Data Communication Between an Expert System Shell and a Conventional Algorithmic Program With Application to Cam Motion Specification

Although more and more expert system shells have begun to provide communication interfaces to conventional procedural languages, the interfaces are basically shell- and language-dependent. This paper presents a simple, shell- and language-independent data communication technique between a shell and a procedural language via a concept analogous to the handshake data transmission used in microprocessors. A control file is used for the action of handshake. The communication interface is between two data files in two different language environments. A program written in a LISP-based expert system shell, OPS 5, and one written in a procedural language, FORTRAN, were tested to verify the presented technique. An expert system for cam motion specification, which needs the following three tasks—symbolic representation, numerical computation, and their communication—is described as one of the possible applications of the technique. These three tasks are essential to automated engineering design and analysis

Data Communication Between an Expert System Shell and a Conventional Algorithmic Program With Application to Cam Motion Specification

Although more and more expert system shells have begun to provide communication interfaces to conventional procedural languages, the interfaces are basically shell- and language-dependent. This paper presents a simple, shell- and language-independent data communication technique between a shell and a procedural language via a concept analogous to the handshake data transmission used in microprocessors. A control file is used for the action of handshake. The communication interface is between two data files in two different language environments. A program written in a LISP-based expert system shell, OPS 5, and one written in a procedural language, FORTRAN, were tested to verify the presented technique. An expert system for cam motion specification, which needs the following three tasks—symbolic representation, numerical computation, and their communication—is described as one of the possible applications of the technique. These three tasks are essential to automated engineering design and analysis

Myofibroblastic conversion of mesothelial cells

Myofibroblastic conversion of mesothelial cells.BackgroundThe continuous chemical, physical, and inflammatory insults of prolonged continuous ambulatory peritoneal dialysis (CAPD) incite mesothelial cell responses, which may result in peritoneal fibrosis. The transforming growth factor-β (TGF-β), especially the isoform TGF-β1, has long been known to play crucial role in the fibrogenic process. Although several studies have implicated TGF-β in peritoneal fibrosis, the underlying mechanism has not been completely elucidated.MethodsTo test the effects of exogenous TGF-β1 on mesothelial cells, we assessed cytoarchitectural changes of human peritoneal mesothelial cells (HPMC) in in vitro culture by light, immunofluorescent, electron and immunoelectron microscopy, and differential gene expression analysis using semiquantitative reverse transcription-polymerase chain reaction (RT-PCR) and cDNA expression array assays.ResultsThe TGF-β1–induced myofibroblastic conversion was a transdifferentiation process resulting in characteristic myofibroblastic phenotype that included prominent rough endoplasmic reticuli (rER) with dilated cisternas, conspicuous smooth muscle actin (SMA) myofilaments, frequent intercellular intermediate and gap junctions, and active deposition of extracellular matrix (ECM) and formation of fibronexus. The gene expression array analysis revealed complex modulation of gene expression involving cytoskeletal organization, cell adhesion, ECM production, cell proliferation, innate immunity, cytokine/growth factor signaling, cytoprotection, stress response, and many other essential metabolic processes in mesothelial cells.ConclusionThis report describes myofibroblastic conversion of mesothelial cells, a previously undefined, yet frequently speculated, cell adaptive or pathogenic process. Our study helps to elucidate the complex molecular and cellular events involved in myofibroblastic conversion of mesothelial cells. We propose that differentiated epithelial cells of mesothelium convert or transdifferentiate into myofibroblasts, which implies the recruitment of fibrogenic cells from mesothelium during serosal inflammation and wound healing

An Efficient Technique for Finding the Desired Global Optimum of Robotic Joint Displacement

For an industrial robot on a daily operation basis such as pick and place, it is desired to minimize the robotic joint displacements when moving the robot from one location to another. The objective of the optimization here is to simultaneously minimize a robot end effector\u27s positional error and the robotic joint displacements. By modifying the searching algorithm in the existing complex optimization method, this article presents a technique for finding the desired global optimum solution more efficiently. To compare the optimum searching capability between the proposed and existing searching algorithms, a modified Himmelblau\u27s function is used as an objective function. The presented technique is then applied to a spatial three-link robot manipulator for global minimization of the joint displacements

Facial Expression Synthesis Based on Imitation

[[abstract]]It is an interesting and challenging problem to synthesise vivid facial expression images. In this paper, we propose a facial expression synthesis system which imitates a reference facial expression image according to the difference between shape feature vectors of the neutral image and expression image. To improve the result, two stages of postprocessing are involved. We focus on the facial expressions of happiness, sadness, and surprise. Experimental results show vivid and flexible results.[[incitationindex]]SCI[[incitationindex]]EI[[booktype]]紙本[[booktype]]電子

Phytochemicals Approach for Developing Cancer Immunotherapeutics

Phytochemicals or their derived compounds are being increasingly recognized as potentially potent complementary treatments for cancer. Among them, some phytochemicals are being actively evaluated for use as adjuvants in anticancer therapies. For instance, shikonin and hypericin were found to induce immunogenic cell death of specific cancer cells, and this effect was able to further activate the recognition activity of tumor cells by the host immune system. On the other hand, some derivatives of phytochemicals, such as dihydrobenzofuran lignan (Q2-3) have been found to induce the secretion of an endogenous anticancer factor, namely IL-25, from non-malignant cells. These findings suggest that phytochemicals or their derivatives confer a spectrum of different pharmacological activities, which contrasts with the current cytotoxic anticancer drugs commonly used in clinics. In this review, we have collected together pertinent information from recent studies about the biochemical and cellular mechanisms through which specific phytochemicals regulate target immune systems in defined tumor microenvironments. We have further highlighted the potential application of these immunotherapeutic modifiers in cell-based cancer vaccine systems. This knowledge provides useful technological support and know how for future applications of phytochemicals in cancer immunotherapy

Asymptotic Boundary-Layer Solutions for Mixed Convection from a Vertical Surface in a Micropolar Fluid

Using the theory of micropolar fluids due to Eringen, asymptotic boundary layer solutions are presented to study the combined convection from a vertical semi-infinite plate to a micropolar fluid. Consideration is given to the region close to the leading edge as well as the region far away from the leading edge. Numerical results are obtained for the velocity, angular velocity and temperature distribution. The missing wall values of the velocity, angular velocity and thermal functions are tabulated. Micropolar fluids display drag reduction and reduced surface heat transfer rate when compared to Newtonian fluids