A Conceptual Artificial Intelligence Application Framework in Human Resource Management

This study proposes a conceptional framework of artificial intelligence (AI) technology application for human resource management (HRM). Based on the theory of the six basic dimensions of human resource management, which includes human resource strategy and planning, recruitment, training and development process, performance management, salary evaluation, and the employee relationship management, is combine with its potential corresponding AI technology application. With the cases analysis on recruitment of leap.ai and online training of Baidu, the recruitment dimension and training dimension with AI are further explored. Finally, the practical implication and future study are supplemented. This AIHRM conceptual model provides suggestions and directions for the development of AI in enterprise human resource management

Metabolism and Excretion Study of Daphnoretin in Rats after Oral Administration

The metabolism and excretion profile in rats were investigated after a single dose of daphnoretin. Metabolites of daphnoretin in rats were characterized by HPLC-MS n analysis. A HPLC-UV method was developed to determine the concentration of daphnoretin in rat urine, feces and bile. Daphnoretin was biotransformed via conjunctive and oxidative pathways to three detected metabolites. The structures of these metabolites were tentatively identified. The cumulative excretion percentage of daphnoretin in urine, feces and bile of rats was 0.13, 52.7, and 0.018 %, respectively. All the metabolites and excretion data are reported for the first time.Colegio de Farmacéuticos de la Provincia de Buenos Aire

Concentration-dependent effects of narciclasine on cell cycle progression in Arabidopsis root tips

<p>Abstract</p> <p>Background</p> <p>Narciclasine (NCS) is an Amaryllidaceae alkaloid isolated from <it>Narcissus tazetta </it>bulbs. NCS has inhibitory effects on a broad range of biological activities and thus has various potential practical applications. Here we examine how NCS represses plant root growth.</p> <p>Results</p> <p>Results showed that the inhibition of NCS on cell division in <it>Arabidopsis </it>root tips and its effects on cell differentiation are concentration-dependent; at low concentrations (0.5 and 1.0 μM) NCS preferentially targets mitotic cell cycle specific/cyclin complexes, whereas at high concentration (5.0 μM) the NCS-stimulated accumulation of Kip-related proteins (KRP1 and RP2) affects the CDK complexes with a role at both G1/S and G2/M phases.</p> <p>Conclusions</p> <p>Our findings suggest that NCS modulates the coordination between cell division and differentiation in <it>Arabidopsis </it>root tips and hence affects the postembryonic development of <it>Arabidopsis </it>seedlings.</p

Metabolism and Excretion Study of Daphnoretin in Rats after Oral Administration

The metabolism and excretion profile in rats were investigated after a single dose of daphnoretin. Metabolites of daphnoretin in rats were characterized by HPLC-MS n analysis. A HPLC-UV method was developed to determine the concentration of daphnoretin in rat urine, feces and bile. Daphnoretin was biotransformed via conjunctive and oxidative pathways to three detected metabolites. The structures of these metabolites were tentatively identified. The cumulative excretion percentage of daphnoretin in urine, feces and bile of rats was 0.13, 52.7, and 0.018 %, respectively. All the metabolites and excretion data are reported for the first time.Colegio de Farmacéuticos de la Provincia de Buenos Aire

Analyzing Dynamic Changes of Laboratory Indexes in Patients with Acute Heart Failure Based on Retrospective Study

Background. Changes of N-terminal probrain natriuretic peptide (NT-proBNP) have been studied whether in the long term or the short term in patients of acute heart failure (AHF); however, changes of NT-proBNP in the first five days and their association with other factors have not been investigated. Aims. To describe the dynamic changes of relevant laboratory indexes in the first five days between different outcomes of AHF patients and their associations. Methods and Results. 284 AHF with dynamic values recorded were analyzed. Changes of NT-proBNP, troponin T, and C-reactive protein were different between patients with different outcomes, with higher values in adverse group than in control group at the same time points ( &lt; 0.05). Then, prognostic use and risk stratification of NT-proBNP were assessed by receiver-operating characteristic curve and logistic regression. NT-proBNP levels at day 3 showed the best prognostic power (area under the curve = 0.730, 95% confidence interval (CI): 0.657 to 0.794) and was an independent risk factor for adverse outcome (odds ratio, OR: 2.185, 95% CI: 1.584-3.015). Classified changes of NT-proBNP may be predictive for adverse outcomes in AHF patients. Conclusions. Sequential monitoring of laboratory indexes within the first 5 days may be helpful for management of AHF patients

Correlation Between Bioelectrical Impedance Analysis and Chest CT-Measured Erector Spinae Muscle Area: A Cross-Sectional Study

BackgroundSkeletal muscle mass (SMM) plays an important part in diverse health and disease states. Bioelectrical impedance analysis (BIA) and computed tomography (CT) are available for its assessment. However, muscle mass assessed by BIA may be influenced by multiple factors. The erector spinae muscle area (ESA) on chest CT is recently presumed to be representative of SMM. This study aimed to derive BIA from the ESA and evaluate the magnitude of association (between ESA measured from chest CT) and BIA.MethodsSubjects hospitalized for health checkups between December 2020 and December 2021, having undergone both BIA (50 kHz, 0.8 mA) and chest CT, were included. ESA was quantified at the level of the 12th thoracic vertebra (T12-ESA) by a standardized semi-automated segmentation algorithm. Low SMM was defined using the Asian Working Group for Sarcopenia criteria. The association between T12-ESA and BIA was then evaluated. Stratified analyses by sex and BMI were also performed.ResultsAmong 606 included subjects (59.7 ± 16.6 years, 63.5% male), 110 (18.2%) had low SMM. BMI in low and normal SMM groups was 20.1 and 24.7 kg/m2, respectively. Current smoking, drinking, chronic obstructive pulmonary disease, and chronic renal dysfunction were more frequently seen in the low SMM group than in the normal SMM group. The final regression model included T12-ESA, weight, BMI, and age, and had an adjusted R2 of 0.806 with BIA. In the validation group, the correlation between T12-ESA-derived BIA and BIA remained high (Pearson correlation = 0.899). Stratified analysis disclosed a stronger correlation between T12-ESA and BIA in male subjects than in female subjects (adjusted R2 = 0.790 vs. adjusted R2 = 0.711, p &lt; 0.05), and a better correlation was observed in obese (BMI ≥ 30 kg/m2) compared with underweight (BMI &lt; 18.5 kg/m2) subjects (adjusted R2 = 0.852 vs. adjusted R2 = 0.723, p &lt; 0.05). Additional analysis revealed a significant correlation between T12-ESA and skeletal muscle cross-sectional area at the 3rd lumbar vertebra (L3-CSA) (adjusted R2 = 0.935, p &lt; 0.001).ConclusionsCT-based assessment of ESA at the T12 level is feasible and correlated well with BIA, especially in male subjects and obese subjects

Comparison of In vitro Nanoparticles Uptake in Various Cell Lines and In vivo Pulmonary Cellular Transport in Intratracheally Dosed Rat Model

In present study, the potential drug delivery of nanoformulations was validated via the comparison of cellular uptake of nanoparticles in various cell lines and in vivo pulmonary cellular uptake in intratracheally (IT) dosed rat model. Nanoparticles were prepared by a bench scale wet milling device and incubated with a series of cell lines, including Caco-2, RAW, MDCK and MDCK transfected MDR1 cells. IT dosed rats were examined for the pulmonary cellular uptake of nanoparticles. The processes of nanoparticle preparation did not alter the crystalline state of the material. The uptake of nanoparticles was observed most extensively in RAW cells and the least in Caco-2 cells. Efflux transporter P-gp did not prevent cell from nanoparticles uptake. The cellular uptake of nanoparticles was also confirmed in bronchoalveolar lavage (BAL) fluid cells and in bronchiolar epithelial cells, type II alveolar epithelial cells in the intratracheally administrated rats. The nanoparticles uptake in MDCK, RAW cells and in vivo lung epithelial cells indicated the potential applications of nanoformulation for poorly soluble compounds. The observed limited direct uptake of nanoparticles in Caco-2 cells suggests that the improvement in oral bioavailability by particle size reduction is via increased dissolution rate rather than direct uptake

DEM numerical investigation of wet particle flow behaviors in multiple-spout fluidized beds

Spout fluidized beds are important for industrial processing, and multiple-spout fluidized beds play an important role in chemical reactions. However, particle flow behaviors in multiple-spout fluidized beds are not well known in wet particle systems. In this study, the flow behaviors of particles were investigated in dry and humid multiple-spout fluidized beds using a discrete element method (DEM). The simulated spout fluidized beds are similar to the ones used in the Buijtenen et al.’s experiment (published in Chemical Engineering Science, 2011, 66(11): 2368-2376). In the reference, particle flow behaviors were measured and investigated by PIV and PEPT in multiple spout fluidized beds. In this work, the simulated results are compared with the experimental data in single and double spout fluidized beds from Buijtenen et al., and the time-averaged particle velocities are compared to validate the simulation method. In contrast, simulated results with a liquid content of 1% in the bed showed good agreement with the data in the experimental results with an air relative humidity of 50%. Different liquid contents of the particles were applied to investigate the particle flow behaviors in wet granular systems. The liquid bridge force had a strong influence on the flow behaviors of the particles in the dense region, which resulted in different hydrodynamic characteristics between the dry and wet particles. In addition, the drag force dominated the particle flow behavior in the dry and wet particle systems. Moreover, in a wet granular system, the mass particle fluxes decreased, and the fluctuation of the pressure drops increased with an increasing influence of the liquid bridge force on the particles. Furthermore, with an increasing liquid content, the energy fluctuation of the particles and bubbles weakened gradually with less active motions. A comparison of the hydrodynamic flow behaviors in single-spout and double-spout fluidized beds was carried out as well. Comparisons of the solid circulation rate and the colliding characteristics between single-spout and double-spout fluidized beds were conducted. Particularly, a comparison of the mixing characteristics demonstrated that the particles were mixed more completely in a double-spout fluidized bed. Therefore, the double-spout fluidized bed could provide more adequate space for mass and heat transfer under the same condition. This was important in providing a theory for designing the industrial reactor