IMECE2002-32095 CFD ANALYSIS OF LIQUID-COOLED EXHAUST MANIFOLDS IN A REAL ENGINE CYCLE

ABSTRACT Liquid-cooled exhaust manifolds are used in turbocharged diesel and gas engines in the marine and various industrial applications in order to minimize heat rejection to surrounding areas, maximize energy to the turbocharger, and maintain a maximum allowable skin temperature. A commercial CFD software FLUENT ® was used to analyze liquid-cooled exhaust manifolds in a real time engine cycle. Detailed information of flow property distributions and heat transfer were obtained in order to provide a fundamental understanding of the manifold operation. Experimental data was compared with the CFD results to validate the numerical simulation. Computations were performed to investigate the parametric effects of operating conditions on the performance of the manifold. Two different geometries were compared. One of them was found to have better performance, resulting in an approximately 2 to 3% fuel consumption improvement. INTRODUCTION Liquid-cooled exhaust manifolds are used on turbocharged diesel engines for marine, oilrig, and other industrial applications. The purpose of cooling the manifold is to prevent possible fire hazards by maintaining a maximum safe temperature on the exposed surfaces or "skin" of the manifold. The adverse effec

Common variants at 19p13 are associated with susceptibility to ovarian cancer

Epithelial ovarian cancer (EOC) is the leading cause of death from gynecological malignancy in the developed world, accounting for 4% of the deaths from cancer in women(1). We performed a three-phase genome-wide association study of EOC survival in 8,951 individuals with EOC (cases) with available survival time data and a parallel association analysis of EOC susceptibility. Two SNPs at 19p13.11, rs8170 and rs2363956, showed evidence of association with survival (overall P = 5 x 10(-4) and P = 6 x 10(-4), respectively), but they did not replicate in phase 3. However, the same two SNPs demonstrated genome-wide significance for risk of serous EOC (P = 3 x 10(-9) and P = 4 x 10(-11), respectively). Expression analysis of candidate genes at this locus in ovarian tumors supported a role for the BRCA1-interacting gene C19orf62, also known as MERIT40, which contains rs8170, in EOC development