Stability versus progress: finding an effective model of supported housing for formerly homeless people with mental health needs

Finding an effective model of support that enables homeless people with mental health needs to sustain accommodation has presented a continuous challenge to both policy makers and practitioners. This article is based on a study of a residential hostel for formerly homeless men with a variety of mental health conditions in a Midlands city. The hostel was selected because it appeared to work in terms of anecdotal evidence of reduced hospital re-admissions and engagement with support services. By studying the views, experiences and perspectives of all stakeholders, the research sought to understand what was distinctive about the hostel, what worked well and for whom. The findings revealed that three things were of particular importance to stakeholders: residents’ willingness to engage with support services; increased stability in residents’ lives; and increased independence. A common element in the factors that contributed to the hostel’s success against these criteria was the sense of community between staff and residents, which was maintained following moves to independent accommodation. The policy implications for the long-term sustainability of this model will be explored in the conclusion

Helium ion microscopy and energy selective scanning electron microscopy – two advanced microscopy techniques with complementary applications

Both scanning electron microscopes (SEM) and helium ion microscopes (HeIM) are based on the same principle of a charged particle beam scanning across the surface and generating secondary electrons (SEs) to form images. However, there is a pronounced difference in the energy spectra of the emitted secondary electrons emitted as result of electron or helium ion impact. We have previously presented evidence that this also translates to differences in the information depth through the analysis of dopant contrast in doped silicon structures in both SEM and HeIM. Here, it is now shown how secondary electron emission spectra (SES) and their relation to depth of origin of SE can be experimentally exploited through the use of energy filtering (EF) in low voltage SEM (LV-SEM) to access bulk information from surfaces covered by damage or contamination layers. From the current understanding of the SES in HeIM it is not expected that EF will be as effective in HeIM but an alternative that can be used for some materials to access bulk information is presented

Death and life after death: Children’s concepts and their place in religious education

The thesis addresses the issue of what are primary school age children's concepts of death and life after death and explores their place in the teaching of Religious Education in the UK.A synopsis of the doctrines and death rite practices of the six major religions are reviewed. The place of those concepts in Religious Education is presented and discussed. Qualitative and quantitative research method techniques are employed using semi- structured interviews and questionnaires. Two age groups of primary school children are targeted for the purposes of the interviews and main research study questionnaire 一 7-8 (Year 3) and 10-11 (Year 6) year olds. A total of fifteen interviews was conducted as a pilot study. The main research study questionnaire involved 763 respondents from eleven schools ― 406 from a multi-faith and multi-cultural region and 357 from a culturally more homogenous region. These elements allow for age and gender demographic factors and for the environmental factors ― belonging to a faith community and living in a multi-faith and multi-cultural region to be analysed. Four hypotheses were formulated and focused on the patterns of association between children’s concepts of death and life after death and four independent variables —— age, faith, gender and location. The following hypotheses were tested for evidence of the patterns of association between the variables through a quantitative test of significance:1. Age: Younger children are as able as older children to conceptualize death and life after death2. Faith: Children with no faith-base are as able as those with a faith-base to conceptualize death and life after death3. Gender: Boys are as able as girls to conceptualize death and life after death4. Location: Children not living in a multi-faith and multi-cultural region are as able as those who do to conceptualize death and life after death The results of the analysis were as follows: Age hypothesis: there was a difference between younger and older children. Faith hypothesis: it was possible to trace differences according to faith-base. Gender hypothesis: there was only a difference between boys and girls with respect to what they think comes after death. Location hypothesis: there was a difference according to location. The tests of significance were then complemented by examining patterns in the qualitative data to explore trends and exceptions where appropriate. A range of examples of the children’s responses are used to illustrate the findings and are evaluated. This research shows that children are willing and able to express their concepts of death and life after death regardless of age, faith, gender or location. The research affirms that children are capable of considering the concepts of death and life after death and they should be given the opportunity to explore them further. School is m advantageous and universally available place where meaningful consideration of the search of these concepts should occur as school is a familiar environment for discovery, learning and understanding for children. Religious Education is the most relevant area of the school curriculum where children’s discovery and learning can be focused on the exploration of these concepts through investigating ultimate questions with the rites of passage and doctrines of the major world religions. The quantitative and qualitative data produced and analysed in this thesis provide sufficient confirmation to support the meaningful and worthwhile updating of Religious Education syllabi for implementation by teachers and those responsible for Religious Education

O-mannosylation in Candida albicans enables development of interkingdom biofilm communities

Peer reviewedPublisher PD

Factors influencing the relationship between the dose of amlodipine required for blood pressure control and change in blood pressure in hypertensive cats

BACKGROUND: Hypertension is a common problem in elderly cats. In most cats, systolic blood pressure (SBP) of <160 mmHg is achieved in response to amlodipine besylate at either 0.625 or 1.25 mg q24h. The individual cat factors determining dose requirement dose have not been explored. AIMS: To determine whether individual cat factors influence the dose of amlodipine required to achieve adequate blood pressure control and to determine whether factors other than the prescribed dose of drug alter the achieved plasma amlodipine concentrations. METHODS: Fifty‐nine hypertensive cats that required 0.625 mg (A) and 41 cats that required 1.25 mg (B) amlodipine to reach a target SBP of <160 mmHg were identified, and plasma amlodipine concentrations were determined. Comparisons were made between groups, and multivariable linear regression models were performed to investigate predictors of antihypertensive response. RESULTS: Cats that required a greater dose of amlodipine had significantly higher SBP at diagnosis of hypertension (A: (median [25th, 75th percentile]) 182 [175,192] mmHg; B: 207 [194,217] mmHg, P < .001), but comparable blood pressure was achieved after treatment. Plasma amlodipine concentrations were directly related to the dose of amlodipine administered. At diagnosis, cats in group B had significantly lower plasma potassium concentration (A: 4.1 [3.8,4.5]; B: 3.8 [3.6,4.2] mEq/L, P < .01). Weight did not differ between groups. The decrease in SBP was directly and independently associated with the SBP at diagnosis and the plasma amlodipine concentration. CONCLUSIONS AND CLINICAL IMPORTANCE: Cats with higher blood pressure at diagnosis might require a greater dose of amlodipine to control their blood pressure adequately. Differences in amlodipine pharmacokinetics between cats do not seem to play a role in the antihypertensive response

Spatiotemporal patterns and agro-ecological risk factors for cutaneous and renal glomerular vasculopathy (Alabama Rot) in dogs in the UK

Seasonal outbreaks of cutaneous and renal glomerular vasculopathy (CRGV) have been reported annually in UK dogs since 2012, yet the aetiology of the disease remains unknown. The objectives of this study were to explore whether any breeds had an increased or decreased risk of being diagnosed with CRGV, and to report on age and sex distributions of CRGV cases occurring in the UK. Multivariable logistic regression was used to compare 101 dogs diagnosed with CRGV between November 2012 and May 2017 with a denominator population of 446,453 dogs from the VetCompass database. Two Kennel Club breed groups—hounds (odds ratio (OR) 10.68) and gun dogs (OR 9.69)—had the highest risk of being diagnosed with CRGV compared with terriers, while toy dogs were absent from among CRGV cases. Females were more likely to be diagnosed with CRGV (OR 1.51) as were neutered dogs (OR 3.36). As well as helping veterinarians develop an index of suspicion for the disease, better understanding of the signalment risk factors may assist in the development of causal models for CRGV and help identify the aetiology of the disease

Renal fibrosis in feline chronic kidney disease: known mediators and mechanisms of injury

Chronic kidney disease (CKD) is a common medical condition of ageing cats. In most cases the underlying aetiology is unknown, but the most frequently reported pathological diagnosis is renal tubulointerstitial fibrosis. Renal fibrosis, characterised by extensive accumulation of extra-cellular matrix within the interstitium, is thought to be the final common pathway for all kidney diseases and is the pathological lesion best correlated with function in both humans and cats. As a convergent pathway, renal fibrosis provides an ideal target for the treatment of CKD and knowledge of the underlying fibrotic process is essential for the future development of novel therapies. There are many mediators and mechanisms of renal fibrosis reported in the literature, of which only a few have been investigated in the cat. This article reviews the process of renal fibrosis and discusses the most commonly cited mediators and mechanisms of progressive renal injury, with particular focus on the potential significance to feline CKD

Signalment risk factors for cutaneous and renal glomerular vasculopathy (Alabama rot) in dogs in the UK

Seasonal outbreaks of cutaneous and renal glomerular vasculopathy (CRGV) have been reported annually in UK dogs since 2012, yet the aetiology of the disease remains unknown. The objectives of this study were to explore whether any breeds had an increased or decreased risk of being diagnosed with CRGV, and to report on age and sex distributions of CRGV cases occurring in the UK. Multivariable logistic regression was used to compare 101 dogs diagnosed with CRGV between November 2012 and May 2017 with a denominator population of 446,453 dogs from the VetCompass database. Two Kennel Club breed groups—hounds (odds ratio (OR) 10.68) and gun dogs (OR 9.69)—had the highest risk of being diagnosed with CRGV compared with terriers, while toy dogs were absent from among CRGV cases. Females were more likely to be diagnosed with CRGV (OR 1.51) as were neutered dogs (OR 3.36). As well as helping veterinarians develop an index of suspicion for the disease, better understanding of the signalment risk factors may assist in the development of causal models for CRGV and help identify the aetiology of the disease

Critical success factors for implementing risk management systems in developing countries

A review of published studies on risk management in developing countries reveals that critical success factors for implementing risk management has remained an under-researched area of investigation. This paper is aimed at investigating the perceptions of construction professionals concerning the critical success factors (CSFs) for implementation of risk management systems (IRMS). Survey data was collected from 87 construction professionals from the Iranian construction industry as a developing country. The results indicate that four factors are regarded as highly critical: &lsquo;support from managers&rsquo;, &lsquo;inclusion of risk management in construction education and training courses for construction practitioners&rsquo;, &lsquo;attempting to deliver projects systematically&rsquo;, and &lsquo;awareness and knowledge of the process for implementing risk management&rsquo;. Assessing the associations among CSFs also highlighted the crucial role of enhancing the effectiveness of knowledge management practices in construction organisations. Study also revealed that parties involved in projects do not agree on the level of importance of CSFs for implementing risk management in developing countries. This study contributes to practice and research in several ways. For practice, it increases understanding of how closely knowledge management is associated with the implementation of risk management systems in developing countries. For research, the findings would encourage construction practitioners to support effective knowledge management as a precursor to higher levels of risk management implementation on construction projects

The association of bacteriuria with survival and disease progression in cats with azotemic chronic kidney disease

Background Cats with chronic kidney disease (CKD) have an increased prevalence of positive urine cultures (PUC). Limited information is available regarding the prognosis of cats with CKD and concurrent PUC. Objective To determine the association of PUC with survival time and disease progression in cats with CKD. Animals Medical records of 509 cats diagnosed with azotemic CKD between 1997 and 2018. Methods Cats were classified as having “no‐PUC” or “PUC.” The PUC cats were further classified as having 1 or multiple PUC, and also were classified based on the presence or absence of clinical signs of urinary tract infection (UTI). Progression of CKD was defined as a plasma creatinine concentration increase of ≥25% within 365 days of CKD diagnosis; PUC also must have occurred within this time frame. Survival time and frequency of CKD progression were compared between groups. Results No significant difference in survival time was found between cats with no‐PUC and cats with any number of PUC (P = .91), or between cats with no‐PUC, 1 PUC or multiple PUC (P = .37). Also, no significant difference was found in the frequency of CKD progression between PUC and no‐PUC cats (P = .5), or among no‐PUC, 1 PUC and multiple PUC cats (P = .22). When assessing cats with clinical signs of lower UTI, no significant difference was found in the frequency of CKD progression between cats with true UTI, subclinical bacteriuria or no‐PUC (P = .8). Conclusions and Clinical Importance When treated with antibiotics, PUC in cats with CKD do not affect disease progression or survival time