14 research outputs found
Estimating the Non-Monetary Burden of Neurocysticercosis in Mexico
Neurocysticercosis (NCC) is a major public health problem caused by the larvae of the parasite Taenia solium. The condition occurs when humans ingest eggs of the pork tapeworm Taenia solium, which then develop into larvae in the central nervous system. The disease is predominantly found and considered important in Latin American, Asian, and African countries and is associated with a large social and economic burden. Very few studies have been conducted to evaluate the burden of NCC and there are no estimates from Mexico. We estimated the disability adjusted life years (DALYs) lost due to NCC in Mexico incorporating morbidity and mortality due to NCC-associated epilepsy, and morbidity due to NCC-associated severe chronic headaches. NCC-associated epilepsy and severe chronic headaches were estimated to cause a loss of approximately 0.25 healthy year of life per 1,000 persons annually in Mexico. This is the first estimate of DALYs associated with NCC in Mexico. However, this value is likely to be underestimated since only the clinical manifestations of epilepsy and severe chronic headaches were included
Pre-hospitalization, hospitalization, and post-hospitalization costs of patients with neurocysticercosis treated at the Instituto Nacional de Neurologia y Neurocirugia (INNN) in Mexico City, Mexico
ABSTRACT The objective of this study was to estimate the direct costs associated with the diagnosis and treatment of neurocysticercosis (NCC) during pre-hospitalization, hospitalization, and post-hospitalization periods for 108 NCC patients treated at the Instituto Nacional de Neurologia y Neurocirugia (INNN) in Mexico City, Mexico. Information on clinical manifestations, diagnostic tests, hospitalizations, surgical procedures, prescription medication, and other treatments was collected via medical chart reviews. Uncertain values for costs and frequency of treatments were imputed using bootstrap techniques. The average per-patient pre-hospitalization and hospitalization costs were US 2,576 (95% CI: 2,244 – 2,908), respectively. Post-hospitalization costs tended to decrease over time, with estimates for the first five years post-hospitalization of US 228 (95% CI: 167 – 288), US 150 (95% CI: 106 – 204), and US$ 91 (95% CI: 27 – 154), respectively. NCC results in a significant economic burden for patients requiring hospitalization, with this burden continuing years post-hospitalization
The monetary burden of cysticercosis in Mexico.
BackgroundTaenia solium cysticercosis is a public health and agricultural problem in many low and middle-income countries where health education, sanitation, pig management practices and meat inspection infrastructure are insufficient. Cysticercosis affects both human and animal health and has important economic consequences. Very few studies have been conducted to evaluate the monetary burden of cysticercosis. This study aimed at estimating the 2015 costs associated with cysticercosis in humans and pigs in Mexico.MethodsThe monetary burden of human cysticercosis was estimated based on costs incurred by living with and treating epilepsy and severe chronic headaches associated with neurocysticercosis (NCC). The estimated cost of porcine cysticercosis took into consideration losses due to the reduction in the price of cysticercosis-infected animals. Epidemiologic and economic data were obtained from the published literature, government reports, and setting-specific questionnaires. Latin hypercube sampling methods were employed to sample the distributions of uncertain parameters and to estimate 95% credible regions (95% CRs). All results are reported in 2015 U.S.215,775,056 (95% CR U.S.361,924,224), with U.S.296 -U.S.54.26 million, assuming that these individuals earned Mexico's median wage salary. An additional U.S.5,734,782 -U.S.$35,913,487) was estimated to be lost due to porcine cysticercosis.ConclusionsThis study suggests that T. solium cysticercosis results in considerable monetary losses to Mexico
Sensitivity analysis of the total NCC-associated DALYs estimate for Mexico.
<p>Note: DW = Disability Weight.</p
Annual number of DALYs lost due to NCC-associated epilepsy and severe chronic headaches in Mexico.
<p>(A) DALYs lost due to NCC-associated epilepsy. (B) DALYs lost due to NCC-associated severe chronic headaches. (C) DALYs lost due to NCC-associated epilepsy and severe chronic headaches. Note: The bar height in the figure represents the estimated number of DALYs lost. The plot whiskers represent the 95% CR.</p
Flowchart of study selection for the literature review of epilepsy prevalence in Mexico.
<p>Flowchart of study selection for the literature review of epilepsy prevalence in Mexico.</p
Flowchart for estimating the incidence of NCC-associated epilepsy in Mexico.
<p>Note: Please refer to <a href="http://www.plosntds.org/article/info:doi/10.1371/journal.pntd.0001521#pntd-0001521-t001" target="_blank">Table 1</a> for information concerning the uncertainty distributions associated with the specific parameters. All data were stratified by rural/urban residence.</p
Estimated annual number of DALYS due to NCC-associated epilepsy and severe chronic headaches in Mexico.
<p>*credible region.</p
Estimated annual incidence cases of NCC-associated epilepsy and severe chronic headaches in Mexico.
<p>*credible region.</p