Measuring and Correcting Response Heaping Arising From the Use of Prototypes

Imprecision in respondent recall can cause response heaping in frequency data for particular values (e.g., 5, 10, 15). In human dimensions research, heaping can occur for variables such as days of participation (e.g., hunting, fishing), animals/fish harvested, or money spent on licenses. Distributions with heaps can bias population estimates because the means and totals can be inflated or deflated. Because bias can result in poor management decisions, determining if the bias is large enough to matter is important. This note introduces the logic and flow of a deheaping program that estimates bias in means and totals when people use approximate responses (i.e., prototypes). The program can make estimates even when spikes occur due to bag limits. The program is available online, and smooths heaps at multiples of 5 (numbers ending in 5 and 0) and 7 (e.g., 7, 14, 21), and produces standard deviations in estimates

Expression profile of CREB knockdown in myeloid leukemia cells.

BackgroundThe cAMP Response Element Binding Protein, CREB, is a transcription factor that regulates cell proliferation, differentiation, and survival in several model systems, including neuronal and hematopoietic cells. We demonstrated that CREB is overexpressed in acute myeloid and leukemia cells compared to normal hematopoietic stem cells. CREB knockdown inhibits leukemic cell proliferation in vitro and in vivo, but does not affect long-term hematopoietic reconstitution.MethodsTo understand downstream pathways regulating CREB, we performed expression profiling with RNA from the K562 myeloid leukemia cell line transduced with CREB shRNA.ResultsBy combining our expression data from CREB knockdown cells with prior ChIP data on CREB binding we were able to identify a list of putative CREB regulated genes. We performed extensive analyses on the top genes in this list as high confidence CREB targets. We found that this list is enriched for genes involved in cancer, and unexpectedly, highly enriched for histone genes. Furthermore, histone genes regulated by CREB were more likely to be specifically expressed in hematopoietic lineages. Decreased expression of specific histone genes was validated in K562, TF-1, and primary AML cells transduced with CREB shRNA.ConclusionWe have identified a high confidence list of CREB targets in K562 cells. These genes allow us to begin to understand the mechanisms by which CREB contributes to acute leukemia. We speculate that regulation of histone genes may play an important role by possibly altering the regulation of DNA replication during the cell cycle

GAS: A Gaussian Mixture Distribution-Based Adaptive Sampling Method for PINNs

With recent study of the deep learning in scientific computation, the PINNs method has drawn widespread attention for solving PDEs. Compared with traditional methods, PINNs can efficiently handle high-dimensional problems, while the accuracy is relatively low, especially for highly irregular problems. Inspired by the idea of adaptive finite element methods and incremental learning, we propose GAS, a Gaussian mixture distribution-based adaptive sampling method for PINNs. During the training procedure, GAS uses the current residual information to generate a Gaussian mixture distribution for the sampling of additional points, which are then trained together with history data to speed up the convergence of loss and achieve a higher accuracy. Several numerical simulations on 2d to 10d problems show that GAS is a promising method which achieves the state-of-the-art accuracy among deep solvers, while being comparable with traditional numerical solvers

Exactly solvable configuration mixing scheme in the vibrational limit of the interacting boson model

An intruder configuration mixing scheme with 2n-particle and 2n-hole configurations from n=0 up to n→ in the U(5) (vibrational) limit of the interacting boson model is proposed. A simple Hamiltonian suitable to describe the intruder and normal configuration mixing is found to be exactly solvable, and its eigenstates can be expressed as the SU(1,1) coherent states built on the U(5) basis vectors of the interacting boson model. It is shown that the configuration mixing scheme keeps lower part of the vibrational spectrum unchanged and generates the intruder states due to the mixing. Some low-lying level energies and experimentally known B(E2) ratios of Cd108,110 are fitted and compared with the experimental results

Incrementally updating the high average-utility patterns with pre-large concept

High-utility itemset mining (HUIM) is considered as an emerging approach to detect the high-utility patterns from databases. Most existing algorithms of HUIM only consider the itemset utility regardless of the length. This limitation raises the utility as a result of a growing itemset size. High average-utility itemset mining (HAUIM) considers the size of the itemset, thus providing a more balanced scale to measure the average-utility for decision-making. Several algorithms were presented to efficiently mine the set of high average-utility itemsets (HAUIs) but most of them focus on handling static databases. In the past, a fast-updated (FUP)-based algorithm was developed to efficiently handle the incremental problem but it still has to re-scan the database when the itemset in the original database is small but there is a high average-utility upper-bound itemset (HAUUBI) in the newly inserted transactions. In this paper, an efficient framework called PRE-HAUIMI for transaction insertion in dynamic databases is developed, which relies on the average-utility-list (AUL) structures. Moreover, we apply the pre-large concept on HAUIM. A pre-large concept is used to speed up the mining performance, which can ensure that if the total utility in the newly inserted transaction is within the safety bound, the small itemsets in the original database could not be the large ones after the database is updated. This, in turn, reduces the recurring database scans and obtains the correct HAUIs. Experiments demonstrate that the PRE-HAUIMI outperforms the state-of-the-art batch mode HAUI-Miner, and the state-of-the-art incremental IHAUPM and FUP-based algorithms in terms of runtime, memory, number of assessed patterns and scalability.publishedVersio