64 research outputs found

    Operational Mechanism of Digital Humanistic Crowdsourcing Project Based on Actor Network Theory

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    This article is to promote the development of digital humanity-related crowdsourcing projects based on actor network theory (ANT). A case study on Shengxuanhuai Documents from Shanghai Library is selected as our research object. The article employs qualitative research approach to investigate core concepts, namely Problematization, Obligatory Passage Point, Interestment, and Mobilisation involved in the underway of the digital humanity-related crowdsourcing project. This study conducts interviews with 32 respondents, including the 10 contractees and 22 users. The crowdsourcing actors in humanity-related projects are mainly the organizers from public libraries, museums, archives, and other digital humanity institutions. Based on the project development documents and semi-structured interview data, we find that the main obstacles to prevent actors engaging in crowdsourcing projects include task guidance, user motivations, platform designs, and competition evaluations. The paper demonstrates the usefulness of ANT’s concepts and explores the contribution of each ANT analytical concept

    Helical structures with switchable and hierarchical chirality

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    Chirality is present as a trend of research in biological and chemical communities for it has a significant effect on physiological properties and pharmacological effects. Further, manipulating specific morphological chirality recently has emerged as a promising approach to design metamaterials with tailored mechanical, optical, or electromagnetic properties. However, the realization of many properties found in nature, such as switchable and hierarchical chirality, which allows electromagnetic control of the polarization of light and enhancement of mechanical properties, in man-made structures has remained a challenge. Here, we present helical structures with switchable and hierarchical chirality inspired by origami techniques. We propose eggbox-based chiral units for constructing homogeneous and heterogeneous chiral structures and demonstrate a theoretical approach for tuning the chirality of these structures by modulating their geometrical parameters and for achieving chirality switching through mechanism bifurcation. Finally, by introducing a helical tessellation between the chiral units, we design hierarchical structures with chirality transferring from construction elements to the morphological level and discover a helix with two zero-height configurations during the unwinding process. We anticipate that our design and analysis approach could facilitate the development of man-made metamaterials with chiral features, which may serve in engineering applications, including switchable electromagnetic metamaterials, morphing structures, and bionic robots

    A novel servo control method based on feedforward control – Fuzzy-grey predictive controller for stabilized and tracking platform system

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    Through analysis of the time-delay characteristics of stabilized and tracking platform position tracking loop and of attitude disturbance exciting in stabilization and tracking platform systems, a compound control method based on adaptive fuzzy-grey prediction control (CAGPC) is proposed to improve the disturbance suppression performance and system response of stabilized and tracking platform system. Firstly, the feedforward controller which is to improve disturbance suppression performance of stabilized and tracking platform servo system and aiming at the external disturbances is introduced. Secondly, aiming at the disadvantages of conventional fixed step size of Fuzzy-grey prediction and the prediction error forecast model has, an adaptive adjustment module adjusting the prediction step and comprehensive error weight at the same time is proposed, according to the actual control system error and the prediction error, the Fuzzy-grey prediction step and the prediction error weights are regulated while to improve the control precision and the adaptability of the system prediction model; At last, Numerical simulation results and the stabilized and tracking platform experimental verification illustrate that the compound control method can improve the stable platform servo system response and the ability of suppress external disturbances and the CAGPC control method has better performance in the stabilized and tracking platform system

    A numerical study of residual flow induced by eddy viscosity-shear covariance in a tidally energetic estuary

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    Abstract(#br)The inner regime of an estuary has unique tidal mixing processes but received relatively less attention. A numerical model was developed to investigate the tidal variability of vertical mixing and the residual flow induced by eddy viscosity–shear covariance (ESCO) in the inner regime of a tidally energetic estuary in Southeastern China. Because of migration of the saltwater/freshwater interface, the water column in the inner regime undergoes a saltwater-dominant high-water period and a freshwater-dominant low-water period during a tidal cycle. The different mixing processes of high- and low-water periods led to typical (reverse) internal tidal asymmetry, i.e. stronger (weaker) mixing during flood tides than ebb tides when the tidal range was large (small). Tidal straining was the main driver of internal tidal asymmetry during the high-water period, while the asymmetries of duration and current velocity between flood and ebb were the main drivers during the low-water period. For typical internal tidal asymmetry, the ESCO stress was negative and the ESCO flow had a two-layer structure with landward flow near the bottom and seaward flow near the surface. For reverse internal tidal asymmetry, the ESCO stress was positive and the vertical pattern of the ESCO flow was reversed. The magnitude of the ESCO flow was several times greater than that of the density-driven flow. The reverse internal tidal asymmetry occurred in the freshwater-dominant low-water period indicates that the ESCO stress could be an important driver of tidal rectification flow in homogeneous coastal waters

    Skin transcriptome profiles associated with coat color in sheep

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    Background Previous molecular genetic studies of physiology and pigmentation of sheep skin have focused primarily on a limited number of genes and proteins. To identify additional genes that may play important roles in coat color regulation, Illumina sequencing technology was used to catalog global gene expression profiles in skin of sheep with white versus black coat color. Results There were 90,006 and 74,533 unigenes assembled from the reads obtained from white and black sheep skin, respectively. Genes encoding for the ribosomal proteins and keratin associated proteins were most highly expressed. A total of 2,235 known genes were differentially expressed in black versus white sheep skin, with 479 genes up-regulated and 1,756 genes down-regulated. A total of 845 novel genes were differentially expressed in black versus white sheep skin, consisting of 107 genes which were up-regulated (including 2 highly expressed genes exclusively expressed in black sheep skin) and 738 genes that were down-regulated. There was also a total of 49 known coat color genes expressed in sheep skin, from which 13 genes showed higher expression in black sheep skin. Many of these up-regulated genes, such as DCT, MATP, TYR and TYRP1, are members of the components of melanosomes and their precursor ontology category. Conclusion The white and black sheep skin transcriptome profiles obtained provide a valuable resource for future research to understand the network of gene expression controlling skin physiology and melanogenesis in sheep

    Functional Role of Cyclin-Dependent Kinase 5 in the Regulation of Melanogenesis and Epidermal Structure

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    The mammalian integumentary system plays important roles in body homeostasis, and dysfunction of melanogenesis or epidermal development may lead to a variety of skin diseases, including melanoma. Skin pigmentation in humans and coat color in fleece-producing animals are regulated by many genes. Among them, microphthalmia-associated transcription factor (MITF) and paired-box 3 (PAX3) are at the top of the cascade and regulate activities of many important melanogenic enzymes. Here, we report for the first time that cyclin-dependent kinase 5 (Cdk5) is an essential regulator of MITF and PAX3. Cdk5 knockdown in mice causes a lightened coat color, a polarized distribution of melanin and hyperproliferation of basal keratinocytes. Reduced expression of Keratin 10 (K10) resulting from Cdk5knockdown may be responsible for an abnormal epidermal structure. In contrast, overexpression of Cdk5 in sheep (Ovis aries) only produces brown patches on a white background, with no other observable abnormalities. Collectively, our findings show that Cdk5 has an important functional role in the regulation of melanin production and transportation and in normal development of the integumentary system
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