Processes and continuous change in a SAT-based planner

AbstractThe TM-LPSAT planner can construct plans in domains containing atomic actions and durative actions; events and processes; discrete, real-valued, and interval-valued fluents; reusable resources, both numeric and interval-valued; and continuous linear change to quantities. It works in three stages. In the first stage, a representation of the domain and problem in an extended version of PDDL+ is compiled into a system of Boolean combinations of propositional atoms and linear constraints over numeric variables. In the second stage, a SAT-based arithmetic constraint solver, such as LPSAT or MathSAT, is used to find a solution to the system of constraints. In the third stage, a correct plan is extracted from this solution. We discuss the structure of the planner and show how planning with time and metric quantities is compiled into a system of constraints. The proofs of soundness and completeness over a substantial subset of our extended version of PDDL+ are presented

Up-regulation of ZO-1 expression and barrier function in cultured human corneal epithelial cells by substance P

AbstractThe effects of the sensory neurotransmitter substance P on the expression of tight junction proteins and on barrier function in human corneal epithelial cells were investigated. The expression of ZO-1, but not that of occludin or claudin-1, was increased by substance P in a concentration- and time-dependent manner. This effect was inhibited by the NK-1 receptor antagonist GR82334 and by KN62, an inhibitor of Ca2+- and calmodulin-dependent protein kinase II. Substance P also increased the transepithelial electrical resistance of a cell monolayer in a manner sensitive to GR82334. Substance P may therefore play a role in maintenance of tight junctions in the corneal epithelium

Draft genome sequence of Kocuria sp. strain UCD-OTCP (phylum Actinobacteria)

© 2013 Coil et al. Here, we present the draft genome of Kocuria sp. strain UCD-OTCP, a member of the phylum Actinobacteria, isolated from a restaurant chair cushion. The assembly contains 3,791,485 bp (G+C content of 73%) and is contained in 68 scaffolds

Growth Response of Explants of Irvingia Gabonensis (O'rorke, Baill) to In Vitro Treatment

Growth response of explants of Irvingia gabonensis to in vitro treatment was investigated using full, half and one quarter strength mineral components based on Murashige and Skoog medium. Plant growth regulator (kinetin-Kin) with concentration levels of 0, 1, 2, 3, 4 and 5mg/l were used for shoots initiation, while axillary formed shoots were rooted in various concentration levels of 0, 1, 2, 3, 4 and 5mg/l of indole butyric acid (IBA). One quarter strength growth medium containing 3mg/l kinetin, which supported the highest growth performance was used to study the effect of explant source and number of leaf primordia on shoot initiation of the species. Shoot length of axillary bud explant significantly (P<0.05) increased in one quarter strength medium than those of half and full strength media. Axillary bud explants with 1-2 leaf primordia gave optimum response in terms of regeneration frequency and coefficient of velocity of bud burst. High regeneration frequency and coefficient of velocity of bud burst with low percentage contamination were recorded by seedling and stump sprout explants. This study suggests that axillary bud explants of Irvingia gabonensis can respond to in vitro treatment under optimum culture conditions

Activation of channel activity of the NMDA receptor-PSD-95 complex by guanylate kinase-associated protein (GKAP)

AbstractThe channel-associated protein PSD-95 functionally modulates NMDA receptor channels, interacting with the channels via PDZ domain of PSD-95. PSD-95 also interacts with guanylate kinase-associated protein (GKAP) through the guanylate kinase-like domain of PSD-95. Here we report that GKAP markedly potentiates the channel activity of the receptor-PSD-95 complex. However, GKAP had no effect on basic properties of the channels nor on PSD-95-induced changes in channel properties. Thus, GKAP affects the channel activity of the NMDA receptor via PSD-95 quantitatively, which may make signal transmission more efficient at postsynaptic sites

The effect of urban greenspace on adolescent sleep patterns

We investigated the effects of long-term greenspace deprivation on sleep during adolescence. Using data from a UK birth cohort, we studied deviations from age-recommended sleep duration through Time Use Diaries. Our sample (N = 1370; 53% female) of urban adolescents had been exposed to the same levels of neighbourhood greenspace from birth up to age 14 years when their time use was tracked. We factored in sex and ethnicity, family income, long-term illness, sharing of a bedroom, access to a garden, as well as air pollution and perceived area safety. Even after full adjustment, there was a significant interaction between greenspace availability and income when predicting sleep duration, such that low-income adolescents living in the greyest urban areas were found to sleep more than the 8–10 h recommended for their age group, while the inverse was true for their counterparts living in areas with more greenspace

Inhibitory Effects of Ambrosia trifida L. on the Development of Root Hairs and Protein Patterns of Radicles

Ambrosia trifida L. is designated as invasive alien species by the Act on the Conservation and Use of Biodiversity by the Ministry of Environment, Korea. The purpose of present paper was to investigate the inhibitory effects of aqueous extracts of A.trifida on the development of root hairs of Triticum aestivum L., and Allium tuberosum Rottler ex Spreng and the electrophoretic protein patterns of their radicles. The development of root hairs was inhibited by increasing of aqueous extract concentrations. Through SDS-PAGE, the electrophoretic protein bands of extracted proteins from their radicles were appeared in controls, but protein bands of specific molecular weight disappeared or weakened in treatments. In conclusion, inhibitory effects of A. trifida made two receptor species changed morphologically, and at the molecular level in early growth stage

Inhibitory Effects of Ambrosia trifida L. on the Development of Root Hairs and Protein Patterns of Radicles

Ambrosia trifida L. is designated as invasive alien species by the Act on the Conservation and Use of Biodiversity by the Ministry of Environment, Korea. The purpose of present paper was to investigate the inhibitory effects of aqueous extracts of A.trifida on the development of root hairs of Triticum aestivum L., and Allium tuberosum Rottler ex Spreng and the electrophoretic protein patterns of their radicles. The development of root hairs was inhibited by increasing of aqueous extract concentrations. Through SDS-PAGE, the electrophoretic protein bands of extracted proteins from their radicles were appeared in controls, but protein bands of specific molecular weight disappeared or weakened in treatments. In conclusion, inhibitory effects of A. trifida made two receptor species changed morphologically, and at the molecular level in early growth stage

Inhibitory Effects of Ambrosia trifida L. on the Development of Root Hairs and Protein Patterns of Radicles

Ambrosia trifida L. is designated as invasive alien species by the Act on the Conservation and Use of Biodiversity by the Ministry of Environment, Korea. The purpose of present paper was to investigate the inhibitory effects of aqueous extracts of A.trifida on the development of root hairs of Triticum aestivum L., and Allium tuberosum Rottler ex Spreng and the electrophoretic protein patterns of their radicles. The development of root hairs was inhibited by increasing of aqueous extract concentrations. Through SDS-PAGE, the electrophoretic protein bands of extracted proteins from their radicles were appeared in controls, but protein bands of specific molecular weight disappeared or weakened in treatments. In conclusion, inhibitory effects of A. trifida made two receptor species changed morphologically, and at the molecular level in early growth stage