The Health Experiences of Long-haul Truck Drivers and their Relationship with their Primary Care Provider

Long-haul truck drivers in North America experience greater health risks than people employed in other occupations. The magnitude of their health risks is directly associated with crash risk which has implications for public road safety. The health experiences of long-haul truck drivers residing in Ontario, Canada and their relationship with their primary care provider were explored using a phenomenological approach. Themes of perseverance, isolation, dehumanization and living in a hidden, separate world emerged from the analysis. Focus groups were held where family physicians and nurse practitioners were asked for their responses to these findings and for their experiences caring for long-haul truck driver patients. Integration of these two studies revealed barriers to receiving and providing primary care including the fitness to drive examination and the long-haul truck driver context. Continuous exposure to an unhealthy work environment and inadequate access to primary care suggests long-haul truck drivers are a vulnerable population

Targeting STAT3 in Cancer with Nucleotide Therapeutics.

Signal transducer and activator of transcription 3 (STAT3) plays a critical role in promoting the proliferation and survival of tumor cells. As a ubiquitously-expressed transcription factor, STAT3 has commonly been considered an "undruggable" target for therapy; thus, much research has focused on targeting upstream pathways to reduce the expression or phosphorylation/activation of STAT3 in tumor cells. Recently, however, novel approaches have been developed to directly inhibit STAT3 in human cancers, in the hope of reducing the survival and proliferation of tumor cells. Several of these agents are nucleic acid-based, including the antisense molecule AZD9150, CpG-coupled STAT3 siRNA, G-quartet oligodeoxynucleotides (GQ-ODNs), and STAT3 decoys. While the AZD9150 and CpG-STAT3 siRNA interfere with STAT3 expression, STAT3 decoys and GQ-ODNs target constitutively activated STAT3 and modulate its ability to bind to target genes. Both STAT3 decoy and AZD9150 have advanced to clinical testing in humans. Here we will review the current understanding of the structures, mechanisms, and potential clinical utilities of the nucleic acid-based STAT3 inhibitors

A Search for Binary Stars at Low Metallicity

We present initial results measuring the companion fraction of metal-poor stars ([Fe/H]$<-$2.0). We are employing the Lick Observatory planet-finding system to make high-precision Doppler observations of these objects. The binary fraction of metal-poor stars provides important constraints on star formation in the early Galaxy (Carney et al. 2003). Although it has been shown that a majority of solar metallicity stars are in binaries, it is not clear if this is the case for metal-poor stars. Is there a metallicity floor below which binary systems do not form or become rare? To test this we are determining binary fractions at metallicities below [Fe/H]$=-2.0$. Our measurments are not as precise as the planet finders', but we are still finding errors of only 50 to 300 m/s, depending on the signal-to-noise of a spectrum and stellar atmosphere of the star. At this precision we can be much more complete than previous studies in our search for stellar companions.Comment: To appear in conference proceedings,"First Stars III", eds. B. O'Shea, A. Heger & T. Abel. 3 pages, 5 figure

Preferring print: The planned behavior and preferences of first-generation college students in the academic library

Background: Academic libraries have been adapting and changing their collections with technology. Often this technology has accompanied a transition from physical collections, such as print books, to electronic collections and electronic books. Understanding how this shift away from print formats might affect certain campus populations is essential as electronic collections continue to grow and expand in various academic institutions. Methods: This mixed methods case study aimed to understand how first-generation college students at a public research university use print books versus electronic books. Data was collected in two phases, with the first phase consisting of a Likert scale survey distributed to 4419 potential participants. The second phase was a qualitative semi-structured interview with 19 self-identified participants from the survey. Results: The survey did not indicate a strong preference for print books over electronic books. However, the qualitative interviews did indicate that first-generation students preferred using print to facilitate their reading styles. Conclusion: The study showed that students prefer to use print books over electronic formats daily at their academic institutions for various factors, including the ability to focus and review information. However, the primary reason first-generation college students prefer print books is that it helps them retain information for classes better than electronic books

Biochemical Properties of a Decoy Oligodeoxynucleotide Inhibitor of STAT3 Transcription Factor.

Cyclic STAT3 decoy (CS3D) is a second-generation, double-stranded oligodeoxynucleotide (ODN) that mimics a genomic response element for signal transducer and activator of transcription 3 (STAT3), an oncogenic transcription factor. CS3D competitively inhibits STAT3 binding to target gene promoters, resulting in decreased expression of proteins that promote cellular proliferation and survival. Previous studies have demonstrated antitumor activity of CS3D in preclinical models of solid tumors. However, prior to entering human clinical trials, the efficiency of generating the CS3D molecule and its stability in biological fluids should be determined. CS3D is synthesized as a single-stranded ODN and must have its free ends ligated to generate the final cyclic form. In this study, we report a ligation efficiency of nearly 95 percent. The ligated CS3D demonstrated a half-life of 7.9 h in human serum, indicating adequate stability for intravenous delivery. These results provide requisite biochemical characterization of CS3D that will inform upcoming clinical trials

Chemical Abundances For Evolved Stars In M5: Lithium Through Thorium

We present analysis of high-resolution spectra of a sample of stars in the globular cluster M5 (NGC 5904). The sample includes stars from the red giant branch (RGB; seven stars), the red horizontal branch (two stars), and the asymptotic giant branch (AGB; eight stars), with effective temperatures ranging from 4000 K to 6100 K. Spectra were obtained with the HIRES spectrometer on the Keck I telescope, with a wavelength coverage from 3700 angstrom to 7950 angstrom for the HB and AGB sample, and 5300 angstrom to 7600 angstrom for the majority of the RGB sample. We find offsets of some abundance ratios between the AGB and the RGB branches. However, these discrepancies appear to be due to analysis effects, and indicate that caution must be exerted when directly comparing abundance ratios between different evolutionary branches. We find the expected signatures of pollution from material enriched in the products of the hot hydrogen burning cycles such as the CNO, Ne-Na, and Mg-Al cycles, but no significant differences within these signatures among the three stellar evolutionary branches especially when considering the analysis offsets. We are also able to measure an assortment of neutron-capture element abundances, from Sr to Th, in the cluster. We find that the neutron-capture signature for all stars is the same, and shows a predominately r-process origin. However, we also see evidence of a small but consistent extra s-process signature that is not tied to the light-element variations, pointing to a pre-enrichment of this material in the protocluster gas.National Science Foundation AST-0802292NSF AST-0406988, AST-0607770, AST-0607482DFGW. M. Keck FoundationAstronom

Cultivating literacies of access and liberation: A case study on the use of oral language, hybrid literacies, and culture in the 21st century

This multi-year critical ethnographic study examined the development and use of oral languages, and academic, digital, and critical literacies among high school debaters who participated in the Ivy League Debate Institute (ILDI), an intense academic apprenticeship for low-income Black and Brown youth attending public high schools in a large northeastern city. The study documented and analyzed a high school intervention that sought to foster powerful readers, writers, speakers, and engaged citizens through critical debate education that embraces new literacies, critical theory, empirical research, community-based literacies, and Hip-Hop culture. In addition to documenting the language and literacy practices of the majority of students participating in the apprenticeship during an eight week summer workshop, the research also followed a subset of ILDI students over the course of three years as they participated in after school trainings, weekend debate tournaments, public presentations, and researched and practiced at summer debate institutes. Drawing upon African American literacies and rhetoric(s) and sociocultural and critical education theories, this research investigated the role of critical debate in the development of participants’ academic literacies, civic engagement, and identities. A sociocultural lens that views learning as changing participation over time in communities of practice (Lave, 1991) was used to analyze a wide range of data: field notes and researcher memos from after school meetings and events; video recordings of meetings, public presentations and debate tournaments; online correspondence; student generated speeches, academic essays and research notes; and semi-structured interviews with participants elucidating on the role of the debate apprenticeship in the development of academic and critical literacies. The study reveals the role of the critical debate apprenticeship in supporting students to become more dexterous users of multiple literacies, languages, and discourses, and to leverage these resources in academic and civic spaces for self- and social justice advocacy. The study expands what counts as academic discourse and literacy development to create more room for cultivating both literacies of access and social justice. Combining student-led instruction in evidence-based advocacy skills and print-based and new literacies with oral language and Hip-Hop can support participants in employing diverse cultural and linguistic practices and academic, new, and critical literacies to develop well-reasoned and persuasive texts that speak to social injustices, offering new possibilities for literacy education in high schools, first-year college classrooms, preservice teacher training, and in out-of-school spaces

Carbon and Strontium Abundances of Metal-Poor Stars

We present carbon and strontium abundances for 100 metal-poor stars measured from R$\sim$7000 spectra obtained with the Echellette Spectrograph and Imager at the Keck Observatory. Using spectral synthesis of the G-band region, we have derived carbon abundances for stars ranging from [Fe/H]$=-1.3$ to [Fe/H]$=-3.8$. The formal errors are $\sim 0.2$ dex in [C/Fe]. The strontium abundance in these stars was measured using spectral synthesis of the resonance line at 4215 {\AA}. Using these two abundance measurments along with the barium abundances from our previous study of these stars, we show it is possible to identify neutron-capture-rich stars with our spectra. We find, as in other studies, a large scatter in [C/Fe] below [Fe/H]$= -2$. Of the stars with [Fe/H]$<-2$, 9$\pm$4% can be classified as carbon-rich metal-poor stars. The Sr and Ba abundances show that three of the carbon-rich stars are neutron-capture-rich, while two have normal Ba and Sr. This fraction of carbon enhanced stars is consistent with other studies that include this metallicity range.Comment: ApJ, Accepte

Unique Challenges Testing SDRs for Space

This paper describes the approach used by the Space Communication and Navigation (SCaN) Testbed team to qualify three Software Defined Radios (SDR) for operation in space and the characterization of the platform to enable upgrades on-orbit. The three SDRs represent a significant portion of the new technologies being studied on board the SCAN Testbed, which is operating on an external truss on the International Space Station (ISS). The SCaN Testbed provides experimenters an opportunity to develop and demonstrate experimental waveforms and applications for communication, networking, and navigation concepts and advance the understanding of developing and operating SDRs in space. Qualifying a Software Defined Radio for the space environment requires additional consideration versus a hardware radio. Tests that incorporate characterization of the platform to provide information necessary for future waveforms, which might exercise extended capabilities of the hardware, are needed. The development life cycle for the radio follows the software development life cycle, where changes can be incorporated at various stages of development and test. It also enables flexibility to be added with minor additional effort. Although this provides tremendous advantages, managing the complexity inherent in a software implementation requires a testing beyond the traditional hardware radio test plan. Due to schedule and resource limitations and parallel development activities, the subsystem testing of the SDRs at the vendor sites was primarily limited to typical fixed transceiver type of testing. NASA s Glenn Research Center (GRC) was responsible for the integration and testing of the SDRs into the SCaN Testbed system and conducting the investigation of the SDR to advance the technology to be accepted by missions. This paper will describe the unique tests that were conducted at both the subsystem and system level, including environmental testing, and present results. For example, test waveforms were developed to measure the gain of the transmit system across the tunable frequency band. These were used during thermal vacuum testing to enable characterization of the integrated system in the wide operational temperature range of space. Receive power indicators were used for Electromagnetic Interference tests (EMI) to understand the platform s susceptibility to external interferers independent of the waveform. Additional approaches and lessons learned during the SCaN Testbed subsystem and system level testing will be discussed that may help future SDR integrator