92 research outputs found
Porkohászati mĂłdszerekkel előállĂtott ultrafinom szemcsĂ©s fĂ©mek mikroszerkezete Ă©s mechanikai tulajdonságai
Characterization of Defect Structure in Electrodeposited Nanocrystalline Ni Films
The microstructure of electrodeposited Ni films produced without and with
organic additives (saccharin and formic acid) was investigated by X-ray
diffraction (XRD) line profile analysis and cross-sectional transmission
electron microscopy (TEM). Whereas the general effect of these additives on the
microstructure (elimination of columnar growth as well as grain refinement) was
reproduced, the pronounced intention of this study was to compare the results
of various seldom-used high-performance structural characterization methods on
identical electrodeposited specimens in order to reveal fine details of
structural changes qualitatively not very common in this field. In the film
deposited without additives, a columnar structure was observed showing
similarities to the T-zone of structure zone models. Both formic acid and
saccharin additives resulted in equiaxed grains with reduced size, as well as
increased dislocation and twin fault densities in the nanocrystalline films.
Moreover, the structure became homogeneous and free of texture within the total
film thickness due to the additives. Saccharin yielded smaller grain size and
larger defect density than formic acid. A detailed analysis of the grain size
and twin boundary spacing distributions was carried out with the complementary
application of TEM and XRD, by carefully distinguishing between the TEM and XRD
grain sizes.Comment: 26 pages, 11 figure
Influence of pack cementation time on the microstructure of Cu nanofoams processed by dealloying
Az MHC I. sejtfelszĂni szervezĹ‘dĂ©se = Cell surface organization of MHC I.
A pályázat keretĂ©ben tanulmányoztuk a T limfociták sejtfelszĂni fehĂ©rjĂ©inek eloszlását. MegállapĂtottuk, hogy a Kv1.3 K+ csatornák Ă©s a T sejt receptor integráns rĂ©szĂ©t kĂ©pzĹ‘ CD3 molekulák átfedĹ‘ membrán domĂ©nekben helyezkednek el. Konfokális mikroszkĂłpos eredmĂ©nyeinket áramlási citometriás energia transzfer mĂ©rĂ©sekkel is megerĹ‘sĂtettĂĽk. FelismertĂĽk, hogy a CTL-target sejt kölcsönhatás során a Kv1.3 K+ csatornák az immunolĂłgiai szinapszisban feldĂşsulnak. Megalkottuk az IL-2/IL-15R rendszer dinamikus heterotetramer modelljĂ©t: a citokin kötĹ‘dĂ©se az alegysĂ©gek konformáciĂłjának/közelsĂ©gĂ©nek megváltoztatásával kialakĂtja a megfelelĹ‘ nagy affinitásĂş αβγc heterotrimert. Fluoreszcenciás festĂ©kek Ă©s arany nanorĂ©szecskĂ©k közti energia transzferen alapulĂł távolságmĂ©rĹ‘ mĂłdszert dolgoztunk ki. Energia transzfer mĂ©rĂ©sek hatĂ©kony vĂ©gzĂ©sĂ©re számĂtĂłgĂ©pes programokat hoztunk lĂ©tre, melyek működĂ©sĂ©t számos rendszeren teszteltĂĽk. | In the frame of the project we studied the distribution of cell surface proteins of T lymphocytes. We proved that the Kv1.3 K+ channels are located in the same membrane domains as the CD3 molecules which are part of the T cell receptor. Confocal microscopic data were in good agreement with those of the flow cytometric energy transfer measurements. We showed that the Kv1.3 K+ channels are expressed at higher concentrations in the immunological synapse during CTL-target cell interaction. We described the dynamic heterotetramer model of the IL-2/IL-15R system: the binding of the appropriate cytokine results in the formation of high-affinity αβγc heterotrimeric receptors. We introduced a novel energy transfer method for measuring distances on the cell surfaces using fluorescent dyes and nanoparticles. We elaborated computer programs for determining energy transfer efficiencies and tested them on several biological systems
Annealing-Induced Changes in the Microstructure and Mechanical Response of a Cu Nanofoam Processed by Dealloying
Activation-dependent clustering of the erbB2 receptor tyrosine kinase detected by scanning near-field optical microscopy
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