Cost-Effectiveness of Laparoscopic Hysterectomy With Morcellation Compared With Abdominal Hysterectomy for Presumed Myomas

Hysterectomy for presumed leiomyomata is one of the most common surgical procedures performed in non-pregnant women in the United States. Laparoscopic hysterectomy (LH) with morcellation is an appealing alternative to abdominal hysterectomy (AH), but may result in dissemination of malignant cells and worse outcomes in the setting of an occult leiomyosarcoma. We sought to evaluate the cost-effectiveness of LH versus AH

Diverse functions for acyltransferase-3 proteins in the modification of bacterial cell surfaces

The acylation of sugars, most commonly via acetylation, is a widely used mechanism in bacteria that uses a simple chemical modification to confer useful traits. For structures like lipopolysaccharide, capsule and peptidoglycan, that function outside of the cytoplasm, their acylation during export or post-synthesis requires transport of an activated acyl group across the membrane. In bacteria this function is most commonly linked to a family of integral membrane proteins - acyltransferase-3 (AT3). Numerous studies examining production of diverse extracytoplasmic sugar-containing structures have identified roles for these proteins in O-acylation. Many of the phenotypes conferred by the action of AT3 proteins influence host colonisation and environmental survival, as well as controlling the properties of biotechnologically important polysaccharides and the modification of antibiotics and antitumour drugs by Actinobacteria. Herein we present the first systematic review, to our knowledge, of the functions of bacterial AT3 proteins, revealing an important protein family involved in a plethora of systems of importance to bacterial function that is still relatively poorly understood at the mechanistic level. By defining and comparing this set of functions we draw out common themes in the structure and mechanism of this fascinating family of membrane-bound enzymes, which, due to their role in host colonisation in many pathogens, could offer novel targets for the development of antimicrobials

The Healthy Lifestyles Programme (HeLP), a novel school-based intervention to prevent obesity in school children: study protocol for a randomised controlled trial

Background: Over the last three decades there has been a substantial increase in the proportion of children who are overweight or obese. The Healthy Lifestyles Programme (HeLP) is a novel school-based intervention, using highly interactive and creative delivery methods to prevent obesity in children. Methods/Design: We describe a cluster randomised controlled trial to evaluate the effectiveness and cost effectiveness of HeLP. The intervention has been developed using intervention mapping (involving extensive stakeholder involvement) and has been guided by the Information, Motivation, Behavioural Skills model. HeLP includes creating a receptive environment, drama activities, goal setting and reinforcement activities and runs over three school terms. Piloting showed that 9 to 10 year olds were the most receptive and participative. This study aims to recruit 1,300 children from 32 schools (over half of which will have ≥19% of pupils eligible for free school meals) from the southwest of England. Participating schools will be randomised to intervention or control groups with baseline measures taken prior to randomisation. The primary outcome is change in body mass index standard deviation score (BMI SDS) at 24 months post baseline. Secondary outcomes include, waist circumference and percent body fat SDS and proportion of children classified as overweight or obese at 18 and 24 months and objectively measured physical activity and food intake at 18 months. Between-group comparisons will be made using random effects regression analysis taking into account the hierarchical nature of the study design. An economic evaluation will estimate the incremental cost-effectiveness of HeLP, compared to control, from the perspective of the National Health Service (NHS)/third party payer. An in-depth process evaluation will provide insight into how HeLP works, and whether there is any differential uptake or engagement with the programme. Discussion: The results of the trial will provide evidence on the effectiveness and cost effectiveness of the Healthy Lifestyles Programme in affecting the weight status of children

The Institutional Learning Objectives (ILOs) and Undergraduate Assessment

This poster presents undergraduate assessment results for critical thinking, information literacy, quantitative reasoning, and written communication based on a 2015-2016 qualitative review, led by the Assessment Office, of WASC-defined core competencies using the VALUE Rubrics and the expertise of instructional faculty from across campus. These results are presented as baseline data as well as the jumping off point for faculty and administrators regarding discussions about how to ensure all students graduate with the knowledge and skills we intend them to have. Suggestions for utilizing the findings toward improvement as well as next steps are discussed

Laparoscopic hysterectomy with morcellation vs abdominal hysterectomy for presumed fibroid tumors in premenopausal women: a decision analysis

To model outcomes in laparoscopic hysterectomy with morcellation compared to abdominal hysterectomy for the presumed fibroid uterus, examining short-and long-term complications, as well as mortality

Students' attitudes towards the introduction of a Personal and Professional Development portfolio: potential barriers and facilitators

Peer reviewedPublisher PD

Associations of risk factors of e-cigarette and cigarette use and susceptibility to use among baseline PATH study youth participants (2013–2014)

Introduction: Improved understanding of the distribution of traditional risk factors of cigarette smoking among youth who have ever used or are susceptible to e-cigarettes and cigarettes will inform future longitudinal studies examining transitions in use. Methods: Multiple logistic regression analysis was conducted using data from youth (ages 12–17 years) who had ever heard of e-cigarettes at baseline of the PATH Study (n = 12,460) to compare the distribution of risk factors for cigarette smoking among seven mutually exclusive groups based on ever cigarette/e-cigarette use and sus- ceptibility status. Results: Compared to committed never users, youth susceptible to e-cigarettes, cigarettes, or both had increasing odds of risk factors for cigarette smoking, with those susceptible to both products at highest risk, followed by cigarettes and e-cigarettes. Compared to e-cigarette only users, dual users had higher odds of nearly all risk factors (aOR range = 1.6–6.8) and cigarette only smokers had higher odds of other (non-e-cigarette) tobacco use (aOR range=1.5–2.3), marijuana use (aOR=1.9, 95%CI=1.4–2.5), a high GAIN substance use score (aOR = 1.9, 95%CI = 1.1–3.4), low academic achievement (aOR range = 1.6–3.4), and exposure to smoking (aOR range = 1.8–2.1). No differences were observed for externalizing factors (depression, anxiety, etc.), sen- sation seeking, or household use of non-cigarette tobacco. Conclusions: Among ever cigarette and e-cigarette users, dual users had higher odds of reporting traditional risk factors for smoking, followed by single product cigarette smokers and e-cigarette users. Understanding how e- cigarette and cigarette users differ may inform youth tobacco use prevention efforts and advise future studies assessing probability of progression of cigarette and e-cigarette use

The Vehicle, Spring 2009

Table of Contents Idyllic Has an EndJustine Fittonpage 28 The RemedyJosh Boykinpage 29 True NatureStephen Garciapage 30 We Are All Eaters of SoulsDan Davispage 31 Scarlet on the WindJustin Sudkamppage 34 IlluminatedRashelle McNairpage 35 Lightning RodKim Hunter-Perkinspage 36 TrialDan Davispage 49 Dear GodKristi Kohlenbergpage 50 A Cheap Metaphor Is What We Have for DeathKeith Stewartpage 51 Sad MoonJennifer O\u27Neilpage 52 The Transported ManStephen Garciapage 61 Divine InsanityGrace Lawrencepage 62 Moonglow MemoriesJustin Sudkamppage 63 Poetry The Habits of HusbandsKim Hunter-Perkinspage 4 Young AmericanMaria Rhodespage 5 Kevin Doesn\u27t Live Here AnymoreJustine Fittonpage 6 Summer VacationMary Lieskepage 8 PerfectChristie Cheatlepage 9 Hate for OneMiranda Whitepage 10 The Witch\u27s GraveDan Davispage 16 Medicine WomanLindsey Durbinpage 18 Epistle to a BombshellKim Hunter-Perkinspage 19 GuardedAaron Dillardpage 20 Lean and Hungry in YesteryearTim Ernstpage 21 Dirty TearsBrittany Morganpage 27 I Left the Radio OnSerena Heathpage 83 Untitled, for CourtneyKellen Fasnachtpage 84 Ermine DriveStephen Garciapage 85 Prose TwigDaniel Paquinpage 11 Coyote MoonDan Davispage 22 BloodGretchen Schaiblepage 32 IntroductionSam Sottosantopage 53 The Guitar ManDan Davispage 75 Art Picasso InspirationAlycia Rockeycover StageSarah Fairchildpage 37 ConnectedBrittany Morganpage 65 SpringAnthony Travis Shootpage 66 BodhisattvaSarah Fairchildpage 67 What About Love?Justin Sudkamppage 68 Angry MoonJennifer O\u27Neilpage 69 HauntedKellen Fasnachtpage 70 Haiku #1Justin Sudkamppage 72 ImmobileRashelle McNairpage 73 The ChurningJosh Boykinpage 74 The Old Boat DockJosh Boykinpage 79 Saltwater RaindropsTim Ernstpage 80 Slow MotionGrace Lawrencepage 81 Solid AdviceAnthony Travis Shootpage 82 TreeAlycia Rockeypage 38 TireSarah Fairchildpage 39 What to WearKristy Pearsonpage 40 Figure 1Sean Walkerpage 41 GreenhouseAlycia Rockeypage 42 RomeAlycia Rockeypage 43 Me at the Lamp PostElizabeth Surbeckpage 44 Little Miss LizKristy Pearsonpage 45 DoudnaAlycia Rockeypage 46 FlagAlycia Rockeypage 47 Flag ProtestAlycia Rockeypage 48 Features Note From the EditorRebecca Griffithpage 1 Fall 2008-Spring 2009 Vehicle Award Winnerspage 2 James K. Johnson Creative Writing Awardpage 86 Winning Entry (Nonfiction)Daniel Paquinpage 87 Winning Entries (Poetry)Anthony Travis Shootpage 98 Contributorspage 103https://thekeep.eiu.edu/vehicle/1091/thumbnail.jp