Pseudoepitheliomatous Hyperplasia of the Larynx Requiring Total Laryngectomy

Medicin

Aceleradores de Partículas en España: Centro Nacional de Aceleradores. Cultura Científica para y con la Sociedad

Trabajo presentado en el III Foro Iberoamericano de Divulgación y Cultura Científica, celebrado en Córdoba (España), el 25 de noviembre de 2017El avance científico ha de tener como objetivo buscar la solución de problemas existentes y la mejora de las condiciones de vida de la sociedad pero sin dejar de lado la investigación básica puesto que los avances que se consigan en ella puede que originen un impacto positivo en el bienestar social en un futuro. La Cultura Científica y de la Innovación, CC+i, engloba todas aquellas acciones que tienen por objetivo el trasmitir conocimiento científico desde los actores de la Ciencia hacia el público y permitir que este público participe activamente en la toma de decisiones de política científica. Las acciones que se llevan a cabo en el CNA dentro del campo de la Cultura Científica son las siguientes: Visitas Guiadas, Ferias, Talleres Experimentales, Conferencias, Exposiciones, Estudios de Sociales de la Ciencia y Comunicación escrita de la Ciencia. Según la interacción entre emisor del mensaje y público, las acciones en CC se pueden clasificar en divulgativas y comunicación científica.Peer reviewe

UCC+i del Centro Nacional de Aceleradores (CNA)

Centro Nacional de Aceleradores (CNA), centro de investigación de titularidad pública. El número de investigadores/personal docente es de 30. La UCC+i es una Unidad de Trabajo propia del centro (http://bit.do/uccicna). La Unidad está especializada en comunicación científi ca y divulgación.Peer Reviewe

Experiencia de aprendizaje mediante grupos interactivos, en un contexto de desventaja sociocultural, como medida para prevenir el fracaso escolar y la violencia

Se ha pretendido introducir en el centro un proceso innovador basado en una metodología de enseñanza-aprendizaje centrada en el valor educativo de los grupos interactivos. Las actividades del Primer Ciclo se han agrupado en cinco tiempo de 20 minutos. En Segundo Ciclo y PGS se han organizado actividades para consolidar habilidades instrumentales y desarrollar valores, en tiempos de 30 minutos. Se ha observado una mejora tanto en la evolución curricular del alumnado como en el trabajo cooperativo, comportamiento y actitud reduciéndose las agresiones verbales y físicas, las continuas faltas de respeto y el absentismo que hasta ahora padecía el centro.Junta de Andalucía. Consejería de EducaciónAndalucíaIES Siglo XXI; Calle Torrelaguna, sin número; 41017 Sevilla; +34954409773; +34954475042; [email protected]

Kidins220 accumulates with tau in human Alzheimer's disease and related models: Modulation of its calpain-processing byGSK3β/PP1 imbalance

Failures in neurotrophic support and signalling play key roles in Alzheimer's disease (AD) pathogenesis. We previously demonstrated that downregulation of the neurotrophin effector Kinase D interacting substrate (Kidins220) by excitotoxicity and cerebral ischaemia contributed to neuronal death. This downregulation, triggered through overactivation of N-methyl-d-aspartate receptors (NMDARs), involved proteolysis of Kidins220 by calpain and transcriptional inhibition. As excitotoxicity is at the basis of AD aetiology, we hypothesized that Kidins220 might also be downregulated in this disease. Unexpectedly, Kidins220 is augmented in necropsies from AD patients where it accumulates with hyperphosphorylated tau. This increase correlates with enhanced Kidins220 resistance to calpain processing but no higher gene transcription. Using AD brain necropsies, glycogen synthase kinase 3-β (GSK3β)-transgenic mice and cell models of AD-related neurodegeneration, we show that GSK3β phosphorylation decreases Kidins220 susceptibility to calpain proteolysis, while protein phosphatase 1 (PP1) action has the opposite effect. As altered activities of GSK3β and phosphatases are involved in tau aggregation and constitute hallmarks in AD, a GSK3β/PP1 imbalance may also contribute to Kidins220 decreased clearance, accumulation and hampered neurotrophin signalling from early stages of the disease pathogenesis. These results encourage searches for mutations in Kidins220 gene and their possible associations to dementias. Finally, our data support a model where the effects of excitotoxicity drastically differ when occurring in cerebral ischaemia versus progressively sustained toxicity along AD progression. The striking differences in Kidins220 stability resulting from chronic versus acute brain damage may also have important implications for the therapeutic intervention of neurodegenerative disorders. © The Author 2012. Published by Oxford University Press. All rights reserved.This work was supported by the Ministerio de Economía y Competitividad (SAF2011-26233 to T.I., BFU2010-18380/BFI to M.D.-G., SAF2010-15125 to M.R.C., SAF2006-02424 to F.H., SAF2010-15525 to J.A.); Comunidad de Madrid (P2010/BMD-2332-Neurodegmodels to T.I., F.H. and J.A.); and Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas – CIBERNED, Instituto de Salud Carlos III, to T.I., F.H., J.A. and I.F. C.L.-M. is a recipient of a contract from SAF2011-26233; A.G.-M. has been funded by Noscira S.A. and a contract from P2010/BMD-2332; J.J.-A. is a recipient of a pre-doctoral fellowship/contract from Consejo Superior de Investigaciones Científicas and A.M.H. is a recipient of a contract from Hospital Nacional de Parapléjicos/Servicio de Salud de Castilla-La Mancha.Peer Reviewe

Concomitant administration of seasonal influenza and COVID-19 mRNA vaccines

ABSTRACTCurrent clinical guidelines support the concomitant administration of seasonal influenza vaccines and COVID-19 mRNA boosters vaccine. Whether dual vaccination may impact vaccine immunogenicity due to an interference between influenza or SARS-CoV-2 antigens is unknown. We aimed to understand the impact of mRNA COVID-19 vaccines administered concomitantly on the immune response to influenza vaccines. For this, 128 volunteers were vaccinated during the 22-23 influenza season. Three groups of vaccination were assembled: FLU vaccine only (46, 35%) versus volunteers that received the mRNA bivalent COVID-19 vaccines concomitantly to seasonal influenza vaccines, FluCOVID vaccine in the same arm (42, 33%) or different arm (40, 31%), respectively. Sera and whole blood were obtained the day of vaccination, +7, and +28 days after for antibody and T cells response quantification. As expected, side effects were increased in individuals who received the FluCOVID vaccine as compared to FLU vaccine only based on the known reactogenicity of mRNA vaccines. In general, antibody levels were high at 4 weeks post-vaccination and differences were found only for the H3N2 virus when administered in different arms compared to the other groups at day 28 post-vaccination. Additionally, our data showed that subjects that received the FluCOVID vaccine in different arm tended to have better antibody induction than those receiving FLU vaccines for H3N2 virus in the absence of pre-existing immunity. Furthermore, no notable differences in the influenza-specific cellular immune response were found for any of the vaccination groups. Our data supports the concomitant administration of seasonal influenza and mRNA COVID-19 vaccines

Clinical Presentation of the SARS-CoV-2 Virus Infection and Predictive Validity of the PCR Test in Primary Health Care Worker Patients of the Spanish National Health System.

Despite the impact that the SARS-CoV-2 virus infection has presented in Spain, data on the diagnostic capacity of the symptoms associated with this infection are limited, especially among patients with mild symptoms and who are detected in the primary care field (PC). The objective of the present study was to know the associated symptoms and their predictive criterial validity in SARS-CoV-2 infection among professionals working in PC. A cross-sectional, multicenter study was carried out in the Spanish National Health System, through an epidemiological survey directed to patients who underwent the PCR test for SARS-CoV-2 in the PC setting. A total of 1612 patients participated, of which 86.6% were PC healthcare professionals, and of these, 67.4% family doctors. Hyposmia, with a sensitivity of 42.69% (95% CI: 37.30-48.08) and a specificity of 95.91% (95% CI: 94.78-97.03), and ageusia with a sensitivity of 39.47% (34.15-44.80) and a specificity of 95.20% (93.98-96.41) were the symptoms with the highest criteria validity indexes. This study identifies the specific symptoms of loss of smell or taste as the most frequently associated with SARS-CoV-2 infection, essential in the detection of COVID-19 given its high frequency and predictive capacity

Long COVID Symptomatology and Associated Factors in Primary Care Patients: The EPICOVID-AP21 Study

Persistent COVID-19 condition includes a wide variety of symptoms and health problems of indeterminate duration. The present study examined the sociodemographic and clinical characteristics of the population with Long COVID seen in Primary Care using a questionnaire based on the existing scientific literature. It was an observational and descriptive study of the characteristics of the Spanish population with Long COVID over 14 years of age. The responses were analysed by means of a descriptive analysis of the variables recorded, in addition to a bivariate analysis to determine the existence of a relationship between persistent COVID-19 and variables such as gender, age, vaccination status or concomitant pathology. The results obtained clearly describe the sociodemographic characteristics of the population, highlighting the predominance of female gender and the prevalence of tiredness and fatigue. Furthermore, relevant information was obtained on the differences in symptomatology according to gender, age, previous pathologies and alterations derived from infection and/or vaccination. These data are important for better detection, diagnosis and treatment of Long COVID and the improvement of the quality of life of this population

Concomitant administration of seasonal influenza and COVID-19 mRNA vaccines

Current clinical guidelines support the concomitant administration of seasonal influenza vaccines and COVID-19 mRNA boosters vaccine. Whether dual vaccination may impact vaccine immunogenicity due to an interference between influenza or SARS-CoV-2 antigens is unknown. We aimed to understand the impact of mRNA COVID-19 vaccines administered concomitantly on the immune response to influenza vaccines. For this, 128 volunteers were vaccinated during the 22-23 influenza season. Three groups of vaccination were assembled: FLU vaccine only (46, 35%) versus volunteers that received the mRNA bivalent COVID-19 vaccines concomitantly to seasonal influenza vaccines, FluCOVID vaccine in the same arm (42, 33%) or different arm (40, 31%), respectively. Sera and whole blood were obtained the day of vaccination, +7, and +28 days after for antibody and T cells response quantification. As expected, side effects were increased in individuals who received the FluCOVID vaccine as compared to FLU vaccine only based on the known reactogenicity of mRNA vaccines. In general, antibody levels were high at 4 weeks post-vaccination and differences were found only for the H3N2 virus when administered in different arms compared to the other groups at day 28 post-vaccination. Additionally, our data showed that subjects that received the FluCOVID vaccine in different arm tended to have better antibody induction than those receiving FLU vaccines for H3N2 virus in the absence of pre-existing immunity. Furthermore, no notable differences in the influenza-specific cellular immune response were found for any of the vaccination groups. Our data supports the concomitant administration of seasonal influenza and mRNA COVID-19 vaccines.Premio Mensual Publicación Científica Destacada de la US. Facultad de Medicin