Corridors of Connectivity and Infrastructural Land Grabbing in Laos

In this chapter we argue that megaprojects are a critical feature and technology of global land grabbing within the current infrastructure boom. We contribute a land-oriented perspective to the turn towards infrastructure within the social sciences by studying the role of large infrastructure and SEZs in land grabbing. We suggest that the extant land grab literature can benefit from theoretical, methodological, and empirical attention to the effects of infrastructure on land, land governance, and dispossession. The chapter looks to the Laos-China Economic Corridor (LCEC) as a case to consider how the corridor model and related megaprojects of capital accumulation are designed to territorialize. By examining specific cases within the LCEC, we discuss and illustrate how megaprojects contribute to land grabbing and to what effect. We conclude with suggestions on how to expand this research agenda

Grounding Global China in Northern Laos: The Making of the Infrastructure Frontier

This dissertation provides an ethnography of global China centered on one infrastructural corridor in Northern Laos. Through an analysis of three interrelated infrastructure projects that have become emblematic of China&rsquo;s Belt and Road Initiative&mdash;the Laos&ndash;China Railway, Laos&ndash;China Economic Corridor, and Boten Special Economic Zone&mdash;I offer a grounded view on a story that is often told from faraway, geopolitical perspectives. I propose the concept of the infrastructure frontier as a more nuanced way to think about China&rsquo;s global expansion. A discursive and material phenomena, the infrastructure frontier is a capitalist project that remakes space and time to create conditions to accumulate capital. The infrastructure frontier is made through the discursive repetition of the need to unblock Laos; undervaluation of land; spectacle and performance to attract capital; more-than-economic logics of Chinese capital; and both Lao and Chinese state-support. Infrastructure frontier-making simultaneously encloses space to open it to certain types of &ldquo;development,&rdquo; capital, or exploitation. I show how the corridor and Boten were reinvented as zones of opportunity through performance, spectacle, and speculation. In addition, I show how the Lao state assembles land for railway construction and in anticipation for future value appropriation through techniques that create a lack of calculability and undervalue land. Furthermore, the dissertation demonstrates that rather than predatory, debt provides an outlet for overaccumulation by delaying devaluation of domestic Chinese capital. This is possible due to the involvement of Chinese SOEs and joint ventures that can take on long-term risk or transfer it to lower-level actors. Finally, this dissertation details local experiences of land loss and compensation. Rather than foregrounding dispossession, it explores how displacement and infrastructural temporalities work together to illuminate how people navigate suspension despite long periods of waiting, uncertainty around land, knowledge that past projects did not materialize, and feelings that participation and redress are not possible. In sum, this dissertation illustrates how the frontier is made and remade by capital and the state through infrastructure.</p

The new cold war and the rise of the 21st‐century infrastructure state

From Wiley via Jisc Publications RouterHistory: received 2020-03-07, rev-recd 2021-05-03, accepted 2021-06-14, pub-electronic 2021-08-02Article version: VoRPublication status: PublishedFunder: American Association of Geographers; Id: http://dx.doi.org/10.13039/100010262Funder: Association of Asian Studies, Chinese Academy of Sciences; Id: http://dx.doi.org/10.13039/501100002367Funder: University of Colorado Boulder; Id: http://dx.doi.org/10.13039/100007493Abstract: The unipolar international order led by the USA has given way to a multipolar order with the emergence of China as a great power competitor. According to many commentators, the deterioration of Sino–US relations in recent years heralds a “new Cold War.” The new Cold War differs from its namesake in many respects, and in this paper we focus on its novel territorial logic. Containing the USSR was the overriding objective of American foreign policy for nearly four decades, but in contrast, the USA and China are engaged in geopolitical‐economic competition to integrate territory into value chains anchored by their domestic lead firms through the financing and construction of transnational infrastructure (e.g., transportation networks and regional energy grids). We show this competition poses risks as well as opportunities for small states to articulate and realise spatial objectives. We present cases from Nepal and Laos that demonstrate that by hedging between China and the USA and its partners, their governments are able to pursue spatial objectives. In order to achieve them, however, they must implement significant reforms or state restructuring. The result is the emergence of what we term the 21st‐century infrastructure state, which seeks to mobilise foreign capital for infrastructure projects designed to enhance transnational connectivity

Chronic Stroke Sensorimotor Impairment Is Related to Smaller Hippocampal Volumes: An ENIGMA Analysis

Background. Persistent sensorimotor impairments after stroke can negatively impact quality of life. The hippocampus is vulnerable to poststroke secondary degeneration and is involved in sensorimotor behavior but has not been widely studied within the context of poststroke upper‐limb sensorimotor impairment. We investigated associations between non‐lesioned hippocampal volume and upper limb sensorimotor impairment in people with chronic stroke, hypothesizing that smaller ipsilesional hippocampal volumes would be associated with greater sensorimotor impairment. Methods and Results. Cross‐sectional T1‐weighted magnetic resonance images of the brain were pooled from 357 participants with chronic stroke from 18 research cohorts of the ENIGMA (Enhancing NeuoImaging Genetics through Meta‐Analysis) Stroke Recovery Working Group. Sensorimotor impairment was estimated from the FMA‐UE (Fugl‐Meyer Assessment of Upper Extremity). Robust mixed‐effects linear models were used to test associations between poststroke sensorimotor impairment and hippocampal volumes (ipsilesional and contralesional separately; Bonferroni‐corrected, P<0.025), controlling for age, sex, lesion volume, and lesioned hemisphere. In exploratory analyses, we tested for a sensorimotor impairment and sex interaction and relationships between lesion volume, sensorimotor damage, and hippocampal volume. Greater sensorimotor impairment was significantly associated with ipsilesional (P=0.005; β=0.16) but not contralesional (P=0.96; β=0.003) hippocampal volume, independent of lesion volume and other covariates (P=0.001; β=0.26). Women showed progressively worsening sensorimotor impairment with smaller ipsilesional (P=0.008; β=−0.26) and contralesional (P=0.006; β=−0.27) hippocampal volumes compared with men. Hippocampal volume was associated with lesion size (P<0.001; β=−0.21) and extent of sensorimotor damage (P=0.003; β=−0.15). Conclusions. The present study identifies novel associations between chronic poststroke sensorimotor impairment and ipsilesional hippocampal volume that are not caused by lesion size and may be stronger in women.S.-L.L. is supported by NIH K01 HD091283; NIH R01 NS115845. A.B. and M.S.K. are supported by National Health and Medical Research Council (NHMRC) GNT1020526, GNT1045617 (A.B.), GNT1094974, and Heart Foundation Future Leader Fellowship 100784 (A.B.). P.M.T. is supported by NIH U54 EB020403. L.A.B. is supported by the Canadian Institutes of Health Research (CIHR). C.M.B. is supported by NIH R21 HD067906. W.D.B. is supported by the Heath Research Council of New Zealand. J.M.C. is supported by NIH R00HD091375. A.B.C. is supported by NIH R01NS076348-01, Hospital Israelita Albert Einstein 2250-14, CNPq/305568/2016-7. A.N.D. is supported by funding provided by the Texas Legislature to the Lone Star Stroke Clinical Trial Network. Its contents are solely the responsibility of the authors and do not necessarily represent the of ficial views of the Government of the United States or the State of Texas. N.E.-B. is supported by Australian Research Council NIH DE180100893. W.F. is sup ported by NIH P20 GM109040. F.G. is supported by Wellcome Trust (093957). B.H. is funded by and NHMRC fellowship (1125054). S.A.K is supported by NIH P20 HD109040. F.B. is supported by Italian Ministry of Health, RC 20, 21. N.S. is supported by NIH R21NS120274. N.J.S. is supported by NIH/National Institute of General Medical Sciences (NIGMS) 2P20GM109040-06, U54-GM104941. S.R.S. is supported by European Research Council (ERC) (NGBMI, 759370). G.S. is supported by Italian Ministry of Health RC 18-19-20-21A. M.T. is sup ported by National Institute of Neurological Disorders and Stroke (NINDS) R01 NS110696. G.T.T. is supported by Temple University sub-award of NIH R24 –NHLBI (Dr Mickey Selzer) Center for Experimental Neurorehabilitation Training. N.J.S. is funded by NIH/National Institute of Child Health and Human Development (NICHD) 1R01HD094731-01A1

Safety of procuring research tissue during a clinically indicated kidney biopsy from patients with lupus: data from the Accelerating Medicines Partnership RA/SLE Network

Objectives In lupus nephritis the pathological diagnosis from tissue retrieved during kidney biopsy drives treatment and management. Despite recent approval of new drugs, complete remission rates remain well under aspirational levels, necessitating identification of new therapeutic targets by greater dissection of the pathways to tissue inflammation and injury. This study assessed the safety of kidney biopsies in patients with SLE enrolled in the Accelerating Medicines Partnership, a consortium formed to molecularly deconstruct nephritis.Methods 475 patients with SLE across 15 clinical sites in the USA consented to obtain tissue for research purposes during a clinically indicated kidney biopsy. Adverse events (AEs) were documented for 30 days following the procedure and were determined to be related or unrelated by all site investigators. Serious AEs were defined according to the National Institutes of Health reporting guidelines.Results 34 patients (7.2%) experienced a procedure-related AE: 30 with haematoma, 2 with jets, 1 with pain and 1 with an arteriovenous fistula. Eighteen (3.8%) experienced a serious AE requiring hospitalisation; four patients (0.8%) required a blood transfusion related to the kidney biopsy. At one site where the number of cores retrieved during the biopsy was recorded, the mean was 3.4 for those who experienced a related AE (n=9) and 3.07 for those who did not experience any AE (n=140). All related AEs resolved.Conclusions Procurement of research tissue should be considered feasible, accompanied by a complication risk likely no greater than that incurred for standard clinical purposes. In the quest for targeted treatments personalised based on molecular findings, enhanced diagnostics beyond histology will likely be required

Association of Brain Age, Lesion Volume, and Functional Outcome in Patients With Stroke

BACKGROUND AND OBJECTIVES: Functional outcomes after stroke are strongly related to focal injury measures. However, the role of global brain health is less clear. In this study, we examined the impact of brain age, a measure of neurobiological aging derived from whole-brain structural neuroimaging, on poststroke outcomes, with a focus on sensorimotor performance. We hypothesized that more lesion damage would result in older brain age, which would in turn be associated with poorer outcomes. Related, we expected that brain age would mediate the relationship between lesion damage and outcomes. Finally, we hypothesized that structural brain resilience, which we define in the context of stroke as younger brain age given matched lesion damage, would differentiate people with good vs poor outcomes. METHODS: We conducted a cross-sectional observational study using a multisite dataset of 3-dimensional brain structural MRIs and clinical measures from the ENIGMA Stroke Recovery. Brain age was calculated from 77 neuroanatomical features using a ridge regression model trained and validated on 4,314 healthy controls. We performed a 3-step mediation analysis with robust mixed-effects linear regression models to examine relationships between brain age, lesion damage, and stroke outcomes. We used propensity score matching and logistic regression to examine whether brain resilience predicts good vs poor outcomes in patients with matched lesion damage. RESULTS: We examined 963 patients across 38 cohorts. Greater lesion damage was associated with older brain age (β = 0.21; 95% CI 0.04-0.38, DISCUSSION: We provide evidence that younger brain age is associated with superior poststroke outcomes and modifies the impact of focal damage. The inclusion of imaging-based assessments of brain age and brain resilience may improve the prediction of poststroke outcomes compared with focal injury measures alone, opening new possibilities for potential therapeutic targets

Recovery and adaptation after the 2015 Nepal earthquakes: a smallholder household perspective

Communities reliant on subsistence and small-scale production are typically more vulnerable than others to disasters such as earthquakes. We study the earthquakes that struck Nepal in the spring of 2015 to investigate their impacts on smallholder communities and the diverse trajectories of recovery at the household and community levels. We focus on the first year following the earthquakes because this is when households were still devastated, yet beginning to recover and adapt. Through survey questionnaires, focus group discussions, open-ended interviews, and observations at public meetings we analyze physical impacts to farming systems and cropping cycles. We investigate respondent reports of loss and recovery through a new social-ecological recovery assessment instrument and find that diversification of livelihoods and access to common resources, alongside robust community institutions, were critical components of coping and recovery. There was widespread damage to subsistence farming infrastructure, which potentially accelerated ongoing transitions to cash crop adoption. We also find that perceptions of recovery varied widely among and within the typical predictors of recovery, such as caste and farm size, in sometimes unexpected ways. Although postdisaster recovery has material and psychosocial dimensions, our work shows that these may not change in the same direction