Navigating interdisciplinarity:Negotiating discipline, embodiment, and materiality on a field methods training course

This article elucidates some of the opportunities and challenges of interdisciplinary collaboration in teaching, drawing on our participant observation as both instructors of anthropological methods and honorary students of marine ecology and geomorphology methods on a research training field course. We argue that interdisciplinary methods training offers educators opportunities for self-reflexivity, recognition of the taken-for-granted aspects of our knowledge, and improved communication of the value of our work to others. However, we also show how decisions about course structure can reinforce disciplinary boundaries, limiting inter-epistemic knowledge production; how one epistemological approach may overshadow others, hindering interdisciplinary learning; and how methods training involves tacit and embodied knowledge and mastery of material methods, requiring repetition and experimentation. We offer insights into how we as educators can improve our communication of the value of anthropology and its methods. First, instructors in any discipline should develop an awareness of how their tacit knowledge affects the pedagogical process. Second, instead of enskilling instructors to teach a variety of methods, it may be more beneficial for instructors to teach their own areas of expertise, in dialogue and collaboration with other disciplines. Third, interdisciplinary courses must be carefully planned to allow equal participation of different disciplines, so that anthropology is understood on its own terms and embedded in the course from the outset

Defining and Testing EMR Usability: Principles and Proposed Methods of EMR Usability Evaluation and Rating

For more information about the Information Experience Laboratory, visit http://ielab.missouri.edu/Electronic medical record (EMR) adoption rates have been slower than expected in the United States, especially in comparison to other industry sectors and other developed countries. A key reason, aside from initial costs and lost productivity during EMR implementation, is lack of efficiency and usability of EMRs currently available. Achieving the healthcare reform goals of broad EMR adoption and “meaningful use” will require that efficiency and usability be effectively addressed at a fundamental level. We conducted a literature review of usability principles, especially those applicable to EMRs. The key principles identified were simplicity, naturalness, consistency, minimizing cognitive load, efficient interactions, forgiveness and feedback, effective use of language, effective information presentation, and preservation of context. Usability is often mistakenly equated with user satisfaction, which is an oversimplification. We describe methods of usability evaluation, offering several alternative methods for measuring efficiency and effectiveness, including patient safety. We provide samples of objective, repeatable and cost‐efficient test scenarios applicable to evaluating EMR usability as an adjunct to certification, and we discuss rating schema for scoring the results. (42 pages

Distribution of Angiostrongylus vasorum and Crenosoma vulpis in red foxes (Vulpes vulpes) in Newfoundland, Canada

Angiostrongylus vasorum, the French heartworm, and Crenosoma vulpis, a lungworm, infect the pulmonary arteries and the bronchi and bronchioles, respectively, o f red foxes (Vulpes vulpes). Both are widespread in Europe, but within North America the distribution of A. vasorum is limited to the island of Newfoundland, Canada. During 2000-2002, 366 fox carcasses were collected from 6 regions o f the island. This study is unique in being the first large-scale survey of A. vasorum and C. vulpis in a natural fox population. Its objectives were to determine the precise distribution o f both parasites in Newfoundland and to examine the possibility of interaction between them. Crenosoma vulpis occurred in all 6 regions at an overall prevalence o f 87% and a mean intensity o f 230 ± 20.8 (mean ± S.E.). Young-of-the-year foxes had higher mean intensities (260 ± 39.4) than yearlings (91 ± 31.2) or adults (78 ± 41.1) (F[2, 153] = 11.07, p < 0.001). The intensity o f C. vulpis was not related to host sex, omental fat ratio, or body fat index. There was a weak positive relationship between number of adult worms and output of first-stage larvae in feces (r2 = 0.199, Ff[1,135] = 34.84, p < 0.001); larval output decreased with increasing fox age (F[2,127 ] = 18.99,p< 0.001). Angiostrongylus vasorum occurred only in the 3 southeast regions of the island; the Avalon Peninsula, the North East Coast, and the South Coast/Burin Peninsula. Its distribution may be limited by cold temperatures as it did not occur in areas where mean winter temperatures were lower than -4°C . The prevalence was 56% and mean intensity 72 ± 7.6. The number of adult worms did not differ with host age, sex, omental fat ratio, or body fat index. Although named the French heartworm, 88% of all A. vasorum were recovered from the pulmonary arteries while the remainder were in the right ventricle. However, 78% o f infected foxes had at least one worm in the right ventricle. Although the number of A. vasorum did not differ between the pulmonary arteries o f the left and right lobes (F[1, 164] = 1.70, p= 0.194), there were more worms in the arteries o f the posterior lobes (47 ± 5.4) than in the anterior (24 ± 2.5) (F[1, 161] = 13.39, p < 0.001). Also, there were no relationships between the number of A vasorum and larval output, heart weight ratio, or ventricular ratio. Although 40% of foxes from the A. vasorum positive regions had both A. vasorum and C. vulpis infections, there was no interaction between the two parasites (Gc[1] = 0.10). Furthermore, there was no linear relationship between the two parasites, and the mean intensity of each nematode did not differ between single and dual infections. Eight coyotes (Canis latrans) from Newfoundland were also examined. None had A. vasorum, but 38% had C. vulpis, although the mean intensity (16 ± 10.2) was lower than that in foxes

Limitations in Predicting Radiation-Induced Pharmaceutical Instability during Long-Duration Spaceflight

As human spaceflight seeks to expand beyond low-Earth orbit, NASA and its international partners face numerous challenges related to ensuring the safety of their astronauts, including the need to provide a safe and effective pharmacy for long-duration spaceflight. Historical missions have relied upon frequent resupply of onboard pharmaceuticals; as a result, there has been little study into the effects of long-term exposure of pharmaceuticals to the space environment. Of particular concern are the long-term effects of space radiation on drug stability, especially as missions venture away from the protective proximity of the Earth. Here we highlight the risk of space radiation to pharmaceuticals during exploration spaceflight, identifying the limitations of current understanding. We further seek to identify ways in which these limitations could be addressed through dedicated research efforts aimed towards the rapid development of an effective pharmacy for future spaceflight endeavors.Comment: in press, Nature Microgravit

Role of renal prostaglandins during antidiuresis and water diuresis in man

Role of renal prostaglandins during antidiuresis and water diuresis in man. The relationship of renal prostaglandins to antidiuretic hormone action and water diuresis was examined in 13 normal subjects and 2 subjects with diabetes insipidus. Following overnight water deprivation, an oral water load caused a prompt and sustained rise in the rate of urinary PGE2 excretion from 7.7 ± 1.2 to 81.6 ± 26.4 ng/hr (P < 0.0001) in 7 normal subjects. Because the simultaneous increase in urinary excretion of urea was only 17% of the rise in urinary PGE2, passive wash-out of renal PGE2 probably accounts for only a small fraction of the increment in PGE2 excretion. Administration of the antidiuretic hormone analogue DDAVP to 6 normal subjects during sustained water diuresis resulted in a decrease in PGE2 excretion and urine flow rate comparable to that of dehydrated subjects. Thus, PGE2 excretion varied directly with urine flow rate over a wide range of states of hydration in all 13 normal subjects. One patient with central diabetes insipidus and one with nephrogenic diabetes insipidus demonstrated a similar positive correlation of PGE2 excretion rate and urinary flow rate in states of hydration, dehydration, and after administration of DDAVP. In the patient with nephrogenic diabetes insipidus, this relationship of PGE2 excretion rate to urine flow rate was unaffected by DDAVP over a broad range of urine flow rates. Inhibition of prostaglandin synthesis with indomethacin in 6 normal subjects resulted in a significant decline in free water clearance (7.7 ± 1.0 to 4.7 ± 0.9 ml/min, P < 0.001) and an increase in the minimal UOSM (61 ± 4 to 93 ± 19 mOsm/kg, P < 0.01) achieved during water diuresis without a change in creatinine or osmolar clearances. Furthermore, the tightly linked relationship of PGE2 excretion rate to urine flow rate was reduced in 5 of 6 subjects during indomethacin treatment. We conclude that urinary PGE2 excretion varies directly with urine flow rate and is not directly dependent on ADH activity or state of hydration in man. The rise in PGE2 excretion during water diuresis may enhance the excretion of free water since indomethacin treatment blunted free water clearance while suppressing the rise in PGE2 excretion.Rôle des prostaglandines rénales au cours de l'antidiurèse et de la diurèse aqueuse chez l'homme. La relation entre les prostaglandines rénales et l'action de l'hormone antidiurétique et la diurèse aqueuse a été étudiée chez 13 sujets normaux et 2 sujets atteints de diabète insipide. A la suite d'une restriction d'eau pendant la nuit précédant l'étude, une charge d'eau par voie orale a déterminé une augmentation rapide et prolongée du débit urinaire de PGE2 de 7,7 ± 1,2 à 81,6 ± 26,4 ng/hr (P < 0,001) chez 7 sujets normaux. Puisque l'augmentation simultanée de l'excrétion urinaire d'urée était seulement de 17% de l'augmentation de la PGE2 urinaire, un lavage passif de la PGE2 rénale explique probablement une partie seulement de l'augmentation de l'excrétion de PGE2. L'administration d'un analogue de l'hormone antidiurétique, DDAVP, à 6 sujets normaux au cours d'une diurèse aqueuse prolongée a eu pour conséquence une diminution de l'excrétion de PGE2 et du débit urinaire comparable à celle des sujets déshydratés. Ainsi l'excrétion de PGE2 varie directement avec le débit urinaire sur un large éventail d'états d'hydratation chez tous les 13 sujets normaux. Un malade atteint de diabète insipide central et un malade atteint de diabète insipide néphrogénique ont eu une corrélation positive semblable du débit d'excrétion de PGE et du débit urinaire dans les états d'hydratation, de déshydratation, et après l'administration de DDAVP. Chez le malade atteint de diabète insipide néphrogénique, cette relation de l'excrétion de PGE2 au débit urinaire n'a pas été affectée par DDAVP sur un large éventail de valeurs du débit urinaire. L'inhibition de la synthèse de prostaglandine par l'indométhacine chez 6 sujets normaux a eu pour conséquence une diminution significative de la clairance de l'eau libre (7,7 ± 1,0 à 4,7 ± 0,9 ml/mn, P < 0,001) et une augmentation de la valeur minimale de UOSM (61 ± 4 à 93 ± 19 mOsm/kg, P < 0,01) obtenues au cours d'une diurèse aqueuse sans modification de la clairance de la créatinine ou de la clairance osmolaire. De plus, la relation étroite entre l'excrétion de PGE2 et le débit urinaire a été réduite chez 5 des 6 sujets au cours du traitement par l'indométhacine. Nous concluons que l'excrétion urinaire de PGE2 varie directement avec le débit urinaire et n'est pas directement dépendante de l'activité de l'ADH ou de l'état d'hydratation chez l'homme. L'augmentation de l'excrétion de PGE2 au cours de la diurèse aqueuse peut accroître l'excrétion d'eau libre puisque le traitement par l'indométhacine atténue la clairance de l'eau libre en même temps qu'il supprime l'augmentation de l'excrétion de PGE2

George’s Island, Labrador - A high-density predator-free refuge for a woodland caribou subpopulation?

The movement patterns and demographic parameters were measured for caribou (Rangifer tarandus caribou) on George&rsquo;s Island (Labrador, Canada) to determine if the population is separate from the Mealy Mountain Caribou Herd. Movements between George&rsquo;s Island caribou and nearby Mealy Mountain caribou were examined through satellite telemetry (April 2005 to April 2006). Demographic information was collected through aerial classification surveys. The predator-free island is currently maintaining a density of 22.5-26.5 caribou/km2. Female survival appears high and the recruitment rate in late fall-early spring was 19.0-29.2% calves. Mainland caribou moved very little throughout the year, travelling no more than 53.7 km on average from their initial collaring locations. Also, satellite data indicated no mixing between animals on George&rsquo;s Island and the mainland. The elevated caribou density and high proportion of calves suggest that George&rsquo;s Island could at times be acting as a predator-free recruitment area and that George&rsquo;s Island may be a subpopulation from which animals disperse to the mainland