Research on Charging Process Strategy of Airborne Compressor

An air tank can be inflated with compressed air at anytime if the aircraft is equipped with an airbone compressor. . The different inlet altitude conditions and residual tank pressures both make it difficult to plan strategy about air tank filling. This paper studied the charging performance of the filling process in these complex working conditions, and proposed an inflating strategy of airborne compressor. A dynamic model is constructed to simulate the filling process of a multi-stage compressor with finite interstage volume. It takes 6 minutes to fill a tank with 2.0L volume from 0.101 MPa to 35 MPa, and startup process merely lasts 6 seconds. The experiment on the compressor was developed on the ground. The results validated with simulation values and shared similar evolution regularity of the pressure. The filling process at high altitude has been simulated. When residual bottle pressure is atmospheric pressure, with the altitude increasing from 0 km to 20km, the charging time increases from 6 minutes to more than 2 hours. Besides, the charging time is proportional to the residual pressure with a negative slope at a certain altitude. The mean torque in startup process declines with altitude rise, which proves filling at high altitude does not heavy the compressor’s load, as well as the electric machine control difficulty. Based on simulation results, a feasible working area satisfying ejection demand is proposed, which can be used to determine the charging time under any filling condition. In order to inflate the tank in thirty minutes, this airborne compressor must work under 19.7 km

Molecular analysis of the diversity of vaginal microbiota associated with bacterial vaginosis

<p>Abstract</p> <p>Background</p> <p>Bacterial vaginosis (BV) is an ecological disorder of the vaginal microbiota that affects millions of women annually, and is associated with numerous adverse health outcomes including pre-term birth and the acquisition of sexually transmitted infections. However, little is known about the overall structure and composition of vaginal microbial communities; most of the earlier studies focused on predominant vaginal bacteria in the process of BV. In the present study, the diversity and richness of vaginal microbiota in 50 BV positive and 50 healthy women from China were investigated using culture-independent PCR-denaturing gradient gel electrophoresis (DGGE) and barcoded 454 pyrosequencing methods, and validated by quantitative PCR.</p> <p>Results</p> <p>Our data demonstrated that there was a profound shift in the absolute and relative abundances of bacterial species present in the vagina when comparing populations associated with healthy and diseased conditions. In spite of significant interpersonal variations, the diversity of vaginal microbiota in the two groups could be clearly divided into two clusters. A total of 246,359 high quality pyrosequencing reads was obtained for evaluating bacterial diversity and 24,298 unique sequences represented all phylotypes. The most predominant phyla of bacteria identified in the vagina belonged to <it>Firmicutes</it>, <it>Bacteroidetes</it>, <it>Actinobacteria </it>and <it>Fusobacteria</it>. The higher number of phylotypes in BV positive women over healthy is consistent with the results of previous studies and a large number of low-abundance taxa which were missed in previous studies were revealed. Although no single bacterium could be identified as a specific marker for healthy over diseased conditions, three phyla - <it>Bacteroidetes</it>, <it>Actinobacteria </it>and <it>Fusobacteria</it>, and eight genera including <it>Gardnerella</it>, <it>Atopobium</it>, <it>Megasphaera</it>, <it>Eggerthella</it>, <it>Aerococcus</it>, <it>Leptotrichia</it>/<it>Sneathia</it>, <it>Prevotella </it>and <it>Papillibacter </it>were strongly associated with BV (<it>p </it>< 0.05). These genera are potentially excellent markers and could be used as targets for clinical BV diagnosis by molecular approaches.</p> <p>Conclusions</p> <p>The data presented here have clearly profiled the overall structure of vaginal communities and clearly demonstrated that BV is associated with a dramatic increase in the taxonomic richness and diversity of vaginal microbiota. The study also provides the most comprehensive picture of the vaginal community structure and the bacterial ecosystem, and significantly contributes to the current understanding of the etiology of BV.</p

Deciphering transcriptional dynamics of cardiac hypertrophy and failure in a chamber-specific manner

Pressure overload-induced pathological cardiac hypertrophy (CH) is a complexed and adaptive remodeling of the heart, predominantly involving an increase in cardiomyocyte size and thickening of ventricular walls. Over time, these changes can lead to heart failure (HF). However, the individual and shared biological mechanisms of both processes remain poorly understood. This study aimed to identify key genes and signaling pathways associated with CH and HF following aortic arch constriction (TAC) at four weeks and six weeks, respectively, and to investigate potential underlying molecular mechanisms in this dynamic transition from CH to HF at the whole cardiac transcriptome level. Initially, a total of 363, 482, and 264 differentially expressed genes (DEGs) for CH, and 317, 305, and 416 DEGs for HF were identified in the left atrium (LA), left ventricle (LV), and right ventricle (RV), respectively. These identified DEGs could serve as biomarkers for the two conditions in different heart chambers. Additionaly, two communal DEGs, elastin (ELN) and hemoglobin beta chain-beta S variant (HBB-BS), were found in all chambers, with 35 communal DEGs in the LA and LV and 15 communal DEGs in the LV and RV in both CH and HF. Functional enrichment analysis of these genes emphasized the crucial roles of the extracellular matrix and sarcolemma in CH and HF. Lastly, three groups of hub genes, including the lysyl oxidase (LOX) family, fibroblast growth factors (FGF) family, and NADH-ubiquinone oxidoreductase (NDUF) family, were determined to be essential genes of dynamic changes from CH to HF

PT{\cal PT} Symmetry and PT{\cal PT}-Enhanced Quantum Sensing in a Spin-Boson System

Open systems, governed by non-Hermitian Hamiltonians, evolve fundamentally differently from their Hermitian counterparts and facilitate many unusual applications. Although non-Hermitian but parity-time (${\cal PT}$) symmetric dynamics has been realized in a variety of classical or semiclassical systems, its fully quantum-mechanical demonstration is still lacking. Here we ingeniously engineer a highly controllable anti-Hermitian spin-boson model in a circuit quantum-electrodynamical structure composed of a decaying artificial atom (pseudospin) interacting with a bosonic mode stored in a microwave resonator. Besides observing abrupt changes in the spin-boson entanglement evolution and bifurcation transition in quantum Rabi splitting, we demonstrate super-sensitive quantum sensing by mapping the observable of interest to a hitherto unobserved ${\cal PT}$-manifested entanglement evolution. These results pave the way for exploring non-Hermitian entanglement dynamics and ${\cal PT}$-enhanced quantum sensing empowered by nonclassical correlations.Comment: 25 pages, 19 figure

The Second-Order Talbot Effect with Entangled Photon Pairs

The second-order Talbot effect is analyzed for a periodic object illuminated by entangled photon pairs in both the quantum imaging and quantum lithography configurations. The Klyshko picture is applied to describe the quantum imaging scheme, in which self-images of the object that may or may not be magnified can be observed nonlocally in the photon coincidences but not in the singles count rate. In the quantum lithography setup, we find that the second-order Talbot length is half that of the classical first-order case, thus the resolution may be improved by a factor of two.Comment: To appear in Phys. Rev.

Processing and characterization of cobalt silicide nanoparticle-containing silicon carbide fibers through a colloidal method and their underlying mechanism

National Natural Science Foundation of China [51002127, 51072169]Cobalt-containing silicon carbide (Co-SiC) fibers were synthesized through a colloidal method. Dicobalt octacarbonyl [Co-2(CO)(8)] was employed to react with low-molecular weight liquid polycarbosilane (LPCS) to prepare a stable Co-containing colloid (Co-colloid), which was subsequently added to high-molecular weight solid polycarbosilane to obtain the precursor. FTIR, GPC, XRD, and TEM were employed to further understand and develop the mechanism for the formation of the Co-colloid. Results show that active Co intermediates derived from the incomplete decomposition of Co-2(CO)(8) promoted LPCS cross-linkage. The effects of the Co-colloid on the oxidation-curing nature of the green fiber were also investigated. Under heat treatment at higher temperature, carbonyls in the fibers completely decomposed and further crystallized in the morphology of cobalt silicide (CoSi) domains. The effects of Co on the electrical resistivity, magnetic properties, dielectric properties, microwave absorption properties and tensile strength of SiC fibers were also studied

Circular RNA Expression Profiling Identifies Prostate Cancer- Specific circRNAs in Prostate Cancer

Background/Aims: Prostate cancer (PCa) is one of the main cancers that damage males’ health severely with high morbidity and mortality, but there is still no ideal molecular marker for the diagnosis and prognosis of prostate cancer. Methods: To determine whether the differentially expressed circRNAs in prostate cancer can serve as novel biomarkers for prostate cancer diagnosis, we screened differentially expressed circRNAs using SBC-ceRNA array in 4 pairs of prostate tumor and paracancerous tissues. A circRNA-miRNA-mRNA regulatory network for the differential circRNAs and their host genes was constructed by Cytoscape3.5.1 software. Quantitative real-time polymerase chain reaction analysis (qRT-PCR) was performed to confirm the microarray data. Results: We found 1021 differentially expressed circRNAs in PCa tumor using SBC-ceRNA array and confirmed the expression of circ_0057558, circ_0062019 and SLC19A1 in PCa cell lines and tumor tissues through qRT-PCR analysis. We demonstrated that combination of PSA level and two differentially expressed circRNAs showed significantly increased AUC, sensitivity and specificity (0.938, 84.5% and 90.9%, respectively) than PSA alone (AUC of serum PSA was 0.854). Moreover, circ_0057558 was correlated positively with total cholesterol. The functional network of circRNA-miRNA-mRNA analysis showed that circ_0057558 and circ_0034467 regulated miR-6884, and circ_0062019 and circ_0060325 regulated miR-5008. Conclusion: Our results demonstrated that differentially expressed circRNAs (circ_0062019 and circ_0057558) and host gene SLC19A1 of circ_0062019 could be used as potential novel biomarkers for prostate cancer

Ultrasound-guided median nerve electrical stimulation to promote upper limb function recovery after stroke

Peripheral electrical nerve stimulation enhances hand function during stroke rehabilitation. Here, we proposed a percutaneous direct median nerve stimulation guided by ultrasound (ultrasound‐guided median nerve electrical stimulation, UG-MNES) and evaluated its feasibility and effectiveness in the treatment of stroke patients with upper limb extremity impairments. Sixty-three stroke patients (2-3 months of onset) were randomly divided into control and UG-MNES groups. Both groups received routine rehabilitation and the UG-MNES group received an additional ultrasound-guided electrical stimulation of the median nerve at 2 Hz, 0.2 ms pulse-width for 20 minutes with gradual intensity enhancement. The Fugl-Meyer Assessment for upper extremity motor function (FMA-UE) was used as the primary outcome. The secondary outcomes were the Functional Test for the Hemiplegic Upper Extremity (FTHUE-HK), Hand Function Rating Scale, Brunnstrom Stages, and Barthel Index scores for motor and daily functions. All the participants completed the trial without any side effects or adverse events during the intervention. After 4 weeks of intervention, the functions of the upper limbs on the hemiplegic side in both groups achieved significant recovery. Compared to the control group, all evaluation indices used in this trial were improved significantly in the UG-MNES group after 2 and 4 weeks of intervention; particularly, the first intervention of UG-MNES immediately improved all the assessment items significantly. In conclusion, the UG-MNES is a safe and feasible treatment for stroke patients with upper limb extremity impairments and could significantly improve the motor function of the affected upper limb, especially in the first intervention. The UG-MNES could be an effective alternative intervention for stroke with upper limb extremity impairments

Synergies and Prospects for Early Resolution of the Neutrino Mass Ordering

The measurement of neutrino Mass Ordering (MO) is a fundamental element for the understanding of leptonic flavour sector of the Standard Model of Particle Physics. Its determination relies on the precise measurement of $\Delta m^2_{31}$ and $\Delta m^2_{32}$ using either neutrino vacuum oscillations, such as the ones studied by medium baseline reactor experiments, or matter effect modified oscillations such as those manifesting in long-baseline neutrino beams (LB$\nu$B) or atmospheric neutrino experiments. Despite existing MO indication today, a fully resolved MO measurement ($\geq$5$\sigma$) is most likely to await for the next generation of neutrino experiments: JUNO, whose stand-alone sensitivity is $\sim$3$\sigma$, or LB$\nu$B experiments (DUNE and Hyper-Kamiokande). Upcoming atmospheric neutrino experiments are also expected to provide precious information. In this work, we study the possible context for the earliest full MO resolution. A firm resolution is possible even before 2028, exploiting mainly vacuum oscillation, upon the combination of JUNO and the current generation of LB$\nu$B experiments (NOvA and T2K). This opportunity is possible thanks to a powerful synergy boosting the overall sensitivity where the sub-percent precision of $\Delta m^2_{32}$ by LB$\nu$B experiments is found to be the leading order term for the MO earliest discovery. We also found that the comparison between matter and vacuum driven oscillation results enables unique discovery potential for physics beyond the Standard Model.Comment: Entitled in arXiv:2008.11280v1 as "Earliest Resolution to the Neutrino Mass Ordering?