High-stakes Testing and Special Populations

This opinion paper critically examines the use of high-stakes testing on special populations. Without appropriate accommodations, standardized exams are not valid for some students with special needs. Unfortunately, many classroom teachers who must initiate testing accommodations lack knowledge of appropriate accommodations and regularly fail to provide the necessary testing accommodations. The deficit understanding of testing accommodations makes comparisons between classrooms, schools, and districts invalid since some scores loose validity. Solutions specific to standardized testing and students with special needs are offered and a more encompassing solution to the problems incurred from these tests when used for high-stakes is suggested

Implementing Collective Bargaining Enabling Legislation : Washington Universities Join the Party

In 2002, Washington passed enabling legislation that, for the first time, expressly granted to the faculty at the state’s public four-year colleges and universities the right to bargain regarding their terms and conditions of employment. To date, faculty at four of the state’s six four-year public institutions of higher education have formed unions, and two of those unions have negotiated first contracts. This paper describes the history of that process, the legal framework in which it took place, and the issues of greatest importance at the bargaining table

Effects of stream flow regulation on the alluvial aquifer near Muskogee Oklahoma and the suitability of the ground water for irrigation

Environmental Scienc

An Aglorithm for Two Phase Rating of Dynamically Composed Services

Many computer science researchers are pursuing the vision of service-oriented software architectures through which end-users can seamlessly access customised, potentially disposable services to aid them carry out a myriad of everyday tasks. Full realisation of this vision requires deployment of facilities for the dynamic discovery, composition, interoperation and execution monitoring of preexisting networked software services, possibly administered by different organisations or originated by multiple developers. Significant research efforts are addressing the development of frameworks and process-oriented techniques for service composition, much of it focussing on specification of services in terms of formal process semantics. Although increasingly powerful methodologies, languages and algorithms supporting the construction, execution and adaptation of dynamically composed services have emerged, little attention has been paid to the supporting infrastructure necessary for their widespread deployment. In particular, accounting systems target charging of services on a one-by-one basis; they do not consider the possibility that services can be collectively orchestrated in an arbitrary manner to fulfil changing requirements. Existing accounting systems, including their rating engines, typically are manually configured to account for specific services at the time those services are initially deployed. However, in environments where services can be dynamically composed this approach is no longer possible: service compositions are created and executed within a short time span, so there is no time for manual configuration of appropriate accounting operations. Accounting operations must be automatically configured when service compositions are initially constructed, or subsequently modified. In this paper we present a two-phase rating process incorporating an algorithm that generation of charge for dynamically composed services. The algorithm treats composed services as a tree structure in which groups of services comprise a composed service which can itself be part of a group of services comprising a composed service at the next level upwards of the tree. The tree is traversed in a depth first fashion, in order to attribute charges to all composed services. To do so the algorithm calculates changes in charges for those services based on the presence or lack of presence of named services in the group of service comprising that composed service. Application of this algorithm enables the rating engine to generate charges for services that are dynamically composed and for which the rating engine can have no prior knowledge. This method also provides a means to closely map real-world business relationships between service providers to the charges applied when their services are used together

Cosmology without cosmic variance

We examine the improvements in constraints on the linear growth factor G and its derivative f=d ln G / dln a that are available from the combination of a large-scale galaxy redshift survey with a weak gravitational lensing survey of background sources. In the linear perturbation theory limit, the bias-modulation method of McDonald & Seljak allows one to distinguish the real-space galaxy clustering from the peculiar velocity signal in each Fourier mode. The ratio of lensing signal to galaxy clustering in transverse modes yields the bias factor b of each galaxy subset (as per Pen 2004), hence calibrating the conversion from galaxy real-space density to matter density in every mode. In combination these techniques permit measure of the growth rate f in each Fourier mode. This yields a measure of the growth rate free of sample variance, i.e. the uncertainty in f can be reduced without bound by increasing the number of redshifts within a finite volume. In practice, the gain from the absence of sample variance is bounded by the limited range of bias modulation among dark-matter halos. Nonetheless, the addition of background weak lensing data to a redshift survey increases information on G and f by an amount equivalent to a 10-fold increase in the volume of a standard redshift-space distortion measurement---if the lensing signal can be measured to sub-percent accuracy. This argues that a combined lensing and redshift survey over a common low-redshift volume is a more powerful test of general relativity than an isolated redshift survey over larger volume at high redshift. An example case is that a survey of ~10^6 redshifts over half the sky in the redshift range $z=0.5\pm 0.05$ can determine the growth exponent \gamma for the model $f=\Omega_m^\gamma$ to an accuracy of $\pm 0.015$, using only modes with k<0.1h/Mpc, but only if a weak lensing survey is conducted in concert. [Abridged]Comment: 9 pages, 3 figures, accepted by MNRAS, minor changes to match the accepted versio

Particle-based platforms for malaria vaccines

Recombinant subunit vaccines in general are poor immunogens likely due to the small size of pep-tides and proteins, combined with the lack or reduced presentation of repetitive motifs and missing complementary signal(s) for optimal triggering of the immune response. Therefore, recombinant sub-unit vaccines require enhancement by vaccine delivery vehicles in order to attain adequate protective immunity. Particle-based delivery platforms, including particulate antigens and particulate adjuvants,are promising delivery vehicles for modifying the way in which immunogens are presented to both theinnate and adaptive immune systems. These particle delivery platforms can also co-deliver non-specific immunostimodulators as additional adjuvants. This paper reviews efforts and advances of the Particle-based delivery platforms in development of vaccines against malaria, a disease that claims over 600,000lives per year, most of them are children under 5 years of age in sub-Sahara Africa

Scorpion toxin peptide action at the ion channel subunit level

This review categorizes functionally validated actions of defined scorpion toxin (SCTX) neuropeptides across ion channel subclasses, highlighting key trends in this rapidly evolving field. Scorpion envenomation is a common event in many tropical and subtropical countries, with neuropharmacological actions, particularly autonomic nervous system modulation, causing significant mortality. The primary active agents within scorpion venoms are a diverse group of small neuropeptides that elicit specific potent actions across a wide range of ion channel classes. The identification and functional characterisation of these SCTX peptides has tremendous potential for development of novel pharmaceuticals that advance knowledge of ion channels and establish lead compounds for treatment of excitable tissue disorders. This review delineates the unique specificities of 320 individual SCTX peptides that collectively act on 41 ion channel subclasses. Thus the SCTX research field has significant translational implications for pathophysiology spanning neurotransmission, neurohumoral signalling, sensori-motor systems and excitation-contraction coupling

Aquilegia, Vol. 23 No. 4, July-August 1999: Newsletter of the Colorado Native Plant Society

https://epublications.regis.edu/aquilegia/1175/thumbnail.jp

CD81 and claudin 1 coreceptor association: role in hepatitis C virus entry.

Hepatitis C virus (HCV) is an enveloped positive-stranded RNA hepatotropic virus. HCV pseudoparticles infect liver-derived cells, supporting a model in which liver-specific molecules define HCV internalization. Three host cell molecules have been reported to be important entry factors or receptors for HCV internalization: scavenger receptor BI, the tetraspanin CD81, and the tight junction protein claudin-1 (CLDN1). None of the receptors are uniquely expressed within the liver, leading us to hypothesize that their organization within hepatocytes may explain receptor activity. Since CD81 and CLDN1 act as coreceptors during late stages in the entry process, we investigated their association in a variety of cell lines and human liver tissue. Imaging techniques that take advantage of fluorescence resonance energy transfer (FRET) to study protein-protein interactions have been developed. Aequorea coerulescens green fluorescent protein- and Discosoma sp. red-monomer fluorescent protein-tagged forms of CD81 and CLDN1 colocalized, and FRET occurred between the tagged coreceptors at comparable frequencies in permissive and nonpermissive cells, consistent with the formation of coreceptor complexes. FRET occurred between antibodies specific for CD81 and CLDN1 bound to human liver tissue, suggesting the presence of coreceptor complexes in liver tissue. HCV infection and treatment of Huh-7.5 cells with recombinant HCV E1-E2 glycoproteins and anti-CD81 monoclonal antibody modulated homotypic (CD81-CD81) and heterotypic (CD81-CLDN1) coreceptor protein association(s) at specific cellular locations, suggesting distinct roles in the viral entry process