First-line therapy with gemcitabine and paclitaxel in locally, recurrent or metastatic breast cancer: A phase II study

BACKGROUND: This phase II study evaluated the efficacy and safety of gemcitabine (G) plus paclitaxel (T) as first-line therapy in recurrent or metastatic breast cancer. METHODS: Patients with locally, recurrent or metastatic breast cancer and no prior chemotherapy for metastatic disease received G 1200 mg/m(2 )on days 1 and 8, and T 175 mg/m(2 )on day 1 (before G) every 21 days for a maximum of 10 cycles. RESULTS: Forty patients, 39 metastatic breast cancer and 1 locally-advanced disease, were enrolled. Their median age was 61.5 years, and 85% had a World Health Organization performance status (PS) of 0 or 1. Poor prognostic factors at baseline included visceral involvement (87.5%) and ≥2 metastatic sites (70%). Also, 27 (67.5%) patients had prior adjuvant chemotherapy, 25 of which had prior anthracyclines. A total of 220 cycles (median 6; range, 1–10) were administered. Of the 40 enrolled patients, 2 had complete response and 12 partial response, for an overall response rate of 35.0% for intent-to-treat population. Among 35 patients evaluable for efficacy the response rate was 40%. Additional 14 patients had stable disease, and 7 had progressive disease. The median duration of response was 12 months; median time to progression, 7.2 months; median survival, 25.7 months. Common grade 3/4 toxicities were neutropenia in 17 (42.5%) patients each, grade 3 leukopenia in 19 (47.5%), and grade 3 alopecia in 30 (75.0%) patients; 1 (2.5%) patient had grade 4 thrombocytopenia. CONCLUSION: GT exhibited encouraging activity and tolerable toxicity as first-line therapy in metastatic breast cancer. Phase III trials for further evaluation are ongoing

LatHyS hybrid simulation of the August, 10 2021 BepiColombo Venus flyby

International audienceThe 2nd Venus flyby of BepiColombo has been examined and compared by the newly developed global hybrid simulation LatHyS for the Venusian environment. The LatHyS has been first validated by comparison with Venus Express observations, then using the observation from Solar Orbiter, which was located in the upstream region and both observed the same solar wind, it is applied for the Venus flyby. The simulation successfully reproduced the observed signatures and it shows that BepiColombo passed through the stagnation region of Venus, which supports the results obtained by data-analysis. In addition, we have sampled the plasma information along the trajectory and constructed the energy spectrum for three species (solar wind proton, planetary proton, and planetary oxygen ion) and possible effect due to the limited field of view is discussed. Moreover, ion escape from Venus for planetary species have been discussed and the escape rate is estimated

LatHyS global hybrid simulation of the BepiColombo second Venus flyby

International audiencePlasma and magnetic field observations by BepiColombo during its 2nd Venus flyby in August 10, 2021 have been examined and compared with the newly developed global hybrid simulation LatHyS for the Venusian environment. The LatHyS-Venus simulation was first validated by a comparison with Venus Express observations obtained during average solar wind conditions, before it was applied to the BepiColombo flyby using as inputs solar wind parameters measured upstream of Venus by Solar Orbiter. The simulation confirms that BepiColombo passed through the stagnation region of Venus, which supports the results obtained by data analysis. In addition, we have sampled the plasma parameters along the BepiColombo trajectory and constructed the energy spectrum for two species, i.e., protons of both solar wind and planetary origin, and planetary oxygen ions, and discussed the possible effects due to the limited field of views of the plasma instruments onboard BepiColombo. The most intense observational features are properly captured in the LatHyS-Venus simulation, which show that the model is a powerful tool for interpreting and understanding in-situ data obtained from the instruments with a limited field of views. The estimated ion escape for protons and oxygen ions at Venus during the BepiColombo flyby is of the order of ≃ 1024 ions/s, which is the same order of magnitude compared to the estimation from Venus Express observations at the solar minimum