Interplay between Quantum Size Effect and Strain Effect on Growth of Nanoscale Metal Thin Film

We develop a theoretical framework to investigate the interplay between quantum size effect (QSE) and strain effect on the stability of metal nanofilms. The QSE and strain effect are shown to be coupled through the concept of "quantum electronic stress. First-principles calculations reveal large quantum oscillations in the surface stress of metal nanofilms as a function of film thickness. This adds extrinsically additional strain-coupled quantum oscillations to surface energy of strained metal nanofilms. Our theory enables a quantitative estimation of the amount of strain in experimental samples, and suggests strain be an important factor contributing to the discrepancies between the existing theories and experiments

microRNA-33a-5p increases radiosensitivity by inhibiting glycolysis in melanoma.

Glycolysis was reported to have a positive correlation with radioresistance. Our previous study found that the miR-33a functioned as a tumor suppressor in malignant melanoma by targeting hypoxia-inducible factor1-alpha (HIF-1α), a gene known to promote glycolysis. However, the role of miR-33a-5p in radiosensitivity remains to be elucidated. We found that miR-33a-5p was downregulated in melanoma tissues and cells. Cell proliferation was downregulated after overexpression of miR-33a-5p in WM451 cells, accompanied by a decreased level of glycolysis. In contrast, cell proliferation was upregulated after inhibition of miR-33a-5p in WM35 cells, accompanied by increased glycolysis. Overexpression of miR-33a-5p enhanced the sensitivity of melanoma cells to X-radiation by MTT assay, while downregulation of miR-33a-5p had the opposite effects. Finally, in vivo experiments with xenografts in nude mice confirmed that high expression of miR-33a-5p in tumor cells increased radiosensitivity via inhibiting glycolysis. In conclusions, miR-33a-5p promotes radiosensitivity by negatively regulating glycolysis in melanoma

Polar NURBS surface with curvature continuity

International audiencePolar NURBS surface is a kind of periodic NURBS surface, one boundary of which shrinks to a degenerate polarpoint. The specific topology of its control-point mesh offers the ability to represent a cap-like surface, which iscommon in geometric modeling. However, there is a critical and challenging problem that hinders its application:curvature continuity at the extraordinary singular pole. We first propose a sufficient and necessary condition ofcurvature continuity at the pole. Then, we present constructive methods for the two key problems respectively:how to construct a polar NURBS surface with curvature continuity and how to reform an ordinary polar NURBSsurface to curvature continuous. The algorithms only depend on the symbolic representation and operations ofNURBS, and they introduce no restrictions on the degree or the knot vectors. Examples and comparisons demonstratethe applications of the curvature-continuous polar NURBS surface in hole-filling and free-shape modeling