Cervical HI-RTE elastography and pregnancy outcome: a prospective study

International audienceObjective: To study cervix elastography measurement and its relation with pregnancy outcome. Design: A two year prospective longitudinal study evaluated cervical elasticity by HI-RTE (Hitachi real-time tissue elastography) imaging during three trimesters of pregnancy. The main outcome measure was elastography index the cervical elastogram color-coded. Results: Three hundred eighty seven measurements were realized among 72 pregnant women prospectively enrolled. In the first trimester, the elasticity index was significantly lower in women who subsequently had unfavorable outcome than in women who delivered at term (respectively, EI = 0.51 (+/- 0.04) and 0.59 (+/- 0.02); P = 0.037). The negative predictive value of posterior lip color (blue, blue-green = hard cervix) was high NPV = 83.8 95% CI [68.8-92.4] in the first trimester (SE = 64.7 95% CI [41.3-82.7]; SP = 60.8 95% CI [47.1-72.9]; VPP = 35.5 95% CI [21.1-53.1]). A first-trimester elasticity index threshold value <= 0.38 had a specificity of 98.0% and a NPV of 80.9% (Se 29.4%, PPV 83.3%). This index value, when combined with a cervical length less than or equal to 36 mm, increased the risk of adverse outcome (HR 8.87 95% CI [3.22-23.7]). Conclusions: Cervical elastography index is associated with unfavorable obstetrical outcomes, independently of cervical length

Olegusella massiliensis gen. nov., sp nov., strain KHD7(T), a new bacterial genus isolated from the female genital tract of a patient with bacterial vaginosis

International audienceStrain KHD7(T), a Gram-stain-positive rod-shaped, non-sporulating, strictly anaerobic bacterium, was isolated from the vaginal swab of a woman with bacterial vaginosis. We studied its phenotypic characteristics and sequenced its complete genome. The major fatty acids were C16:0 (44%), C18:2n6 (22%), and C18:1n9 (14%). The 1,806,744 bp long genome exhibited 49.24% G+C content; 1549 protein-coding and 51 RNA genes. Strain KHD7(T) exhibited a 93.5% 16S rRNA similarity with Olsenella uli, the phylogenetically closest species in the family Coriobacteriaceae. Therefore, strain KHD7(T) is sufficiently distinct to represent a new genus, for which we propose the name Olegusella massiliensis gen. nov., sp. nov. The type strain is KHD7(T). (C) 2017 Elsevier Ltd. All rights reserved