Occupational Contributions to Respiratory Health Disparities.

Occupation is an important contributor to disparities in respiratory disease, affecting financial status, health-care access, and exposure to hazardous substances. Although occupation and associated exposures are included in the socioecological models, work exposures remain persistently absent from research on health inequities and their contribution to health. This article focuses on the occupational contribution to disparities in asthma, chronic obstructive pulmonary disease, silicosis, coronavirus disease 2019, and lung cancer. Because occupational exposures are largely preventable through proper workplace controls, the recognition of occupational causes of disease can provide an opportunity for interventions to bring about health equity

Volatile chemical emissions from essential oils with therapeutic claims

Essential oils emit many volatile organic compounds (VOCs), with some considered potentially hazardous. However, little is known about specific emissions from essential oils that make therapeutic claims for health and well-being. This study investigated VOCs emitted from 14 commercially available essential oils with therapeutic claims, such as beneficial for coughs, colds, flus, relaxation, sleep, tension, headaches, stress, or skin irritation. The essential oils were selected from different brands and types, such as tea tree oil, lavender oil, eucalyptus oil, geranium oil, peppermint oil, bergamot oil, orange oil, and oil blends. Analyses were performed using headspace gas chromatography/mass spectrometry (GC/MS). The analyses found 1034 VOCs emitted from the 14 essential oils, representing 378 VOC identities. The most prevalent VOCs (in more than 90% of the oils) were acetaldehyde, alpha-phellandrene, alpha-pinene, camphene, limonene, methanol, terpinolene, 3-carene, acetone, beta-phellandrene, ethanol, and gamma-terpinene. Among the 1034 VOCs emitted, 251 VOCs, representing 60 VOC identities, are classified as potentially hazardous. The most prevalent potentially hazardous VOCs were acetaldehyde, limonene, methanol, acetone, ethanol, and 3-carene. Toluene was found in more than 70% of the essential oils. Each of the essential oils emitted 9 or more potentially hazardous VOCs. Fewer than 1% of all VOCs identified and fewer than 1% of all potentially hazardous VOCs were listed on any essential oil label, safety data sheet, or website. Results from this study provide new findings on VOC emissions from essential oils with therapeutic claims, which can help to improve public awareness about potential exposures and risks

Volatile chemical emissions from car air fresheners

Air fresheners, used in a variety of indoor environments, emit a range of volatile chemicals, including some classified as hazardous. However, little is known about the emissions from air fresheners designed for use in cars. This study investigates the volatile organic compounds emitted from car air fresheners, identifies potentially hazardous compounds, compares emissions between so-called natural and regular versions, and assesses whether ingredients are disclosed. Using gas chromatography/mass spectrometry, 12 car air fresheners were analyzed for their volatile emissions. Air freshener types included car vent clips, wraps, hanging ornaments, cans, and spray. Results reveal that the air fresheners collectively emitted 546 VOCs with 30 VOCs classified as potentially hazardous. All air freshener types emitted one or more potentially hazardous compounds. Comparing regular air fresheners with so-called natural or green air fresheners, no significant difference was found in the emissions of hazardous compounds. Notably, all products emitted at least one VOC classified as potentially hazardous. Among all of the 546 compounds emitted, fewer than 2% of all VOCs, and none of the potentially hazardous VOCs, were disclosed on any product label or safety data sheet. This study reveals that car air fresheners can be a source of exposure to numerous volatile compounds, including potentially hazardous VOCs, most of which are undisclosed. Of particular concern for human exposure is the small and enclosed breathing space within vehicles, as well as involuntary exposure in commercial vehicles such as taxi cabs and rideshares

Volatile organic compounds in regular and organic vaping liquids:a public health concern

Electronic cigarettes (e-cigarettes) are a growing public health concern. Vaping liquids used in e-cigarettes emit a range of chemicals, including potentially hazardous volatile organic compounds (VOCs). Exposure to VOCs is associated with adverse effects including asthma attacks, neurological disorders, and increased risk of cancer. This study investigated the VOCs emitted into the headspace of a gas chromatograph/mass spectrometer from e-cigarette vaping liquids, identified potentially hazardous compounds, and compared emissions between regular and organic versions. Vaping liquids (n = 25) were randomly selected from the market and analysed for their volatile emissions using headspace gas chromatography/mass spectrometry. The products were available for sale in the US, Australia, and New Zealand, and included regular (flavoured and flavourless) and organic (flavoured) versions. Results revealed that the vaping liquids collectively emitted 162 VOCs with 47 classified as potentially hazardous. Notably, all of the flavoured vaping liquids (regular and organic) emitted one or more VOCs classified as potentially hazardous. Further, among the 47 VOC occurrences classified as potentially hazardous, none were listed on any vaping liquid label or related product website. We found no significant difference in VOCs emitted between the regular (flavoured) and organic (flavoured) vaping liquids, and 40% of the hazardous VOCs detected were the same among these regular and organic versions. This study adds to the growing body of evidence that vaping liquids are a source of exposure to numerous volatile compounds, including potentially hazardous VOCs such as benzene, toluene and xylene. Moreover, the long-term health effects of vaping liquids are not well understood, highlighting the need for improved information on ingredients and health risks.</p

Silicosis Among Immigrant Engineered Stone (Quartz) Countertop Fabrication Workers in California

ImportanceSilicosis associated with inhalation of respirable crystalline silica among engineered stone countertop fabrication workers is an emerging health concern.ObjectiveTo describe clinical, socioeconomic, and occupational characteristics of patients diagnosed with silicosis associated with engineered stone in California.Design, setting, and participantsThis case series included reported cases of silicosis associated with fabrication of engineered stone countertops, as identified by statewide surveillance by the California Department of Public Health (2019-2022). Data analysis was performed from October 2022 to March 2023.ExposuresPatient interviews and medical record abstractions were used to assess occupational exposure to respirable crystalline silica, including duration of work tenure and preventive measures undertaken.Main outcomes and measuresDemographics, clinical characteristics, health care utilization, and clinical outcomes were obtained, including vital status, hypoxia, and lung transplant.ResultsThis case series identified 52 male patients meeting inclusion criteria; median (IQR) age was 45 (40-49) years, and 51 were Latino immigrants. Ten (19%) were uninsured, and 20 (39%) had restricted-scope Medi-Cal; 25 (48%) presented initially to an emergency department. A delay in diagnosis occurred in 30 (58%) patients, most commonly due to alternative initial diagnoses of bacterial pneumonia (9 [30%]) or tuberculosis (8 [27%]). At diagnosis, 20 (38%) patients had advanced disease (progressive massive fibrosis) with severely or very severely reduced forced expiratory volume in 1 second in 8 (18%) and 5 (11%), respectively. Of the cases, 10 (19%) were fatal; median (IQR) age at death was 46 (38-51) years, and 6 patients (12%) were alive with chronic resting hypoxia. Eleven were referred for lung transplant: 3 underwent transplant with 1 fatality; 7 were declined transplant, with 6 fatalities; and 1 died prior to listing. Median (IQR) work tenure was 15 (10-20) years; 23 (45%) reported use of water suppression for dust mitigation, and 25 (48%) continued to fabricate stone after being diagnosed with silicosis.Conclusions and relevanceIn this case series performed in California, silicosis associated with occupational exposure to dust from engineered stone primarily occurred among young Latino immigrant men. Many patients presented with severe disease, and some cases were fatal

Silicosis Among Immigrant Engineered Stone (Quartz) Countertop Fabrication Workers in California

Key Points: Question: What are the characteristics of patients in California with silicosis from occupational exposure to dust from engineered stone (quartz), a popular material that is high in silica content and that is used to fabricate countertops? Findings: In this case series of 52 patients, the median age was 45 years at diagnosis, and nearly all were Latino immigrant men. Diagnosis was delayed in 58%, with 38% presenting with advanced disease (progressive massive fibrosis), and 19% died. Meaning: In California, silicosis associated with occupational exposure to dust from engineered stone primarily occurred among young Latino immigrant men; many patients presented with severe disease, and some cases were fatal

Cleaning products and work-related asthma

To describe the characteristics of individuals with work-related asthma associated with exposure to cleaning products, data from the California-, Massachusetts-, Michigan-, and New Jersey state-based surveillance systems of work-related asthma were used to identify cases of asthma associated with exposure to cleaning products at work. From 1993 to 1997, 236 (12%) of the 1915 confirmed cases of work-related asthma identified by the four states were associated with exposure to cleaning products. Eighty percent of the reports were of new-onset asthma and 20 % were work-aggravated asthma. Among the new-onset cases, 22 % were consistent with reactive airways dysfunction syndrome. Individuals identified were generally women (75%), white non-Hispanic (68%), and 45 years or older (64%). Their most likely exposure had been in medical settings (39%), schools (13%), or hotels (6%), and they were most likely to work as janitor/cleaners (22%), nurse/nurses ’ aides (20%), or clerical staff (13%). However, cases were reported with exposure to cleaning products across a wide range of job titles. Cleaning products contain a diverse group of chemicals that are used in a wide range of industries and occupations as well as in the home. Their potential to cause or aggravate asthma has recently been recognized. Furthe

Chemical Genomics-Based Antifungal Drug Discovery: Targeting Glycosylphosphatidylinositol (GPI) Precursor Biosynthesis

Steadily increasing antifungal drug resistance and persistent high rates of fungal-associated mortality highlight the dire need for the development of novel antifungals. Characterization of inhibitors of one enzyme in the GPI anchor pathway, Gwt1, has generated interest in the exploration of targets in this pathway for further study. Utilizing a chemical genomics-based screening platform referred to as the Candida albicans fitness test (CaFT), we have identified novel inhibitors of Gwt1 and a second enzyme in the glycosylphosphatidylinositol (GPI) cell wall anchor pathway, Mcd4. We further validate these targets using the model fungal organism Saccharomyces cerevisiae and demonstrate the utility of using the facile toolbox that has been compiled in this species to further explore target specific biology. Using these compounds as probes, we demonstrate that inhibition of Mcd4 as well as Gwt1 blocks the growth of a broad spectrum of fungal pathogens and exposes key elicitors of pathogen recognition. Interestingly, a strong chemical synergy is also observed by combining Gwt1 and Mcd4 inhibitors, mirroring the demonstrated synthetic lethality of combining conditional mutants of GWT1 and MCD4. We further demonstrate that the Mcd4 inhibitor M720 is efficacious in a murine infection model of systemic candidiasis. Our results establish Mcd4 as a promising antifungal target and confirm the GPI cell wall anchor synthesis pathway as a promising antifungal target area by demonstrating that effects of inhibiting it are more general than previously recognized.Genome Canada (Firm)Genome Quebe