RASIO MONOSIT LIMFOSIT SEBAGAI PREDIKTOR KEPARAHAN NEFROPATI DIABETIK PADA PASIEN DIABETES MELITUS TIPE 2

Diabetic nephropathy is a complication that often occurs in diabetics. In this disease, there is damage to the kidney filter, known as the glomerulus. Due to glomerular damage, diabetic nephropathy is closely related to the mechanism of inflammation. The Monocyte-Lymphocyte Ratio is a relatively new marker of inflammation. This study aims to explore the significance of the prediction of the Monocyte-Lymphocyte Ratio as a predictor of the severity of diabetic nephropathy in Type 2 Diabetes Mellitus (DMT2) patients at H. Adam Malik Hospital, Medan. The research was conducted using the cross-section method. This study took blood samples from 44 patients with type 2 diabetes mellitus with diabetic nephropathy, 22 patients with macroalbuminuria, and 22 patients with microalbuminuria. Then blood was drawn from the vein, and the Monocyte-Lymphocyte Ratio was assessed in all patients. In this study, the average MLR for all patients was 0.41±0.037. There was a significant difference between MLR values ​​in diabetic nephropathy patients with macroalbuminuria compared to diabetic nephropathy patients with microalbuminuria (p<0.001). The optimal cut-off value of MLR in predicting diabetic nephropathy with macroalbuminuria and microalbuminuria was 0.37 with a specificity of 81.8% and a sensitivity of 81.8%. The MLR value in type 2 diabetic patients with diabetic nephropathy can be used as a prognostic factor for the incidence of microalbuminuria and macroalbuminuria

Correlation between Apolipoprotein B Levels with Coronary Lesion Area Based on the Gensini Scores in Coronary Heart Disease Patients

Background: Coronary heart disease (CHD) is caused by atherosclerosis. apolipoprotein B (Apo B) is a large glycoprotein, that plays a role in lipoprotein metabolism and human lipid transport, reflecting atherogenic cholesterol transport. The Gensini scoring system has the highest correlation with the severity of coronary artery stenosis as assessed by angiography. This study aims to determine the correlation between apolipoprotein B levels with the area of ​​coronary lesions based on the Gensini score in patients with CHD Methods: This research is an observational study with cross cross-sectional data collection method of 76 coronary heart disease patients who were treated at H. Adam Malik General Hospital Medan (December 2021 – April 2022). Examination of the Apo B value was carried out by the immunoturbidimetry method (Architect). Coronary lesion area calculated from coronary angiography with Gensini score. The research was conducted after obtaining ethical approval and informed consent. Result: There were 57 male subjects (75 %). The mean age of the subjects was 56.17 years with the youngest age being 24 years and the oldest being 77 years. Most of the subjects who experienced STEMI amounted to 38 people (50 %). The mean Apo B level was 89.18 mg/dL. The mean Gensini score was 62.84. By using the Pearson correlation test, it was found that a significant correlation was found between Apo B and Gensini score, r = 0,288 (p = 0.012) Conclusions: There was a significant correlation between the levels of Apo B and coronary artery lesions based on the Gensini score. Apo B examination and Gensini score can be used as a risk assessment of severity in CHD patients. Further research is needed to involve a larger number of coronary heart disease patients

Detection of SARS-CoV-2 Post COVID-19 Vaccination in Health Workers in the COVID-19 Isolation Room

Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) is a type of virus that causes COVID-19 and is a global health problem that has a significant impact on the health of people around the world, including Indonesia. Health workers (nakes) as the frontline have a higher risk of exposure, especially health workers who work in the COVID-19 isolation room in hospitals. Health workers are the main priority for COVID-19 vaccine recipients, but post-vaccine infection does not rule out the possibility of COVID-19 infection due to health workers as health service providers who interact with other health workers or patients, or in patients who are not on transmission-based alert. Detection of SARS-CoV-2 should continue to be investigated and further action to reduce the risk of infection to health workers. This community service activity was carried out to help facilitate health workers during the post-vaccination SARS-CoV-2 examination (I, II and booster III). Of the 73 health workers, nurses are the health workers who mostly work in the COVID-19 isolation room 56 (77%), doctors 11 (15%), midwives 4 (5%) and laboratory assistants 2 (3%). Based on the results of the COVID-19 examination using the RT-PCR method from the nasopharyngeal swab sample, it showed that there were 19 health workers who were infected with COVID-19 before vaccination, namely 1 (1.3%) doctors and 18 (24.6%) nurses. The decrease in infection with health workers decreased after health workers received the first vaccination, where only 1 (1.3%) doctors and 2 (2.7) nurses were reinfected, the increase in the number of health workers infected with SARS-CoV-2 after vaccination II was 3 (4.1%) doctors, 12 (16.4%) and 2 (2.7%) midwives. The results of the detection of SARS-CoV-2 in 73 health workers who had been vaccinated with booster III (moderna) did not find any SARS-CoV-2 infection, indicating that vaccine III increases self-protection against SARS-CoV-2 infection

Relationship between Vascular Cell Adhesion Molecule-1 (Vcam-1) Level with Severity Degree of COVID-19 Patients at General Hospital H. Adam Malik Medan

Background: The mechanism and pathogenesis of COVID-19 that distinguishes asymptomatic, mild, moderate, severe to critical symptoms is not yet known with certainty. Endothelial dysfunction and immune thrombosis serve as a profound pathogenic mechanism in COVID-19. Vascular Cell Adhesion Molecule-1 (VCAM-1) is a major regulator of leukocyte adhesion that contributes to the formation of thrombosis. The purpose of the study determine the relationship between VCAM-1 level with the severity degree in COVID-19 patients. Methods: An analytical study with a cross-sectional design was conducted from September – March 2022. This study was followed by 50 patients aged over 18 years with moderate, severe, and critical degrees of COVID-19 admitted to Haji Adam Malik General Hospital Medan by excluding malignancy and pregnancy patients. Serum VCAM-1 levels were measured using Chemwell Analyzer.  Results: Among 50 patients, 33 patients (66%) were male and 17 patients (34%) were female. The mean age was 57 years with the youngest 19 years old and the oldest 81 years old. The median level of VCAM-1 was 23,02 ng/mL (10.96 ng/mL - 50.63 ng/mL). The median concentration of VCAM-1 was 37.85 ng/mL (15,59 – 50.63), 36.68 ng/mL (19.58 – 49.71), and 18.83 ng/mL (10.96 – 46.32) for critical, severe, and moderate degree respectively (p = 0.001). The cut-off value of VCAM-1 levels to predict the severity of COVID-19 is 32.01 ng/mL. Conclusions: There is a significant relationship between VCAM-1 levels and the severity of COVID-19

Malpraktik Tenaga Kesehatan Dalam Perspektif Hukum Islam

Menurut Undang-Undang No 36 Tahun 2009 tentang Kesehatan, tenaga kesehatan merupakan sumber energi yang sangat penting bagi kesehatan. Malpraktik merupakan tindakan medis yang dilakukan dengan melanggar hukum, kepatutan, asas kesusilaan, dan prinsip profesional, baik dengan sengaja maupun karena kurang hati-hati. Dalam Islam, malpraktik dianggap sebagai kejahatan yang menimbulkan kerugian bagi orang lain, dan prinsip dasar pengobatan Islam adalah melindungi dan memelihara kehidupan manusia. Kajian dari peneltian ini menggunakan jenis penelitian bersifat kualitatif deskriptif dengan metode studi literatur. Teknik pengumpulan data yang digunakan dalam penelitian ini adalah penggunaan jurnal, ebook, skripsi dan buku cetak dalam bentuk tulisan. Teknik analisis data yang digunakan dalam penelitian ini adalah analisis induktif yaitu mengambil hal hal yang berkaitan dengan topik yang dibahas. Seperti kita ketahui bahwa Islam adalah agama kesempurnaan. Ajaran Islam mencakup seluruh aspek kehidupan. Islam memberikan segala bekal yang dibutuhkan manusia termasuk masalah malpraktik tenaga kesehatan. Tulisan ini mencoba untuk mengetahui konsep malpraktik tenaga kesehatan dalam perspektif hukum Islam untuk mengetahui bagaimana tanggung jawab tenaga medis yang dapat dijalankan

Pengaruh DAR, WCTO, NPM, Dan Pertumbuhan Penjualan Terhadap Nilai Perusahaan Food And Beverage

The size of the company's value can be measured through stock prices. The higher the stock price, the higher the profit gained by the company. This study aims to examine the effect of debt to asset ratio, working capital turnover, net profit margin, and Sales Growth on company value on Food and Beverage companies listed on the Indonesia Stock Exchange in 2012-2017. The analysis model used is multiple regression. The population of this study was 21 companies with a sample of 12 companies. This sampling technique uses purposive sumpling. The results of this study indicate simultaneously debt to asset ratio, working capital turnover, net profit margin, and Sales Growth have no significant effect on firm value. While partially debt to asset ratio has no significant effect, working capital turnover partially has no significant effect, net profit margin partially has a significant effect and Sales Growth partially has no significant effect

Factors affecting HBV DNA suppression in chronic hepatitis B patients treated with tenofovir disoproxil fumarate [version 2; peer review: 2 approved]

Background: This study aims to determine the factors affecting HBV DNA suppression in chronic hepatitis B patients with tenofovir disoproxil fumarate (TDF). Methods: A case-control was carried out from October 2021 to August 2022 on 182 chronic hepatitis B patients who had TDF therapy regularly for 24 weeks at H. Adam Malik and USU Hospitals in Medan, Indonesia. The history of the samples was obtained, followed by physical examination, and blood collection. CTLA-4 polymorphism examination was carried out using real-time PCR, while the serum CTLA-4 levels were assessed with ELISA. Results: The CTLA-4 -1661G>A polymorphism, genotype GG+AG, increased 1.52 times risk of not achieving HBV DNA suppression to TDF compared to genotype AA (p=0.041). High CTLA-4 levels increased 2.28 times risk, high HBV DNA levels increased 2.09 times risk, low ALT levels increased 1.95 times risk of not achieving HBV DNA suppression (p= 0.009, 0.026, 0.036, respectively). There was no relationship between gender, age, ethnicity, obesity, baseline AST, HBeAg, genotype, liver fibrosis and HBV DNA suppression after 24 weeks of treatment (p>0.05). Conclusions: The levels of CTLA-4, HBV DNA, ALT, and CTLA-4 -1661G>A polymorphism have a potential relationship with the suppression of HBV DNA in chronic hepatitis B patients with TDF

PEMBINAAN NILAI-NILAI KARAKTER KRISTIANI MELALUI KREATIVITAS PAJANGAN BINGKAI DENGAN PEMBERDAYAAN KARDUS BEKAS DI SEKOLAH DASAR KRISTEN TEOLOGI SAHABAT BATAM

Pada usia anak umur 8-9 tahun tentunya anak-anak akan diberikan pengarahan dan bimbingan pada saat pembelajaran, agar anak-anak bisa mengerti dan mengenal nilai-nilai karakter Kristiani dalam kehidupan mereka terkhususnya di Sekolah Dasar Teologi Kristen Sahabat Batam. Anak-anak yang berusia 8-9 tahun ini perlu adanya bimbingan dari pihak guru supaya mereka bisa menerapkan nilai-nilai karakter Kristiani di sekolah. Kegiatan Pengabdian Kepada Masyarakat ini dilakukan sebagai bentuk kepedulian kepada anak-anak usia 8-9 tahun di Sekolah Dasar Teologi Kristen Sahabat Batam yang memberikan penguatan bagi Kognitif mereka melalui Kreativitas Pajangan Bingkai dengan  Pemberdayaan kardus bekas serta memberikan alat-alat untuk membuat pajangan bingkai supaya mereka semangat untuk mengerjakan kreativitas tersebut. Kegiatan yang dilakukan dengan menggunakan metode kardus bekas dan memberikan cara-cara bagaimana anak-anak bisa membuat pajangan bingkai dari kardus bekas. Melalui kreativitas pajangan bingkai ini bisa memberikan anak-anak lebih mudah untuk membuat kreativitas dan bisa lebih semangat ketika belajar. Dari pengamatan yang dilakukan oleh tim PKM ditemukan bahwa anak-anak sangat antusias dalam mengikuti pembelajaran dari awal sampai akhir. Setelah melakukan kegiatan ini anak-anak bisa menunjukkan hasil dari kreativitas pajangan bingkai mereka dan bisa lebih mengerti dalam hal nilai-nilai Karakter Kristiani

The Effect of Work Discipline and Career Development on Employee Performance at the Manpower Office of North Sumatra Province

Penelitian ini memiliki tujuan untuk mengetahui apakah disiplin kerja, pengembangan karir berpengaruh positif signifikan secara parsial maupun simultan terhadap kinerja pegawai pada Dinas Tenaga Kerja Provinsi Sumatera Utara. Penelitian di lakukan dengan angket yang disebarkan kepada 157 orang sampel yang terdiri dari pegawai Dinas Tenaga Kerja Provinsi Sumatera Utara. Jenis penelitian ini adalah penelitian Asosiatif yaitu penelitian yang bertujuan untuk mengetahui adakah pengaruh variabel bebas terhadap variabel terikat. Teknik analisis data yang digunakan adalah regresi linear berganda. Hasil yang diperoleh dari penelitian ini adalah disiplin kerja, pengembangan karir berpengaruh positif signifikan secara parsial maupun simultan terhadap kinerja pegawai pada Dinas Tenaga Kerja Provinsi Sumatera Utara.This study aims to determine whether work discipline and career development have a significant positive effect partially or simultaneously on employee performance at the Dinas Tenaga Kerja Provinsi Sumatera Utara. The research was conducted with a questionnaire distributed to 157 samples consisting of employees of the Dinas Tenaga Kerja Provinsi Sumatera Utara. This type of research is associative research, namely research that aims to determine whether there is an effect of independent variables on the dependent variable. The research technique used is multiple linear regression analysis techniques. The results obtained from this study are work discipline, career development has a significant positive effect partially and simultaneously on employee performance at the Dinas Tenaga Kerja Provinsi Sumatera Utara

Correlation of Hepatocyte Growth Factor Levels with Myopia Degree and Axial Length in Outpatient Myopic Adolescents

Myopia is the most common ophthalmic condition worldwide, with an estimated 22.9% of the population or 1.406 billion people affected. Studies of candidate gene-associated refraction abnormalities have also identified several genes that cause vulnerability myopia, including the hepatocyte growth factor (HGF) and  hepatocyte growth factor receptor (MET) genes. The purpose of the study was to analyze the correlation between hepatocyte growth factor (HGF) levels, degrees of myopia, and long axial in adolescents with myopia treated as outpatients in Universitas Sumatera Utara Hospital. This study applied the cross-sectional analytical approach. The inclusion criterion for the participants was patients diagnosed as suffering from myopia by the Ophthalmology Outpatient Clinic of the Universitas Sumatera Utara Hospital. Sampling was performed consecutively with a minimum sample size of 25 patients in control group and 25 patients in the case group. This study revealed that the mean axial length of the right eye in the case group was 23.82 mm, with a significant difference in the axial length between the case and control groups. The mean HGF level in the myopia group was 510.49 ng/mL, which was not significantly different from the mean HGF level in the control or emmetropic group. The HGF levels were highest in the group of subjects with moderate myopia, with an average of 551.87 ng/mL, and differences in HGF levels were identified in different degrees of myopia. Thus, no significant correlation is identified between the HGF levels, axial length, and myopia degree