Hospitalizations for Anorexia Nervosa during the COVID-19 Pandemic in France: A Nationwide Population-Based Study

The COVID-19 pandemic has had a detrimental impact on mental health, including on food-related behaviors. However, little is known about the effect of the pandemic on anorexia nervosa (AN). We sought to assess an association between the COVID-19 pandemic and a potential increase in hospitalizations for AN in France. We compared the number of hospitalizations with a diagnosis of AN during the 21-month period following the onset of the pandemic with the 21-month period before the pandemic using Poisson regression models. We identified a significant increase in hospitalizations for girls aged 10 to 19 years (+45.9%, RR = 1.46[1.43–1.49]; p < 0.0001), and for young women aged 20 to 29 (+7.0%; RR = 1.07[1.04–1.11]; p < 0.0001). Regarding markers of severity, there was an increase in hospitalizations for AN associated with a self-harm diagnosis between the two periods. Multivariate analysis revealed that the risk of being admitted for self-harm with AN increased significantly during the pandemic period among patients aged 20–29 years (aOR = 1.39[1.06–1.81]; p < 0.05 vs. aOR = 1.15[0.87–1.53]; NS), whereas it remained high in patients aged 10 to 19 years (aOR = 2.40[1.89–3.05]; p < 0.0001 vs. aOR = 3.12[2.48–3.98]; p < 0.0001). Furthermore, our results suggest that the pandemic may have had a particular effect on the mental health of young women with AN, with both a sharp increase in hospitalizations and a high risk of self-harming behaviors

Spécificité de la recherche en psychiatrie ; exemple d'une étude au sein du CHU de Dijon ; étude du système télomères-télomérase et de l'expression de gênes candidats dans les leucocytes de patients atteints de troubles dépressifs (recherche de marqueurs périphériques du stress somatique)

Bien qu enjeu majeur des systèmes de santé avec presque une personne sur cinq qui vivra au cours de sa vie un trouble psychique, la recherche en psychiatrie et santé mentale n a pas encore un essor comparable aux autres disciplines médicales. Ce fait semble résulter d une double problématique : -Intrinsèque ; spécialité pluridisciplinaire par excellence, la psychiatrie pose la question de la définition de la maladie mentale, du choix d un modèle théorique, et surtout épistémologique. On observe ainsi un manque d outils ou de méthodes adaptés et standardisés. -Extrinsèque ; le manque d information du grand public et la difficulté du monde politique à prendre en considération ce champ de la santé, peuvent peut-être expliquer que la psychiatrie se trouve particulièrement sous dotée et que l on observe une importante désorganisation de la recherche avec l absence de centres de référence ou d objectifs pratiques concrets. Cette problématique a été remise en exergue par la confrontation des psychothérapies à l EVIDENCE BASED MEDECINE dans un rapport fortement polémique de l INSERM en 2004. Ce sujet est abordé à travers les difficultés rencontrées lors d une étude en cours au sein du service de psychiatrie du CHU de Dijon, et les moyens mis en œuvre pour tenir compte des différents aspectsDIJON-BU Médecine Pharmacie (212312103) / SudocSudocFranceF

Approche psychosomatique et psychiatrique du diabète (présentation de l'étude "diabète et profil psychologique")

DIJON-BU Médecine Pharmacie (212312103) / SudocSudocFranceF

Characteristics of the Depressed and Control Subjects.

<p>Characteristics of the Depressed and Control Subjects.</p

Correlative pattern of gene expression (Pearson's coefficient) in the blood leucocytes of controls and MDD subjects. For each gene the |r| value of control subjects (when significant) is in normal font weight on the upper row, and the |r| of the depressed patients in bold font weight on the lower row.

<p>Correlative pattern of gene expression (Pearson's coefficient) in the blood leucocytes of controls and MDD subjects. For each gene the |r| value of control subjects (when significant) is in normal font weight on the upper row, and the |r| of the depressed patients in bold font weight on the lower row.</p

Increased Risk of Rehospitalization for Acute Diabetes Complications and Suicide Attempts in Patients With Type 1 Diabetes and Comorbid Schizophrenia

IF 13.397 (2017)International audienceOBJECTIVE The aim of this large retrospective cohort study was to estimate the supplementary morbidity and mortality risks conferred by the co-occurrence of schizophrenia among young people with type 1 diabetes.RESEARCH DESIGN AND METHODS This nationwide population-based study included individuals aged 15–35 years hospitalized in France for type 1 diabetes from 2009 to 2012 with or without schizophrenia. For assessment of the occurrence of rehospitalization for acute diabetes complications, suicide attempts, and hospital mortality, multivariate logistic regressions and survival analysis adjusted for age, sex, and Charlson Comorbidity Index scores were performed. The association between hospitalization for suicide attempts and acute diabetes complications was further explored in a survival analysis, with the exposure of acute diabetes complications as a time-dependent covariate.RESULTS Among 45,655 individuals aged 15–35 years who were hospitalized for type 1 diabetes, 341 (0.75%) had a previous or contemporary hospitalization for schizophrenia. Within 3 years of follow-up, schizophrenia was associated with increased risks of rehospitalization for hypoglycemia (adjusted odds ratio 3.21 [95% CI 1.99–5.20]), hyperglycemia (7.01 [3.53–13.90]), ketoacidosis (2.01 [1.49–2.70]), and coma (3.17 [1.90–5.27]); hospitalization for suicide attempts (12.15 [8.49–17.38]); and hospital mortality (2.83 [1.50–5.36]). Hospitalization for a suicide attempt was associated with an increased risk of hospitalization for acute diabetes complications independently from schizophrenia (hazard ratio 3.46 [95% CI 2.74–4.38]).CONCLUSIONS Patients suffering from the combination of type 1 diabetes and schizophrenia are at increased risk of hospitalization for acute diabetes complications as well as suicide and hospital mortality. These individuals may require specific care programs and close monitoring of mental, somatic, and social health

The mean and standard deviation (inter-individual variability) of the Ct values in the depressed and control group. The I-WV value is the mean of the inter-well Ct variation (triplicate runs).

<p>The mean and standard deviation (inter-individual variability) of the Ct values in the depressed and control group. The I-WV value is the mean of the inter-well Ct variation (triplicate runs).</p