Odd-flavored QCD_3 and Random Matrix Theory

We consider QCD_3 with an odd number of flavors in the mesoscopic scaling region where the field theory finite-volume partition function is equivalent to a random matrix theory partition function. We argue that the theory is parity invariant at the classical level if an odd number of masses are zero. By introducing so-called pseudo-orthogonal polynomials we are able to relate the kernel to the kernel of the chiral unitary ensemble in the sector of topological charge $\nu={1/2}$. We prove universality and are able to write the kernel in the microscopic limit in terms of field theory finite-volume partition functions.Comment: 12 pages, Latex2e, 1 figure. Misprints corrected, minor changes in wording, one reference change

Wood Ant (Formica polyctena) Services and Disservices in a Danish Apple Plantation

Ants possess properties that can be used to optimize plant production in agricultural systems. Ant services can be herbivore and pathogen protection and fertilization of their plant partners. They may, however, also harm plants by facilitating ant-attended herbivorous homopterans. To assess whether wood ants can be used in IPM-systems to improve apple production, we transplanted wood ants into a Danish apple plantation and tested whether ants (i) reduced the number of herbivores, (ii) led to higher amounts of leaf nutrients, (iii) controlled apple pathogens, (iv) increased homopteran abundance and (iv) whether these effects affected apple yields. During a two year study, we found that the wood ants significantly reduced the numbers of winter moth larvae, increased magnesium content in apple leaves (but did not affect 10 other nutrients), reduced the number of apples infected with apple brown rot and apple scab (on one apple variety) and increased aphid infections. In the first year, this led to higher apple production on ant trees, whereas ants had no effect on yields in the second year. It was evident that ants provided both services and disservices. If mutualistic ant-homopteran interactions can be disrupted, this would favor plant growth and open for the use of wood ants in sustainable plant management. We discuss how this may be accomplished. Alternatively, ants may be used short term to knock down pest outbreaks (before building up homopteran populations) or used in crops that do not host ant-attended homopterans

Improved silencing properties using small internally segmented interfering RNAs

RNA interference is mediated by small interfering RNAs (siRNAs) that upon incorporation into the RNA-induced silencing complex (RISC) can target complementary mRNA for degradation. Standard siRNA design usually feature a 19–27 base pair contiguous double-stranded region that is believed to be important for RISC incorporation. Here, we describe a novel siRNA design composed of an intact antisense strand complemented with two shorter 10–12 nt sense strands. This three-stranded construct, termed small internally segmented interfering RNA (sisiRNA), is highly functional demonstrating that an intact sense strand is not a prerequisite for RNA interference. Moreover, when using the sisiRNA design only the antisense strand is functional in activated RISC thereby completely eliminating unintended mRNA targeting by the sense strand. Interestingly, the sisiRNA design supports the function of chemically modified antisense strands, which are non-functional within the context of standard siRNA designs. This suggests that the sisiRNA design has a clear potential of improving the pharmacokinetic properties of siRNA in vivo

Isolated Proofs of Knowledge and Isolated Zero Knowledge

We introduce a new notion called $\ell$-isolated proofs of knowledge ($\ell$-IPoK). These are proofs of knowledge where a cheating prover is allowed to exchange up to $\ell$ bits of communication with some external adversarial environment during the run of the proof. Without any additional setup assumptions, no witness hiding protocol can be an $\ell$-IPoK for \emph{unbounded} values of $\ell$. However, for any \emph{pre-defined} threshold $\ell$, and any relation in NP and we construct an $\ell$-IPoK protocol for that relation. The resulting protocols are zero knowledge (ZK) in the standard sense, i.e., w.r.t. a verifier that communicates only with the prover during the proof. The cost of having a large threshold $\ell$ is a large communication complexity of the constructed protocol. We analyze these costs and present a solution that is asymptotically optimal. If a cheating verifier is allowed to communicate arbitrarily with an external environment, it is not possible to construct an $\ell$-IPoK that is also ZK with respect to such a verifier. As another new notion, we define $\ell$-isolated zero knowledge ($\ell$-IZK) where the verifier is $\ell$-isolated. For every relation in NP and every $\ell$, we construct an $\ell$-IPoK protocol that is also $\ell$-IZK. We describe several applications of $\ell$-IPoK protocols under the physical assumption that one can $\ell$-isolate a prover for the duration of the proof phase. Firstly, we can use a witness indistinguishable (WI) $\ell$-IPoK to prevent ``man-in-the-middle\u27\u27 attacks on identification schemes. Prior results for this scenario required all verifiers to register keys under a PKI, or the ability to fully isolate the prover. Secondly, a partially isolated prover can register a public key and use a WI $\ell$-IPoK to prove knowledge of the corresponding secret key to another party acting as a verifier. This allows us to set up a PKI where the key registrant does not need to trust the Certificate Authority. The PKI is not perfect since the proof is only witness indistinguishable and not zero knowledge. In a companion paper, we show how to set up such a PKI and use it to implement arbitrary multiparty computation securely in the UC framework without relying on any trusted third parties

Mål og prioritering, vejsektorplan for Storstrøms Amt

Dette paper beskriver det grundlag omkring mål, planer og proces, som er anvendt i arbejdet med Storstrøms Amts vejsektorplan. Hensigten er, at vejsektorplanen både i dag og senere skal være et helhedpræget og aktuelt grundlag for amtets prioritering af investeringerne i landevejene. For vejområdet er formuleret seks hovedmål under følgende overskrifter: · Trafiksikkerhed· Miljø· Fremkommelighed· Vejtilstand· Service· Tilgængelighed Disse hovedmål sigter mod at "sætte brugeren i centrum". I vejplanlægningen fastlægges en række mere specifikke delmål for de forskellige behov hos brugerne, som amtet ønsker at tilgodese. Gennem en række delplaner tilstræbes en helhed i vejsektorplanens prioritering af de forskellige virkemidler på landevejene. Vejsektorplanen beskriver forudsætninger, metoder og mål for amtets vejplanlægning. Delplanernes tekniske prioritering af projekter sammenfattes, og der beskrives en politisk prioritering af budgettet på tværs af delplanerne. Vejsektorplanen angiver perspektiverne for indsats på 12 års sigt og foreslår investeringer i en 4 års budgetoverslagsperiode som udgangspunkt for den årlige handlingsplan. For at vejplanlægningen til stadighed kan være et aktuelt grundlag for amtets prioritering af projekter er det nødvendigt med mellemrum at opdatere delplanerne og vejsektorplanen. I sammenhæng med opdateringen kan der vurderes målopfyldelse og behov for anvendelse af nye strategier eller virkemidler. Vejsektorplanen revideres hvert 4. år i koordination med regionplanen og således, at der i hver amtsrådsperiode kan drøftes nye problemstillinger og mål for vejområdet. &nbsp

Illusory Sensation of Movement Induced by Repetitive Transcranial Magnetic Stimulation

Human movement sense relies on both somatosensory feedback and on knowledge of the motor commands used to produce the movement. We have induced a movement illusion using repetitive transcranial magnetic stimulation over primary motor cortex and dorsal premotor cortex in the absence of limb movement and its associated somatosensory feedback. Afferent and efferent neural signalling was abolished in the arm with ischemic nerve block, and in the leg with spinal nerve block. Movement sensation was assessed following trains of high-frequency repetitive transcranial magnetic stimulation applied over primary motor cortex, dorsal premotor cortex, and a control area (posterior parietal cortex). Magnetic stimulation over primary motor cortex and dorsal premotor cortex produced a movement sensation that was significantly greater than stimulation over the control region. Movement sensation after dorsal premotor cortex stimulation was less affected by sensory and motor deprivation than was primary motor cortex stimulation. We propose that repetitive transcranial magnetic stimulation over dorsal premotor cortex produces a corollary discharge that is perceived as movement

Metaproteomics of saliva identifies human protein markers specific for individuals with periodontitis and dental caries compared to orally healthy controls

Background The composition of the salivary microbiota has been reported to differentiate between patients with periodontitis, dental caries and orally healthy individuals. To identify characteristics of diseased and healthy saliva we thus wanted to compare saliva metaproteomes from patients with periodontitis and dental caries to healthy individuals. Methods Stimulated saliva samples were collected from 10 patients with periodontitis, 10 patients with dental caries and 10 orally healthy individuals. The proteins in the saliva samples were subjected to denaturing buffer and digested enzymatically with LysC and trypsin. The resulting peptide mixtures were cleaned up by solid-phase extraction and separated online with 2 h gradients by nano-scale C18 reversed-phase chromatography connected to a mass spectrometer through an electrospray source. The eluting peptides were analyzed on a tandem mass spectrometer operated in data-dependent acquisition mode. Results We identified a total of 35,664 unique peptides from 4,161 different proteins, of which 1,946 and 2,090 were of bacterial and human origin, respectively. The human protein profiles displayed significant overexpression of the complement system and inflammatory markers in periodontitis and dental caries compared to healthy controls. Bacterial proteome profiles and functional annotation were very similar in health and disease. Conclusions Overexpression of proteins related to the complement system and inflammation seems to correlate with oral disease status. Similar bacterial proteomes in healthy and diseased individuals suggests that the salivary microbiota predominantly thrives in a planktonic state expressing no disease-associated characteristics of metabolic activity