CO2 lasers in the management of potentially malignant and malignant oral disorders

The CO2 laser was invented in 1963 by Kumar Patel. Since the early 1970s, CO2 laser has proved to be an effective method of treatment for patients with several types of oral lesions, including early squamous cell carcinoma. Laser surgery of oral premalignant disorders is an effective tool in a complete management strategy which includes careful clinical follow-up, patient education to eliminate risk factors, reporting and biopsying of suspicious lesions and any other significant lesions. However, in a number of patients, recurrence and progression to malignancy remains a risk. CO2 laser resection has become the preferred treatment for small oral and oropharyngeal carcinomas. Laser resection does not require reconstructive surgery. There is minimal scarring and thus, optimum functional results can be expected. New and improved applications of laser surgery in the treatment of oral and maxillofacial/head and neck disorders are being explored. As more surgeons become experienced in the use of lasers and as our knowledge of the capabilities and advantages of this tool expands, lasers may play a significant role in the management of different pathologies

Análisis de los resultados electorales del 1-M

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Structural validation of oral mucosal tissue using optical coherence tomography

Background: Optical coherence tomography (OCT) is a non-invasive optical technology using near-infrared light to produce cross-sectional tissue images with lateral resolution. Objectives: The overall aims of this study was to generate a bank of normative and pathological OCT data of the oral tissues to allow identification of cellular structures of normal and pathological processes with the aim to create a diagnostic algorithm which can be used in the early detection of oral disorders. Material and methods: Seventy-three patients with 78 suspicious oral lesions were referred for further management to the UCLH Head and Neck Centre, London. The entire cohort had their lesions surgically biopsied (incisional or excisional). The immediate ex vivo phase involved scanning the specimens using optical coherence tomography. The specimens were then processed by a histopathologist. Five tissue structures were evaluated as part of this study, including: keratin cell layer, epithelial layer, basement membrane, lamina propria and other microanatomical structures. Two independent assessors (clinician and pathologist trained to use OCT) assessed the OCT images and were asked to comment on the cellular structures and changes involving the five tissue structures in non-blind fashion. Results: Correct identification of the keratin cell layer and its structural changes was achieved in 87% of the cohort; for the epithelial layer it reached 93.5%, and 94% for the basement membrane. Microanatomical structures identification was 64% for blood vessels, 58% for salivary gland ducts and 89% for rete pegs. The agreement was “good” between the clinician and the pathologist. OCT was able to differential normal from pathological tissue and pathological tissue of different entities in this immediate ex vivo study. Unfortunately, OCT provided inadequate cellular and subcellular information to enable the grading of oral premalignant disorders. Conclusion: This study enabled the creation of OCT bank of normal and pathological oral tissues. The pathological changes identified using OCT enabled differentiation between normal and pathological tissues, and identification of different tissue pathologies. Further studies are required to assess the accuracy of OCT in identification of various pathological processes involving the oral tissues

Cristianismo, universidad y desafío ético

En el presente trabajo se intenta trazar la relación que ha existido entre el cristianismo y la vida académica, cuya máxima expresión fue la creación de las universidades en el mundo occidental por la iglesia institucional. Las universidades en muchos casos se han salido de la órbita del cristianismo, e incluso se han lanzado contra el mismo en su expresión institucional y simbólica. A pesar de ello, sin embargo, el cristianismo ha considerado la creación y conducción de universidades como parte de su misión en el mundo

Current practice in the management of frontal sinus fractures

Fractures of the frontal sinus are seen predominantly, although not exclusively, in young men and are usually the result of road traffic accidents or falls. These types of injury may present to either ENT, Maxillofacial, Plastic or Neurosurgery teams, and understanding of a clear management protocol is desirable for each of the specialties. The optimal management of these injuries is becoming more uniformly adopted although some areas of contention still persist. The aim of treatment has always been directed at creating a 'safe sinus' that is not complicated by the late sequelae of infection or mucocele formation. The difficulty lies in being able to predict which patients are likely to develop these complications. The aim of this paper is to evaluate the literature and offer a rationale for the management of these injuries

Local Elections and Organised Crime: The Case of Michoacán, Mexico

This study, based on ethnographic analysis, reveals that municipal government elections in Mexico have become spaces of struggle among criminal groups striving to strengthen their presence throughout the territory. In municipal contexts characterised by institutional vacuums, delinquent organisations have succeeded in capturing political spaces. We argue that the continuous violence that has plagued the country since 2013 can be explained largely by factors of an institutional order coupled with distorted electoral processes in municipalities and states, exacerbated by widespread citizen disenchantment with democracy and especially manifest at the level of local government. This situation suggests the need for strategies that address the influence of these criminal groups that go beyond police-based approaches and for actions designed to improve the quality of state institutions