Examining the Relationship Between Markers of Emergency Department Crowding and Physician Wellbeing

Objectives- Explore changes to EP wellbeing over time. Evaluate the relationships between markers of ED crowding and boarding and EP wellbeinghttps://knowledgeconnection.mainehealth.org/lambrew-retreat-2021/1013/thumbnail.jp

Retrospective evaluation of whole exome and genome mutation calls in 746 cancer samples

Funder: NCI U24CA211006Abstract: The Cancer Genome Atlas (TCGA) and International Cancer Genome Consortium (ICGC) curated consensus somatic mutation calls using whole exome sequencing (WES) and whole genome sequencing (WGS), respectively. Here, as part of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium, which aggregated whole genome sequencing data from 2,658 cancers across 38 tumour types, we compare WES and WGS side-by-side from 746 TCGA samples, finding that ~80% of mutations overlap in covered exonic regions. We estimate that low variant allele fraction (VAF < 15%) and clonal heterogeneity contribute up to 68% of private WGS mutations and 71% of private WES mutations. We observe that ~30% of private WGS mutations trace to mutations identified by a single variant caller in WES consensus efforts. WGS captures both ~50% more variation in exonic regions and un-observed mutations in loci with variable GC-content. Together, our analysis highlights technological divergences between two reproducible somatic variant detection efforts

Visuals

Contains the poster file and the alluvial plot showing GMT drug types and variants

Measures

Description of how each measure in the analysis was categorize

ASCO QCS 2023: Socioeconomic survival disparity reduced for patients who receive genome matched treatment

This repository contains the supplemental materials associated with the "Socioeconomic survival disparity reduced for patients who receive genome matched treatment" poster. This poster has been presented at the ASCO Quality Care Symposium on October 27th, 2023

Urban-Rural and Socioeconomic Differences in Patient Knowledge and Perceptions of Genomic Tumor Testing

PURPOSE: Social determinants of health, such as rurality, income, and education, may widen health disparities by driving variation in patients\u27 knowledge and perceptions of medical interventions. This effect may be greatest for medical technologies that are hard to understand and less accessible. This study explored whether knowledge and perceptions (expectations and attitudes) of patients with cancer toward large-panel genomic tumor testing (GTT), an emerging cancer technology, vary by patient rurality independent of other socioeconomic characteristics (education and income). METHODS: Patients with cancer enrolled in a large precision oncology initiative completed surveys measuring rurality, sociodemographic characteristics, and knowledge and perceptions of GTT. We used multivariable linear models to examine differences in GTT knowledge, expectations, and attitudes by patient rurality, education, and income level. Models controlled for age, sex and clinical cancer stage and type. RESULTS: Rural patients had significantly lower knowledge of GTT than urban patients using bivariate models ( = .025). However, this association disappeared when adjusting for education and income level: patients with lower educational attainment and lower income had lower knowledge and higher expectations ( .002), whereas patients with higher income had more positive attitudes ( = .005). Urban patients had higher expectations of GTT compared with patients living in large rural areas ( = .011). Rurality was not associated with attitudes. CONCLUSION: Patients\u27 education and income level are associated with knowledge, expectations, and attitudes toward GTT, whereas rurality is associated with patient expectations. These findings suggest that efforts to promote adoption of GTT should focus on improving knowledge and awareness among individuals with low education and income. These differences may lead to downstream disparities in GTT utilization, which should be explored in future research

Urban-rural and socioeconomic differences in patient knowledge and perceptions of genomic tumor testing (2023)

This repository contains the analysis code associated with the Maine Cancer Genomics Initiative Disparities project, led by Eric Anderson. This manuscript has been published under the title “Urban-rural and socioeconomic differences in patient knowledge and perceptions of genomic tumor testing”. JCO PO published this manuscript on March 9, 2023