Study of time structure pattern in news stories

News articles are a particular type of story that reflects our daily life on various media. The most distinctive characteristics of news story are its discontinuity in the ordering of events and its limited shelf life. These characteristics present difficulties for automated systems which deal with temporal information. Such applications include information extraction, question answering, summarization, machine translation, etc. In recent years, some concrete work has been done in the area of event identification and temporal expression annotation. Some issues still remain regarding implicit temporal information. This major report describes a method to find patterns in news stories that journalists use to organize events. The study will help us better understand the nature of news stories. It may also help to get implicit temporal information by the implication from the event in the same paragraph. The major report also presents an annotation scheme for annotating temporal expressions and paragraphs in new texts. In this study, we manually annotated all temporal expressions and paragraphs in selected news texts. We build the time structure for each of the texts according to the story time of the paragraphs. After all the target news texts are analyzed and annotated, we compare time structures against each other to derive time structure patterns that may exist in news stories

Synchro-Transient-Extracting Transform for the Analysis of Signals with Both Harmonic and Impulsive Components

Time-frequency analysis (TFA) techniques play an increasingly important role in the field of machine fault diagnosis attributing to their superiority in dealing with nonstationary signals. Synchroextracting transform (SET) and transient-extracting transform (TET) are two newly emerging techniques that can produce energy concentrated representation for nonstationary signals. However, SET and TET are only suitable for processing harmonic signals and impulsive signals, respectively. This poses a challenge for each of these two techniques when a signal contains both harmonic and impulsive components. In this paper, we propose a new TFA technique to solve this problem. The technique aims to combine the advantages of SET and TET to generate energy concentrated representations for both harmonic and impulsive components of the signal. Furthermore, we theoretically demonstrate that the proposed technique retains the signal reconstruction capability. The effectiveness of the proposed technique is verified using numerical and real-world signals

Breaking of brightness consistency in optical flow with a lightweight CNN network

Sparse optical flow is widely used in various computer vision tasks, however assuming brightness consistency limits its performance in High Dynamic Range (HDR) environments. In this work, a lightweight network is used to extract illumination robust convolutional features and corners with strong invariance. Modifying the typical brightness consistency of the optical flow method to the convolutional feature consistency yields the light-robust hybrid optical flow method. The proposed network runs at 190 FPS on a commercial CPU because it uses only four convolutional layers to extract feature maps and score maps simultaneously. Since the shallow network is difficult to train directly, a deep network is designed to compute the reliability map that helps it. An end-to-end unsupervised training mode is used for both networks. To validate the proposed method, we compare corner repeatability and matching performance with origin optical flow under dynamic illumination. In addition, a more accurate visual inertial system is constructed by replacing the optical flow method in VINS-Mono. In a public HDR dataset, it reduces translation errors by 93\%. The code is publicly available at https://github.com/linyicheng1/LET-NET.Comment: 7 pages,7 figure

NaMemo: Enhancing Lecturers' Interpersonal Competence of Remembering Students' Names

Addressing students by their names helps a teacher to start building rapport with students and thus facilitates their classroom participation. However, this basic yet effective skill has become rather challenging for university lecturers, who have to handle large-sized (sometimes exceeding 100) groups in their daily teaching. To enhance lecturers' competence in delivering interpersonal interaction, we developed NaMemo, a real-time name-indicating system based on a dedicated face-recognition pipeline. This paper presents the system design, the pilot feasibility test, and our plan for the following study, which aims to evaluate NaMemo's impacts on learning and teaching, as well as to probe design implications including privacy considerations.Comment: DIS '20 Companio

Prioritization of disease microRNAs through a human phenome-microRNAome network

<p>Abstract</p> <p>Background</p> <p>The identification of disease-related microRNAs is vital for understanding the pathogenesis of diseases at the molecular level, and is critical for designing specific molecular tools for diagnosis, treatment and prevention. Experimental identification of disease-related microRNAs poses considerable difficulties. Computational analysis of microRNA-disease associations is an important complementary means for prioritizing microRNAs for further experimental examination.</p> <p>Results</p> <p>Herein, we devised a computational model to infer potential microRNA-disease associations by prioritizing the entire human microRNAome for diseases of interest. We tested the model on 270 known experimentally verified microRNA-disease associations and achieved an area under the ROC curve of 75.80%. Moreover, we demonstrated that the model is applicable to diseases with which no known microRNAs are associated. The microRNAome-wide prioritization of microRNAs for 1,599 disease phenotypes is publicly released to facilitate future identification of disease-related microRNAs.</p> <p>Conclusions</p> <p>We presented a network-based approach that can infer potential microRNA-disease associations and drive testable hypotheses for the experimental efforts to identify the roles of microRNAs in human diseases.</p

Methylation of NF-κB and its Role in Gene Regulation

The nuclear factor κB (NF-κB) is one of the most pivotal transcription factors in mammalian cells. In many pathologies NF-κB is activated abnormally. This contributes to the development of various disorders such as cancer, acute kidney injury, lung disease, chronic inflammatory diseases, cardiovascular disease, and diabetes. This book chapter focuses on how methylation of NF-κB regulates its target genes differentially. The knowledge from this chapter will provide scientific strategies for innovative therapeutic intervention of NF-κB in a wide range of diseases

Comprehensive comparison of molecular portraits between cell lines and tumors in breast cancer

Background: Proper cell models for breast cancer primary tumors have long been the focal point in the cancer’s research. The genomic comparison between cell lines and tumors can investigate the similarity and dissimilarity and help to select right cell model to mimic tumor tissues to properly evaluate the drug reaction in vitro. In this paper, a comprehensive comparison in copy number variation (CNV), mutation, mRNA expression and protein expression between 68 breast cancer cell lines and 1375 primary breast tumors is conducted and presented. Results: Using whole genome expression arrays, strong correlations were observed between cells and tumors. PAM50 gene expression differentiated them into four major breast cancer subtypes: Luminal A and B, HER2amp, and Basal-like in both cells and tumors partially. Genomic CNVs patterns were observed between tumors and cells across chromosomes in general. High C > T and C > G trans-version rates were observed in both cells and tumors, while the cells had slightly higher somatic mutation rates than tumors. Clustering analysis on protein expression data can reasonably recover the breast cancer subtypes in cell lines and tumors. Although the drug-targeted proteins ER/PR and interesting mTOR/GSK3/TS2/PDK1/ER_P118 cluster had shown the consistent patterns between cells and tumor, low protein-based correlations were observed between cells and tumors. The expression consistency of mRNA verse protein between cell line and tumors reaches 0.7076. These important drug targets in breast cancer, ESR1, PGR, HER2, EGFR and AR have a high similarity in mRNA and protein variation in both tumors and cell lines. GATA3 and RP56KB1 are two promising drug targets for breast cancer. A total score developed from the four correlations among four molecular profiles suggests that cell lines, BT483, T47D and MDAMB453 have the highest similarity with tumors. Conclusions: The integrated data from across these multiple platforms demonstrates the existence of the similarity and dissimilarity of molecular features between breast cancer tumors and cell lines. The cell lines only mirror some but not all of the molecular properties of primary tumors. The study results add more evidence in selecting cell line models for breast cancer research