An atlas of cortical circular RNA expression in Alzheimer disease brains demonstrates clinical and pathological associations.

Parietal cortex RNA-sequencing (RNA-seq) data were generated from individuals with and without Alzheimer disease (AD; ncontrol = 13; nAD = 83) from the Knight Alzheimer Disease Research Center (Knight ADRC). Using this and an independent (Mount Sinai Brain Bank (MSBB)) AD RNA-seq dataset, cortical circular RNA (circRNA) expression was quantified in the context of AD. Significant associations were identified between circRNA expression and AD diagnosis, clinical dementia severity and neuropathological severity. It was demonstrated that most circRNA-AD associations are independent of changes in cognate linear messenger RNA expression or estimated brain cell-type proportions. Evidence was provided for circRNA expression changes occurring early in presymptomatic AD and in autosomal dominant AD. It was also observed that AD-associated circRNAs co-expressed with known AD genes. Finally, potential microRNA-binding sites were identified in AD-associated circRNAs for miRNAs predicted to target AD genes. Together, these results highlight the importance of analyzing non-linear RNAs and support future studies exploring the potential roles of circRNAs in AD pathogenesis

Robust Interfacial Exchange Bias and Metal-Insulator Transition Influenced by the LaNiO3 Layer Thickness in La0.7Sr0.3MnO3/LaNiO3 Superlattices

Artificial heterostructures based on LaNiO3 (LNO) have been widely investigated with the aim to realize the insulating antiferromagnetic state of LNO. In this work, we grew [(La0.7Sr0.3MnO3)5-(LaNiO3)n]12 superlattices on (001)-oriented SrTiO3 substrates by pulsed laser deposition and observed an unexpected exchange bias effect in field-cooled hysteresis loops. Through X-ray absorption spectroscopy and magnetic circular dichroism experiments, we found that the charge transfer at the interfacial Mn and Ni ions can induce a localized magnetic moment. A remarkable increase of exchange bias field and a transition from metal to insulator were simultaneously observed upon decreasing the thickness of the LNO layer, indicating the antiferromagnetic insulator state in 2 unit cells LNO ultrathin layers. The robust exchange bias of 745 Oe in the superlattice is caused by an interfacial localized magnetic moment and an antiferromagnetic state in the ultrathin LNO layer, pinning the ferromagnetic La0.7Sr0.3MnO3 layers together. Our results demonstrate that artificial interface engineering is a useful method to realize novel magnetic and transport properties

Rhombohedral lanthanum manganite: A new class of dirac half-metal with promising potential in spintronics

Dirac half-metals have drawn great scientific interests in spintronics because of their outstanding physical properties such as the large spin polarization and massless Dirac fermions. By using first-principles calculations, we investigate the perovskite-type lanthanum manganite (LaMnO3) as a novel Dirac half-metal. Specifically, LaMnO3 displays multiple linear band crossings in the spin-up direction, while it has a large band gap (∼5 eV) in the spin-down orientation. The intriguing linear band dispersions guarantee the ultrafast electron transport and the significant band differences between spin up and down directions promise the realization of 100% spin-polarized current and the extremely low energy consumption. Such a spin-polarized Dirac material is rare among perovskite-type compounds. By adopting the mean-field theory, the estimated Curie temperature Tc is 438.4 K. Importantly, the LaMnO3 crystal has been experimentally realized 2 decades ago, which facilitates the future experimental validation. With the novel spin-polarized electronic properties and the high possibility of experimental fabrication, LaMnO3 is ideal for the spintronic application

Exploring the driving factors of trade-offs and synergies among ecological functional zones based on ecosystem service bundles

In karst mountainous area, the strong spatial heterogeneity of the natural geography and the complexity of the human activities have led to significant variability and uncertainty in the process of ecosystem services (ESs). The trade-offs/synergies of ESs and its driving forces change with space significantly, which are not only related to the natural environment but also affected by socioeconomic factors. Clarifying the spatial distribution and compositional structure of the ecological functional zone and understanding the main driving factors of the trade-offs and synergies among multiple ESs are essential for scientific management and restoration of karst ecosystems. The objective of this study was to explore the driving forces of the trade-offs/synergies for each ecosystem service bundle (ESB) and to develop differentiated ecological management strategies based on the ecological characteristics. In this study, six ESs (i.e., water yield (WY), soil conservation (SC), net primary productivity (NPP), habitat quality (HQ), recreation services (RS), and food production (FP)) were quantified in the Wujiang Basin. Based on this, the spatial distribution and land use types of the coldspots/hotspots were analyzed. Then, the K-means algorithm was used to identify the ESBs. According to the ecological structural characteristics of the ESBs, the ecological functional zones were divided. Furthermore, the trade-offs/synergies and their driving factors among the ESs in each ESB were analyzed using Pearson correlation analysis and geographical detector. The results showed that the land use types significantly affected the spatial distribution of multiple ES coldspots/hotspots. The ES hotspots were mainly concentrated in the forest areas, while the coldspots were concentrated in the urban and farmland areas. Based on the spatial distributions and ecological features of the ESBs, the Wujiang Basin was divided into food supply area, habitat transition area, cultural recreation area, and ecological balance area. There were synergistic relationships between the SC and WY and between the SC and NPP in every functional zone. Precipitation and its interactions with other factors were the main driving forces that influenced the trade-off between the WY and FP in both the food supply area and the habitat transition area. The normalized difference vegetation index (NDVI) was the dominant factor that affected the spatial pattern of the trade-off between the FP and NPP in the cultural recreation area. This deeper understanding of the trade-offs/synergies in each functional zone provides a scientific basis for territorial spatial planning and ES optimization in the karst mountainous area

Study on the Early Cretaceous fluvial-desert sedimentary paleogeography in the Northwest of Ordos Basin

Early Cretaceous desert sedimentary system was developed in Northwest Ordos Basin. At present, the research degree of desert sedimentary paleogeography is low. The research on paleogeographic environment of Early Cretaceous sedimentary sandstone has guiding significance for the exploration of uranium resource and underground water resource in Northwest Ordos Basin. Based on the previous basic geological data of the lower Cretaceous in the Northwest of Ordos, through field geological survey, drilling core observation, and paleocurrent measurement, the sedimentary paleogeographic environments in different periods of Early Cretaceous had been studied. The results show that the lower Cretaceous in Northwestern Ordos Basin can be divided into two sedimentary cycles, the lower sedimentary cycle composed of Luohe Formation and Huachi-Huanhe Formation, and the upper sedimentary cycle composed of Luohandong Formation and Jingchuan Formation. Alluvial, Aeolian, and desert lake depositional systems were developed. The main sedimentary facies were alluvial fan, braided river, sand dune, dry valley, and dry lake. Alluvial fan and braided river facies had mainly developed in Luohe Formation. Braided fluvial facies mainly had developed in Huachi-Huanhe Formation, and alluvial fans locally developed around it. The deposits in Luohandong Formation were mainly aeolian sandstone, and the alluvial fan facies were inherently developed at Western and Northern margins. The depositional environment of Jingchuan formation is mainly river and lake. The tectonic evolution of lower Cretaceous had controlled the development of paleogeographic environment, and sedimentary facies had controlled the development of aquifer system. The paleogeographic environment of Early Cretaceous is conducive to the reduction and enrichment of uranium and the development of metallogenic units

Aquilaria Species (Thymelaeaceae) Distribution, Volatile and Non-Volatile Phytochemicals, Pharmacological Uses, Agarwood Grading System, and Induction Methods

Agarwood is a highly valuable fragrant wood of Aquilaria spp. (Thymelaeaceae) which has been widely utilized in traditional medicine, religious rites, and cultural activities. This study summarizes a review on the identification of Aquilaria cultivars, volatile and non-volatile phytochemicals, pharmacological uses, and agarwood grading system to determine its quality, and different agarwood induction methods. Due to the highly demanding and depleted natural resources, the research on agarwood is still insufficient, and it has broad research and development prospects in many industries. However, due to the significant scientific nature of agarwood application, developing high-quality products and drugs from agarwood have become highly important, while no one has discussed in detail the phytochemicals uses and provided a summary until now. The main phytochemicals of agarwood include terpenoids, dominated by sesquiterpenes. For centuries, terpenoids have been used in traditional Chinese medicine and have been shown to possess various pharmacological properties, including bacteriostatic, antibacterial, sedation, analgesia, anti-inflammation, anti-asthmatic, hypoglycemic, antidepressant, and many others. Alongside biological activity screening, phytochemical advances and pharmacological research have also made certain progress. Therefore, this review discusses the research progress of agarwood in recent years and provides a reference basis for further study of Aquilaria plants and agarwood