Synthesis and Anticancer Activity of 4β-Triazole-podophyllotoxin Glycosides

AbstractThe objective of present study was to investigate the effect of various sounds on the green mustard’s (Brassica Juncea) morphology characteristic and productivity. The plant has been subjected to three various sound, namely classical music (rhythmic violin music), machine and traffic noise, and mixed sound (classical music and traffic noise) with 70-75 dB sound pressure level, from germination to harvest for three hours (7-10 am.) each day. Six parameters, i.e. germination, plant height, leaf width, leaf lenght, total plant lenght, and fresh weight, related with growth and productivity of plant were been monitored on regular basis.The results showed classical music improves germination up to 15% for 36 hours, plant height 13,5%, leaf width 14,8%, leaf length 14,2%, and wet weight 57,1%. In general, exposure to classical music gives thebest results on the morphological characteristics and productivity of green mustard.Keywords: Sound exposure, plant morphology , productivity, green mustardAbstrakPenelitian ini bertujuan untuk menginvestigasi efek paparan variasi suara terhadap karakteristik morfologi dan produktivitas tanaman sawi hijau. suara yang dipaparkan antara lain musik klasik (suara biola), bising lalu lintas dan mesin industri (noise) dan campuran antara musik klasik dan noise. Level suara yang digunakan berkisar antara 70-75 dB dimulai sejak masa perkecambahan hingga panen selama 3 jam tiap harinya dimulai pukul 07.00-10.00. Enam parameter yang diamati dan diambil datanya meliputi, daya berkecambah, tinggi tanaman, lebar daun, panjang daun, panjang tanaman total dan berat basah. Hasil penelitian menunjukkan bahwa musik klasik meningkatkan daya berkecambah sebesar 15%, tinggi tanaman sebesar 13,5%, lebar daun sebesar 14,8%, panjang daun sebesar 14,2%, dan berat basah sebesar 57,1%. Secara umum paparan musik klasik memberikan hasil terbaik terhadap karakteristik morfologi dan produktivitas sawi hijau.Kata kunci: Paparan suara, morfologi, produktivitas, sawi hijauDiterima: 21 Oktober 2013;Disetujui: 28 Januari 201

Application of localization and needle placement guided by mammographic, ultrasound and fiberoptic ductoscopy for resection of non-palpable breast lesions

Aim: To evaluate the usefulness of localization needles under mammographic, ultrasound or fiberoptic ductoscopy guidance for non-palpable breast lesions. Patients and Methods: Eighty-three patients undergoing needle localization and biopsy of non-palpable breast lesions under mammographic, ultrasound or fiberoptic ductoscopy guidance from June 2013 to December 2014 in Beijing Friendship Hospital were included in the study. The preoperative imaging assessment, application of localization needles, surgical operation and pathological examination were recorded and analyzed retrospectively. Results: A total of 83 localization and biopsies were carried out, of which 27 were performed under mammographic guidance, 32 under ultrasound guidance and 24 under fiberoptic ductoscopy guidance. Twenty-seven cases of breast microcalcifications were localized under mammographic guidance and surgically removed, of which eight cases were pathologically diagnosed as malignant. Thirty-two cases of non-palpable breast lesions were localized under ultrasound guidance and 30 pathologically diagnosed, of these, four cases were pathologically diagnosed as malignant. Twenty-four cases of intraductal space–occupying lesions were localized under ductoscopy guidance and surgically removed, of which five cases were pathologically diagnosed as malignant. Conclusion: Utilization of localization needles under mammographic, ultrasound or fiberoptic ductoscopy guidance for non-palpable breast lesions is a safe and effective procedure, and is helpful in the diagnosis of breast cancer. With the help of this procedure, more malignant lesions can be localized and surgically removed

Network pharmacology-based elucidation of the molecular mechanism underlying the anti-migraine effect of Asari Radix et Rhizoma

Purpose: To determine the molecular mechanism involved in the anti-migraine effect of Asari Radix et Rhizoma (ARR) using network pharmacology. Methods: The compounds present in ARR were identified through information retrieval from literature and public databases, and were screened based on absorption, distribution, metabolism, excretion and toxicity. Target genes related to the selected compounds and migraine were identified or predicted from public databases. Hub genes in ARR against migraine were identified through analysis of interactions in overlapping genes between compounds and migraine target genes, based on STRING database. Gene enrichment analysis of overlapping genes was performed using Database for Annotation, Visualization and Integrated Discovery. Results: A total of 138 compounds were selected as potential bioactive compounds in ARR. Target genes related to the selected compounds (611 genes) and migraine (278 genes) were obtained, including 71 overlapping genes. The hub genes in the anti-migraine effect of ARR were BDNF, IL6, COMT, APP and TNF. Gene enrichment analysis showed the top 10 biological processes or pathways involved in the mechanism of anti-migraine action of ARR. The tissue source of the overlapping genes was not limited to the brain. The results from gene enrichment analysis revealed that the effect of ARR on migraine was holistic, which is characteristic of traditional Chinese medicines. Conclusion: Network pharmacology has been used to decipher the molecular mechanism involved in the action of ARR against migraine. The results provide a scientific basis for the clinical effect of ARR on migraine