Pan American Climate Study (PACS) mooring deployment cruise report : R/V Roger Revelle cruise number Genesis 4, 9 April-5 May 1997

Three surface moorings were deployed in the eastern equatorial Pacifc from the R/V Roger Revelle as part of the Pan American Climate Study (PACS). PACS is a NOAA-funded study with the goal of investigating links between sea surface temperature varabilty in the tropical oceans near the Americas and climate over the American continents. The three moorings were deployed near 125°W, spanning the strong meridional sea surface temperature gradient associated with the cold tongue south of the equator and the warmer ocean north of the equator, near the northernmost, summer location of the Intertropical Convergence Zone. The mooring deployment was done to improve understading of the air-sea fluxes and of the processes that control the evolution of the sea surface temperature field in the region. Two surface moorings of the Upper Ocean Processes Group at the Woods Hole Oceanographic Institution (WHOI) were deployed-one at 3°S, 125°W and the other at lO°N, 125°W. One mooring from the Ocean Circulation Group (R. Weisberg) at the University of South Florida (USP) was deployed on the equator at 128°W. The buoys of the two WHOI moorings were each equipped with meteorological instrmentation, including a Vector Averaging Wind Recorder, and an Improved Meteorological (IMET) system. The WHOI moorings also carried Vector Measurng Current Meters, single-point temperature recorders, and conductivity and temperature recorders located in the upper 200 meters of the mooring line. In addition to the instrumentation noted above, a variety of other instruments, including an acoustic current meter, acoustic doppler current meters, bio-optical instrument packages and an acoustic rain gauge, were deployed during the PACS field program. The USF mooring had an IMET system on the surface buoy and for oceanographic instrumentation, two RD Instruments acoustic doppler current profilers, single-point temperature recorders, and conductivity and temperature recorders. Conductivity-temperature-depth (CTD) profiles were made at each mooring site and during the transit between mooring locations. This report describes, in a general manner, the work that took place durig the Genesis 4 cruise aboard the R/V Roger Revelle. The three surface moorings deployed during this cruise will be recovered and re-deployed after approximately nine months, with a final recovery planned for 17 months after the first setting. Details of the mooring designs and preliminary data from the CT profies are included.Funding was provided by the National Oceanic and Atmospheric Administration under Contract No. NA66GP0130

Finishing the euchromatic sequence of the human genome

The sequence of the human genome encodes the genetic instructions for human physiology, as well as rich information about human evolution. In 2001, the International Human Genome Sequencing Consortium reported a draft sequence of the euchromatic portion of the human genome. Since then, the international collaboration has worked to convert this draft into a genome sequence with high accuracy and nearly complete coverage. Here, we report the result of this finishing process. The current genome sequence (Build 35) contains 2.85 billion nucleotides interrupted by only 341 gaps. It covers ∼99% of the euchromatic genome and is accurate to an error rate of ∼1 event per 100,000 bases. Many of the remaining euchromatic gaps are associated with segmental duplications and will require focused work with new methods. The near-complete sequence, the first for a vertebrate, greatly improves the precision of biological analyses of the human genome including studies of gene number, birth and death. Notably, the human enome seems to encode only 20,000-25,000 protein-coding genes. The genome sequence reported here should serve as a firm foundation for biomedical research in the decades ahead

Factors Associated with Revision Surgery after Internal Fixation of Hip Fractures

Background: Femoral neck fractures are associated with high rates of revision surgery after management with internal fixation. Using data from the Fixation using Alternative Implants for the Treatment of Hip fractures (FAITH) trial evaluating methods of internal fixation in patients with femoral neck fractures, we investigated associations between baseline and surgical factors and the need for revision surgery to promote healing, relieve pain, treat infection or improve function over 24 months postsurgery. Additionally, we investigated factors associated with (1) hardware removal and (2) implant exchange from cancellous screws (CS) or sliding hip screw (SHS) to total hip arthroplasty, hemiarthroplasty, or another internal fixation device. Methods: We identified 15 potential factors a priori that may be associated with revision surgery, 7 with hardware removal, and 14 with implant exchange. We used multivariable Cox proportional hazards analyses in our investigation. Results: Factors associated with increased risk of revision surgery included: female sex, [hazard ratio (HR) 1.79, 95% confidence interval (CI) 1.25-2.50; P = 0.001], higher body mass index (fo