1,863 research outputs found
Inverse magnetic catalysis in dense holographic matter
We study the chiral phase transition in a magnetic field at finite
temperature and chemical potential within the Sakai-Sugimoto model, a
holographic top-down approach to (large-N_c) QCD. We consider the limit of a
small separation of the flavor D8-branes, which corresponds to a dual field
theory comparable to a Nambu-Jona Lasinio (NJL) model. Mapping out the surface
of the chiral phase transition in the parameter space of magnetic field
strength, quark chemical potential, and temperature, we find that for small
temperatures the addition of a magnetic field decreases the critical chemical
potential for chiral symmetry restoration - in contrast to the case of
vanishing chemical potential where, in accordance with the familiar phenomenon
of magnetic catalysis, the magnetic field favors the chirally broken phase.
This "inverse magnetic catalysis" (IMC) appears to be associated with a
previously found magnetic phase transition within the chirally symmetric phase
that shows an intriguing similarity to a transition into the lowest Landau
level. We estimate IMC to persist up to 10^{19} G at low temperatures.Comment: 42 pages, 11 figures, v3: extended discussion; new appendix D;
references added; version to appear in JHE
The evolving role of oestrogen receptor beta in clinical breast cancer
Controversy surrounds the potential clinical importance of oestrogen receptor (ER)β in breast cancer, and three recent papers have sought to resolve this. In the present issue of Breast Cancer Research Novelli and colleagues explored the significance of ERβ1 expression in 936 breast cancer patients, and they showed diverse relationships according to lymph node status. A second paper examined 442 breast cancers in which ERβ1 was an independent predictor of recurrence, disease-free survival and overall survival. Finally a third paper showed that ERβ2 was a powerful prognostic indicator in 757 breast cancers but this was dependent on cellular location, with nuclear ERβ2 expression predicting good survival whilst cytoplasmic expression predicted worse outcome. These papers point to a clinical role for ERβ in breast cancer and shall be discussed
Anisotropic field dependence of the magnetic transition in Cu2Te2O5Br2
We present the results of measurements of the thermal conductivity of
Cu2Te2O5Br2, a compound where tetrahedra of Cu^{2+} ions carrying S=1/2 spins
form chains along the c-axis of the tetragonal crystal structure. The thermal
conductivity kappa was measured along both the c- and the a-direction as a
function of temperature between 3 and 300 K and in external magnetic fields H
up to 69 kOe, oriented both parallel and perpendicular to the c-axis. Distinct
features of kappa(T) were observed in the vicinity of T_N=11.4 K in zero
magnetic field. These features are unaltered in external fields which are
parallel to the c-axis, but are more pronounced when a field is applied
perpendicularly to the c-axis. The transition temperature increases upon
enhancing the external field, but only if the field is oriented along the
a-axis.Comment: 5 pages, 3 figure
Holographic chiral magnetic spiral
We study the ground state of baryonic/axial matter at zero temperature
chiral-symmetry broken phase under a large magnetic field, in the framework of
holographic QCD by Sakai-Sugimoto. Our study is motivated by a recent proposal
of chiral magnetic spiral phase that has been argued to be favored against
previously studied phase of homogeneous distribution of axial/baryonic currents
in terms of meson super-currents dictated by triangle anomalies in QCD. Our
results provide an existence proof of chiral magnetic spiral in strong coupling
regime via holography, at least for large axial chemical potentials, whereas we
don't find the phenomenon in the case of purely baryonic chemical potential.Comment: 24 pages, 15 figure
Distance to high-voltage power lines and risk of childhood leukemia:An analysis of confounding by and interaction with other potential risk factors
We investigated whether there is an interaction between distance from residence at birth to nearest power line and domestic radon and traffic-related air pollution, respectively, in relation to childhood leukemia risk. Further, we investigated whether adjusting for potential confounders alters the association between distance to nearest power line and childhood leukemia. We included 1024 cases aged <15, diagnosed with leukemia during 1968-1991, from the Danish Cancer Registry and 2048 controls randomly selected from the Danish childhood population and individually matched by gender and year of birth. We used geographical information systems to determine the distance between residence at birth and the nearest 132-400 kV overhead power line. Concentrations of domestic radon and traffic-related air pollution (NOx at the front door) were estimated using validated models. We found a statistically significant interaction between distance to nearest power line and domestic radon regarding risk of childhood leukemia (p = 0.01) when using the median radon level as cut-off point but not when using the 75th percentile (p = 0.90). We found no evidence of an interaction between distance to nearest power line and traffic-related air pollution (p = 0.73). We found almost no change in the estimated association between distance to power line and risk of childhood leukemia when adjusting for socioeconomic status of the municipality, urbanization, maternal age, birth order, domestic radon and traffic-related air pollution. The statistically significant interaction between distance to nearest power line and domestic radon was based on few exposed cases and controls and sensitive to the choice of exposure categorization and might, therefore, be due to chance
Characterization of the Partitioning System of Myxococcus Plasmid pMF1
pMF1 is the only autonomously replicating plasmid that has been recently identified in myxobacteria. This study characterized the partitioning (par) system of this plasmid. The fragment that significantly increased the retaining stability of plasmids in Myxococcus cells in the absence of selective antibiotics contained three open reading frames (ORFs) pMF1.21-pMF1.23 (parCAB). The pMF1.22 ORF (parA) is homologous to members of the parA ATPase family, with the highest similarity (56%) to the Sphingobium japonicum ParA-like protein, while the other two ORFs had no homologs in GenBank. DNase I footprinting and electrophoretic mobility shift assays showed that the pMF1.23 (parB) product is a DNA-binding protein of iteron DNA sequences, while the product of pMF1.21 (parC) has no binding activity but is able to enhance the DNA-binding activity of ParB to iterons. The ParB protein autogenously repressed the expression of the par genes, consistent with the type Ib par pattern, while the ParC protein has less repressive activity. The ParB-binding iteron sequences are distributed not only near the partitioning gene loci but also along pMF1. These results indicate that the pMF1 par system has novel structural and functional characteristics
Rapid Pathway Evolution Facilitated by Horizontal Gene Transfers across Prokaryotic Lineages
The evolutionary history of biological pathways is of general interest, especially in this post-genomic era, because it may provide clues for understanding how complex systems encoded on genomes have been organized. To explain how pathways can evolve de novo, some noteworthy models have been proposed. However, direct reconstruction of pathway evolutionary history both on a genomic scale and at the depth of the tree of life has suffered from artificial effects in estimating the gene content of ancestral species. Recently, we developed an algorithm that effectively reconstructs gene-content evolution without these artificial effects, and we applied it to this problem. The carefully reconstructed history, which was based on the metabolic pathways of 160 prokaryotic species, confirmed that pathways have grown beyond the random acquisition of individual genes. Pathway acquisition took place quickly, probably eliminating the difficulty in holding genes during the course of the pathway evolution. This rapid evolution was due to massive horizontal gene transfers as gene groups, some of which were possibly operon transfers, which would convey existing pathways but not be able to generate novel pathways. To this end, we analyzed how these pathways originally appeared and found that the original acquisition of pathways occurred more contemporaneously than expected across different phylogenetic clades. As a possible model to explain this observation, we propose that novel pathway evolution may be facilitated by bidirectional horizontal gene transfers in prokaryotic communities. Such a model would complement existing pathway evolution models
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