Management Tool for Assessment of Alternative Fuel Cycles

A new approach to fuel cycle uncertainty analysis and optimization is presented that combines reactor physics information, spent fuel management, and economic forecasting, which may be used to investigate effects of decisions in the design of advanced nuclear fuel cycles. The Matlab-based simulation includes isotopic mass and integral decay heat data produced by reactor physics codes in the SCALE package (SAS2, ORIGEN-ARP, and ORIGEN-S). Reactor physics data for Light Water Reactor (LWR), and metal- and oxide-fueled Liquid Metal-cooled Fast Burner Reactor (LMFBR) designs are stored in databases that the code uses as needed. Detailed models of the once through and hybrid LWR-LMFBR fuel cycles have been developed for repository decay heat analysis, determination of levelized unit electric cost (LUEC), and reprocessing of spent fuel into fast reactor fuel or targets as a means of isotopic inventory minimization. The models may be run for single estimates based on best estimates of model parameters as either a Monte Carlo uncertainty analysis or as an optimization using Genetic Algorithms (GA). Results from the LUEC calculations show the once through cycle has a bus bar cost of about $19.0mills/kWh (excluding repository and interim storage costs), and the hybrid cycle has a bus bar cost of about$26.5mills/kWh. Implementation of the hybrid cycle compared to the closed once through cycle yields an effective repository mass capacity increase by a percentage of about 30% to 60% through full reprocessing of LWR spent fuel compared to original mass definitions of the Yucca Mountain repository. The GA optimization routine allows the user to define any one of the variables present in the output structure as the fitness parameter; thus, optimization of any calculated value is possible, including economic cost, isotopic inventory, or required repository capacity. Optimization of the once through cycle with respect to LUEC gives a result of $19.2 mills/kWh when burn up approaches the upper limit of 60 GWd/t and delay time spent fuel cools after discharge approaches 200 years (including repository and interim storage costs)

Fantasizing Disability: Representation of loss and limitation in Popular Television and Film

Most media texts currently being developed with disabled characters are crafted by individuals who are nondisabled and, as such, are based on what the nondisabled think it would be like to be disabled—a perception that is informed by the fantasy of disability. The fantasy of disability is a net of ideas, created by no single individual but perpetuated and circulated between subjects and which seeks to contain the danger of limitation, to subject it to a set of societal preconceived notions about what it means to be disabled and how a person is expected to act and react to the diagnoses of disablement. With the help of French psychoanalysts Jacques Lacan and Julia Kristeva, this project seeks to answer three key questions currently underserviced by the existing field of media and disability studies: 1. What are the unconscious fantasies circulating in representations of disability? 2. What role do these fantasies play in defining the condition of disability? 3. What can these fantasies teach us about human vulnerability writ large. By looking at war films, such as Coming Home (1978) and Born on the Fourth of July (1989), and modern teen drama, such as Degrassi: The Next Generation (2001) and Glee (2009), this project postulates that depictions of disability in the media are representative of the nondisabled producers encountering their own potential disablement, with the real purpose of the fantasy of disability being to consolidate and strengthen the perception that disability is indeed foreign—there is a difference between the disabled and the nondisabled—a line that must be drawn to safe guard the nondisabled from the perceived threat of castration posed by disability and the risk of suffering a “narcissistic identity wound.” In this way, depictions of disability are formed by anxieties of ruptured identity and crushing emasculation while disabled characters are driven by fantasies of rebirth and reconstitution: dreams constructed to neutralize the anxieties of the nondisabled subject when encountering their own inherent vulnerability

AUGMENTED ABILITY, INTEGRATED IDENTITY: UNDERSTANDING SAPIENISM, ADAPTIVE TECHNOLOGY, AND THE CONSTRUCTION OF DISABILITY

To some, individuals with disabilities are loathsome objects of pity, where wheelchairs are symbolic of confinement. While the words used to identify the disabled have changed, the connotative perceptions linger. Rather than choose another phrase that relies on the language of loss, this thesis calls for a language that depicts the true nature of the disability community, one of technological adaptation: a cyborg community. Ray Kurzweil and Donna Haraway believe the integration of technology into our bodies provides the opportunity to normalize or amplify human ability. David Noble and Willem Vanderburg argue this penetration subverts our humanity, a stance I dub sapienism. With Iain Banks and Richard Morgan’s perceptions on imbedded technology and identity, I suggest that while the adaptive technology used by the disabled may penetrate the body and alter our identity, it is a site for liberation rather than a source of limitation

The Effectiveness of Risk Assessment Training on Self-Reported Safe Behaviors of Employees of a Manufacturing Organization

This study is to examine the effectiveness of risk assessment training on self-reported safe behaviors of individuals who are employed by a manufacturing organization in a central Kentucky organization. The analysis was comprised of 31 participants that worked in the production and office areas of a manufacturing organization. These individuals volunteered to participate in the study through the use of informed consent. A pre-test was conducted prior to a risk assessment training being conducted at the facility. Three weeks after the training was preformed a post-test was taken to evaluate the effectiveness of the training. By determining the a summary score for individual questions and question groups by finding the mean difference between the pre and post-test, effectiveness could be compared. To compare these summary scores a paired sample t-test was performed. Only three questions found statistically significant improvement from pre to post test. However, a significant difference in the risk assessment group pre and post training (t =2.17, p =.04) was found. The mean score of the pre-test was 14.90 (SD = 3.25) while the mean score was 16.32 (SD = 1.81). This study shows that risk assessment training is effective in causing employees to assess and mitigate risk but is inconclusive on its overall effect on self-reported safe behaviors that take place at home and at work

What best prevents exercise-induced bronchoconstriction for a child with asthma?

Inhaled short-acting beta-agonists (SABAs) are most effective in preventing exercise-induced bronchoconstriction, followed by inhaled mast cell stabilizers and anticholinergic agents (strength of recommendation [SOR]: A, multiple randomized control trials [RCTs]). Less evidence supports the use of leukotriene antagonists and inhaled corticosteroids, either individually or in combination (SOR: B). Underlying asthma, which commonly contributes to exercise-induced bronchoconstriction, should be diagnosed and controlled first (SOR: C)

The herpes simplex virus UL20 protein functions in glycoprotein K (gK) intracellular transport and virus-induced cell fusion are independent of UL20 functions in cytoplasmic virion envelopment

The HSV-1 UL20 protein (UL20p) and glycoprotein K (gK) are both important determinants of cytoplasmic virion morphogenesis and virus-induced cell fusion. In this manuscript, we examined the effect of UL20 mutations on the coordinate transport and Trans Golgi Network (TGN) localization of UL20p and gK, virus-induced cell fusion and infectious virus production. Deletion of 18 amino acids from the UL20p carboxyl terminus (UL20 mutant 204t) inhibited intracellular transport and cell-surface expression of both gK and UL20, resulting in accumulation of UL20p and gK in the endoplasmic reticulum (ER) in agreement with the inability of 204t to complement UL20-null virus replication and virus-induced cell fusion. In contrast, less severe carboxyl terminal deletions of either 11 or six amino acids (UL20 mutants 211t and 216t, respectively) allowed efficient UL20p and gK intracellular transport, cell-surface expression and TGN colocalization. However, while both 211t and 216t failed to complement for infectious virus production, 216t complemented for virus-induced cell fusion, but 211t did not. These results indicated that the carboxyl terminal six amino acids of UL20p were crucial for infectious virus production, but not involved in intracellular localization of UL20p/gK and concomitant virus-induced cell fusion. In the amino terminus of UL20, UL20p mutants were produced changing one or both of the Y38 and Y49 residues found within putative phosphorylation sites. UL20p tyrosine-modified mutants with both tyrosine residues changed enabled efficient intracellular transport and TGN localization of UL20p and gK, but failed to complement for either infectious virus production, or virus-induced cell fusion. These results show that UL20p functions in cytoplasmic envelopment are separable from UL20 functions in UL20p intracellular transport, cell surface expression and virus-induced cell fusion

Comparison of Visual Analog Pain Score Reported to Physician vs Nurse in Nonoperatively Treated Foot and Ankle Patients

Background: Patient reported outcome measures (PROMs) are taking a more prominent role in Orthopedics as health care seeks to define treatment outcomes. The Visual Analogue Scale (VAS) is considered a reliable measure of acute pain. A previous study found that operative candidates’ VAS pain score was significantly higher when reported to the surgeon compared to the nurse. This study’s aim is to examine whether this phenomenon occurs in nonoperative patients. We hypothesize that patients’ VAS scores reported to the surgeon and a nurse will be the same Methods: This study is a retrospective cohort of 201 consecutive nonoperative patients treated by a single surgeon. Patients were asked to rate pain intensity by a nurse followed by the surgeon using a horizontal VAS, 0 “no pain” to 10 worst pain”. Differences in reported pain levels were compared with data from the previous cohort of 201 consecutive operative patients. Results: The mean VAS score reported to the nurse was 3.2 whereas the mean VAS score reported to the surgeon was 4.2 (p\u3c.001). The mean difference in VAS scores reported for operative patients was 2.9, whereas the mean difference for nonoperative patients was 1.0 (p \u3c .001). Conclusion: This study found statistically significant differences between VAS scores reported to the surgeon versus the nurse in nonoperative patients which support the trend found in our previous study, where operative patients reported significantly higher scores to the surgeon. The mean difference between reported pain scores is significantly higher for operative patients compared to nonoperative patients

Climate Influences the Content and Chemical Composition of Foliar Tannins in Green and Senesced Tissues of \u3ci\u3eQuercus rubra\u3c/i\u3e

Environmental stresses not only influence production of plant metabolites but could also modify their resorption during leaf senescence. The production-resorption dynamics of polyphenolic tannins, a class of defense compound whose ecological role extends beyond tissue senescence, could amplify the influence of climate on ecosystem processes. We studied the quantity, chemical composition, and tissue-association of tannins in green and freshly-senesced leaves of Quercus rubra exposed to different temperature (Warming and No Warming) and precipitation treatments (Dry, Ambient, Wet) at the Boston-Area Climate Experiment (BACE) in Massachusetts, USA. Climate influenced not only the quantity of tannins, but also their molecular composition and cell-wall associations. Irrespective of climatic treatments, tannin composition in Q. rubra was dominated by condensed tannins (CTs, proanthocyanidins). When exposed to Dry and Ambient*Warm conditions, Q. rubra produced higher quantities of tannins that were less polymerized. In contrast, under favorable conditions (Wet), tannins were produced in lower quantities, but the CTs were more polymerized. Further, even as the overall tissue tannin content declined, the content of hydrolysable tannins (HTs) increased under Wet treatments. The molecular composition of tannins influenced their content in senesced litter. Compared to the green leaves, the content of HTs decreased in senesced leaves across treatments, whereas the CT content was similar between green and senesced leaves in Wet treatments that produced more polymerized tannins. The content of total tannins in senesced leaves was higher in Warming treatments under both dry and ambient precipitation treatments. Our results suggest that, though climate directly influenced the production of tannins in green tissues (and similar patterns were observed in the senesced tissue), the influence of climate on tannin content of senesced tissue was partly mediated by the effect on the chemical composition of tannins. These different climatic impacts on leaves over the course of a growing season may alter forest dynamics, not only in decomposition and nutrient cycling dynamics, but also in herbivory dynamics