Mannose-binding lectin gene polymorphism and the susceptibility of sepsis: A meta-analysis

Objective To assess the association between the Mannose-binding lectin (MBL) gene polymorphism and the susceptibility to sepsis using a meta-analysis. Methods The publications were searched on PubMed, Embase, and Web of Science databases up to December 1, 2019 for relevant literature. Results A total of 32 studies (21 adult and 11 pediatric studies) were selected for analysis. Overall, in the three models of MBL +54 A/B gene polymorphisms, namely the dominant model BB + AB vs. AA ( p = 0.03), the recessive model BB vs. AB + AA ( p < 0.00001), and the allele model B vs. A ( p = 0.04), MBL +54 A/B was significantly related to the risk of sepsis. In the adult group, the MBL A/O gene polymorphism was associated with the risk of sepsis in the dominant model AO + OO vs. AA ( p = 0.006) as well as in the allele model O vs. A ( p = 0.04). The MBL +54 A/B gene polymorphism was significantly related to the risk of sepsis in the recessive model and, therefore, may increase the risk of sepsis. In the pediatric group, no polymorphic loci were significantly associated with sepsis in any of the three models. The results of the publication bias test demonstrated no publication bias in an unadjusted estimate of the relationship between MBL A/O and −211Y/X gene polymorphism and sepsis. Conclusions The polymorphisms of MBL that are related to the occurrence of sepsis are primarily A/O and +54 A/B, while −221Y/X and −550H/L have no clear relationship with the susceptibility of sepsis in various age groups or different models

Optimization of the Well Start-Up Procedure and Operating Parameters for ESP Gas Well Dewatering

The Electrical Submersible Pump (ESP) systems were deployed in two gas wells for the dewatering of the gas reservoir. However, problems, such as the failure to start up the ESP, and changes in reservoir parameters occurred during the production. For the first problem, the well start-up operation records indicate that the ESP’s gas locking happened. To avoid this, an optimization method of the well start-up procedure for the ESP well with a check valve was correspondingly proposed, which can solve the problem without any workovers. Secondly, based on the working characteristics of the ESP and the nodal analysis method, a set of optimization methods for the operating parameters of ESPs were introduced to achieve the inflow and outflow balance. For one well, the original ESP system was planned to be installed after hydraulic fracturing. Traditionally, the ESP operating parameters were designed based on the production rate. However, in this case, the production rate and the ESP operating frequency were designed simultaneously to maximize the pump efficiency

Supplemental Material - Mannose-binding lectin gene polymorphism and the susceptibility of sepsis: A meta-analysis

Supplemental Material for Mannose-binding lectin gene polymorphism and the susceptibility of sepsis: A meta-analysis by Shaowen Cheng, Rong Wang, Hengjie Zhu, Jian Yang, Jiangling Yao, Yunfu Zeng, Hongwang Cui and Binwen Huang in European Journal of Inflammation.</p