
- JP Shah
- JP Shah
- JP Shah
- K Chikamatsu
- K Scherer
- K. Hunter
- KM McMasters
- KT Pitman
- KT Pitman
- KT Robbins
- L Tschopp
- L. Calabrese
- L. W. T. Alkureishi
- LF Glass
- LW Alkureishi
- LWT Alkureishi
- M Koizumi
- M. Lassmann
- M. McGurk
- MT Hornstra
- N Mozzillo
- N Nugent
- NC Hyde
- NN Pandit-Tskar
- OE Nieweg
- P Ambrosch
- P Bostick
- P. Sloan
- R Essner
- R Garrel
- R Kontio
- R Lindberg
- R Lopez
- R. de Bree
- RF Uren
- RF Uren
- RF Uren
- RF Uren
- RM Byers
- RM Byers
- RM Byers
- RM Cabanas
- S Asthana
- S Hoft
- S Klutmann
- S Modi
- S. J. Stoeckli
- SJ Stoeckli
- SJ Stoeckli
- SJ Stoeckli
- SL Stratmann
- SV Kane
- T Sera
- T Shoaib
- T Shoaib
- T Tiourina
- T. Poli
- T. Shoaib
- TL Klausen
- TM Pimenta Amaral
- WA Waddington
- Z. Burak
- Publication venue
- Springer-Verlag
- Publication date
- 01/01/2009
- Field of study
Involvement of the cervical lymph nodes is the most important prognostic factor for patients with oral/oropharyngeal squamous cell carcinoma (OSCC), and the decision of whether to electively treat patients with clinically negative necks remains a controversial topic. Sentinel node biopsy (SNB) provides a minimally invasive method for determining the disease status of the cervical node basin, without the need for a formal neck dissection. This technique potentially improves the accuracy of histologic nodal staging and avoids overtreating three-quarters of this patient population, minimizing associated morbidity. The technique has been validated for patients with OSCC, and larger-scale studies are in progress to determine its exact role in the management of this patient population. This document is designed to outline the current best practice guidelines for the provision of SNB in patients with early-stage OSCC, and to provide a framework for the currently evolving recommendations for its use. Preparation of this guideline was carried out by a multidisciplinary surgical/nuclear medicine/pathology expert panel under the joint auspices of the European Association of Nuclear Medicine (EANM) Oncology Committee and the Sentinel European Node Trial (SENT) Committee
Joint practice guidelines for radionuclide lymphoscintigraphy for sentinel node localization in oral/oropharyngeal squamous cell carcinoma
- Author
- A Bilde
- A Bilde
- A Brobeil
- A Cheng
- A Khafif
- A Terada
- A Wagner
- AC Perkins
- Adorjan F. Kovacs
- AF Kovacs
- AF Kovács
- AF Kovács
- AF Kovács
- AJ Britten
- AJ Cochran
- AJ Wilhelm
- Alan J. Britten
- AM Millar
- Anders Bilde
- Arturo Chiti
- B Frerich
- B Keller
- Brazilian Head and Neck Cancer study group
- C Buchwald von
- C Cicco De
- C. Rene Leemans
- Carlo Chiesa
- CG Gourin
- CG Shores
- CR Leemans
- CT Chone
- D Nejc
- DA Burton
- DL Morton
- DL Morton
- DM Don
- DM Parkin
- DN Krag
- DW Chicken
- E Even-Sapir
- E Yamamoto
- EC Glass
- EC Glass
- EJ Nieuwenhuis
- EJ Rutgers
- F Chiesa
- F Civantos
- FJ Civantos
- FJ Civantos
- G Tartaglione
- Gary L. Ross
- Gerard Mamelle
- Giusepe Trifiro
- GL Ross
- GL Ross
- GL Ross
- GW Carlson
- H Keski-Santti
- Harry W. Gray
- HS Cody
- IR Jimenez
- J Alvarez Amézaga
- J Buscombe
- J Warner
- JA Werner
- JA Werner
- JA Werner
- JA Werner
- JA Woolgar
- JA Woolgar
- James Ballinger
- Jann Mortensen
- JB Thomsen
- JB Thomsen
- JB Thomsen
- JC Alex
- JC Alex
- JC Alex
- JC Papadimitriou
- JD Spiro
- Jens A. Sorensen
- JF Gallegos-Hernandez
- JJ Albertini
- Jochen Werner
- Jorn B. Thomsen
- JP Shah
- JP Shah
- JP Shah
- Julio A. Alvarez
- K Chikamatsu
- K Scherer
- Keith Hunter
- KM McMasters
- KT Pitman
- KT Pitman
- KT Robbins
- L Tschopp
- Lee W. T. Alkureishi
- LF Glass
- Luca Calabrese
- LW Alkureishi
- LW Alkureishi
- M Koizumi
- Mark McGurk
- Michael Lassmann
- MRS Keshtar
- MS Laasanen
- MT Hornstra
- N Mozzillo
- N Nugent
- NC Hyde
- OE Nieweg
- OE Nieweg
- P Ambrosch
- P Bostick
- Philip Sloan
- R Essner
- R Garrel
- R Kontio
- R Lindberg
- R Lopez
- Remco de Bree
- RF Uren
- RF Uren
- RF Uren
- RF Uren
- RM Byers
- RM Byers
- RM Byers
- RM Cabanas
- S Asthana
- S Hoft
- S Klutmann
- S Modi
- Sandro J. Stoeckli
- SJ Stoeckli
- SJ Stoeckli
- SJ Stoeckli
- SL Stratmann
- SV Kane
- T Sera
- T Shoaib
- T Shoaib
- T Shoaib
- T Tiourina
- Taimur Shoaib
- Tito Poli
- TL Klausen
- TM Pimenta Amaral
- WA Waddington
- Zeynep Burak
- Publication venue
- Springer-Verlag
- Publication date
- 01/01/2009
- Field of study
Involvement of the cervical lymph nodes is the most important prognostic factor for patients with oral/oropharyngeal squamous cell carcinoma (OSCC), and the decision whether to electively treat patients with clinically negative necks remains a controversial topic. Sentinel node biopsy (SNB) provides a minimally invasive method of determining the disease status of the cervical node basin, without the need for a formal neck dissection. This technique potentially improves the accuracy of histological nodal staging and avoids over-treating three-quarters of this patient population, minimizing associated morbidity. The technique has been validated for patients with OSCC, and larger-scale studies are in progress to determine its exact role in the management of this patient population. This article was designed to outline the current best practice guidelines for the provision of SNB in patients with early-stage OSCC, and to provide a framework for the currently evolving recommendations for its use. These guidelines were prepared by a multidisciplinary surgical/nuclear medicine/pathology expert panel under the joint auspices of the European Association of Nuclear Medicine (EANM) Oncology Committee and the Sentinel European Node Trial Committee
Effect of the COVID-19 pandemic on surgery for indeterminate thyroid nodules (THYCOVID): a retrospective, international, multicentre, cross-sectional study
- Author
- Abdallah A.
- Abentroth A. L.
- Acheimastos V.
- Agunaoun M.
- Al Bisher H. M.
- Al Ghuzlan A.
- Al-Suhaimi E. A.
- Alakus H.
- Alkan M.
- Almaraz Almaraz M. C.
- Altmeier J.
- Amram K.
- Anajar S.
- Anesidis S.
- Anestiadou E.
- Angelucci D.
- Ansaldo G. L.
- Antonopoulou M. I.
- Arciniegas M.
- Arikan A. E.
- Armellin C.
- Arredondo Saldana G.
- Astl J.
- Athanasakis E.
- Avenia S.
- Aydin H.
- Azaryan I.
- Baba B.
- Babala J.
- Bains L.
- Banus M. V.
- Barba-Valadez L. A.
- Barcons S. V.
- Basili G.
- Battafarano F.
- Bayat A.
- Bella R. M. C.
- Benariba F.
- Bernardi S.
- Bignami E. G.
- Bitenc M.
- Bitsianis S.
- Bolanos de la Torre J. D. D.
- Bolukbasi H.
- Bonati E.
- Bonetti T.
- Bononi M.
- Borges F. A.
- Borumandi F.
- Bouchagier K.
- Boudina M.
- Bourial A.
- Bozan M. B.
- Brenta G.
- Breuskin I.
- Brock P.
- Brunaud L.
- Brunner M.
- Bruns C.
- Buemi A.
- Burlacu M. C.
- Burton T.
- Buta M.
- Buzanakov D.
- Caliseo C.
- Callanan D.
- Calo P. G.
- Calu V.
- Cameselle-Teijeiro J. M.
- Camilo-Junior D. J.
- Canberk S.
- Candalise V.
- Candanedo-Gonzalez F.
- Canu G. L.
- Cappellacci F.
- Carrillo Lizarazo L. J.
- Cartwright S. B.
- Carvalho G. B.
- Casallas D.
- Casolino C.
- Castellani L.
- Castells Fuste I.
- Castillo Morales C.
- Cavalheiro B.
- Cavallaro G.
- Chala A.
- Chambon G.
- Chan S. Y. B.
- Chaplin J.
- Chatzipavlidou V.
- Cheema M. S.
- Chernikov R.
- Chiapponi C.
- Chiofalo M. G.
- Chorti A.
- Chow T. C. M.
- Chrisoulidou A.
- Chrysos E.
- Chrysos E.
- Conrado-Neto S.
- Cordova Garcia D.
- Corigliano A.
- Crocco A.
- Cuesta A.
- Cukman M.
- Curto L. S.
- D'Amore A.
- D'Anna R.
- D'Orazi V.
- Damilano R. A.
- de Cillia M.
- De Crea C.
- De M.
- de Manzini N.
- de Matos L. L.
- De Pasquale L.
- De Virgilio A.
- Del Rio P.
- Dellaportas D.
- Demarchi M. S.
- Demarquet L.
- Devresse A.
- Dhiwakar M.
- Di Meo G.
- Diaz Pedrero R.
- Dimitrov D.
- Dmitry Z.
- Dobrinja C.
- Dominguez Garijo P.
- Donatini G.
- Dora J. M.
- Doulatram Gamgaram V. K.
- Dulgeroglu O.
- Dural A. C.
- Eismontas V.
- Eksi A.
- El Hammoumi M.
- El Kaoui H.
- El Malki H. O.
- Eleni G.
- Elliyanti A.
- Elzahaby I.
- Enciu O.
- Ersoz
- Escobar-Jimenez M.
- Eskander A.
- Fedorova L.
- Feeley L.
- Fernandez Rodriguez E.
- Feroci F.
- Ferreli F.
- Figueroa-Bohorquez D.
- Filis D.
- Filoia A.
- Fingeret A.
- Francescato A.
- Francois G.
- Frias-Fernandez P.
- Gaino F.
- Galiandro F.
- Gallegos-Hernandez J. F.
- Gamboa-Dominguez A.
- Garas G.
- Garcia Lorenzo F.
- Garcia-Chavez J. P.
- Gaudiello M.
- Gay S.
- Genc V.
- Gerasimos S.
- Gerek M.
- Gervasi R.
- Giordano A.
- Giordano D.
- Gjeloshi B.
- Gocky L.
- Golubinskaya E.
- Gomez-Pedraza A.
- Gonzalez Romero S.
- Gonzalez-Minguez C.
- Goran M.
- Gosman A.
- Graceffa G.
- Granados Garcia M.
- Greco E.
- Griffin J.
- Grunbart M.
- Grutzmann R.
- Guerlain J.
- Guerreiro S. C.
- Guirao X. G.
- Gupta K.
- Gupta K. K.
- Gurrado A.
- Guzey D.
- Hajiioannou J.
- Hajjij A.
- Hakala T.
- Hamdy O.
- Hameed M. S.
- Harahap W. A.
- Hargitai L.
- Hartl D.
- Hauth L. A.
- Hellmann A.
- Hernandez-Acevedo J. D.
- Hernandez-Carrillo J. F.
- Hevilla Sanchez F.
- Hlozek J.
- Hoang V. T.
- Hoi H.
- Hongkwon K.
- Hu Zhu R.
- Huang E.
- Hyeung Kyoo K.
- Iacobone M.
- Ignjatovic V.
- Innaro N.
- Ioannidis A.
- Ioannidis O.
- Iossa A.
- Isik A.
- James D.
- Jang J. H. I.
- Jovanovic M.
- Jung Hoon L.
- Kabiri E. H.
- Kaderli R. M.
- Kakamad F.
- Kaliszewski K.
- Kara H.
- Karajovic J.
- Karamanliev M.
- Kartini D.
- Katoh H.
- Khambri D.
- Kholova I.
- Kim S. Y.
- Kisiel M.
- Knezevic M.
- Koh Y. Q.
- Konca C.
- Kosec A.
- Kosmidis C.
- Kotsovolis G.
- Kovacevic B.
- Kowalski L. P.
- Kowalski L. P.
- Kralik R.
- Kralik R.
- Kuczma P.
- Kumorova A.
- Kuravi B. G.
- Kurnia A.
- Kyriaki V.
- Lai C. M.
- Lallemant B.
- Lampridis S.
- Lardhi A. A.
- Lasithiotakis K.
- Leboulleux S.
- Leclere J. -C.
- Lee J. W.
- Lelli G.
- Leong E. K. F.
- Leow M. K. -S.
- Leutner M.
- Lim C. M.
- Lim J. Y.
- Lim M. Y.
- Lino-Silva L. S.
- Liu S. Y. W.
- Llanos A.
- Llorach N. P.
- Lo X.
- Loderer T.
- Lombardi C. P.
- Lopez-Corrales M. A.
- Lopez-Gomez J.
- Lori E.
- Lucchini R.
- Ludwig M.
- Madani A.
- Magnabosco F. F.
- Maheo C.
- Maia A. L.
- Makay O.
- Maksimova P.
- Mallick S.
- Mallouk C.
- Mamani Z.
- Manatakis D.
- Mandal S.
- Manyalich Blasi M.
- Marincola G.
- Markovic I.
- Marulanda M.
- Materazzi G.
- Mavromati M.
- Mayilvaganan S.
- Mazeh H.
- Medas F.
- Mercante G.
- Metso S.
- Meyer-Rochow G. Y.
- Micalizzi A.
- Michalopoulos A.
- Mihaljevic O.
- Miller J. A.
- Min-Su K.
- Minuto M.
- Miron A.
- Mishra A. K.
- Misso C.
- Mittermair C.
- Monacelli M.
- Morosan Allo Y.
- Mourad M.
- Moysidis M.
- Mulita F.
- Mullineris B.
- Munoz-de-Nova J. L.
- Muradas Girardi F.
- Nabhan F.
- Nader S.
- Napadon T.
- Nasiri R.
- Nastos C.
- Nastos C.
- Ngiam K. Y.
- Nomine-Criqui C.
- Ntziovara A. M.
- Nuno Vazquez-Garza J. M.
- Nutautiene V.
- O'Keeffe L.
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- Offi C.
- Okudur N. O.
- Oragano L.
- Orois A.
- Ossola P.
- Ovejero Merino E.
- Ozdemir M.
- Pan Y.
- Panagiotidis E.
- Panchangam R. B.
- Pangonis A.
- Panigoro S. S.
- Panuzi A.
- Papaconstantinou D.
- Papavramidis T.
- Pardo Matamoros N.
- Parida P. K.
- Paschou S.
- Pasculli A.
- Paspala A.
- Paterakis K.
- Peiris K.
- Pennestri F.
- Peppa M.
- Perdikaris I.
- Perdikaris P.
- Perez O. V.
- Perez-Soto R. H.
- Petrovic S.
- Piana S.
- Piccoli M.
- Pietrasanta D.
- Placentino G.
- Pliakos I.
- Polistena A.
- Pongtippan A.
- Potard G.
- Quinn V.
- Quintanilla-Dieck L.
- Raffaelli M.
- Rahul P.
- Ramacciotti C. F.
- Ramos T.
- Rankin A.
- Ratia Gimenez T.
- Ratnayake P.
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- Ridolfo A.
- Rios-Valencia J.
- Riss P.
- Rival E.
- Rivillas J.
- Rivo Vazquez A.
- Roh J. -L.
- Roi D.
- Rollo E. M.
- Romanchishen A.
- Romito M.
- Ronen O.
- Rossi L.
- Rotnagl J.
- Rovcanin B.
- Russo G.
- Sabol M.
- Saki S.
- Saleh S.
- Salih A.
- Saltiki A.
- Salvador-Camarmo G.
- Samal D. K.
- Sanabria A.
- Sanchez-Flores S.
- Santeerapharp A.
- Sapalidis K.
- Sarin D.
- Sarin H.
- Savkovic N.
- Scheffel R. S.
- Scheinpflug A. L.
- Scheuba C.
- Scheyer N.
- Schmidt M.
- Semenov A.
- Senashova O.
- Seneviratne S.
- Serafini E.
- Serdar A.
- Serrano Arevalo M. L.
- Shank J.
- Sheahan P.
- Sheppard S. C.
- Shindo M. L.
- Shoshkova M.
- Shvan M.
- Sicak M.
- Silva T. G.
- Simo Guerrero O.
- Skuletic V.
- Slijepcevic N.
- Slotcavage R. L.
- Slovic Z.
- Smaxwil C.
- Soares P.
- Somova A.
- Sorrenti S.
- Soto S.
- Spartalis E.
- Spiezia S.
- Sriphrapradang C.
- Stankovic V.
- Stephenson K. J.
- Straub E.
- Summa M.
- Surani S.
- Syed A. A.
- Symeonidis S.
- Taciak A.
- Tarallo M.
- Tarle A.
- Tasis N.
- Tausanovic K.
- Tchabashvili L.
- Testini M.
- Thierry M.
- Tokarczyk U.
- Toma E. A.
- Topuz S.
- Torresan F.
- Turk Y.
- Tzikos G.
- Uras C.
- Vabalayte K.
- Vaccaro C.
- Valdes de Anca A.
- Valentini M.
- Varaldo E.
- Vargas-Osorio K.
- Vartanian J. G.
- Vazquez Renteria R. S.
- Velazquez-Fernandez D.
- Verras G. I.
- Vithana S. M. P.
- Vithanage A.
- Wijayalathge H.
- Wiriyaamornchai P.
- Wong Y. L. C.
- Wongwattana P.
- Xavier-Junior J. C.
- Xenaki S.
- Xie S.
- Xu M.
- Yadav S. K.
- Yang W.
- Yilmaz S.
- Yilmaz Y. F.
- Yotsov T.
- Yucel L.
- Yulian E. D.
- Zahid M. T.
- Zahradnikova P.
- Zarogoulidis P.
- Ziablitskaia E.
- Zielke A.
- Zolotoukho A.
- Publication venue
- ELSEVIER SCIENCE INC
- Publication date
- 28/04/2023
- Field of study
Background Since its outbreak in early 2020, the COVID-19 pandemic has diverted resources from non-urgent and elective procedures, leading to diagnosis and treatment delays, with an increased number of neoplasms at advanced stages worldwide. The aims of this study were to quantify the reduction in surgical activity for indeterminate thyroid nodules during the COVID-19 pandemic; and to evaluate whether delays in surgery led to an increased occurrence of aggressive tumours.Methods In this retrospective, international, cross-sectional study, centres were invited to participate in June 22, 2022; each centre joining the study was asked to provide data from medical records on all surgical thyroidectomies consecutively performed from Jan 1, 2019, to Dec 31, 2021. Patients with indeterminate thyroid nodules were divided into three groups according to when they underwent surgery: from Jan 1, 2019, to Feb 29, 2020 (global prepandemic phase), from March 1, 2020, to May 31, 2021 (pandemic escalation phase), and from June 1 to Dec 31, 2021 (pandemic decrease phase). The main outcomes were, for each phase, the number of surgeries for indeterminate thyroid nodules, and in patients with a postoperative diagnosis of thyroid cancers, the occurrence of tumours larger than 10 mm, extrathyroidal extension, lymph node metastases, vascular invasion, distant metastases, and tumours at high risk of structural disease recurrence. Univariate analysis was used to compare the probability of aggressive thyroid features between the first and third study phases. The study was registered on ClinicalTrials.gov, NCT05178186.Findings Data from 157 centres (n=49 countries) on 87 467 patients who underwent surgery for benign and malignant thyroid disease were collected, of whom 22 974 patients (18 052 [78 center dot 6%] female patients and 4922 [21 center dot 4%] male patients) received surgery for indeterminate thyroid nodules. We observed a significant reduction in surgery for indeterminate thyroid nodules during the pandemic escalation phase (median monthly surgeries per centre, 1 center dot 4 [IQR 0 center dot 6-3 center dot 4]) compared with the prepandemic phase (2 center dot 0 [0 center dot 9-3 center dot 7]; p<0 center dot 0001) and pandemic decrease phase (2 center dot 3 [1 center dot 0-5 center dot 0]; p<0 center dot 0001). Compared with the prepandemic phase, in the pandemic decrease phase we observed an increased occurrence of thyroid tumours larger than 10 mm (2554 [69 center dot 0%] of 3704 vs 1515 [71 center dot 5%] of 2119; OR 1 center dot 1 [95% CI 1 center dot 0-1 center dot 3]; p=0 center dot 042), lymph node metastases (343 [9 center dot 3%] vs 264 [12 center dot 5%]; OR 1 center dot 4 [1 center dot 2-1 center dot 7]; p=0 center dot 0001), and tumours at high risk of structural disease recurrence (203 [5 center dot 7%] of 3584 vs 155 [7 center dot 7%] of 2006; OR 1 center dot 4 [1 center dot 1-1 center dot 7]; p=0 center dot 0039).Interpretation Our study suggests that the reduction in surgical activity for indeterminate thyroid nodules during the COVID-19 pandemic period could have led to an increased occurrence of aggressive thyroid tumours. However, other compelling hypotheses, including increased selection of patients with aggressive malignancies during this period, should be considered. We suggest that surgery for indeterminate thyroid nodules should no longer be postponed even in future instances of pandemic escalation.Funding None.Copyright (c) 2023 Published by Elsevier Ltd. All rights reserved
Finishing the euchromatic sequence of the human genome
- Author
- . Haifeng
- . Magner
- . Yin
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- Abbott-Ozersky Amanda
- Abdellah Zahra
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- Jewett Phillip E.
- Jia Jia
- Jia Jia
- Jia Nan
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- Jiang Lu
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- Lowenstein Michael G.
- Lowry Stephen
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- Lu Lingfeng
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- Lucier Raymond L.
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- MacLean Christine
- Madabhushi Ramki
- Madu Renita C.
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- McNinch Jenny
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- Nazareth Lynne V.
- Neal Dearl D.
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- Nwokenkwo Stanley
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- Okumura Reina
- Okwuonu Geoffrey O.
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- Olarnpunsagoon Alisa
- Olivas Jason
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- Olson Maynard V.
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- Paul Heidie A.
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- Pennacchio Len A.
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- Perez Agapito
- Perez Lesette M.
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- Quail Michael
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- Sonnhammer Erik
- Sonnhammer Erik
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- Sutherland Grant R.
- Sutherland Robert D.
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- Zhang Xiuqing
- Zhang Yan
- Zhang Yi
- Zhang Yilin
- Zhang Yilin
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- Zhang Yuzhi
- Zhang Zhengdong
- Zhao Hongmei
- Zhao Lijian
- Zhao Shenru
- Zhao Zhijing
- Zhen Zhicheng
- Zheng Haibo
- Zhong Ming
- Zhou Carol
- Zhou Haixia
- Zhou Jianling
- Zhou Nannan
- Zhou Xinfeng
- Zhou Yan
- Zhou Yang
- Zhou Yi
- Zhu Bingying
- Zhu Bofeng
- Zhu Fenghua
- Zhu Genfeng
- Zhu Genfeng
- Zhu Miao
- Zhu Ning
- Zhu Yongge
- Zhu Zhen
- Zhuang Shitao
- Zierten Deborah
- Zimmer Andrew
- Zody Michael C.
- Zollo Massimo
- Zorrilla Sara E.
- Zuo Lin
- Publication venue
- LSU Digital Commons
- Publication date
- 21/10/2004
- Field of study
The sequence of the human genome encodes the genetic instructions for human physiology, as well as rich information about human evolution. In 2001, the International Human Genome Sequencing Consortium reported a draft sequence of the euchromatic portion of the human genome. Since then, the international collaboration has worked to convert this draft into a genome sequence with high accuracy and nearly complete coverage. Here, we report the result of this finishing process. The current genome sequence (Build 35) contains 2.85 billion nucleotides interrupted by only 341 gaps. It covers ∼99% of the euchromatic genome and is accurate to an error rate of ∼1 event per 100,000 bases. Many of the remaining euchromatic gaps are associated with segmental duplications and will require focused work with new methods. The near-complete sequence, the first for a vertebrate, greatly improves the precision of biological analyses of the human genome including studies of gene number, birth and death. Notably, the human enome seems to encode only 20,000-25,000 protein-coding genes. The genome sequence reported here should serve as a firm foundation for biomedical research in the decades ahead
Robust estimation of bacterial cell count from optical density
- Author
- Aarnio Tiu
- Aaron Leow Chung Yong
- Abbas Anser
- Abduraimova Aiganym
- Abraham Doris
- Acar Beliz Leyla
- Acosta Joaquin
- Adler Nina
- Adulyanukosol Natthawut
- Agena Ejouan
- Agena Ethan
- Aggarwal Priya
- Aguirre Adriana Lizeth Rubio
- Ahlgren Christopher
- Ahuja Janvi
- Aizik Dror
- Akbary Mina
- Akinfenwa Akinwumi
- Akingbesote Ngozi D.
- Akova Umut
- Aldo Ferdinan
- Alexopoulos Ioannis
- Allen Lucy
- Alonso Alejandro
- Altarawneh Dina
- Alvarado Andres Benjamin Sanchez
- Ambre Sanika
- Ameziane Annissa
- Amheine Khadija
- Amin Ihya Fakhrurizal
- Amir Sayeda Sakina
- Amstel Chiel van
- An Yongyan
- Anand Nithishwer Mouroug
- Ananthakrishnan Sathvik
- Anderson Karl
- Angel Sagi
- Annem Vidhya
- Anson Chung Tsun Ho
- Anwar Mariam
- Appel Alana
- Araya Lucas
- Armstrong Alexander
- Arora Neha
- Arora Vasu
- Arruda Beck
- Ashwin F Amal Jude
- Astapenka Artur
- Astles Ben
- Astorino Gabe
- Aubry Celine
- Avileli Rebecca
- Azad Mahnaz Sabeta
- Babar Rehmat
- Babu Priyanka
- Badalli Turan
- Badash Lior
- Baichman-Kass Amichai
- Baldwin Geoff S.
- Baltensperger Oliver Andreas
- Bao Guanke
- Bao Minyue
- Baronaite Ugne
- Barrat Leon Michael
- Barrington Seth
- Barshap Alon
- Bartzoka Natalia
- Basu Anubhav
- Basulto Cynthia
- Bath Scott
- Battina Rohith
- Bauersachs Daniel
- Beal Jacob
- Beale Renee
- Beard Eleanor
- Beck Selina
- Becker Evan
- Benavides Samantha Ayde Pena
- Bennis Nicole
- Bete Anna
- Bhatt Darshak
- Bhowmick Shilpa
- Bian Weixin
- Bijman Eline Yafele
- Bindt Felix
- Blas Karla Soto
- Bo Tang
- Boada Yadira
- Boer Meine
- Bohner Ariel
- Borovko Irina
- Bott Amie
- Bouwmeester Susan
- Bowman Kyle
- Boxem Mike
- Boxuan Cheng
- Boyce Kira
- Boyer Jess
- Brasas Valentas
- Brewer Mathew
- Briand William
- Brink Matilda
- Browne Emily
- Buckley-Taylor Russell
- Budhan Stephanie
- Buller Lisa
- Burckhardt Nele
- Burgland Zachary
- Burns Frank
- Burridge Matt
- Burud Hanna Nedreberg
- Buson Felipe Xavier
- Butterfield Tom
- Byagathvalli Gaurav
- Byatt Gabriel
- Byun Sumin
- Caballero Amalia
- Cai Fu
- Cai Niangui
- Caldwell Sarah
- Camacho Yazmin
- Camille Monteil
- Campbell Robert
- Cao Qinhao
- Cao Yixin
- Cao Yuze
- Carrillo Leo
- Carter Jonah
- Casas Alexis
- Castillo Nora Esther Torres
- Castillo Sandra
- Cave John
- Chai Ruochen
- Chamiec-Case Elizabeth
- Chan Janice
- Chan Yuan-Yao
- Chandramouli Priyanka
- Chang Annabel
- Chang Catherine
- Chang Kevin
- Chang Thomas
- Chang Ting-Chen
- Chang Yu-Ci
- Chapman Tyler
- Chater Dounia
- Chau Anthony
- Chavez Benjamin
- Chavez Francisco
- Chehade Ibrahim
- Chen Carmen
- Chen Chih-Chiang
- Chen Ching-Wei
- Chen Janice
- Chen Junhong
- Chen Junyang
- Chen Junyu
- Chen Pei-Hong
- Chen Ryan
- Chen Weixuan
- Chen Yan
- Chen Yi-Cian
- Chen Yifei
- Chen Zhuoyang
- Cheng Cheng
- Cheng Haolun
- Cheng Hsuan
- Cheng Yu-Hong
- Cheng Yu-Hsuan
- Chenxi Liang
- Cherupalla Arjun
- Chi Jordi
- Chi Shumei
- Chiang Jason
- Chiang Woody
- Ching Lai Tsz
- Ching Lam Kai
- Ching Law Hiu
- Ching Luk Hau
- Chinnathambi Sathivel
- Cho Sungwoo
- Choi Lee Sze
- Choi Youngeun
- Chou Ryan
- Chou Ryan
- Chu Wai Yan
- Chua Yah Tse Sabrina
- Chuang Yi-Chien
- Chulkova Nadezhda
- Chun Cheung Man
- Chun Emily
- Chun Ng Tsz
- Cifuentes Rodrigo Hernandez
- Clapper Jude
- Clapper Jude
- Clark Brittany
- Clemente Borja Sanchez
- Clerc Valerian
- Clodomir Christina
- Coates Ryan
- Cohen Katherine
- Colant Noelle
- Coleman Sarah
- Colgan Cian
- Cone Eli
- Corre Christophe
- Costa Ben
- Cott Rachel Van
- Craw Darilyn
- Crispim Larissa de Souza
- Crone Michael Andrew
- Crooijmans Marjolein
- Crosby Laurel Constanti
- Crowley Peter
- Cruz Frida
- Cubukcu Hande
- Culfogienis Dylan
- Czekster Clarissa
- Dai Leijie
- Dalangin Rochelin
- Daniel Benjamin
- Daniels Lea
- Das Neves Laura
- Das Diptatanu
- Davis Christina
- De Silva Nimaya
- Deb Shalini S.
- Deepak Kumar S.
- Deibel Emilie
- Dejoie Julianne
- Dejoux Alice
- DeKloe Jackson
- Del Toro Mariano
- Delalez Nicolas
- Delgadillo Sabrina
- Delhomme Jean
- Demchuk Aubrey
- Deng Nian Ruei
- Deng Rui
- Denter Jennifer
- Deshmukh-Reeves Ed
- Despres Philippe C.
- Devi Velvizhi
- Dhaliwal Gurpreet
- Diaz Fernanda
- Ding Shizhi
- Ding Yiming
- Ding Zhipeng
- Dingyue Tang
- Dirven Yvette
- Dissmann Jil-Sophie
- Do Stephanie
- Dogra Arushi
- Dominguez Viana Isabel Perez
- Dong Dongyang
- Dong Haitao
- Dong Jason
- Dong Shan
- Dong Shan
- Dong Shan
- Dong Shangzhi
- Dong Shangzhi
- Doyle David
- Doyle Shannon
- Dube Alexandre
- Dubuc Emilien
- Dunstan Izzy
- Dusseaux Theodore A.
- Dvorkin Steve
- Edelmayer Marco
- Ehrenworth Amy
- Eidloth Franziska
- Eijkens Bruno
- Eilers Keno
- El Moubayed Yorgo
- Elcin Evrim
- Elias Noel
- Elikan Max
- Ellermeier Craig
- Elliott Hannah
- Elsa Yeung Hoi Lam
- Emilov Kristian
- Espinoza Diego
- Evans Rhys
- Faidh Mohammed
- Falgenhauer Elisabeth
- Fan Catherine
- Fang Chengzhu
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- Farias Sebastian
- Farny Natalie
- Farny Natalie G.
- Farrell Jennifer
- Fassler Jan
- Faurdal David
- Faustova Ilona
- Feng Xinhua
- Fernandez Cesar Ibrahym Rodriguez
- Fierro Daniela Olono
- Figueroa Ana Cristina
- Figueroa Jose Arnulfo Juarez
- Fikry Clara
- Filzen Rachael
- Fischer Matthew
- Fitzgerald Kevin
- Fitzgerald Liza
- Flores Vinicius
- Foda Asmaa
- Fong Yuhui Deborah
- Forman Victor
- Frank Stefanie
- Frankel Eva
- Freire Paulo J. C.
- Friedman Yonatan
- Frohlich Lisa
- Fu Wenhan
- Fu Yousi
- Fuentes Ernie
- Fulton Leah
- Fung Ip Ning
- Fung Yam Shing
- Gabrielli Jacopo
- Gahagan Maddison
- Gaitt Tobias
- Gaizauskaite Aukse
- Gallegos Isabella
- Gamoneda Diego
- Gandhi Rishi
- Gao Cecily
- Garavito Paula
- Garcia Chrismar
- Garcia David
- Garrido Delia
- Garulli Elisa
- Gaspar Camila
- Gaudi Alex
- Ge Gao
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- Gerard Antoine
- Gershater Markus
- Ghosh Souvik
- Giannopoulos Alexandros Dimitriou
- Giannoula Yvoni
- Gilman Daniel Barber James
- Glockner Eleanor
- Goenka Anushya
- Goetz Marley
- Gogineni Namrata
- Gokul [NO FIRST NAME IN SCOPUS]
- Gonzalo Gonzalo Saiz
- Goodson Michael
- Gopaul Deshmukh
- Gou Yanchen
- Govers Jolijn
- Graaf Floor de
- Grace Tsui Shing Yan
- Graves Daniel
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- Greenwald Matthew
- Gu Jiajun
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- Guenther James
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- Guptil Chris
- Guseva Anna
- Ha Jacqueline
- Haddock-Angelli Traci
- Haight Travis
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- Hamady Carla
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- Handal Paola
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- Hartley Zach
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- Herrmann Max
- Heux Stephanie
- Hewitt Amy
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- Hofer Sebastian
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- Hu Zhaoqing
- Hu Zhiyuan
- Huang Fangliang
- Huang Jiaxi
- Huang Morris
- Huang Ray
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- Huang Yansong
- Huang Yaohua
- Huang Yilin
- Huang Yinpin
- Huanying He
- HuaYue Zhang
- Huerta Ana Laura Torres
- Humphreys Christopher
- Hung Chia
- Husnatter Kai
- Huuki Liz
- Huynh Juilanne
- Hwang Michael
- Ibrahim Ahmed
- Ikagawa Yuichiro
- Ikhsan Muhammad
- Ikwuagwu Bon
- Imgold Markus
- Inanc Tugba
- Inckemann Rene
- Isaac Ashley
- Isaacs Farren
- Isogai Tatsuki
- Iwuogo Amanda
- Iyer Aditya
- Iyer Tvarita Shivakumar
- Izzati Nurul
- Jacq Annick
- Jain Rishabh
- Jain Shubham
- Jainarayanan Ashwin Kumar
- Jakutis Gabrielius
- Jaoui Samuel
- Japranata Valdi Ven
- Jaramillo Alfonso
- Jasiunas Simas
- Jasti Naveen
- Jay Leung Chung Yin
- Jayaraman Guhan
- Jayaraman Srimathi
- Jenakendran Jenaagan
- Jensen Joen Haahr
- Jesse Hayley
- Jha Aryaman
- Ji Peicheng
- Jiacheng Wu
- Jiahe Zhang
- Jiamiao Liu
- Jian Liu
- Jiang Nannan
- Jiang Zhenyu
- Jianzhao Yang
- Jiaqi Hu
- Jiaqi Xiao
- Jimenez Carlene
- Jin Kaifeng
- Jingjing Zhao
- Jinyu Zhu
- Jo Kyuhee
- Joe Lam Kai Ching
- Johnson Elizabeth
- Johnson Michael
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- Jones Cara
- Jones Ethan
- Jones Megan
- Jones Melissa
- Jongkees Seino
- Jonsson Martin
- Jude Marcia Smiti
- Jung Younji
- Juskaite Ieva
- Justice Isaac
- Kabbara Ismat
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- Kailash B.P.
- Kalinowski Jorn
- Kalinowski Jorn
- Kalson Pranshu
- Kamble Yash Laxman
- Kanata Eleni
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- Kang Xu
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- Karpus Laurynas
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- Karumanchi Pranathi
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- Katopodi Xanthi Leda
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- Keating Collin
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- Kolosova Anastasia
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- Yang Fuqiang
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- Yang Jianzhe
- Yang Jindian
- Yang Jinshu
- Yang Jun
- Yang Leyi
- Yang Ruofan
- Yang Shaobo
- Yang Shuting
- Yang Xilin
- Yang Yuchen
- Yang Zhuoyi
- Yang Zisang
- Yang Zon En
- Yao Andrew
- Yarbrough Hayden
- Yaxi Zhang
- Ye Yusheng
- Yee Chong Yuk
- Yeh Chan-yu
- Yehouessi Tamara
- Yeliseyeva Hanna
- Yesley Phillip
- Yeung Wong Tsz
- Yifan Li
- Yihang Qiu
- Yiming Quan
- Yin Jiacheng
- Yin Lee Ka
- Yin Xianqi
- Yong Nur Liyana Binte Ayub Ow
- Yong Zhangxiang
- Yongjie Lin
- Yoo Hojun
- Yoon Soohyun
- You Jaewon
- Young Cam
- Yu Haimeng
- Yu Jiacheng
- Yu Kai-Chiang
- Yu Liuhong
- Yu Tam Chi
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- Yu Yuen Wai
- Yuan Hetian
- Yuan Long
- Yuan Xing
- Yuan Zhe
- Yuanxu Jiang
- Yucheng Chen
- Yue Qing
- Yueyi Li
- Yuhan Cheng
- Yujie Peng
- Yun Yejie
- Yung Jay
- Yutong Pan
- Zadeh Daniel
- Zamora Alejandro Robles
- Zanoni Paul
- Zanotti Violetta
- Zeng Chenxu
- Zeng Yuanhong
- Zepeng Xu
- Zerva Anastasia
- Zhan Yang
- Zhang Alice
- Zhang Bonan
- Zhang Jianxiang
- Zhang Jige
- Zhang Jinhan
- Zhang Kaida
- Zhang Kecheng
- Zhang Qian
- Zhang Shuyan
- Zhang Tianyi
- Zhang Wanli
- Zhang Xianyin
- Zhang Xinyu
- Zhang Yihao
- Zhang Yuanzhen
- Zhang Yunqian
- Zhang Zixuan
- Zhao Nannan
- Zhao Peng
- Zhao Tianyan
- Zhao Wenxue
- Zhao Yihang
- Zhaoting Li
- Zhecheng Huang
- Zheng Daniel
- Zheng Jiyang
- Zhiwei Song
- Zhong Yanling
- Zhou Hanmi
- Zhou Jiajie
- Zhou Jianan
- Zhou Rui
- Zhou Shuyao
- Zhou Xuanhao
- Zhou Yanjun
- Zhou Yi
- Zhou Yinchi
- Zhou Yineng
- Zhou Yuezhang
- Zhou Yuxin
- Zhou Zhiyu
- Zhu Chushu
- Zhu Ke
- Zhu Xueqian
- Zi Lihan
- Zilinskaite Nemira
- Zimmermann Andreas
- Zimmermann Jennifer
- Zirong Zeng
- Ziwei Zhou
- Ziyi Zhao
- Zorrilla Francisco
- Zou Jiahua
- Zukauskaite Kristina
- Zulueta Patricia
- Zvirblyte Justina
- Publication venue
- Publication date
- 01/01/2020
- Field of study
Optical density (OD) is widely used to estimate the density of cells in liquid culture, but cannot be compared between instruments without a standardized calibration protocol and is challenging to relate to actual cell count. We address this with an interlaboratory study comparing three simple, low-cost, and highly accessible OD calibration protocols across 244 laboratories, applied to eight strains of constitutive GFP-expressing E. coli. Based on our results, we recommend calibrating OD to estimated cell count using serial dilution of silica microspheres, which produces highly precise calibration (95.5% of residuals <1.2-fold), is easily assessed for quality control, also assesses instrument effective linear range, and can be combined with fluorescence calibration to obtain units of Molecules of Equivalent Fluorescein (MEFL) per cell, allowing direct comparison and data fusion with flow cytometry measurements: in our study, fluorescence per cell measurements showed only a 1.07-fold mean difference between plate reader and flow cytometry data
Experimental and Molecular Modeling Study of the Three-Phase Behavior of ( n
- Author
- Amparo Galindo
- Aparicio-Martínez S.
- Bamberger A.
- Beltràn J. G.
- Blas F. J.
- Blas F. J.
- Blunt M.
- Briones J. A.
- Brunner G.
- Buckingham A. D.
- Chapman W. G.
- Chapman W. G.
- Chapoy A.
- Chester T. L.
- Chou G. F.
- Ciotta F.
- Clark G. N. I.
- Coan C. R.
- Dhima A.
- Diamond L. W.
- dos Ramos M. C.
- dos Ramos M. C.
- Economou I. G.
- Economou I. G.
- Emborsky C. P.
- Esther Forte
- Forte E.
- Galindo A.
- Galindo A.
- Galindo A.
- Gil L.
- Gil-Villegas A.
- Gross J.
- Gross J.
- Gross J.
- Gurdial G. S.
- Han B.
- Harned H. S.
- Haslam A. J.
- Hudson G. H.
- Inomata H.
- Iwai Y.
- J. P. Martin Trusler
- Jarne C.
- Jennings D. W.
- Jimenez-Gallegos R.
- Kane A. V.
- Karakatsani E. K.
- Kiepe J.
- Kontogeorgis G. M.
- Kontogeorgis G. M.
- Kontogeorgis G. M.
- Kontogeorgis G. M.
- Kulkarni A. A.
- Lemmon E. W.
- Li X.-S.
- Lide D. R.
- Llovell F.
- Mac Dowell N.
- McCabe C.
- McCabe C.
- McCabe C.
- Moberg R.
- Míguez J. M.
- Müller E. A.
- Müller E. A.
- Nagarajan N.
- Namiot A. Y.
- Nguyen-Huynh D.
- Nighswander J. A.
- Oliveira M. B.
- Orr F. M.
- Papaioannou V.
- Paricaud P.
- Patel B. H.
- Peleties F.
- Peng D.-Y.
- Pereira F. E.
- Polikhronidi N.
- Preston C.
- Prutton C. F.
- Qin J.
- Reamer H. H.
- Ruffine L.
- Scott R. L.
- Sengers J. M. H. L.
- Seo Y.-T.
- Shaver R. D.
- Shaw D. G.
- Soave G.
- Song K. Y.
- Spycher N.
- Sultanov R. G.
- Sun L.
- Tan S. P.
- Tsonopoulos C.
- Valtz A.
- van der Waals J. D.
- van Konynenburg P. H.
- Vega L. F.
- Voutsas E. C.
- Wertheim M. S.
- Wertheim M. S.
- Wertheim M. S.
- Wertheim M. S.
- Wertheim M. S.
- Wertheim M. S.
- Yakoumis I. V.
- Zhang Y.
- Publication venue
- 'American Chemical Society (ACS)'
- Publication date
- Field of study
Effects of Once-Weekly Exenatide on Cardiovascular Outcomes in Type 2 Diabetes.
- Author
- 6hman P
- Abbott L
- Acheatel R
- Adamkova V
- Adawi F
- Adler A
- Aguliera D
- Aizenberg D
- Akerblom A
- Akinboboye O
- Akpunonu B
- Al-Khatib S
- Alcocer Gamba MA
- Alexander K
- Alfonso L
- Almeida CA
- Alvarez L
- Alvarisqueta A
- Ambrish M
- Ambrosio G
- Amerena J
- Anastasi L
- Anderson H
- Andersone I
- Anekwe A
- Ang E
- Angelescu LM
- Angustias Quesada M
- Anoop M
- Aomar I
- Appel KF
- Arauz-Pacheco C
- Argoud G
- Arguelles I
- Armaganijan L
- Aron G
- Aronoff S
- Asamoah-Owusu NJ
- Athwal R
- Augusteniene A
- Azad N
- Azizad M
- Badat A
- Bain C
- Bajaj M
- Baldauf C
- Bandeira e Farias F
- Barbarash O
- Barber T
- Barkai L
- Baron M
- Barrientos Perez M
- Barros e Silva P
- Barros P
- Barsiene L
- Bartkowiak A Jr
- Bartolacci I
- Bashkin A
- Batit M
- Batra P
- Becker B
- Bell A
- Bellary S
- Bellido D
- Benjasuratwong Y
- Benson M
- Bental T
- Berenfus V
- Bergenstal R
- Berk M
- Bernacki G
- Bernandez S
- Bestermann W Jr
- Bethel MA
- Bezzegh K
- Bhargava A
- Bhatt B
- Bickel L
- Bieler T
- Biscoveanu M
- Bland V
- Blignaut S
- Bloomfield G
- Blumberg E
- Bobeva R
- Boenninghoff AH
- Boggs B
- Bondar I
- Borges J
- Botella Serrano M
- Botero Lopes R
- Botsyurko V
- Bourgeois R
- Braun M
- Bressler P
- Brychta T
- Buganova I
- Bundy C
- Busch K
- Busch R
- Buse JB
- Butnaru A
- Bybee K
- Cabrera Jardines R
- Calella P
- Calvert J
- Campbell C
- Canadas R
- Caponis J
- Carim-Ganey N
- Carr K
- Caterson I
- Catindig EA
- Cavale A
- Cavarape A
- Chacra A
- Chadha C
- Chan JC
- Chane M
- Chang A
- Chang A
- Chang M
- Chatterjee S
- Chaudhri O
- Cheah WK
- Chen JF
- Cheung BM
- Cheung S
- Cheung-Wong MM
- Choi J
- Choi KM
- Choi SH
- Chu DW
- Cignarelli M
- Clark J
- Clausen E
- Claxton E Jr
- Coetzee K
- Coetzer T
- Cohen J
- Coleman R
- Collier T
- Colman P
- Colquhoun D
- Constantinescu S
- Contreras Gilbert J
- Conway R
- Corder C
- Coronel Arroyo J
- Costa e Forti A
- Cox K
- Crawford V
- Crimmins D
- Cruciani A
- Cuddihy R
- Culman MI
- Cure Cure CA
- Custodio M
- Cutfield R
- Cylkowska B
- Czegany Z
- D\u2019Agostino R
- Damyanova V
- Dang C
- Danyte E
- Darbyshire J
- Dauber I
- Dauksiene D
- Davies M
- Davis C
- Dawson A
- Dayamani P
- De La Fuente RL
- De La Garza Hernandez NE
- de Salvo M
- De Souza Brito F
- de Valk HW
- Dean J
- del Prato S
- Delcourt C
- Deng H
- Denham D
- Denopol M
- Detweiler R
- DeVore A
- Dezso E
- Diamant M
- Diaz R
- DiGiovanna M
- Dimitropoulos I
- Distiller L
- Dixon P
- Dogadin S
- Dombrowski K
- Dong Y
- Donovan D
- Dreval A
- Dreval AV
- Drexel H
- Du Y
- Dube F
- Duengen HD
- Dugano-Daphnis P
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- Kaczmarek G
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- Wysham C
- Yakov A
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- Yale JF
- Yan BPY
- Yang CY
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- Yeung VT
- Yong H
- Yoon KH
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- Zaharie DG
- Zaharieva S
- Zaidman C
- Zaluska R
- Zannad F
- Zazula A
- Zeitler E
- Zhang L
- Zhou S
- Zilahi Z
- Zimering M
- Zimmerman R
- Zinman B
- Zrahevskiy K
- Publication venue
- 'Massachusetts Medical Society'
- Publication date
- 01/01/2017
- Field of study
Abstract
BACKGROUND:
The cardiovascular effects of adding once-weekly treatment with exenatide to usual care in patients with type 2 diabetes are unknown.
METHODS:
We randomly assigned patients with type 2 diabetes, with or without previous cardiovascular disease, to receive subcutaneous injections of extended-release exenatide at a dose of 2 mg or matching placebo once weekly. The primary composite outcome was the first occurrence of death from cardiovascular causes, nonfatal myocardial infarction, or nonfatal stroke. The coprimary hypotheses were that exenatide, administered once weekly, would be noninferior to placebo with respect to safety and superior to placebo with respect to efficacy.
RESULTS:
In all, 14,752 patients (of whom 10,782 [73.1%] had previous cardiovascular disease) were followed for a median of 3.2 years (interquartile range, 2.2 to 4.4). A primary composite outcome event occurred in 839 of 7356 patients (11.4%; 3.7 events per 100 person-years) in the exenatide group and in 905 of 7396 patients (12.2%; 4.0 events per 100 person-years) in the placebo group (hazard ratio, 0.91; 95% confidence interval [CI], 0.83 to 1.00), with the intention-to-treat analysis indicating that exenatide, administered once weekly, was noninferior to placebo with respect to safety (P<0.001 for noninferiority) but was not superior to placebo with respect to efficacy (P=0.06 for superiority). The rates of death from cardiovascular causes, fatal or nonfatal myocardial infarction, fatal or nonfatal stroke, hospitalization for heart failure, and hospitalization for acute coronary syndrome, and the incidence of acute pancreatitis, pancreatic cancer, medullary thyroid carcinoma, and serious adverse events did not differ significantly between the two groups.
CONCLUSIONS:
Among patients with type 2 diabetes with or without previous cardiovascular disease, the incidence of major adverse cardiovascular events did not differ significantly between patients who received exenatide and those who received placebo. (Funded by Amylin Pharmaceuticals; EXSCEL ClinicalTrials.gov number, NCT01144338 .)
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- Abdala Antonio
- Abidi Khalid
- Abillama Fayez François
- Abos Francisco Javier Saenz
- Aboufray Ahmed Ali
- Abregal Giancarlo
- Abroug Fekri
- Achilleos Eleni
- Acosta Ysica
- Adam Višnja Nesek
- Adamina Ileana
- Adams John
- Adamuz Jordi
- Adejumo Prisca Olabisi
- Adekola Oyebola
- Ademokun Jane
- Adenekan Anthony
- Adib Nik Azman Nik
- Adipa Faustina Excel
- Afonso Elsa
- Aganon Ferdinand
- Agarwal Sonika
- Aguirre Joaquin
- Aguirre Lydia Gallego
- Aguirre-Bermeo Hernan
- Ahmad Fatima Kasem El
- Ahmad Meraj
- Ahmed Hazem
- Ahn Jong-Joon
- Ahtiala Maarit
- Akbas Turkay
- Akdağ Devrim
- Akker Mustafa
- Akselsen Gro Ringstad
- Al-Alawi Maram Milud Said
- Alabuzidi Aya
- Alampi Daniela
- Albaiceta Guillermo Muñiz
- Albert Patricia
- Albrecht Lea
- Albrett Jonathan
- Alexandropoulou Paraskevi
- Alexandrou Anna
- Ali Ashwaq
- Ali Mohd Nazri
- Alias Anita
- Alkhumsi Soad Imhmed R.
- Allaert Silvie
- Allison Nicola
- Almekhlafi Ghaleb
- Alonso Helena Fernandez
- Alsheikhly Ahmed Subhy
- Alshrif Abdualhamid I
- Alvarenga Gloria
- Alvarez Diana
- Alvarez Gonzalo Martín
- Alvarez Gustavo Andres
- Alvarez Jorge Duerto
- Alvarez Josep Trenado
- Alvarez Raquel Garcia
- Alves Paulo
- Andersen Marit Hildegunn
- Andersen Yvonne
- Andresen Hanne
- Anisoglou Souzana
- Antonio Maria Gracia San
- Antunes Nelson
- Anvelt Eneli
- Aperocho Cristal April Jane
- Aponte Cesar
- Araya Paola
- Arcas María Luisa Bravo
- Arikan Huseyin
- Arntsen Wenche
- Arteta Arteta Donaldo S.
- Ashour Firas
- Assiri Amer
- Atchade Enora
- Ateya Zainab
- Attwood Ben
- Aucapina Alejandra
- Avalos Fernando
- Aves Emma
- Avogadro Prune
- Avramopoulou Lamprini
- Ay Mustafa
- Ay Serap Avcı
- Aya Umeda
- Ayala Maria
- Aydemir Semih
- Aydin Demet Tok
- Azencot Mazal
- Azoia Joao
- Baasanjav Battsetseg
- Babych Volodymyr
- Baccaro Fernando
- Badariotti Gustavo
- Bae Jung-Min
- Baek Jonghyun
- Baftiu Nehat
- Bagshaw Sean
- Bahrin Laila Kamaliah Kamalul
- Bai Dongmei
- Bai Xiaowu
- Baini Matías
- Bakas Apostolos
- Baker Helen
- Baker Nerilee
- Balasubramanian Madhu
- Balbay Abidin Oner
- Balon Sandrine
- Bantar Ana
- Banwarie Preveen
- Bao Guijun
- Baptiste-Savoie Jacqueline
- Barakat-Johnson Michelle
- Barefield Cindy
- Barkas Diane
- Barnes Christopher
- Barone Antonio
- Baronia Arvind
- Barr Louise
- Barreiro Emma Moreno
- Barros Elaine
- Barrowcliffe Suzanne
- Barrueco-Francioni Jesus Emilio
- Bartoli Julio Ricardo
- Baruah Rosaleen
- Bascary Carlos Alejandro
- Baskakov Danil
- Baskoro Windu
- Bastani Styliani
- Baumber Rachel
- Baxter Karen
- Bayraktar Yesim Serife
- Bealer Cheryl
- Bean Sarah
- Becker Cathy
- Becker Delmiro
- Behan Helena
- Beker Tatjana
- Bekos Vasileios
- Belii Adrian
- Belkhair Wesal Ali
- Belskiy Vladislav
- Ben-Hamouda Nawfel
- Ben-Jacob Talia
- Benbenishty Julie
- Bench Suzanne
- Bendelari Valentina
- Benlamin Mohamed
- Berry Gillian
- Bertoletti Fernando Pablo
- Besbes Lamia
- Besbes Lamia Ouanes
- Besch Guillaume
- Bestle Morten
- Beuret Pascal
- Bhakhtiani Lakshay
- Bhargava Vaibhav
- Bi AiPing
- Bianchini Suzana
- Bielskute Egidija
- Bilawicz Jan
- Binda Filipo
- Birgisdottir Hrönn
- Birgisdóttir Hrönn
- Bispo Bruno Miguel
- Biston Patrick
- Bjorgen Hege
- Blackwood Bronagh
- Blanc Agnès
- Blanco Daniel
- Blanco Maria Pilar Sogues
- Blasco Maria Luisa
- Bliksted Inger Abildgaard
- Blondal Asbjorn
- Bloos Frank
- Blot Stijn I.
- Bo Qi
- Bocui Nie
- Boedjawan Naraindath N.
- Bogarin Javier
- Bogoevska-Miteva Zaneta
- Bonaccorso Luciano
- Bongiorno Benjamin
- Bonsignore Pablo Julio Maldonaldo
- Borgognoni Cinzia
- Borin Christophe
- Borkowska Marta
- Bormans Laura
- Boroli Filippo
- Borys Michal
- Boschetto Margherita
- Bossolasco Matteo
- Bota Marc
- Boulanger Carole
- Boulton Karen
- Bowes Bonnie
- Boyer Laetitia
- Bozbay Suha
- Bozena Armanda
- Bratsberg Bjorn
- Bravo Silvina
- Brett Carole
- Brett Stephen
- Brett Stephen J.
- Briva Arturo
- Brizio Elisabetta
- Brizuela Patricia
- Broadhurst Phil
- Brown Wendy
- Browne Troy
- Bruel Cédric
- Bruhn Louise
- Brumwell Sarah
- Bruni Andrea
- Bruno Anna Vita
- Buckley Sarah
- Bull Rhian
- Bumbasirevic Vesna
- Buregeya Egide
- Burns Karen
- Butcher Rand
- Byers Heather
- Bösl Kathrin
- Cabral Dolly Mabel Bordon
- Cabral João
- Cabrita Paula
- Caddell Paul
- Caicedo Nestor
- Calamai Italo
- Calili Duygu Kayar
- Caliskan Gulbahar
- Calleja Pablo Lopez-Arcas
- Calpe Neus
- Calvino-Gunther Silvia
- Campanili Ticiane
- Campbell Elizabeth
- Campos Pierina Arias
- Campos-Perez Margarita
- Camputaro Luis
- Camsooksai Julie
- Canales Julieta
- Canete Fidelina
- Cani Alma
- Cano Anastasio Espejo
- Cao Deyan
- Cao Wenzhen
- Cao Ying
- Cao Zu Qing
- Capuzzi Fabio
- Cardenas Yenny
- Carey Annette
- Carney Dominic
- Carter Charlotte
- Casaioli Simona
- Castelain Vincent
- Castiglione Giacomo
- Cata Juan
- Cavaco Raquel
- Cengiz Melike
- Cerezo Franklin Dean
- Cesar Helena
- Cespedes Laura
- Chaboyer Wendy
- Chadwick Llesley
- Chang Shu Chuan
- Chang Youjin
- Chantziara Vasiliki
- Chao Yu
- Chaparro Javiera
- Chaparro Silvia
- Chapeta Edwin
- Chapman Carmel
- Charalabous Iwy
- Chatzis Marinos
- Chee Hyun Keun
- Chen Feifei
- Chen Haiyan
- Chen Hongjuan
- Chen Jingfang
- Chen Lei
- Chen Meili
- Chen Tianfei
- Chen Wenmin
- Chen Xiaoyan
- Chen Zhihong
- Cheng
- Cheng Jiyin
- Chime Christiana
- Chimunda Tim
- Chinardet Benoît
- Chovas Achilleas
- Christ Martin
- Christofis Christos
- Chueca Ramon Molina
- Chunhua Gao
- Cinel İsmail
- Ciorba Paolo
- Clark Michele
- Clement Ana Isabel
- Clesi Tara
- Cody Caitriona
- Collet Marie
- Collins Amy
- Coman Mary
- Conde Belen Burgos
- Conejo Isabel
- Constantinou Constantina
- Corcoran Ailesh
- Coremans Stefano
- Correia Malcolm C.
- Corso Amalia
- Cortegiani Andrea
- Cortellazi Paolo
- Cosano Rosario
- Cossu Maria
- Costa Humberto
- Cotoia Antonella
- Coyer Fiona
- Craig Geraldine
- Craig Jayne
- Cranmer Karen
- Cranshaw Julius
- Creber Peter
- Crone Petra
- Cui Xia
- Cummings Donna
- Cupitt Jason
- Curilen Veronica
- Czuczwar Miroslaw
- Dagooc Rica
- Dai Zhaoxing
- Dal Hayriye Cankar
- Dallaire Julie
- Das Sasidharan Nair Vishnu
- Daubin Cédric
- Davidow Jon
- Davidson Cheryl
- Dawn Frances
- Dayan Meneses
- de Almeida Angelica Olivetto
- de Anda Gilberto Felipe Vazquez
- De Bels David
- de Ceballos José Peral Gutierrez
- De Decker Koen
- De Haan Marina
- de Jesús Ortiz Alberto
- de la Ventana Ana Belén Sánchez
- De lange Dylan
- De Lange Dylan
- de Molina Serrano José Ivan Rodriguez
- De Montmollin Etienne
- De Pablo Ana María
- De Rosa Silvia
- De Sanctis Francesca
- De Schryver Nicolas
- De Wit Irene
- Dean Emiliano
- Debue Anne-Sophie
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- Simon Philipp
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- Skorstad Elin Mari
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- Spångfors Martin
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- von Lewinski Dirk
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- Wahab Sherliza
- Wahlbom Ewa
- Waibel Hansjoerg
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- Wang Haiyan
- Wang Jing
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- Wang Shuhui
- Wang Shuo
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- Wang Xiaomin
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- Wang Ying
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- Xiao Lina
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- Xie Yan
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- Xiong Yunfeng
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- Xu Xuelian
- Xu Yan
- Xue Xiujuan
- Yaghi Aktham
- Yakubu Yakubu H.
- Yamamoto Ryohey
- Yan Howe
- Yan Xiaoli
- Yan Yan
- Yang Fan
- Yang Fengling
- Yang Huai
- Yang Jing
- Yang Lei
- Yang Qiao
- Yang Shunzhu
- Yang Yanping
- Yang YongXia
- Yao Xiuying
- Yao Yanlan
- Yao Zhiru
- Ye Man
- Ye Mei
- Yeni Nomhle Princess
- Yeon-Joo Lee
- Yildiz İsmail
- Yilmaz Hakan
- Yin Hai
- Yin Li
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- Young-Jae Cho
- Yu Jing
- Yu Min
- Yu Tingting
- Yu Zhu Jun
- Yuan Cui
- Yuan Weilian
- Yuan Yuxia
- Yuchen Wu
- Yuemen Ly
- Yumei Chen
- Zahra Hajer Ben
- Zainudin Asmah
- Zakalik Graciela
- Zaki Ahmed
- Zalba-Etayo Begoña
- Zamora Purificacion Sanchez
- Zamorano Matias Jesús Flamm
- Zan Tao
- Zand Farid
- Zarei Fatemeh
- Zeng Jing Mei
- Zeng Qi
- Zepoy Sofia
- Zerman Avşar
- Zermeno Jorge Macias
- Zgrzheblovska Lesia
- Zhang Aizhi
- Zhang Baoke
- Zhang Feifei
- Zhang Guiping
- Zhang Hong
- Zhang Hongsu
- Zhang Hui
- Zhang Jing
- Zhang Jundi
- Zhang Libing
- Zhang Ling
- Zhang Na
- Zhang Wei
- Zhang Yali
- Zhang Ying
- Zhang Zhenxia
- Zhao Hui Min
- Zhao Lijuan
- Zhao Lina
- Zhao Qian
- Zhao Qingli
- Zhao Rong Hua
- Zhao Ronghua
- Zhao Wenwen
- Zhao Yingjuan
- Zhedaeva Marina
- Zheng Hong
- Zheng Jing
- Zheng Xianhong
- Zhigang Zhang
- Zhijuan Wang
- Zhiping Sun
- Zhivotneva Trina
- Zhou Yuming
- Zhu Guoyan
- Zhu JiFen
- Zhu Jin Yu
- Zivanovic-Posilovic Gordana
- Zorko Nika
- Zubareva Nadezhda
- Zuev Evgeniy
- Zueva Oksana
- Zulkifli Zulkifli
- Ágoston Zsuzsann
- Åkerman Eva
- Çelik Jale Bengi
- Ñamendys-Silva Silvio A.
- Özcan Beysim
- Özserezli Boğaç
- Ünlü Nurdan
- Čuljak Hemena
- Şentürk Evren
- Šuput Aleksandar
- Publication venue
- 'Organisation for Economic Co-Operation and Development (OECD)'
- Publication date
- 26/02/2021
- Field of study
Funder: European Society of Intensive Care Medicine; doi: http://dx.doi.org/10.13039/501100013347Funder: Flemish Society for Critical Care NursesAbstract: Purpose: Intensive care unit (ICU) patients are particularly susceptible to developing pressure injuries. Epidemiologic data is however unavailable. We aimed to provide an international picture of the extent of pressure injuries and factors associated with ICU-acquired pressure injuries in adult ICU patients. Methods: International 1-day point-prevalence study; follow-up for outcome assessment until hospital discharge (maximum 12 weeks). Factors associated with ICU-acquired pressure injury and hospital mortality were assessed by generalised linear mixed-effects regression analysis. Results: Data from 13,254 patients in 1117 ICUs (90 countries) revealed 6747 pressure injuries; 3997 (59.2%) were ICU-acquired. Overall prevalence was 26.6% (95% confidence interval [CI] 25.9–27.3). ICU-acquired prevalence was 16.2% (95% CI 15.6–16.8). Sacrum (37%) and heels (19.5%) were most affected. Factors independently associated with ICU-acquired pressure injuries were older age, male sex, being underweight, emergency surgery, higher Simplified Acute Physiology Score II, Braden score 3 days, comorbidities (chronic obstructive pulmonary disease, immunodeficiency), organ support (renal replacement, mechanical ventilation on ICU admission), and being in a low or lower-middle income-economy. Gradually increasing associations with mortality were identified for increasing severity of pressure injury: stage I (odds ratio [OR] 1.5; 95% CI 1.2–1.8), stage II (OR 1.6; 95% CI 1.4–1.9), and stage III or worse (OR 2.8; 95% CI 2.3–3.3). Conclusion: Pressure injuries are common in adult ICU patients. ICU-acquired pressure injuries are associated with mainly intrinsic factors and mortality. Optimal care standards, increased awareness, appropriate resource allocation, and further research into optimal prevention are pivotal to tackle this important patient safety threat