A generic domain pruning technique for GDL-based DCOP algorithms in cooperative multi-agent systems

Generalized Distributive Law (GDL) based message passing algorithms, such as Max-Sum and Bounded Max-Sum, are often used to solve distributed constraint optimization problems in cooperative multi-agent systems (MAS). However, scalability becomes a challenge when these algorithms have to deal with constraint functions with high arity or variables with a large domain size. In either case, the ensuing exponential growth of search space can make such algorithms computationally infeasible in practice. To address this issue, we develop a generic domain pruning technique that enables these algorithms to be effectively applied to larger and more complex problems. We theoretically prove that the pruned search space obtained by our approach does not affect the outcome of the algorithms. Moreover, our empirical evaluation illustrates a significant reduction of the search space, ranging from 33% to 81%, without affecting the solution quality of the algorithms, compared to the state-of-the-art

A Strategy for Deploying Large-Scale Volunteer Continuous Bag Valve Tube (BVT) Ventilation

Part 1: Hospital Guide The hospital guide outlines steps and considerations for the healthcare system to successfully implement a manual ventilation strategy Part 2: Online BVT Training Module We created an online articulate evidence based training module for safe and effective Bag-Valve-Tube (BVT) ventilation for medical and nonmedical providers

Interaction of the La-related protein Slf1 with colliding ribosomes maintains translation of oxidative-stress responsive mRNAs

In response to oxidative stress cells reprogram gene expression to enhance levels of antioxidant enzymes and promote survival. In Saccharomyces cerevisiae the polysome-interacting La-related proteins (LARPs) Slf1 and Sro9 aid adaptation of protein synthesis during stress by undetermined means. To gain insight in their mechanisms of action in stress responses, we determined LARP mRNA binding positions in stressed and unstressed cells. Both proteins bind within coding regions of stress-regulated antioxidant enzyme and other highly translated mRNAs in both optimal and stressed conditions. LARP interaction sites are framed and enriched with ribosome footprints suggesting ribosome-LARP-mRNA complexes are identified. Although stress-induced translation of antioxidant enzyme mRNAs is attenuated in slf1Δ, these mRNAs remain on polysomes. Focusing further on Slf1, we find it binds to both monosomes and disomes following RNase treatment. slf1Δreduces disome enrichment during stress and alters programmed ribosome frameshifting rates. We propose that Slf1 is a ribosome-associated translational modulator that stabilises stalled/collided ribosomes, prevents ribosome frameshifting and so promotes translation of a set of highly-translated mRNAs that together facilitate cell survival and adaptation to stress

The positive soundscape project : a synthesis of results from many disciplines

This paper takes an overall view of ongoing findings from the Positive Soundscape Project, a large inter-disciplinary soundscapes study which is nearing completion. Qualitative fieldwork (soundwalks and focus groups) and lab-based listening tests have revealed that two key dimensions of the emotional response are calmness and vibrancy. In the lab these factors explain nearly 80% of the variance in listener response. Physiological validation is being sought using fMRI measurements, and these have so far shown significant differences in the response of the brain to affective and neutral soundscapes. A conceptual framework which links the key soundscape components and which could be used for future design is outlined. Metrics are suggested for some perceptual scales and possibilities for soundscape synthesis for design and user engagement are discussed, as are the applications of the results to future research and environmental noise policy

AED: An Anytime Evolutionary DCOP Algorithm

Evolutionary optimization is a generic population-based metaheuristic that can be adapted to solve a wide variety of optimization problems and has proven very effective for combinatorial optimization problems. However, the potential of this metaheuristic has not been utilized in Distributed Constraint Optimization Problems (DCOPs), a well-known class of combinatorial optimization problems prevalent in Multi-Agent Systems. In this paper, we present a novel population-based algorithm, Anytime Evolutionary DCOP (AED), that uses evolutionary optimization to solve DCOPs. In AED, the agents cooperatively construct an initial set of random solutions and gradually improve them through a new mechanism that considers an optimistic approximation of local benefits. Moreover, we present a new anytime update mechanism for AED that identifies the best among a distributed set of candidate solutions and notifies all the agents when a new best is found. In our theoretical analysis, we prove that AED is anytime. Finally, we present empirical results indicating AED outperforms the state-of-the-art DCOP algorithms in terms of solution quality.Comment: 9 pages, 6 figures, 2 tables. Appeared in the proceedings of the 19th International Conference on Autonomous Agents and Multi-Agent Systems (AAMAS 2020

A Web-Based Application to Simulate Manual Bag-Valve-Tube Ventilation

What’s the Problem? The COVID-19 pandemic has threatened ventilator capacity in many locations which has led to alternative solutions to meet surge ventilator capacity including a strategy for deploying large-scale volunteer continuous bag-valve-tube (BVT) ventilation While an online training module may teach the manual ventilation volunteer force requisite knowledge, evidence suggests technology enhanced simulation training in health professions training is associated with improved outcomes for desired knowledge, skills and behavior

Characterisation of micro turbine generator as a range extender using an automotive drive cycle for series hybrid electric vehicle application

This study investigated a micro turbine generator (MTG) as a range extender for a series hybrid electric vehicle application for a range of constant and dynamic power demand strategies. The power demands were calculated through a mathematical model based on a specific vehicle platform using the New European Drive Cycle (NEDC). The power demands were then used to characterize the MTG in a controlled test environment. Each of the strategies produced interesting results in terms of fuel consumption, specific emissions, net efficiency, and power responses. The experimental results revealed the lowest specific emissions, and fuel consumption while the MTG operated at constant power demand. One of the dynamic power demand strategies also produced low fuel consumption, but with higher specific emissions. Although exhaust emissions in each strategy were well below the Euro 6c limits. These results indicate the potential of MTG as a range extender in a series hybrid vehicle. Even, the MTG can be operated dynamically with relatively low fuel consumption and very low specific emissions, compared to the traditional approach of a constant power demand

Effect of exogenous surfactants on viability and DNA synthesis in A549, immortalized mouse type II and isolated rat alveolar type II cells

<p>Abstract</p> <p>Background</p> <p>In mechanically ventilated preterm infants with respiratory distress syndrome (RDS), exogenous surfactant application has been demonstrated both to decrease DNA-synthesis but also and paradoxically to increase epithelial cell proliferation. However, the effect of exogenous surfactant has not been studied directly on alveolar type II cells (ATII cells), a key cell type responsible for alveolar function and repair.</p> <p>Objective</p> <p>The aim of this study was to investigate the effects of two commercially available surfactant preparations on ATII cell viability and DNA synthesis.</p> <p>Methods</p> <p>Curosurf^®and Alveofact^®were applied to two ATII cell lines (human A549 and mouse iMATII cells) and to primary rat ATII cells for periods of up to 24 h. Cell viability was measured using the redox indicator resazurin and DNA synthesis was measured using BrdU incorporation.</p> <p>Results</p> <p>Curosurf^®resulted in slightly decreased cell viability in all cell culture models. However, DNA synthesis was increased in A549 and rat ATII cells but decreased in iMATII cells. Alveofact^®exhibited the opposite effects on A549 cells and had very mild effects on the other two cell models.</p> <p>Conclusion</p> <p>This study showed that commercially available exogenous surfactants used to treat preterm infants with RDS can have profound effects on cell viability and DNA synthesis.</p

Middle Pleistocene vertebrate fossils from the Nefud Desert, Saudi Arabia: Implications for biogeography and palaeoecology

The current paucity of Pleistocene vertebrate records from the Arabian Peninsula - a landmass of over 3 million km2 - is a significant gap in our knowledge of the Quaternary. Such data are critical lines of contextual evidence for considering animal and hominin dispersals between Africa and Eurasia generally, and hominin palaeoecology in the Pleistocene landscapes of the Arabian interior specifically. Here, we describe an important contribution to the record and report stratigraphically-constrained fossils of mammals, birds and reptiles from recent excavations at Ti’s al Ghadah in the southwestern Nefud Desert. Combined U-series and ESR analyses of Oryx sp. teeth indicate that the assemblage is Middle Pleistocene in age and dates to ca. 500 ka. The identified fauna is a biogeographical admixture that consists of likely endemics and taxa of African and Eurasian affinity and includes extinct and extant (or related Pleistocene forms of) mammals (Palaeoloxodon cf. recki, Panthera cf. gombaszogenis, Equus hemionus, cf. Crocuta crocuta, Vulpes sp., Canis anthus, Oryx sp.), the first Pleistocene records of birds from the Arabian Peninsula (Struthio sp., Neophron percnopterus, Milvus cf. migrans, Tachybaptus sp. Anas sp., Pterocles orientalis, Motacilla cf. alba) and reptiles (Varanidae/Uromastyx sp.). We infer that the assemblage reflects mortality in populations of herbivorous animals and their predators and scavengers that were attracted to freshwater and plant resources in the inter-dune basin. At present, there is no evidence to suggest hominin agency in the accumulation of the bone assemblages. The inferred ecological characteristics of the taxa recovered indicate the presence, at least periodically, of substantial water-bodies and open grassland habitats