Hand Lettered

Around this time last year, I discovered hand lettering on chalkboards around Folk for the NASAD accreditation show. I found these pieces to be particularly inspiring and wanted to learn how to create something similar. Having absolutely no experience with hand lettering I knew that this was going to be a long process. I tasked myself with creating 100 small pieces in varying styles to teach myself hand lettering. I was inspired to end the project with a large chalkboard mural about the school of art to then be donated to the school when the project is complete. The reason I chose to give the board back to the school is that I wish to see more artwork hanging in the halls. To bring hand lettering into the modern era of technology visitors to the exhibition can download the Layar App and hold it up to the board to view a time-lapse of the mural being drawn

Special education students\u27 perceptions of inclusion versus pull-out placements

The purpose of this study was to examine the perceptions of special education students toward their placement in inclusion and/or pull-out resource settings. Inclusion and pull-out special education students were interviewed individually regarding their perceptions of the academic and social ramifications of their respective placements. Fourth and fifth grade students (N = 15) currently enrolled in inclusion or pull-out settings from a suburban middle class elementary school were interviewed. The data collected from this phenomenological study was analyzed in order to create broad statements that may be generalized to a more extensive population. This study demonstrated that the majority of inclusion and pull-out students are content with their respective placements in special education. The students in pull-out are cognizant of the academic support offered to them through the pull-out program, and many of them prefer pull-out because of the academic advantages inherent in the small group setting. The students in both types of settings revealed very few social consequences of receiving support from a special education teacher in either placement

Anforderungen an Musik-Discovery-Systeme: Handreichungen zur Optimierung von Benutzeroberflächen

This is an English language version of the German language article cited below. “Discovery” has become a library buzzword but it refers to a traditional concept: enabling users to find library information and materials. Discovery was first facilitated by print indexes and card catalogs, then later by online library catalogs and search engines. Today, the discovery environment is changing rapidly both within libraries and externally. Within the library realm, FRBR, RDA, discovery tools, and faceted browsing are key factors related to these changes in the way our users navigate searches and encounter library data. The newest discovery interfaces aim to remove barriers between different types of data and incorporate aspects of non-library online searching environments familiar to users. When discovery interfaces work well, everyone benefits: the library’s collections are more fully exposed, and users do not have to adhere to nor struggle with the shortcomings of complicated search vocabularies and strategies. Discovery is optimized

Differential involvement of the microtubule cytoskeleton in insulin receptor substrate 1 (IRS-1) and IRS-2 signaling to AKT determines the response to microtubule disruption in breast carcinoma cells

The insulin receptor substrate (IRS) proteins serve as essential signaling intermediates for the activation of PI3K by both the insulin-like growth factor 1 receptor (IGF-1R) and its close family member, the insulin receptor (IR). Although IRS-1 and IRS-2 share significant homology, they regulate distinct cellular responses downstream of these receptors and play divergent roles in breast cancer. To investigate the mechanism by which signaling through IRS-1 and IRS-2 results in differential outcomes, we assessed the involvement of the microtubule cytoskeleton in IRS-dependent signaling. Treatment with drugs that either stabilize or disrupt microtubules reveal that an intact microtubule cytoskeleton contributes to IRS-2- but not IRS-1-mediated activation of AKT by IGF-1. Proximal IGF-1R signaling events, including IRS tyrosine phosphorylation and recruitment of PI3K, are not inhibited by microtubule disruption, indicating that IRS-2 requires the microtubule cytoskeleton at the level of downstream effector activation. IRS-2 colocalization with tubulin is enhanced upon Taxol-mediated microtubule stabilization, which, together with the signaling data, suggests that the microtubule cytoskeleton may facilitate access of IRS-2 to downstream effectors such as AKT. Of clinical relevance is that our data reveal that expression of IRS-2 sensitizes breast carcinoma cells to apoptosis in response to treatment with microtubule-disrupting drugs, identifying IRS-2 as a potential biomarker for the response of breast cancer patients to Vinca alkaloid drug treatment

Infection control and the significance of sputum and other respiratory secretions from adult patients with cystic fibrosis

BACKGROUND: There is limited data available on the environmental and public health impact of the microbiological hazards associated with sputa from patients with cystic fibrosis [CF]. Pseudomonas aeruginosa, Burkholderia cenocepacia (formerly Burkholderia cepacia genomovar III), Staphylococcus aureus and Stenotrophomonas maltophilia are bacterial pathogens which are commonly found in the sputum of CF patients. A study was performed to ascertain the amount of sputum produced relating to microbial loading, as well as the diversity of bacteria present in a population of adult patients, with particular attention to pathogenic organisms. METHODS: Sputum from adult [>18 years old] CF patients [n = 20], chosen randomly from a population of 138 CF patients, was collected over a 24 h period on admission to the in-patient CF unit and enumerated quantitatively, as well as the sputa from 138 adult CF patients was examined qualitatively for the presence of infecting microflora. In addition, all different phenotypes from the sputum of each patient were identified phenotypically employing a combination of conventional identification methods [e.g. oxidase], as well as the API Identification schemes [API 20 NE, API 20 E]. RESULTS: This study demonstrated that patients with cystic fibrosis generate large numbers of bacteria in their sputum, approximating to 10(9 )organisms per patient per day. Although these organisms are introduced to the environment from the respiratory tract mainly via sputum, relatively few represent true bacterial pathogens and therefore are not clinically important to the general public who are immunocompotent. The greatest risk of such environmental microbial loading is to other patients with CF and therefore CF patients should be made aware of the hazards of acquiring such organisms from the environment, as well as socializing with other CF patients with certain transmissible types, such as Pseudomonas aeruginosa and Burkholderia cenocepacia. CONCLUSIONS: Environmental health professionals should therefore be aware that CF patients are a greater risk to their peer grouping rather than to the general public or health care workers and that good personal hygiene practices with CF patients should be encouraged to minimize environmental contamination and potential acquistion

Cattle grazing for invasive Phragmites australis (common reed) management in Northern Utah wetlands

This fact sheet provides suggestions for how cattle grazing can be integrated into Phragmites management programs in Northern Utah

Airborne lidar detection and characterization of internal waves in a shallow fjord

A dual-polarization lidar and photography are used to sense internal waves in West Sound, Orcas Island, Washington, from a small aircraft. The airborne lidar detected a thin plankton layer at the bottom of the upper layer of the water, and this signal provides the depth of the upper layer, amplitude of the internal waves, and the propagation speed. The lidar is most effective when the polarization filter on the receiver is orthogonal to the transmitted light, but this does not depend significantly on whether the transmitted light is linearly or circularly polarized. The depolarization is greater with circular polarization, and our results are consistent with a single parameter Mueller scattering matrix. Photographs of the surface manifestation of the internal waves clearly show the propagation direction and width of the phase fronts of the internal waves, even though the contrast is low (2%). Combined with the lidar profile, the total energy of the internal wave packet was estimated to be 9 MJ

Insulin Receptor Substrate-1 (IRS-1) and IRS-2 expression levels are associated with prognosis in non-small cell lung cancer (NSCLC)

The insulin-like growth factor-1 (IGF-1) signaling pathway has been implicated in non-small cell lung cancer (NSCLC) outcomes and resistance to targeted therapies. However, little is known regarding the molecular mechanisms by which this pathway contributes to the biology of NSCLC. The insulin receptor substrate (IRS) proteins are cytoplasmic adaptor proteins that signal downstream of the IGF-1R and determine the functional outcomes of this signaling pathway. In this study, we assessed the expression patterns of IRS-1 and IRS-2 in NSCLC to identify associations between IRS-1 and IRS-2 expression levels and survival outcomes in the two major histological subtypes of NSCLC, adenocarcinoma (ADC) and squamous cell carcinoma (SCC). High IRS-2 expression was significantly associated with decreased overall survival in adenocarcinoma (ADC) patients, whereas low IRS-1 cytoplasmic expression showed a trend toward association with decreased overall survival in squamous cell carcinoma (SCC) patients. Tumors with low IRS-1 and high IRS-2 expression were found to be associated with poor outcomes in ADC and SCC, indicating a potential role for IRS-2 in the aggressive behavior of NSCLC. Our results suggest distinct contributions of IRS-1 and IRS-2 to the biology of ADC and SCC that impact disease progression

Extinction and the Radial Distribution of Supernova Properties in Their Parent Galaxies

We use a Monte Carlo technique and assumed spatial distributions of dust and supernova (SN) progenitors in a simple model of a characteristic SN--producing disk galaxy to explore the effects of extinction on the radial distributions of SN properties in their parent galaxies. The model extinction distributions and projected radial number distributions are presented for various SN types. Even though the model has no core-collapse SNe within three kpc of the center, a considerable fraction of the core-collapse SNe are projected into the inner regions of inclined parent galaxies owing to their small vertical scale height. The model predicts that because of extinction, SNe projected into the central regions should on average appear dimmer and have a much larger magnitude scatter than those in the outer regions. In particular, the model predicts a strong deficit of bright core-collapse events inside a projected radius of a few kpc. Such a deficit is found to be present in the observations. It is a natural consequence of the characteristic spatial distributions of dust and core-collapse SNe in galaxies, and it leads us to offer an alternative to the conventional interpretation of the Shaw effect.Comment: 14 pages, 4 figure