D'errance et d'espace chez Marie Guyart (essai) ; : suivi de D'errance et d'espace. Accompagnement de Marie Guyart (création) et de Poésie et mystique : au coeur d'une rencontre (essai)

Cette thèse de doctorat en recherche-création se veut une rencontre avec Marie Guyart, autant dans la partie création que dans le segment recherche. La partie création de la thèse, D’errance et d’espace. Accompagnement de Marie Guyart, est constituée de textes poétiques versifiés (ayant comme thèmes l’errance et l’espace de la nature : mer – forêts – Nord – fleuve – froid – ciel – terres) accompagnés des écrits épistolaires de Marie Guyart traitant des mêmes thèmes. Cet accompagnement littéraire a comme double objectif d’employer les textes de l’Ursuline comme élément déclencheur de la création poétique, ainsi que de produire une oeuvre au caractère inédit réunissant deux femmes des XVIIe et XXIe siècles. Une oeuvre de création doctorale qui expose la mystérieuse fondation de la parole s’étant tissée au-delà du temps et de l’espace. L’essai D’errance et d’espace chez Marie Guyart a comme objectif, d’une part, de démontrer la pertinence du choix des textes de l’Ursuline au regard des thèmes abordés dans la partie création et, d’autre part, de montrer la vie de la Mère de la Nouvelle-France sous un angle neuf. La grande majorité des chercheurs reviennent souvent sur l’aspect d’une existence cloîtrée à l’intérieur de laquelle la religieuse ne recherche qu’à s’abîmer en Dieu. Si cette vision de Guyart s’avère pertinente, il m’apparaît important d’élargir celle-ci en approfondissant le lien de l’Ursuline à l’espace de la Nouvelle-France à partir principalement de ses textes épistolaires portant sur des terres lointaines. Nous découvrons alors comment la religieuse vit son désir d’errance dans sa relation singulière au territoire. Par ses mots, Marie Guyart se rend aux quatre coins de son pays d’adoption. Elle s’évade, elle parcourt, elle nourrit son besoin d’espace mystique. L’essai Poésie et mystique : au coeur d’une rencontre traite de la naissance du lien entre Guyart et la doctorante, lequel s’est poursuivi dans le segment création de la thèse. J’explique et interroge la manière dont s’est vécue cette rencontre littéraire entre une mystique écrivaine et une poète en quête d’absolu, et ouvre la discussion en abordant plus largement des questionnements sur tout acte créateur.This research-creation doctoral thesis is a rendezvous with Marie Guyart, in both segments of its composition. The creation part, D’errance et d’espace. Accompagnement de Marie Guyart, is composed of versified poetic lyrics (with themes of wandering and nature: ocean – forest – North – river – cold – sky – land) accompanied by some of Marie Guyart’s written correspondence treating of the same themes. This literary accompaniment has the double objective of employing the Ursuline’s words as a trigger element of the poetic creation as well as producing a work of original character bringing together two women of the XVIIth et XXIst centuries. A doctoral creative work demonstrating the mysterious foundation of speech woven beyond time and space. The first research segment, D’errance et d’espace chez Marie Guyart, has as objective, on the one hand, to demonstrate the relevance of the Ursuline’s texts with regard to the themes treated in the creation part and, on the other hand, to show the life of the Mother of New France from a new angle. The vast majority of researchers often deal with the aspect of a cloistered life within which the nun seeks only to lose herself in God. Even if this vision of Guyart is relevant, I consider it important to broaden this view by looking at the connection between the Ursuline and space in New France as witnessed mainly in her letters treating of distant lands. This allows us to see how the nun lives out her desire for journeying through her unique relation to the territory. Through her words, Marie Guyart travels to the four corners of her adopted land. She breaks free, she journeys, she feeds her need for mystical space. The second research segment, Poésie et mystique : au coeur d’une rencontre, treats of the birth of a bond between Guyart and the doctoral student, which bond held fast throughout the creation segment of the thesis. I illustrate and question the manner in which this literary encounter occurred between a mystical writer and a poet in search of the absolute and thus open discussion to a broader approach to the creative act in general

Identification and characterization of novel human tissue-specific RFX transcription factors

<p>Abstract</p> <p>Background</p> <p>Five regulatory factor X (RFX) transcription factors (TFs)–RFX1-5–have been previously characterized in the human genome, which have been demonstrated to be critical for development and are associated with an expanding list of serious human disease conditions including major histocompatibility (MHC) class II deficiency and ciliaophathies.</p> <p>Results</p> <p>In this study, we have identified two additional RFX genes–RFX6 and RFX7–in the current human genome sequences. Both RFX6 and RFX7 are demonstrated to be winged-helix TFs and have well conserved RFX DNA binding domains (DBDs), which are also found in winged-helix TFs RFX1-5. Phylogenetic analysis suggests that the RFX family in the human genome has undergone at least three gene duplications in evolution and the seven human RFX genes can be clearly categorized into three subgroups: (1) RFX1-3, (2) RFX4 and RFX6, and (3) RFX5 and RFX7. Our functional genomics analysis suggests that RFX6 and RFX7 have distinct expression profiles. RFX6 is expressed almost exclusively in the pancreatic islets, while RFX7 has high ubiquitous expression in nearly all tissues examined, particularly in various brain tissues.</p> <p>Conclusion</p> <p>The identification and further characterization of these two novel RFX genes hold promise for gaining critical insight into development and many disease conditions in mammals, potentially leading to identification of disease genes and biomarkers.</p

Texas STATEMAP Program Summary, FY19 (2019–2020)

Five geologic maps have been completed at a 1:24,000 scale in four project areas with support from STATEMAP and the Bureau of Economic Geology's State of Texas Advanced Resource Recovery program (STARR). Three of these maps were on the Texas Coastal Plain, including one (the Lake Stephenson quadrangle) on the upper Texas Coastal Plain in the Galveston Bay area and two (the Bloomington and Olivia quadrangles) on the middle Texas Coastal Plain in the Matagorda Bay area. These maps continue efforts to: 1. Better understand the evolution of the coastal plain in response to sea-level changes associated with numerous Quaternary glacial and interglacial cycles. 2. Develop more effective methods to map low-relief coastal deposits using high-resolution topographic maps produced from airborne lidar data and near-surface geophysical methods. High-resolution topography and geophysical methods both aid in the identification of stratal units and their distribution in areas where exposures are poor or nonexistent. Mineral-resource mapping produced one map (the Katemcy quadrangle) to extend recent mapping of an industrial sand resource area in central Texas. This map facilitates the development of mineral resources of the state, emphasizing those that will help meet the demand for industrial sand for hydraulic fracturing and construction. The detailed map can be used to evaluate and explore the mineral-resource potential of the area. Mapping in the central Texas urban growth corridor northeast of Austin produced one map (the Taylor quadrangle) that extends previous mapping in this critical urban growth and transportation corridor. This map addresses the ongoing need for planning and managing groundwater, surface water, land use, and construction projects where rapid population growth and suburban development have caused an increased demand for water and earth resources.Bureau of Economic Geolog

Oxygen fugacity and volatile content of syntectonic magmatism in the Neoarchean Abitibi greenstone belt, Superior Province, Canada

Neoarchean syntectonic intrusions from the Chibougamau area, northeastern Abitibi Subprovince (greenstone belt), may be genetically related to intrusion related gold mineralization. These magmatic-hydrothermal systems share common features with orogenic gold deposits, such as spatial and temporal association with syntectonic magmatism. Genetic association with magmatism, however, remains controversial for many greenstone belt hosted Au deposits. To precisely identify the link between syntectonic magmas and gold mineralization in the Abitibi Subprovince, major and trace-element compositions of whole rock, zircon, apatite, and amphibole grains were measured for five intrusions in the Chibougamau area; the Anville, Saussure, Chevrillon, Opémisca, and Lac Line Plutons. The selected intrusions are representative of the chemical diversity of synvolcanic (TTG suite) and syntectonic (e.g., sanukitoid, alkaline intrusion) magmatism. Chemical data enable calculation of oxygen fugacity and volatile content, and these parameters were interpreted using data collected by electron microprobe and laser ablation-inductively coupled plasma-mass spectrometry. The zircon and apatite data and associated oxygen fugacity values in magma indicate that the youngest magmas are the most oxidized. Moreover, similar oxygen fugacity and high volatile content for both the Saussure Pluton and the mineralized Lac Line intrusion may indicate a possible prospective mineralized system associated with the syntectonic Saussure intrusion

Medulloblastoma has a global impact on health related quality of life: Findings from an international cohort.

BackgroundUnderstanding the global impact of medulloblastoma on health related quality of life (HRQL) is critical to characterizing the broad impact of this disease and realizing the benefits of modern treatments. We evaluated HRQL in an international cohort of pediatric medulloblastoma patients.MethodsSeventy-six patients were selected from 10 sites across North America, Europe, and Asia, who participated in the Medulloblastoma Advanced Genomics International Consortium (MAGIC). The Health Utilities Index (HUI) was administered to patients and/or parents at each site. Responses were used to determine overall HRQL and attributes (ie specific subdomains). The impact of various demographic and medical variables on HRQL was considered-including molecular subgroup.ResultsThe majority of patients reported having moderate or severe overall burden of morbidity for both the HUI2 and HUI3 (HUI2&nbsp;=&nbsp;60%; HUI3&nbsp;=&nbsp;72.1%) when proxy-assessed. Self-care in the HUI2 was rated as higher (ie better outcome) for patients from Western versus Eastern sites, P&nbsp;=&nbsp;.02. Patients with nonmetastatic status had higher values (ie better outcomes) for the HUI3 hearing, HUI3 pain, and HUI2 pain, all P&nbsp;&lt;&nbsp;.05. Patients treated with a gross total resection also&nbsp;had better outcomes for the HUI3 hearing (P&nbsp;=&nbsp;.04). However, those who underwent a gross total resection reported&nbsp;having worse outcomes on the HUI3 vision (P&nbsp;=&nbsp;.02). No differences in HRQL were evident as a function of subgroup.ConclusionsBy examining an international sample of survivors, we characterized the worldwide impact of medulloblastoma. This is a critical first step in developing global standards for evaluating long-term outcomes