护理安全品管圈在血管外科护理中的应用效果

Objective: To study the effects of nursing safety quality control circle in the nursing in department of vascular surgery. Methods: Totally 230 patients in vascular surgery department from January 2015 to January 2016 were randomly divided into 2 groups. Assessment the risk factors of disease for each patient , 115 cases in the control group, the shift nurses nurse by traditional method; 115 cases in experimental group ,who were given quality control circle to improve the nursing quality., and the adverse event and compliance,satisfaction to nurses of the patients were compared. Results: The incidence of adverse events and complications (6%) in the experimental group were lower than those in the control group (15.5%). The patients' satisfaction with nurses' job (97.4%) was higher than that of the control group (87%). Conclusion: The implementation of nursing safety quality control circle activities in vascular surgery nursing, effectively reduce the incidence of adverse events and complications during hospitalization, improve the quality of nursing and help patients recover soon.目的  探讨护理安全品管圈在血管外科护理中的应用效果。方法  随机选取2015年1月—2016年1月在本科住院患者230例并随机将其分为两组，对每位患者进行疾病危险因素评估，对照组115例，各交接班护士采用传统护理方法；实验组115例，对患者实施护理安全品管圈活动提高护理质量，比较两组的不良事件和并发症的发生率、患者对护士工作的满意度、患者住院天数。结果  实验组不良事件和并发症的发生率（6%）均低于对照组（15.5%）；患者对护士工作的满意度（97.4%）高于对照组（87%），住院天数较对照组也大大缩短。结论  在血管外科护理中实施护理安全品管圈活动，有效的降低了患者住院期间不良事件和并发症的发生率，提高了护理质量，有助于患者早日康复

Identification of key bioactive anti-migraine constituents of Asari radix et rhizoma using network pharmacology and nitroglycerin-induced migraine rat model

Purpose: To elucidate the bioactive constituents of Asari radix et rhizoma (ARR) in treating migraine based on network pharmacology and nitroglycerin-induced migraine rat model. Methods: The potential bioactive constituents of ARR were identified with the aid of literature retrieval and virtual screening, and the migraine-related hub genes were identified using protein-protein interaction and topology analyses. Then, the interaction between the potential bioactive constituents and hub genes was determined with molecular docking and topology, leading to the prediction of the anti-migraine constituents of ARR. Moreover, a rat model of nitroglycerin-induced migraine was used to confirm the prediction by measuring the frequency of head-scratching and head-shaking behavior (FHHB) in the rats. In addition, levels of nitric oxide (NO) and calcitonin gene-related peptide (CGRP) in blood, norepinephrine (NE) and 5-hydroxytryptamine (5-HT) in brain were measured using appropriate commercial kits. Results: Network pharmacology revealed that naringenin-7-O-β-D-glucopyranoside and higenamine might be the key anti-migraine bioactive constituents of ARR. On addition of naringenin-7-O-β-D- glucopyranoside or higenamine to ARR, there was marked enhancement of the mitigating effect of ARR on nitroglycerin-induced abnormalities in levels of NO, CGRP, 5-HT and NE, as well as FHHB in rats (p < 0.05 or 0.01). Conclusion: These findings indicate that naringenin-7-O-β-D-glucopyranoside and higenamine might be the key bioactive and anti-migraine constituents of ARR. However, in addition to naringenin-7-O-β-D- glucopyranoside and higenamine, there were many other anti-migraine constituents in ARR. Therefore, there is need for further investigations on the actual contributions of these two constituents of ARR in treating migraine

Homogenized finite element analysis on effective elastoplastic mechanical behaviors of composite with imperfect interfaces

A three-dimensional (3D) representative volume element (RVE) model was developed for analyzing effective mechanical behavior of fiber-reinforced ceramic matrix composites with imperfect interfaces. In the model, the fiber is assumed to be perfectly elastic until its tensile strength, and the ceramic material is modeled by an elasto-plastic Drucker-Prager constitutive law. The RVE model is then used to study the elastic properties and the tensile strength of composites with imperfect interfaces and validated through experiments. The imperfect interfaces between the fiber and the matrix are taken into account by introducing some cohesive contact surfaces. The influences of the interface on the elastic constants and the tensile strengths are examined through these interface models

A role of corazonin receptor in larval-pupal transition and pupariation in the oriental fruit fly Bactrocera dorsalis (Hendel) (Diptera: Tephritidae)

Corazonin (Crz) is a neuropeptide hormone, but also a neuropeptide modulator that is internally released within the CNS, and it has a widespread distribution in insects with diverse physiological functions. Here, we identified and cloned the cDNAs of Bactrocera dorsalis that encode Crz and its receptor CrzR. Mature BdCrz has 11 residues with a unique Ser11 substitution (instead of the typical Asn) and a His in the evolutionary variable position 7. The BdCrzR cDNA encodes a putative protein of 608 amino acids with 7 putative transmembrane domains, typical for the structure of G-protein-coupled receptors. When expressed in Chinese hamster ovary (CHO) cells, the BdCrzR exhibited a high sensitivity and selectivity for Crz (EC50 approximate to 52.5 nM). With qPCR, the developmental stage and tissue-specific expression profiles in B. dorsalis demonstrated that both BdCrz and BdCrzR were highly expressed in the larval stage, and BdCrzR peaked in 2-day-old 3rd-instar larvae, suggesting that the BdCrzR may play an important role in the larval-pupal transition behavior. Immunochemical localization confirmed the production of Crz in the central nervous system (CNS), specifically by a group of three neurons in the dorso-lateral protocerebrum and eight pairs of lateral neurons in the ventral nerve cord. qPCR analysis located the BdCrzR in both the CNS and epitracheal gland, containing the Inka cells. Importantly, dsRNA-BdCrzR-mediated gene-silencing caused a delay in larval-pupal transition and pupariation, and this phenomenon agreed with a delayed expression of tyrosine hydroxylase and dopa-decarboxylase genes. We speculate that CrzR-silencing blocked dopamine synthesis, resulting in the inhibition of pupariation and cuticular melanization. Finally, injection of Crz in head-ligated larvae could rescue the effects. These findings provide a new insight into the roles of Crz signaling pathway components in B. dorsalis and support an important role of CrzR in larval-pupal transition and pupariation behavior

贴片式动态心电记录仪在临床教学中可行性研究

Objective: To explore effectiveness of clinical application of the patch type dynamic ecg recorder by comparing with conventional dynamic ecg recorder Holter. And the clinical ecg teaching models is discussed in this paper. Methods: Using parallel controlled trial method, 60 patients in two hospitals received Holter examination, and patch heart testing at the same time. A comparative analysis of two kinds of inspection methods on testing the average heart rate, supraventricular premature beats and ventricular premature beat was made. Results: The average heart rate of patch type ECG and Holter were 71.87±9.28 and 72.55±9.06 (P = 0.0879). Two kinds of detection methods, chamber on the coincidence rate of premature beat (PPS) was 98.33%, 95% CI (91.06, 99.96), Kappa = 0.9462, 95% CI (0.84, 1.00), good consistency. The accuracy of ventricular premature beat (PPS) was 98.33%, 95% CI (91.06, 99.63), Kappa = 0.9850, 95% CI (0.90, 1.00), good consistency. Patch type heart all platform is suitable for self-study and clinical care study, and professional skill assessment,etc.Conclusion: The effectiveness of patch type heart all on testing the average heart rate, supraventricular premature beat is the same as Holter. it is also suitable for to carry out clinical ECG teaching at the same time.目的 通过和常规动态心电记录仪 Holter比较，研究贴片式的动态心电记录仪临床应用的有效性。并探讨其在临床心电教学中的模式。方法 采用自身平行对照试验方法，在两医院60例患者用Holter检查时，同时用贴片心电仪检测，比较分析两种检查方法在检测平均心率、室上性早搏和室性早搏方面的情况。结果 贴片式心电仪和Holter的平均心率分别为71.87±9.28和72.55±9.06（P＝0.0879）。两种检测方法，室上性早搏的符合率（PPS）为 98.33%，95%CI为（91.06,99.96），Kappa=0.9462, 95%CI为（0.84,1.00）,一致性良好。室性早搏的符合率（PPS）为 98.33%，95%CI为（91.06,99.63），Kappa=0.9850, 95%CI为（0.90, 1.00）。贴片式心电仪平台适合自学、临床监护学习、大课和专业技能考核等临床心电教学。结论 贴片式心电仪在检测平均心率、室上性早搏和室性早搏方面的有效性和Holter相同。同时也适合以此平台开展临床心电教学

A Scoring Model Based on Neutrophil to Lymphocyte Ratio Predicts Recurrence of HBV-Associated Hepatocellular Carcinoma after Liver Transplantation

Neutrophil to lymphocyte ratio (NLR) has been proposed to predict prognosis of hepatocellular carcinoma (HCC). However, the cut-off values are empirical. We determined the optimal cut-off value to predict HCC recurrence after liver transplantation (LT) and further established a scoring model based on NLR.<0.001). Univariate analysis revealed that tumor size >5 cm, tumor number >3, macrovascular invasion, AFP≥400 µg/L, NLR≥3, and HBV-DNA level >5 log10 copies/mL were preoperative predictors of DFS. Cox regression analysis showed macrovascular invasion, tumor number, and high NLR were independent prognostic factors. We then established a preoperative prognostic score based on multivariate analysis. Each factor was given a score of 1. Area under the ROC curve of the score was 0.781. All nine patients with score 3 developed recurrence within 6 months after LT. Of 71 patients without vascular invasion, three patients with both tumor number >3 and NLR≥3 developed recurrence within 14 months after LT while the 5-year DFS and OS for patients with a score of 0 or 1 were 68.1% and 62.8%, respectively.Preoperative elevated NLR significantly increases the risk of recurrence in patients underwent LT for HCC. Patients with both NLR≥3 and tumor number >3 are not a good indication for LT. Our score model may aid in the selection of patients that would most benefit from transplantation for HCC

Limonoids and triterpenoids from the twigs and leaves of Dysoxylum hainanense

Four new limonoids, dysohainanins A–D (1–4), and two new triterpenoids, dysohainanins E and F (5 and 6), together with seven known ones were isolated from the twigs and leaves of Dysoxylum hainanense Merr. The structures of the new compounds were determined by a variety of spectroscopic methods. The cytotoxic activities of these compounds were evaluated, and the known compound ent-19-nor-4,16,18-trihydroxy-8(14)-pomaren-15-one (13) showed in vitro cytotoxicity against HL-60, A-549, MCF-7, and SW480 cells, with IC(50) values of 24.3, 28.1, 30.7, and 22.5 µM, respectively. Compounds 2 and 3 were tested their insecticidal activities using brine shrimp and both of them were inactive. [Image: see text] ELECTRONIC SUPPLEMENTARY MATERIAL: Supplementary material is available for this article at 10.1007/s13659-011-0030-8 and is accessible for authorized users