Tunable, multi-modal, and multi-directional vibration energy harvester based on three-dimensional architected metastructures

Conventional vibration energy harvesters based on two-dimensional planar layouts have limited harvesting capacities due to narrow frequency bandwidth and because their vibratory motion is mainly restricted to one plane. Three-dimensional architected structures and advanced materials with multifunctional properties are being developed in a broad range of technological fields. Structural topologies exploiting compressive buckling deformation mechanisms however provide a versatile route to transform planar structures into sophisticated three-dimensional architectures and functional devices. Designed geometries and Kirigami cut patterns defined on planar precursors contribute to the controlled formation of diverse three-dimensional forms. In this work, we propose an energy harvesting system with tunable dynamic properties, where piezoelectric materials are integrated and strategically designed into three-dimensional compliant architected metastructures. This concept enables energy scavenging from vibrations not only in multiple directions but also across a broad frequency bandwidth, thus increasing the energy harvesting efficiency. The proposed system comprises a buckled ribbon with optional Kirigami cuts. This platform enables the induction of vibration modes across a wide range of resonance frequencies and in arbitrary directions, mechanically coupling with four cantilever piezoelectric beams to capture vibrations. The multi-modal and multi-directional harvesting performance of the proposed configurations has been demonstrated in comparison with planar systems. The results suggest this is a facile strategy for the realization of compliant and high-performance energy harvesting and advanced electronics systems based on mechanically assembled platforms

Realization of corner and helical edge states in topologically trivial band gap by twig edge

The twig edge states in graphene-like structures are viewed as the fourth states complementary to their zigzag, bearded, and armchair counterparts. In this work, we study a rod-in-plasma system in honeycomb lattice with twig edges under external magnetic fields and lattice scaling and show that twig edge states can exist in different phases of the system, such as quantum Hall phase, quantum spin Hall phase and insulating phase. The twig edge states in the quantum Hall phase exhibit robust one-way transmission property immune to backscattering and thus provide a novel avenue for solving the plasma communication blackout problem. Moreover, we demonstrate that corner and edge states can exist within the trivial band gap of the insulating phase by modulating the on-site potential of the twig edges. Especially, helical edge states with the unique feature of pseudospin-momentum locking that could be exited by chiral sources are demonstrated at the twig edges within the trivial band gap. Our results show that many topological-like behaviors of electromagnetic waves are not necessarily tied to the exact topology of the systems and the twig edges and interface engineering can bring new opportunities for more flexible manipulation of electromagnetic waves

M2-Polarized tumor-associated macrophages are associated with poor prognoses resulting from accelerated lymphangiogenesis in lung adenocarcinoma

OBJECTIVES: Tumor-associated macrophages have been implicated in promoting tumor growth, progression and metastasis. However, the activated phenotype (M1 or M2) of tumor-associated macrophages remains unknown in solid tumors. Therefore, this study examined the density and prognostic significance of M2-polarized tumor-associated macrophages in lung adenocarcinoma. METHODS: Tumor specimens from 65 lung adenocarcinoma patients were assessed by ELISA for Th1/Th2 cytokine concentrations. The activated phenotype (M1 or M2) of tumor-associated macrophages was determined utilizing immunofluorescence staining. Additionally, to evaluate lymphangiogenesis, peritumoral lymphatic microvessel density was measured using D2-40. The correlation between tumor-associated macrophage subtype and overall patient survival was analyzed using the Kaplan-Meier method and compared using the log-rank test. RESULTS: A shift toward Th2 cytokine expression was detected within lung adenocarcinoma microenvironments. Approximately 79.71±16.27% of tumor-associated macrophages were M2 polarized; the remaining 20.35±5.31% were M1 polarized. The infiltration of M2-polarized macrophages was significantly associated with P-TNM staging and lymph node metastasis. The peritumoral lymphatic microvessel density was significantly higher in the high M2-polarized tumor-associated macrophage group than in the low M2-polarized tumor-associated macrophage group. A significant difference in overall patient survival was detected not only between patients with tumors with high and low macrophage counts but also between patients with tumors with high and low counts of M2-polarized macrophages. CONCLUSION: Tumor-associated macrophages in lung adenocarcinoma have an M2-polarized subtype and are associated with poor prognoses, perhaps resulting from accelerated lymphangiogenesis and lymph node metastasis

Two-dimensional graded metamaterials with auxetic rectangular perforations

This work describes the in-plane uniaxial tensile mechanical properties of two-dimensional graded rectangular perforations metamaterials using numerical homogenization finite element approaches benchmarked by experimental results. The metamaterial configuration is based on graded patterns of centre-symmetric perforated cells that can exhibit an auxetic (negative Poisson's ratio) behavior. Global and local equivalent mechanical properties of the metamaterial are measured using digital image correlation techniques mapped over Finite Element models to identify strain patterns and related stress distributions at different scales. The samples and their numerical counterpart are parametrized against the spacing and aspect ratios of the cells. The overall stiffness behavior of the graded perforated metamaterial plates features a higher degree of compliance that depends both on the geometries of the cells of the graded areas, but also on the graded pattern used. Local Poisson's ratio effects show a general constraint of the auxetic behavior compared to the case of uniform plates, but also interesting and controllable shape changes due to the uniaxial tensile loading applied

M2-polarized macrophages promote metastatic behavior of Lewis lung carcinoma cells by inducing vascular endothelial growth factor-C expression

OBJECTIVES: Tumor-associated macrophages that generally exhibit an alternatively activated (M2) phenotype have been linked to tumor progression and metastasis. However, the role of M2-polarized macrophages in the growth and metastasis of lung adenocarcinoma remains enigmatic. The aim of this study was to explore the effect of M2 macrophages on the proliferation and migration of mouse Lewis lung carcinoma cells and tumor-induced lymphangiogenesis. METHODS: Trypan blue staining and the Transwell migration assay were performed to evaluate the effects of activated (M1 or M2) macrophages on the proliferation and migration of Lewis cells. Furthermore, vascular endothelial growth factor-C expression in Lewis cells and nitric oxide secretion from activated macrophages were detected during the co-culture assay. Following treatment with activated macrophages, lymphatic endothelial cells differentiated into capillary-like structures, and the induction of Lewis cell migration was assessed using a twodimensional Matrigel-based assay. RESULTS: In the co-culture Transwell system, the proliferation and migration of Lewis cells were promoted by M2 macrophages. Moreover, the co-culture significantly increased the expression of vascular endothelial growth factor-C by Lewis cells and reduced the secretion of nitric oxide from M2 macrophages, which subsequently led to the capillary morphogenesis of lymphatic endothelial cells. Interestingly, following co-culture with Lewis cells, the function of RAW264.7 cells was polarized toward that of the M2 macrophage phenotype. CONCLUSION: M2-polarized macrophages promoted the metastatic behavior of Lewis cells by inducing vascular endothelial growth factor-C expression. Thus, the interruption of signaling between M2 macrophages and Lewis cells may be considered to be a new therapeutic strategy