Simulation of the White Dwarf -- White Dwarf galactic background in the LISA data

LISA (Laser Interferometer Space Antenna) is a proposed space mission, which will use coherent laser beams exchanged between three remote spacecraft to detect and study low-frequency cosmic gravitational radiation. In the low-part of its frequency band, the LISA strain sensitivity will be dominated by the incoherent superposition of hundreds of millions of gravitational wave signals radiated by inspiraling white-dwarf binaries present in our own galaxy. In order to estimate the magnitude of the LISA response to this background, we have simulated a synthesized population that recently appeared in the literature. We find the amplitude of the galactic white-dwarf binary background in the LISA data to be modulated in time, reaching a minimum equal to about twice that of the LISA noise for a period of about two months around the time when the Sun-LISA direction is roughly oriented towards the Autumn equinox. Since the galactic white-dwarfs background will be observed by LISA not as a stationary but rather as a cyclostationary random process with a period of one year, we summarize the theory of cyclostationary random processes and present the corresponding generalized spectral method needed to characterize such process. We find that, by measuring the generalized spectral components of the white-dwarf background, LISA will be able to infer properties of the distribution of the white-dwarfs binary systems present in our Galaxy.Comment: 14 pages and 6 figures. Submitted to Classical and Quantum Gravity (Proceedings of GWDAW9

The SGLT2 inhibitor Empagliflozin attenuates interleukin-17A-induced human aortic smooth muscle cell proliferation and migration by targeting TRAF3IP2/ROS/NLRP3/Caspase-1-dependent IL-1β and IL-18 secretion

Chronic inflammation and persistent oxidative stress contribute to the development and progression of vascular proliferative diseases. We hypothesized that the proinflammatory cytokine interleukin (IL)-17A induces oxidative stress and amplifies inflammatory signaling in human aortic smooth muscle cells (SMC) via TRAF3IP2-mediated NLRP3/caspase-1-dependent mitogenic and migratory proinflammatory cytokines IL-1β and IL-18. Further, we hypothesized that these maladaptive changes are prevented by empagliflozin (EMPA), an SGLT2 (Sodium/Glucose Cotransporter 2) inhibitor. Supporting our hypotheses, exposure of cultured SMC to IL-17A promoted proliferation and migration via TRAF3IP2, TRAF3IP2-dependent superoxide and hydrogen peroxide production, NLRP3 expression, caspase-1 activation, and IL-1β and IL-18 secretion. Furthermore, NLRP3 knockdown, caspase-1 inhibition, and pretreatment with IL-1β and IL-18 neutralizing antibodies and IL-18BP, each attenuated IL-17A-induced SMC migration and proliferation. Importantly, SMC express SGLT2, and pre-treatment with EMPA attenuated IL-17A/TRAF3IP2-dependent oxidative stress, NLRP3 expression, caspase-1 activation, IL-1β and IL-18 secretion, and SMC proliferation and migration. Importantly, silencing SGLT2 attenuated EMPA-mediated inhibition of IL-17A-induced cytokine secretion and SMC proliferation and migration. EMPA exerted these beneficial antioxidant, anti-inflammatory, anti-mitogenic and anti-migratory effects under normal glucose conditions and without inducing cell death. These results suggest the therapeutic potential of EMPA in vascular proliferative diseases

First results from the VIRIAL survey: the stellar content of UVJUVJ-selected quiescent galaxies at 1.5<z<21.5 < z < 2 from KMOS

We investigate the stellar populations of 25 massive, galaxies ($\log[M_\ast/M_\odot] \geq 10.9$) at $1.5 < z < 2$ using data obtained with the K-band Multi-Object Spectrograph (KMOS) on the ESO VLT. Targets were selected to be quiescent based on their broadband colors and redshifts using data from the 3D-HST grism survey. The mean redshift of our sample is $\bar{z} = 1.75$, where KMOS YJ-band data probe age- and metallicity-sensitive absorption features in the rest-frame optical, including the $G$ band, Fe I, and high-order Balmer lines. Fitting simple stellar population models to a stack of our KMOS spectra, we derive a mean age of $1.03^{+0.13}_{-0.08}$ Gyr. We confirm previous results suggesting a correlation between color and age for quiescent galaxies, finding mean ages of $1.22^{+0.56}_{-0.19}$ Gyr and $0.85^{+0.08}_{-0.05}$ Gyr for the reddest and bluest galaxies in our sample. Combining our KMOS measurements with those obtained from previous studies at $0.2 < z < 2$ we find evidence for a $2-3$ Gyr spread in the formation epoch of massive galaxies. At $z < 1$ the measured stellar ages are consistent with passive evolution, while at $1 < z \lesssim2$ they appear to saturate at $\sim$1 Gyr, which likely reflects changing demographics of the (mean) progenitor population. By comparing to star-formation histories inferred for "normal" star-forming galaxies, we show that the timescales required to form massive galaxies at $z \gtrsim 1.5$ are consistent with the enhanced $\alpha$-element abundances found in massive local early-type galaxies.Comment: 6 pages, 5 figures, accepted for publication in ApJ

Progress in Interferometry for LISA at JPL

Recent advances at JPL in experimentation and design for LISA interferometry include the demonstration of Time Delay Interferometry using electronically separated end stations, a new arm-locking design with improved gain and stability, and progress in flight readiness of digital and analog electronics for phase measurements.Comment: 11 pages, 9 figures, LISA 8 Symposium, Stanford University, 201

Salmonella Outbreaks in Restaurants in Minnesota, 1995 through 2003: Evaluation of the Role of Infected Foodworkers

ABSTRACT The 23 restaurant-associated salmonellosis outbreaks that occurred in Minnesota from 1995 through 2003 were reviewed to characterize the role of infected foodworkers. The median duration of the outbreaks was 21 days (range, 1 to 517 days). The median number of culture-confirmed patron cases per outbreak was seven (range, 1 to 36 cases). The median incubation for patron cases ranged from 9 h to 5.9 days. A specific food vehicle was implicated in four outbreaks and suspected in five

Early-type galaxies in the SDSS. I. The sample

A sample of nearly 9000 early-type galaxies, in the redshift range 0.01 < z < 0.3, was selected from the Sloan Digital Sky Survey using morphological and spectral criteria. This paper describes how the sample was selected, presents examples of images and seeing corrected fits to the observed surface brightness profiles, describes our method for estimating K-corrections, and shows that the SDSS spectra are of sufficiently high quality to measure velocity dispersions accurately. It also provides catalogs of the measured photometric and spectroscopic parameters. In related papers, these data are used to study how early-type galaxy observables, including luminosity, effective radius, surface brightness, color, and velocity dispersion, are correlated with one another.Comment: 63 pages, 21 figures. Accepted by AJ (scheduled for April 2003). This paper is part I of a revised version of astro-ph/0110344. The full version of Tables 2 and 3, i.e. the tables listing the photometric and spectroscopic parameters of ~ 9000 galaxies, are available at http://astrophysics.phys.cmu.edu/~bernardi/SDSS/Etypes/TABLE

The Kinematics of Massive Quiescent Galaxies at 1.4 &lt; z &lt;2.1: Dark Matter Fractions, IMF Variation, and the Relation to Local Early-type Galaxies

We study the dynamical properties of massive quiescent galaxies at 1.4 DM[e]. Comparing our high-redshift sample to their likely descendants at low redshift, we find that f DM[e] has increased by a factor of more than 4 since z ≈ 1.8, from f DM[e] = 6.6% ± 1.0% to ~24%. The observed increase appears robust to changes in the methods used to estimate dynamical masses or match progenitors and descendants. We quantify possible variation of the stellar IMF through the offset parameter α, defined as the ratio of dynamical mass in stars to the stellar mass estimated using a Chabrier IMF. We demonstrate that the correlation between stellar velocity dispersion and α reported among quiescent galaxies at low redshift is already in place at z = 2, and we argue that subsequent evolution through (mostly minor) merging should act to preserve this relation while contributing significantly to galaxies' overall growth in size and stellar mass

Predictive modeling for determination of microscopic residual disease at primary cytoreduction: An NRG Oncology/Gynecologic Oncology Group 182 Study

Microscopic residual disease following complete cytoreduction (R0) is associated with a significant survival benefit for patients with advanced epithelial ovarian cancer (EOC). Our objective was to develop a prediction model for R0 to support surgeons in their clinical care decisions.Demographic, pathologic, surgical, and CA125 data were collected from GOG 182 records. Patients enrolled prior to September 1, 2003 were used for the training model while those enrolled after constituted the validation data set. Univariate analysis was performed to identify significant predictors of R0 and these variables were subsequently analyzed using multivariable regression. The regression model was reduced using backward selection and predictive accuracy was quantified using area under the receiver operating characteristic area under the curve (AUC) in both the training and the validation data sets.Of the 3882 patients enrolled in GOG 182, 1480 had complete clinical data available for the analysis. The training data set consisted of 1007 patients (234 with R0) while the validation set was comprised of 473 patients (122 with R0). The reduced multivariable regression model demonstrated several variables predictive of R0 at cytoreduction: Disease Score (DS) ( < 0.001), stage ( = 0.009), CA125 ( < 0.001), ascites ( < 0.001), and stage-age interaction ( = 0.01). Applying the prediction model to the validation data resulted in an AUC of 0.73 (0.67 to 0.78, 95% CI). Inclusion of DS enhanced the model performance to an AUC of 0.83 (0.79 to 0.88, 95% CI).We developed and validated a prediction model for R0 that offers improved performance over previously reported models for prediction of residual disease. The performance of the prediction model suggests additional factors (i.e. imaging, molecular profiling, etc.) should be explored in the future for a more clinically actionable tool

Control of intestinal stem cell function and proliferation by mitochondrial pyruvate metabolism.

Most differentiated cells convert glucose to pyruvate in the cytosol through glycolysis, followed by pyruvate oxidation in the mitochondria. These processes are linked by the mitochondrial pyruvate carrier (MPC), which is required for efficient mitochondrial pyruvate uptake. In contrast, proliferative cells, including many cancer and stem cells, perform glycolysis robustly but limit fractional mitochondrial pyruvate oxidation. We sought to understand the role this transition from glycolysis to pyruvate oxidation plays in stem cell maintenance and differentiation. Loss of the MPC in Lgr5-EGFP-positive stem cells, or treatment of intestinal organoids with an MPC inhibitor, increases proliferation and expands the stem cell compartment. Similarly, genetic deletion of the MPC in Drosophila intestinal stem cells also increases proliferation, whereas MPC overexpression suppresses stem cell proliferation. These data demonstrate that limiting mitochondrial pyruvate metabolism is necessary and sufficient to maintain the proliferation of intestinal stem cells