Adrian Daub, La Pensée selon la tech. Le paysage intellectuel de la Silicon Valley

Adrian Daub est professeur de littérature comparée à l’Université de Stanford. Son livre retrace l’histoire d’idées et de concepts mobilisés par les entreprises technologiques de la Silicon Valley pour expliquer combien leurs produits méritent de s’émerveiller alors qu’ils n’ont rien de spectaculaire en soi. Pour rendre les transformations qu’ils engendrent plausibles et acceptables, une contextualisation reste indispensable. Elle passe par des histoires de genèse. A. Daub les introduit par ..

Livio Belloi, Michel Delville, Christophe Levaux, Christophe Pirenne, éds, Boucle et répétition. Musique, littérature, arts visuelsBoucle et répétition. Musique, littérature, arts visuels

Au sein de cet ouvrage collectif, neuf contributions décrivent les usages et sens de la boucle et de la répétition dans des œuvres de la sphère artistique du début du xxe siècle à nos jours. Dans le chapitre intitulé « Raymond Roussel, James Joyce : “extremes meet” » (pp. 15-28), Mathieu Jung met en relation les deux écrivains à travers Impressions d’Afrique (1910), Locus Solus (1914) et Comment j’ai écrit certains de mes livres (1935) pour le premier, et Ulysse (1922) et Finnegans Wake (1939..

Gabriel Mugny, Juan Manuel Falomir-Pichastor, Alain Quiamzade, Influences sociales

On a généralement tendance à attribuer à l’influençabilité des traits peu flatteurs (dépendance, faiblesse de caractère) plutôt que de vouloir reconnaître ses vertus. L’image valorisée dans la société occidentale d’un individu autonome et responsable est peu compatible avec la conception du même individu soumis à des phénomènes d’influence. Pourtant, force est de constater que ceux-ci infusent à travers des dynamiques complexes, généralement faites d’interactions sociales, contribuant à façon..

Identification of OCA2 as a novel locus for the co-morbidity of asthma-plus-eczema

Background: Numerous genes have been associated with the three most common allergic diseases (asthma, allergic rhinitis or eczema) but these genes explain only a part of the heritability. In the vast majority of genetic studies, complex phenotypes such as co- morbidity of two of these diseases, have not been considered. This may partly explain missing heritability. Objective: To identify genetic variants specifically associated with the co-morbidity of asthma-plus-eczema. Methods: We first conducted a meta-analysis of four GWAS (Genome-Wide Association Study) of the combined asthma-plus-eczema phenotype (total of 8807 European-ancestry subjects of whom 1208 subjects had both asthma and eczema). To assess whether the association with SNP(s) was specific to the co- morbidity, we also conducted a meta-analysis of homogeneity test of association according to disease status (“asthma-plus-eczema” vs. the presence of only one disease “asthma only or eczema only”). We then used a joint test by combining the two test statistics from the co-morbidity-SNP association and the phenotypic heterogeneity of SNP effect meta-analyses. Results: Seven SNPs were detected for specific association to the asthma-plus-eczema co-morbidity, two with significant and five with suggestive evidence using the joint test after correction for multiple testing. The two significant SNPs are located in the OCA2 gene (Oculocutaneous Albinism II), a new locus never detected for significant evidence of association with any allergic disease. This gene is a promising candidate gene, because of its link to skin and lung diseases, and to epithelial barrier and immune mechanisms. Conclusion: Our study underlines the importance of studying sub-phenotypes as co-morbidities to detect new susceptibility genes

Genome-wide interaction study of early-life smoking exposure on time-to-asthma onset in childhood

Background: Asthma, a heterogeneous disease with variable age of onset, results from the interplay between genetic and environmental factors. Early-life tobacco smoke (ELTS) exposure is a major asthma risk factor. Only a few genetic loci have been reported to interact with ELTS exposure in asthma. Objective: Our aim was to identify new loci interacting with ELTS exposure on time-to-asthma onset (TAO) in childhood.Methods: We conducted genome-wide interaction analyses of ELTS exposure on time-to-asthma onset in childhood in five European-ancestry studies (totaling 8,273 subjects) using Cox proportional-hazard model. The results of all five genome-wide analyses were meta-analyzed.Results: The 13q21 locus showed genome-wide significant interaction with ELTS exposure (P=4.3x10-8 for rs7334050 within KLHL1 with consistent results across the five studies). Suggestive interactions (P<5x10-6) were found at three other loci: 20p12 (rs13037508 within MACROD2; P=4.9x10-7), 14q22 (rs7493885 near NIN; P=2.9x10-6) and 2p22 (rs232542 near CYP1B1; P=4.1x10-6). Functional annotations and the literature showed that the lead SNPs at these four loci influence DNA methylation in the blood and are located nearby CpG sites reported to be associated with exposure to tobacco smoke components, which strongly support our findings.Conclusion and Clinical Relevance: We identified novel candidate genes interacting with ELTS exposure on time-to-asthma onset in childhood. These genes have plausible biological relevance related to tobacco smoke exposure. Further epigenetic and functional studies are needed to confirm these findings and to shed light on the underlying mechanisms

Fictional Representations of Surveillance. Contemporary Dystopias from repetition to innovation

Une quinzaine d'oeuvres provenant de champs artistiques et culturels différents [littérature et cinéma] réunies par un dénominateur commun, seront soumises à notre questionnement : existe-t-il un idéal type de société sous surveillance ? A travers l'usage de la taxinomie et une approche comparatiste, nous dresserons une typologie des images comme éléments clés des représentations. Au système de multiplication de référents symboliques interne à chaque oeuvre s'ajoute celui d'un réseau de correspondances visuelles exogène basé sur un référentiel d'images quasi immuable. Les oeuvres se révèlent riches en sens et en symboles. Les nombreuses images convoquées par l'écrivain par le biais de métaphores ou autres tropes, rejoignent celles du réalisateur. Une étude transversale aboutit à un répertoire de codifications visuelles portant sur des univers imaginaires. On constate ainsi par ce biais un processus incessant de recyclage d'idées et d'histoires, qui se muent en standard et permettent de capturer une audience de plus en plus internationale, tout en forgeant un imaginaire social qui s'instaure par contagion. Les propos servis sont sérieux. L'ensemble dissémine une vision du monde qui obéit le plus souvent au principe de rationalisation, censé de s ' inscrire dans un ordre du contrôle et de la manipulation. Jaillissent des mondes nouveaux, comme porteurs de révélations quasi universelles. Nos auteurs [de science-fiction] s'inscrivent dans une longue tradition [l'utopie]. Mais la pression du genre, des motifs obligés et des conventions, n'entame pas leur capacité au renouveau, et la redite n'est pas un frein à l'innovation.About fifteen works from different artistic and cultural backgrounds [literature and cinema], and sharing a common denominator, will be submitted to our questioning: is there an ideal type of society under surveillance? Through the use of taxonomy and a comparatist approach, we will draw up a typology of images as key elements of our representations. The system of multiplying symbolic referents inherent in each work completes a network of visual exogenous correspondence based on a relatively steady image referential. Works prove to be rich, both in meaning and symbol. The many images used by the writer, by means of metaphors or other tropes, meet that of a fiction director. A transversal study leads to a directory of visual codifications bearing upon imaginary worlds. This is how we observe an incessant process of recycling ideas and stories, that evolve into standards, thus enabling to capture the eye of an ever more international public, while forging a social imaginary world, settling in by way of contagion. The topics dealt with are serious. As a whole, they disseminate a vision of the world that obeys, most of the time, a rationalization principle that is supposed to be in line with control and manipulation. New worlds arise, bringing out universal eye-openers. Our [science-fiction] authors fall in with a long tradition [utopia]. But the genre, via obligated topics and conventions, do not for as much pressure one to diminish their capacity for renewal, and repetition does not curb their innovation

Delphine SAURIER (2013), La fabrique des illustres. Proust, Curie, Joliot et lieux de mémoire

Pourquoi certains artistes fêtés de leur vivant tombent-ils dans l’anonymat après leur mort, tandis que d’autres, contestés, voire délaissés au cours de leur vie, connaissent une brillante carrière et accèdent à la renommée de façon posthume ? C’est pour répondre à cette interrogation que Delphine Saurier entreprend d’analyser, sur un mode comparatiste et une période de 50 ans, la construction d’hommes et de femmes célèbres. Plus encore, les figures, choisies notamment sur la base de leurs di..

Dental status of new caledonian children: is there a need for a new oral health promotion programme?

Before implementing a new oral health promotion program in the French overseas territory of Nouvelle Calédonie, the health authorities needed recent data about dental status of the New Caledonian child population.This study aimed to describe the dental status of 6, 9 and 12-yr-old New Caledonian children and to investigate the environmental and behavioural risk factors related to oral health.A randomly selected sample of 2734 children (744 6-yr-olds, 789 9-yr-olds, and 1201 12-yr-olds) was examined clinically by seven calibrated investigators and participants responded to a questionnaire. The main variables were objective criteria about dental status and subjective criteria about experience of dental care, dental fear, self-perception of oral health, cultural or ethnic identity and environmental and behavioural risk factors.Overall, most of the children had infectious oral diseases: more than 50% had gingivitis, and 60% of 6- and 9 yr-olds had at least one deciduous or permanent tooth with untreated caries. The mean 12-yr-old number of decayed missing and filled teeth (DMFT) was 2.09±2.82. The number of carious lesions was related to the unfavourable lifestyle, deprived social status and no preventive dental care. Kanak, Polynesians and Caledonians (respectively 27%, 18% and 45% of the study sample) were more affected by caries than metropolitan French and Asian children. Children with many untreated carious lesions had negative perceptions of their oral health; they complained of chewing difficulty and had higher scores for dental anxiety.This study highlights the need for new strategies aimed at improving oral health and at reducing inequalities in New Caledonia. An oral health promotion program would need to be developed in connection with other health programmes using the common risk factor approach within the context of the local environment

Common risk indicators for oral diseases and obesity in 12-year-olds: a South Pacific cross sectional study

Abstract Background Despite the increasing need to prevent obesity and oral diseases in adolescents worldwide, few studies have investigated the link existing between these conditions and their common risk factors. This study aims to evaluate the oral health and weight status of New Caledonian Children (aged 6,9,12 years) and to identify, amongst 12-year-olds, risk indicators that may characterize the groups of children affected by oral diseases, obesity or both diseases. Methods This survey evaluated in 2011–2012 the oral health and stature-weight status and related risk indicators in a national representative sample of 6, 9 and 12 years-old children in New Caledonia. Dental status, chewing efficiency, height, weight and waist circumference were clinically recorded at school. The body mass index (BMI) and the waist to height ratio (WtHR) were calculated. For BMI the WHO Cut-offs were used. Twelve years-old participants responded to a questionnaire concerning socio-demographic and behavioural variables. For statistical analysis, the Clinical Oral and Global Health Index (COGHI) was developed and used. Twelve years-old children were categorised into four groups; Oral Diseases (ODG), Obesity (OG), Obesity and Oral Diseases (ODOG) and a Healthy Group (HG). A multivariate analysis was conducted using mixed-effects multinomial logistic regression models. Results Prevalence of overweight and obesity was greatly increasing from 6 years (respectively 10.8% [8.8;13.3] and 7.8% [6.0;9.9]) to 12 years (respectively 22.2% [19.9;24.7] and 20.5% [18.2;22.9]) and one third of the 12-yr-olds had an excess of abdominal adiposity. At age 12, 36.6% of the children were healthy (HG), 27.3% had oral diseases (ODG), 19.7% were obese (OG) and 16.5% had both conditions (ODOG). Geographical location, ethnicity, tooth-brushing frequency and masticatory disability were significant risk factors for the OG, ODOG and ODG groups. Ethnicity and masticatory impairment were common risk indicators for the association of oral diseases and obesity. Conclusions In NC health promotion programs should be specifically addressed towards Native populations who are particularly exposed to oral diseases and obesity, integrating a multiple risk factors approach, in order to prevent the onset of chronic diseases in adulthood. The impact of masticatory ability on children’s weight status is a major issue for future research