Spatially Sparse Precoding in Wideband Hybrid Terahertz Massive MIMO Systems

In terahertz (THz) massive multiple-input multiple-output (MIMO) systems, the combination of huge bandwidth and massive antennas results in severe beam split, thus making the conventional phase-shifter based hybrid precoding architecture ineffective. With the incorporation of true-time-delay (TTD) lines in the hardware implementation of the analog precoders, delay-phase precoding (DPP) emerges as a promising architecture to effectively overcome beam split. However, existing DPP approaches suffer from poor performance, high complexity, and weak robustness in practical THz channels. In this paper, we propose a novel DPP approach in wideband THz massive MIMO systems. First, the optimization problem is converted into a compressive sensing (CS) form, which can be solved by the extended spatially sparse precoding (SSP) algorithm. To compensate for beam split, frequency-dependent measurement matrices are introduced, which can be approximately realized by feasible phase and delay codebooks. Then, several efficient atom selection techniques are developed to further reduce the complexity of extended SSP. In simulation, the proposed DPP approach achieves superior performance, complexity, and robustness by using it alone or in combination with existing DPP approaches

Precise measurement of position and attitude based on convolutional neural network and visual correspondence relationship

Accurate measurement of position and attitude information is particularly important. Traditional measurement methods generally require high-precision measurement equipment for analysis, leading to high costs and limited applicability. Vision-based measurement schemes need to solve complex visual relationships. With the extensive development of neural networks in related fields, it has become possible to apply them to the object position and attitude. In this paper, we propose an object pose measurement scheme based on convolutional neural network and we have successfully implemented end-toend position and attitude detection. Furthermore, to effectively expand the measurement range and reduce the number of training samples, we demonstrated the independence of objects in each dimension and proposed subadded training programs. At the same time, we generated generating image encoder to guarantee the detection performance of the training model in practical applications

On the laboratory calibration of dielectric permittivity models for agricultural soils: Effect of systematic porosity variation

Dielectric techniques are fundamental methods for measuring soil water content, and they commonly rely on the conventional laboratory calibration of the dielectric permittivity models between a dielectric constant and water content. As a non-negligible factor, porosity has been constructed differently in some models as a calibration constant, but the systematic porosity variations during the laboratory model calibration and field applications are not yet well addressed. Based on time-domain reflectometer laboratory calibration experiments, this study investigated this issue using three preestablished dielectric permittivity models: the Purdue calibration equation (American Society for Testing and Materials model [ASTM]), the complex refractive index model (CRIM), and a piecewise CRIM model (CRIMP). Results demonstrate that a generalized porosity constant used in the calibration would bring in additional structural bias compared with the calibration using variable porosities, and its magnitude varies with the model structure. The deviation of the generalized porosity constant can further amplify the structural bias of ASTM and CRIM for soils with low clay content, but it is insensitive for the soils with high clay content due to the overwhelming role of model structure error. Only the model CRIMP with a “perfect” model structure can effectively cope with the systematic porosity variation and keep a stable built-in capability for estimating calibration constants from readily available soil data. These findings highlight ignoring porosity variation should not be taken for granted for calibrating and applying the preestablished models

Efficacy and safety of neoadjuvant immunotherapy in resectable esophageal or gastroesophageal junction carcinoma: A pooled analysis of prospective clinical trials

Neoadjuvant chemoradiotherapy (NCRT) plus radical esophagectomy is currently the standard treatment for resectable esophageal or gastroesophageal junction (GEJ) carcinoma. The aim of this study is to evaluate the efficacy and safety of neoadjuvant immunotherapy in resectable esophageal or GEJ carcinoma. Prospective clinical trials investigating efficacy and/or safety of neoadjuvant immunotherapy with immune checkpoint inhibitors (ICIs) followed by radical esophagectomy in patients with newly diagnosed resectable esophageal or GEJ carcinoma were identified through literature search. Quality assessment was performed by using the Newcastle–Ottawa scale. Preliminary treatment outcomes of pathologically complete response (pCR, ypT0N0) and grade 3-4 adverse effects (AEs) were pooled together and then compared with standard NCRT of the historical control CROSS study by Chi-square (χ2) test. A two-sided P value < 0.05 was considered statistically significant. A total of 17 eligible non-randomized trials with 455 participants were included into analysis. The most common primary endpoint was pCR (n = 7, 41%), and the median sample size and follow-up period was 23 patients and 7.9 months, respectively. For patients receiving neoadjuvant immunotherapy, the overall pCR, R0 resection, and grade 3-4 AE rates were 33.2%, 95.5%, and 35.1%, respectively. For esophageal squamous cell carcinoma (ESCC) and adenocarcinoma (EAC), neoadjuvant immunochemoradiotherapy showed no significant improvement in pCR rate than NCRT (ESCC, 50% vs 48.7%, P = 0.9; EAC, 32.6% vs 23.1%, P = 0.22). Grade 3-4 AEs were the most common in patients with neoadjuvant immunochemoradiotherapy, significantly higher than immunochemotherapy (46.7% vs 32.8%, P = 0.04) and NCRT (46.7% vs 18.1%, P < 0.0001). In conclusion, for patients with resectable esophageal or GEJ carcinoma, the addition of ICIs to standard NCRT could not improve pCR rate in both ESCC and EAC, but significantly increased the risk of severe AEs. Large-scale phase 3 randomized trials were urgently needed to further confirm the survival benefit and safety profile of neoadjuvant immunotherapy

Inhibition of protein FAK enhances 5-FU chemosensitivity to gastric carcinoma via p53 signaling pathways

Abstract(#br)The small molecule drug 5-fluorouracil (5-FU) is widely used in the treatment for gastric cancer (GC), however, it exerts poor efficacy and is associated with acquired and intrinsic resistance. Focal adhesion kinase (FAK), a non-receptor tyrosine kinase, plays a key role in adhesion, migration, and proliferation of gastric carcinoma cells, suggesting that this kinase may be a promising therapeutic target. Differentially expressed FAK in GC tissue was detected by RT-qPCR and TCGA database analysis. To investigate the biological functions of FAK, loss-of-function experiments were performed. CCK-8 assay, colony formation assay, flow cytometry, dual-luciferase reporter assays, and western blot assays were conducted to determine the underlying mechanisms of FAK in 5-FU chemosensitivity in GC. FAK is overexpressed in GC patients, and positively correlated with poor prognosis. The use of shRNA interference to target FAK decreased proliferation and increased apoptosis of GC cells in vitro. Importantly, FAK silencing enhanced the therapeutic efficacy of 5-FU, leading to reduced tumor growth in vivo . We further demonstrated that FAK silencing increased 5-FU-induced caspase-3 activity, and promoted p53 transcriptional activities. Clinical data also has shown that patients with higher levels of FAK had significantly shorter overall survival (OS) and time to first progression (FP) than those with lower levels of FAK. These findings indicate that FAK plays a critical role in 5-FU chemosensitivity in GC, and the use of FAK inhibitors as an adjunct to 5-FU might be an effective strategy for patients who undergo chemotherapy